Drug Week

Finance - Total revenues of $1.3B reported by biopharmaceutical company

HIV/AIDS Dementia - Ethanol strongly potentiates virus-induced apoptosis in brain microvascular cells

HIV/AIDS Therapy - Estrogenic steroids protect against virus-induced neural damage

HIV/AIDS Therapy - FK506 is neuroprotective in a model of antiretroviral toxic neuropathy

HIV/AIDS Therapy - Low-dose probenecid protects against cidofovir toxicity

HIV/AIDS Therapy - Protease inhibitors should target substrate-recognition residues

Healtcare Financing - Canadian online pharmacy calls for Americans to boycott Glaxo

Healthcare Marketing - Pharmaceutical ads may help African-Americans

Hemodialysis - Polysporin ointment helps prevent catheter infections

Hemorrhagic Stroke - NIH grant will support U.S. phase II clinical trials of Cerebril

Hemorrhoid Therapy - New single-use hemorrhoid treatment introduced

Hepatitis C Virus - Initial Multiferon shipment dispatched to Taiwan

Infectious Disease Therapy - ABT-773 active against human mycoplasmas

Infectious Disease Therapy - Asp-90 homolog mutations seen in ciprofloxacin-resistant Bartonella bacilliformis

Infectious Disease Therapy - Calcium-fortified foods lower gatifloxacin levels

Infectious Disease Therapy - Gemifloxacin targets staphylococcal topoisomerase IV

Infectious Disease Therapy - Linezolid activity against resistant pathogens is not oxygen-dependent

Infectious Disease Therapy - Novel cephalosporin active against Gram-positive bacteria

Infectious Disease Therapy - Novel ketolides active against resistant Streptococcus pneumoniae

Infectious Disease Therapy - Terbinafine resistance seen in clinical Trichophyton rubrum strain

Infectious Disease Therapy - Vancomycin heightens intracellular penetration of gentamicin

Influenza - FDA gives CRL for FluMist, an intranasal flu vaccine

Information Technology - PRA launches global electronic document management

Insomnia - Sepracor submits NDA for eszopiclone

Joint Ventures - Agreement with Baxter restructured

Legal Issues - U.S. Court of Appeals issues ruling on "McCormick" patents litigation

Legal Issues - Valentis wins ruling on pegylated liposome patent in Japan

Lung Cancer - Enrollment ends in squalamine trial

Malaria Therapy - Dihydroartemisinin accumulates in cerebrospinal fluid during artesunate treatment

Malaria Therapy - Dose levels, parasite genotype provide limited drug efficacy data in endemic areas

Malaria Therapy - Recombinant PfEMP1 peptide blocks P. falciparum cytoadherence

Management Changes - Holaday steps down as chairman, director, CSO

Management Changes - New chairman named at cryotherapy company

Mechanical Engineering - Mutant bacteria become microscopic motors

Mergers and Acquisitions - Biotech companies merge to form Nuvelo

Mergers and Acquisitions - Primary care business unit acquired from Elan

Methamphetamine - The emergence of potent forms of methamphetamine in Sydney, Australia

Methotrexate Resistance - An E45K-reduced folate carrier mutation may be partially responsible

Migraine Headache - Sumatriptan exposures to be avoided during pregnancy

Monoclonal Antibodies - Termination notice received; agreement breached

Mucopolysaccharidosis I - FDA issues response letter on Aldurazyme

Myocardial Infarction - Nicorandil and Amlodipine have protective effect during cardiac damage

Nodular Acne - FDA grants approval to manufacture and market Isotretinoin capsules

Osteoarthritis - Corticosteroid injections as good as Synvisc for knee osteoarthritis

Osteoporosis - Hormone PTHrP leads to significant increase in bone mineral density

Ovarian Cancer - Phase II OvaRex study demonstrates survival benefit

Ovarian Cancer - Phase II OvaRex survival data presented

Pain Therapy - Injectable acetaminophen licensing agreement signed

Patents - Infringement suit filed related to Vanamide urea cream

Pharmacology - Insect antibiotic bypasses outer defenses to kill bacteria from inside

Pharmacy Fulfillment - Priority Healthcare Corp. announces agreement for Amevive pharmacy services

Psoriasis - FDA approval of new drug signals new era of care

Pulmonary Arterial Hypertension - Company to reacquire full development and marketing rights to sitaxsentan

Quality Assurance - Pharmaceutical facility in Costa Rica certified ISO 9001

Research Funding - Two million pounds of yeast could triple available drug treatments

Rheumatoid Arthritis - ARMADA study with Humira shows improvement in patients with RA

Rheumatoid Arthritis - Enrollment completed in phase IIb trial of Eculizumab

Rheumatoid Arthritis - FDA approves IND to investigate HuMax-IL15 to treat rheumatoid arthritis

Sepsis - Catheter for early assessment of sepsis launched

Sepsis - Drotrecogin alfa is a cost-effective treatment for severe sepsis patients

Shock - Opioid receptor antagonists block arterial muscle cell Ca2+-activated K+ channels

Small Molecule Drugs - Psychiatric Genomics selects chemistry partner for drug discovery and development

Smallpox - Protection project launched to counter bioterrorism

Stem Cell Transplantation - Skeletal effects of cyclosporin A are gender related in rats

Stock Market - Nasdaq staff determination letter issued to biopharmaceutical company

Thioridazine Cardiotoxicity - Dysrhythmia due to CYP2D6 hydroxylation capacity and thioridazine plasma levels

Trends - Report: New technology adds value in huge worldwide wound management market

Vaccine Development - CEL-1000 is a potential agent against bioterrorism

Vitreous Hemorrhage - FDA panel to consider Vitrase NDA