Infectious Disease

Novel assay enables quantification of ofloxacin isomers

Published in Drug Week, May 2nd, 2003

A novel assay enables the quantification of ofloxacin isomers in serum.

"Ofloxacin, a chiral fluoroquinolone, possesses two optical isomers. The antibacterial activity of S-(-)-ofloxacin is reported to be 8-128 times higher than that of R-(+)-ofloxacin," researchers in Germany explained.

B. Awadallah and colleagues at the University of Tuebingen developed a capillary zone electrophoresis-based assay "to quantify the enantiomers of ofloxacin in highly diluted samples (20-700 ng/mL for each enantiomer)."

"After fluid-fluid extraction of ofloxacin from physiological solution, electrokinetic injection was employed to improve the...

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Source: Drug Week (2003-05-02)

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