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Drug Week

Susan Hasty, Publisher

Table of Contents . . . January 10th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Drug Week | Other Publications

HIV/AIDS Therapy - Cosalane additives improve intestinal absorption

Parkinson Disease - Rasagiline appears to be an effective therapy for early disease

Fabry Disease - Preliminary results reported from new clinical study of Replagal

Hairy Cell Leukemia - Data presented on Nipent shows its capability as a franchise compound

Hodgkin Lymphoma - Phase I trial data on novel bispecific molecule H22xKi-4 reported

Infectious Disease Therapy - Continuous linezolid infusion effective against resistant S. aureus

Malignant Glioma - Phase I/II data presented for IL13-PE38

Paralysis - Atorvastatin promotes a Th2 bias, reverses paralysis in CNS autoimmune disease

Acne - Phase IIa clinical trials initiated for PCL-016 in mild-to-moderate acne

Alzheimer Disease - Alzheimer and inflammation clinical trials results reported

Anthrax - Antibiotics combined with antigen-based vaccine protects guinea pigs against anthrax

Antithrombin Deficiency - Clinical safety and efficacy trial of rhATIII begins

Anxiety Disorder - Lexapro better than placebo in trial

Arthritis - Enbrel offered to additional 40,000 arthritis patients

Arthritis - Results announced from phase III study of Enbrel dosed once weekly

Atrial Arrhythmias - Pharmaceutical company reports oral absorption of RSD1235 in humans

Attention Deficit Hyperactivity Disorder - Atomoxetine to account for about 25% of ADHD drug sales

Barrett Esophagus - Approvable letter received for Photofrin; final approval expected in 2003

Brain Metastases - Update provided on regulatory status of RSR13

Breast Cancer - Herceptin pretreatment enhances Taxol's effect in ErbB2-overexpressing cells

Cancer Therapy - Additional phase I data presented on liposomal antisense agent

Cancer Therapy - Pilot program explores viability of cell-penetrating peptide-based drugs

Cataplexy - Update provided on prescription levels for Xyrem oral solution

Chronic Lymphocytic Leukemia - Genasense shows single-agent activity in patients with advanced CLL

Clinical Trial Guidelines - NCQA issues draft standards for Human Research Protection Accreditation Program

Depression - FDA approves Lexapro oral solution

Duchenne Muscular Dystrophy - Scientists reveal potential new approach to treating muscle degeneration

Erectile Dysfunction - New study of Viagra's onset finds most men respond within 20 minutes

Erectile Dysfunction - Study: Vardenafil HCl improves ability to maintain erection to completion

Exocrine Pancreatic Deficiency - Axcan to acquire worldwide rights to Panzytrat enzyme product

Gaucher Disease - Worldwide license agreement extends Zavesca partnership

Generic Drugs - Caraco Pharmaceutical signs new R&D agreement for 25 new drugs

Glioma - Cotara receives orphan drug designation in Europe

HIV/AIDS Therapy - Glutathione-loaded erythrocytes enhance antiretroviral treatment

HIV/AIDS Therapy - Leptin levels linked to antiretroviral-induced immune recovery

HIV/AIDS Therapy - Protease inhibitor prodrugs show improved pharmacokinetics

Health Information - No more medical roulette: Publisher says internet will change in 2003

Hepatitis B Immune Globulin Therapy - Liver transplant indication BLA submitted for Nabi-HB Intravenous

Hepatitis C Therapy - Civacir receives orphan drug designation

Hormone Therapy - Hormone therapy technology licensed From Wake Forest

Hypertension - Forest updates status of lercanidipine regulatory submission

Immunosuppression - Butyrate has multiple effects on human monocyte-derived DCs, macrophages

Infectious Disease Therapy - Azithromycin effective against Shiga toxin-producing E. coli

Infectious Disease Therapy - Yeast adhesin analogs can prevent intestinal C. albicans infection

Lymphocytic Leukemia - Phase II study data reported on rituximab + fludarabine immunotherapy

Macular Edema - Enrollment complete for in phase II trial for PME treatment

Malaria - New drug shows early promise

Medication Errors - Baxter launches enhanced bar coding and information system technology

Metastatic Breast Cancer - Enrollment for pivotal phase III trial of ABI-007 completed

Migraine - Clinical data: Zomig-ZMT delivers early and sustained headache response

Multiple Myeloma - Novel drug continues to show promise in early study

Multiple Sclerosis - Betaferon now available at room temperature in the E.U.

Multiple Sclerosis - MS patients on Rebif more likely to remain relapse free

Non-Hodgkin Lymphoma - Positive pivotal phase II/III clinical trial results achieved for Onco TCS

Non-Small Cell Lung Cancer - FDA approves Taxotere for first-line treatment of patients

Nosocomial Infections - Increasing antibiotic resistance a major hospital crisis

Ophthalmology - Bucillamine suppresses choroidal neovascularization in rat model

Organ Transplant Rejection - HuMax-TAC program announced

Osteoarthritis - Pennsaid wins approvable letter from Health Canada

Pain Medicine - Company announces SGX 355, drug development candidate for neuropathic pain

Pain Medicine - U.S. Patent issued on Contulakin-G to treat pain; CGX-1160 safety trial over

Percutaneous Coronary Intervention - Long-term treatment with clopidogrel and aspirin significantly cuts risk

Pharmacodynamics - Antiangiogenic agent, Neovastat, induces endothelial cell apoptosis

Pharmacokinetics - Diacetylmorphine degradation in cell culture studied

Postoperative Ileus - Enrollment complete for phase III POI study for alvimopan

Product Rights Acquisition - Barr to acquire currently marketed products, including Ziac

Psoriatic Arthritis - Infliximab is effective, safe in clinical trial

Regulatory Issues - FDA's new head pledges more action against misleading ads

Schering-Plough Corp. - Peg-Intron and Rebetol pass 150,000-patients-treated mark in U.S.

Sleep Apnea - Approval granted to expand marketing of Provigil in the United Kingdom

Stem Cell Transplantation - Granulocyte colony-stimulating factor can hasten pediatric recovery

Therapeutic Programs - Cancer/immunotherapy company updates progress in commercial strategies

Trends - More consumers are asking their doctors for drug samples by name

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