Drug Week

Finance - Guidance issued for estimated net sales, earnings for pharma company

Finance - Net loss of $0.13 per share reported by biotech company

Finance - Pharmaceutical company reports 2002 full year earnings, 2003 outlook

Finance - Pharmaceutical company reports net loss of $0.86 per share

Finance - UK genomics company announces preliminary financial results

Gaucher Disease - Zavesca (miglustat) launched in the European Union

Glioblastoma Multiforme - FDA approves Cotara phase III registration trial design for brain cancer

HIV/AIDS Pediatric - Peptide T bolus can normalize growth hormone secretion

HIV/AIDS Therapy - HIV-based vector systems can be used to find novel antiviral agents

HIV/AIDS Therapy - Inhibitory quotient predicts virological response

HIV/AIDS Therapy - Lamivudine has modest effect against M184V mutants

HIV/AIDS Therapy - Low nelfinavir plasma levels linked to triple-therapy failure

HIV/AIDS Therapy - Two mechanisms seen for viral inhibition by N-terminal-modified RANTES

Hepatitis C Virus - Virtual screening collaboration signed

Hereditary Emphysema - Trials started for recombinant alpha 1-antitrypsin therapy

Hyperphosphataemia - Approvable letter issued from FDA for Fosrenol

Immunology - TaiGen signs licensing and collaborative agreement

Infectious Disease Therapy - Aminoglycosides have varying effects on infant renal function

Infectious Disease Therapy - Novel cephalosporins have improved oral bioavailability

Inflammatory Skin Conditions - FDA approves two generic topical products

Laboratory Techniques - Transfection of myeloma fusion partner cells results in higher hybridoma yield

Legal Issues - Paxil patent ruling issued

Legal Issues - Shire sues over Adderall XR ANDA

Leptin Studies - Leptin fails as a therapy to prevent weight regain

Leukemia - Drug may not treat certain forms of disease

Lung Cancer - New patient accrual temporarily suspended in phase III studies of tariquidar

Malaria Therapy - Sulfadoxine-pyrimethamine dosing in children needs revision

Management Changes - Biotech company announces management transition plan

Market Analysis - Emerging anti-obesity drugs estimated to generate $510M by 2008

Medical Errors - Preventable drug side effects largely caused by doctors' errors

Menopause - Phase II/III clinical trial in climacteric symptoms

Mucopolysaccharidosis - Positive opinion announced for Aldurazyme from European regulatory authority

Nonsteroidal Antiinflammatory Drugs - Intake of cyclooxygenase-2 inhibitor restores impaired monocyte function

Obesity Therapy - Early results for Australian obesity drug released

Obesity Therapy - Weight loss at week 12 of orlistat treatment predictive of weight loss at 2 years

Obstetrics - Study: Oral contraceptive may be effective remedy for menstrual problems

Oral Health - Compound from Morus alba is active against Streptococcus mutans

Osteoarthritis - Options for lowering treatment costs for osteoarthritis explored

Osteoarthritis - Study shows effectiveness of short-, long-term use of cream for knee pain

Osteoporosis - Preclinical data supports Panzem application for osteoporosis

Otolaryngology - Compound licensed from U.S. Navy shown to protect against hearing loss

Ovarian Cancer - OvaRex laboratory data presented at Keystone Symposium

Pain Medicine - Organon to copromote Avinza, once-daily opioid for chronic pain

Personnel Changes - Workforce focused on key research and development programs

Psoriasis - Clinical trials initiated to explore use of Humira

Pulmonary Metastasis - Glycyrrhizin inhibits the pulmonary metastases of B16 melanoma in mice

Sicor, Inc. - FDA gives ANDA approval for norepinephrine bitartrate injection

Smoking Cessation - St. John's Wort oral spray found to reduce withdrawal symptoms

Stem Cell Transplantation - Dexamethasone improves the antiemetic effects of granisetron

Stem Cell Transplantation - Granulocyte colony-stimulating factor upregulates stem cell telomerase activity

Therapy - Design and analysis of non-inferiority mortality trials in oncology

Toxicology - Genotoxicity of lomefloxacin in somatic and germ cells studied in mice

Type 2 Diabetes - FDA approves Avandia for use in combination with insulin