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Cefaclor
Role of Reactive Metabolites in Serum Sickness-Like Reactions
March 31st, 2000
Reactive cefaclor metabolites may promote serum sickness-like reactions (SSLR) to cefaclor by altering the immune response, researchers say. Previous studies have demonstrated that cytokine production suppression is a key determinant of hypersensitive reactions to some drugs. B. Ling and colleagues investigated whether reactive cefaclor metabolites influence the production of the cytokine interferon (IFN) in samples of human peripheral blood mononuclear cells (PBMCs). The researchers reported their study in a conference abstract titled "Suppression of Interferon Production by Reactive Metabolites of Cefaclor," presented at the meeting of the...
Source: Drug Week (2000-03-31)
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