Pharmacokinetics

Technique developed to measure dexloxiglumide in human plasma

Published in Drug Week, March 14th, 2003

Researchers in England have described "a sensitive bioanalytical method for the measurement of dexloxiglumide, a new selective and potent cholecystokinin type-1 (CCK1) receptor antagonist, in plasma."

According to R. Brodie and colleagues, Huntingdon Life Science, their "method is based on reversed-phase liquid chromatography with ultraviolet absorption detection.

"Samples are extracted under acidic conditions into an organic solvent, and following evaporation, reconstitution, and centrifugation stages, the supernatant is injected on to an ODS column with detection at 244 nm."

The researchers report that they've validated the...

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Source: Drug Week (2003-03-14)

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