Published in Drug Week, September 22nd, 2000
G. Cirino and colleagues at the University of Naples in Italy explained that anti-inflammatory non-steroidal drugs that release nitric oxide (NO-NSAIDs) comprise a new class of anti-inflammatory drugs. "These compounds have been shown to retain the anti-inflammatory, analgesic, and antipyretic activity of the parent compound but to be devoid of gastrointestinal (GI) toxicity," they said.
Cirino and colleagues tested the effects of both NO- and non-NO-releasing forms of naproxen on rats with arthritis induced by Freund's adjuvant, studying the effects of...
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