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Cisplatin

Therapy prevents neuropathic effects of cisplatin chemotherapy

Published in Drug Week, October 18th, 2002

by Sonia Nichols, senior medical writer - The neuropathic effects of cisplatin chemotherapy can be combated with viral and nonviral gene therapies.

Cisplatin is just one of several compounds typically incorporated into cancer chemotherapy regimens. One of the side effects of cisplatin is sensory neuropathy, a complication compounded by increased dosing. Neurotrophin-3 (NT-3) gene therapy may avert or reduce sensory complications in patients on cisplatin, according to a new study.

"Neurotrophin-3 (NT-3) promotes the survival of the large fiber sensory neurones that are impaired in cisplatin-induced neuropathy, and may therefore serve as a preventive...

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