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Stroke

Researchers from National Institute of Neurological Disorders & Stroke publish findings in stroke

Published in Drug Law Weekly, January 26th, 2010

According to recent research from the United States, "We investigated the regulatory effects of GRK2 on D2 dopamine receptor signaling and found that this kinase inhibits both receptor expression and functional signaling in a phosphorylation-independent manner, apparently through different mechanisms. Overexpression of GRK2 was found to suppress receptor expression at the cell surface and enhance agonist-induced internalization, whereas short interfering RNA knockdown of endogenous GRK2 led to an increase in cell surface receptor expression and decreased agonist-mediated endocytosis."

"These effects were not due to GRK2-mediated phosphorylation of the D2 receptor as a...

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