Alzheimer Disease

OHSU takes part in unique treatment trial

Published in Drug Week, November 15th, 2002

Researchers at Oregon Health and Science University are taking part in a multicenter, national clinical trial aimed at preventing the progression of dementia and Alzheimer disease.

The trial involves the use of a drug named LY450139, which in mouse models is shown to inhibit an enzyme implicated in the formation of beta-amyloid deposits in the brain. These deposits, also called plaques, may be responsible for brain cell death and decay, and have been connected to Alzheimer disease. A total of six sites in the United States are taking part in the clinical trial.

The double-blind, placebo-controlled trial will involve 70 subjects newly diagnosed with...

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Source: Drug Week (2002-11-15)

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