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Drug Week

Susan Hasty, Publisher

Table of Contents . . . March 7th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Drug Week | Other Publications

Cancer Therapy - New drug targets cancer cells

Epilepsy - Keppra offers sustained efficacy, reduction in seizure frequency

Diabetes Therapy - Liver X receptor agonist demonstrates antidiabetic action

HIV/AIDS Therapy - Novel antiretroviral agent derived from Vicia faba seeds

Insulin Resistance - Insulin dysfunction linked to Alzheimer disease

Malaria Therapy - Atovaquone remains in human sera after treatment

AIDS Therapy - Global Phase III clinical trials launched for non-peptidic protease inhibitor

AIDS Therapy - Many promising new drugs on the horizon

AIDS Therapy - New antiretroviral drugs to expand HIV/AIDS therapies market potential

Allergy Medicine - Private label gains marketing rights to loratadine 10 mg tablet equivalent

Anti-Inflammatory Therapy - Revotar amends license and research and development agreement

Appointments - Biopharmaceutical company names new CEO

Bipolar Disorder - Mania indication sought for Seroquel in Europe

Bipolar Disorder Therapy - Some anticonvulsants appear promising for treatment of bipolar depression

Bladder Cancer - Cyclooxygenase inhibitor shows additive effect against urological malignancy

Bloodstream Infections - Micrologix completes full enrollment in pivotal phase III trial of MBI 226

Breast Cancer - Fulvestrant submitted for approval in Europe

Cancer Chemotherapy - FDA grants Fast Track designation for investigational oral mucositis drug

Cancer Therapy - Antiangiogenesis antibody, 2C3, shown to inhibit tumor growth by 75%

Cancer Therapy - Manufacturing process development completed for Reolysin

Chronic Lymphocytic Leukemia - Schering acquires Japan and Asia marketing rights to Campath

Colorectal Cancer - Cox-2 inhibitor rofecoxib limits metastatic potential of colorectal carcinoma

Complementary and Alternative Medicine - Adrenal hormone and cortisol stress reactions were lowered by some GI drugs

Contraception - Phase II clinical data reported for 7-day patch

Depression - Biotech company discovers major depression gene, DEP1

Diabetes Therapy - Nateglinide provides rapid insulin stimulation in impaired glucose tolerance

Drug Delivery - Oleic acid might increase epidermal permeability to enhance transdermal delivery

Drug Discovery - Agreement grants access to clinical human disease tissue samples

Drug Discovery - Agreement signed to deliver next generation chemistry synthesis platform

Drug Discovery - Patent expands broad intellectual property estate for JNKinase pipeline

Drug Release - Assay is better predictor of in vivo drug transfer than dialysis-based systems

Endocrinology - Testosterone gel launched for treatment of deficiency in men

Epilepsy - Consumer groups accuse makers of Neurontin of "corrupt behavior"

Finance - Drug discovery partner announces fourth quarter 2002 financial results

Glaucoma - SBIR grant awarded for development of neuroprotective drugs for glaucoma

HIV/AIDS Dementia - U50,488 inhibits Tat-induced brain inflammation

HIV/AIDS Therapy - Diverse repertoire of HIV-specific helper T cell clones seen after HAART

HIV/AIDS Therapy - Novel agents derived from Litsea verticillata

HIV/AIDS Therapy - Protein-disulfide isomerase inhibitors block HIV cell entry

Heart Failure - FDA approves digoxin, generic of Lanoxin

Hepatoma - Peroxisome proliferator fenofibrate inhibits growth of human hepatoma cells

Hodgkin Disease - NOVP chemotherapy induces sperm aneuploidies

Human Papillomavirus - European patent granted for HspE7 and other human papillomavirus therapeutics

Huntington's Disease - Further progress reported on LAX-101 clinical development

Hypertension - New study sheds light on responses to diuretics

Infectious Disease - Ceftazidime use raises risk of resistant Klebsiella pneumoniae in Taiwan

Infectious Disease - Development cytomegalovirus vaccine announced

Infectious Disease Therapy - Phenothiazines, thioxanthenes block S. aureus drug efflux

Infectious Disease Therapy - RWJ-54428 effective against several forms of drug resistance

Inflammatory Diseases - Million-dollar grant awarded to identify inhibitors of chemokine receptors

Leukemia - Fludara receives European marketing approval as first-line B-CLL treatment

Leukemia - New HuMax-CD20 and HuMax-EGFr preclinical data presented

Malaria Therapy - Novel triterpenes derived from Caloncoba echinata

Malaria Therapy - Sulfadoxine-pyrimethamine-artesunate therapy planned for malaria in Peru

Mental Illness - Mania indication sought for Seroquel (quetiapine) in Europe

Mergers and Acquisitions - Biomedical firm intends to acquire selected assets of drug company

Multiple Myeloma - European regulatory approval sought for Velcade

Multiple Myeloma - FDA fast track status granted for Revimid in relapsed or refractory disease

Multiple Sclerosis - Interferon beta-1a formulation approved by FDA for early stage disease

Musculoskeletal Pain - Lower-dose Flexeril (cyclobenzaprine HCl) approved for muscle spasm

Neuropathic Pain - Data reported from Phase II trial on amitriptyline plus ketamine

Opportunistic Infection - Clinical trial of P. carinii pneumonia treatment completes enrollment

Oral Creatine - Repeated dosing causes clearance reduction, saturation of skeletal muscle pool

Osteoporosis - Mumie extract induces osteoblastic differentiation of mesenchymal stem cells

Osteoporosis - Preos maker provides clinical update

Parkinson Disease - The Michael J. Fox Foundation commits $2 million to study PD dyskinesia

Parkinson Disease - Worm model could yield new drugs

Pathogen Reduction - Company transfuses initial patients in both phase III trials for Inactine

Portal Hypertension - IND granted for phase I studies of NCX 1000

Prescription Fulfillment - Paragon's SI/BAKER joint venture awarded a $3.8 million contract

Prostate Cancer - Abbott Labs stops tests on key drug

Psoriasis - Raptiva agreement expanded to additional emerging markets in Asia

Pulmonary Medicine - Systemic thrombolytic therapy after recent abdominal aortic aneurysm repair

Renal Cell Carcinoma - Clinical trial of antisense drug expanded to major U.S. oncology centers

Sicor, Inc. - Final ANDA approval granted for Vinorelbine

Staphylococcus Aureus - Lack of synergy may be cause to avoid regimen to treat Staphylococcus aureus

Stem Cell Transplantation - Etoposide alters dendritic cell mobilization

Sunesis Pharmaceuticals, Inc. - Company announces breakthrough using extended tethering

Thrombosis - Extension of research funding granted on thrombin collaboration

Tonsillectomy - Nonsteroidal anti-inflammatory drugs suitable for pain relief

Tooth Whitener - Metagen Pharmaceuticals announces distribution agreement for Sparkling White

Tuberculosis Therapy - Mycobacterial glutamine synthetase inhibition effective

Ventilator-Associated Pneumonia - Phase II/III clinical study of iseganan HCl for VAP launch announced

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