Susan Hasty, Publisher
Table of Contents . . . March 7th, 2003
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Drug Week | Other Publications
Cancer Therapy - New drug targets cancer cells
Epilepsy - Keppra offers sustained efficacy, reduction in seizure frequency
Diabetes Therapy - Liver X receptor agonist demonstrates antidiabetic action
HIV/AIDS Therapy - Novel antiretroviral agent derived from Vicia faba seeds
Insulin Resistance - Insulin dysfunction linked to Alzheimer disease
Malaria Therapy - Atovaquone remains in human sera after treatment
AIDS Therapy - Global Phase III clinical trials launched for non-peptidic protease inhibitor
AIDS Therapy - Many promising new drugs on the horizon
AIDS Therapy - New antiretroviral drugs to expand HIV/AIDS therapies market potential
Allergy Medicine - Private label gains marketing rights to loratadine 10 mg tablet equivalent
Anti-Inflammatory Therapy - Revotar amends license and research and development agreement
Appointments - Biopharmaceutical company names new CEO
Bipolar Disorder - Mania indication sought for Seroquel in Europe
Bipolar Disorder Therapy - Some anticonvulsants appear promising for treatment of bipolar depression
Bladder Cancer - Cyclooxygenase inhibitor shows additive effect against urological malignancy
Bloodstream Infections - Micrologix completes full enrollment in pivotal phase III trial of MBI 226
Breast Cancer - Fulvestrant submitted for approval in Europe
Cancer Chemotherapy - FDA grants Fast Track designation for investigational oral mucositis drug
Cancer Therapy - Antiangiogenesis antibody, 2C3, shown to inhibit tumor growth by 75%
Cancer Therapy - Manufacturing process development completed for Reolysin
Chronic Lymphocytic Leukemia - Schering acquires Japan and Asia marketing rights to Campath
Colorectal Cancer - Cox-2 inhibitor rofecoxib limits metastatic potential of colorectal carcinoma
Complementary and Alternative Medicine - Adrenal hormone and cortisol stress reactions were lowered by some GI drugs
Contraception - Phase II clinical data reported for 7-day patch
Depression - Biotech company discovers major depression gene, DEP1
Diabetes Therapy - Nateglinide provides rapid insulin stimulation in impaired glucose tolerance
Drug Delivery - Oleic acid might increase epidermal permeability to enhance transdermal delivery
Drug Discovery - Agreement grants access to clinical human disease tissue samples
Drug Discovery - Agreement signed to deliver next generation chemistry synthesis platform
Drug Discovery - Patent expands broad intellectual property estate for JNKinase pipeline
Drug Release - Assay is better predictor of in vivo drug transfer than dialysis-based systems
Endocrinology - Testosterone gel launched for treatment of deficiency in men
Epilepsy - Consumer groups accuse makers of Neurontin of "corrupt behavior"
Finance - Drug discovery partner announces fourth quarter 2002 financial results
Glaucoma - SBIR grant awarded for development of neuroprotective drugs for glaucoma
HIV/AIDS Dementia - U50,488 inhibits Tat-induced brain inflammation
HIV/AIDS Therapy - Diverse repertoire of HIV-specific helper T cell clones seen after HAART
HIV/AIDS Therapy - Novel agents derived from Litsea verticillata
HIV/AIDS Therapy - Protein-disulfide isomerase inhibitors block HIV cell entry
Heart Failure - FDA approves digoxin, generic of Lanoxin
Hepatoma - Peroxisome proliferator fenofibrate inhibits growth of human hepatoma cells
Hodgkin Disease - NOVP chemotherapy induces sperm aneuploidies
Human Papillomavirus - European patent granted for HspE7 and other human papillomavirus therapeutics
Huntington's Disease - Further progress reported on LAX-101 clinical development
Hypertension - New study sheds light on responses to diuretics
Infectious Disease - Ceftazidime use raises risk of resistant Klebsiella pneumoniae in Taiwan
Infectious Disease - Development cytomegalovirus vaccine announced
Infectious Disease Therapy - Phenothiazines, thioxanthenes block S. aureus drug efflux
Infectious Disease Therapy - RWJ-54428 effective against several forms of drug resistance
Inflammatory Diseases - Million-dollar grant awarded to identify inhibitors of chemokine receptors
Leukemia - Fludara receives European marketing approval as first-line B-CLL treatment
Leukemia - New HuMax-CD20 and HuMax-EGFr preclinical data presented
Malaria Therapy - Novel triterpenes derived from Caloncoba echinata
Malaria Therapy - Sulfadoxine-pyrimethamine-artesunate therapy planned for malaria in Peru
Mental Illness - Mania indication sought for Seroquel (quetiapine) in Europe
Mergers and Acquisitions - Biomedical firm intends to acquire selected assets of drug company
Multiple Myeloma - European regulatory approval sought for Velcade
Multiple Myeloma - FDA fast track status granted for Revimid in relapsed or refractory disease
Multiple Sclerosis - Interferon beta-1a formulation approved by FDA for early stage disease
Musculoskeletal Pain - Lower-dose Flexeril (cyclobenzaprine HCl) approved for muscle spasm
Neuropathic Pain - Data reported from Phase II trial on amitriptyline plus ketamine
Opportunistic Infection - Clinical trial of P. carinii pneumonia treatment completes enrollment
Oral Creatine - Repeated dosing causes clearance reduction, saturation of skeletal muscle pool
Osteoporosis - Mumie extract induces osteoblastic differentiation of mesenchymal stem cells
Osteoporosis - Preos maker provides clinical update
Parkinson Disease - The Michael J. Fox Foundation commits $2 million to study PD dyskinesia
Parkinson Disease - Worm model could yield new drugs
Pathogen Reduction - Company transfuses initial patients in both phase III trials for Inactine
Portal Hypertension - IND granted for phase I studies of NCX 1000
Prescription Fulfillment - Paragon's SI/BAKER joint venture awarded a $3.8 million contract
Prostate Cancer - Abbott Labs stops tests on key drug
Psoriasis - Raptiva agreement expanded to additional emerging markets in Asia
Pulmonary Medicine - Systemic thrombolytic therapy after recent abdominal aortic aneurysm repair
Renal Cell Carcinoma - Clinical trial of antisense drug expanded to major U.S. oncology centers
Sicor, Inc. - Final ANDA approval granted for Vinorelbine
Staphylococcus Aureus - Lack of synergy may be cause to avoid regimen to treat Staphylococcus aureus
Stem Cell Transplantation - Etoposide alters dendritic cell mobilization
Sunesis Pharmaceuticals, Inc. - Company announces breakthrough using extended tethering
Thrombosis - Extension of research funding granted on thrombin collaboration
Tonsillectomy - Nonsteroidal anti-inflammatory drugs suitable for pain relief
Tooth Whitener - Metagen Pharmaceuticals announces distribution agreement for Sparkling White
Tuberculosis Therapy - Mycobacterial glutamine synthetase inhibition effective
Ventilator-Associated Pneumonia - Phase II/III clinical study of iseganan HCl for VAP launch announced
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