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Drug Week

Susan Hasty, Publisher

Table of Contents . . . May 9th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Drug Week | Other Publications

Acute Myeloid Leukemia - Compound triggers release of nitric oxide to fight leukemia and tumors

Weight Loss - Antiepileptic drug useful in obese adults

Community-Acquired Pneumonia - FDA approves Factive for treatment of respiratory tract infections

HIV/AIDS Therapy - High interlaboratory variability seen in drug level measurements

Heart Disease Risk - FDA announces labeling changes on cholesterol drug Zocor

Obesity Therapy - Herbal antiobesity agent possesses mechanism similar to fluoxetine

Type 2 Diabetes Therapy - Drugs promoting periodicity of insulin release show promise for diabetes therapy

AIDS Research - Stampidine first effective agent against FIV

AIDS Test - FDA clears Cobas Amplicor HIV-1 Monitor Test

AIDS Therapy - Virucort may slow development of HIV

Acute Childhood Diarrhea - Series of studies confirm action of homeopathy on childhood diarrhea

Acute Respiratory Distress Syndrome - Humanized lung surfactant exhibits anti-inflammatory properties

Addiction Research - Promiscuous enzyme could offer treatment for drug overdose, chemical exposure

Adverse Drug Events - Dangerous interaction between cholesterol-lowering drug and antidiabetic drug

Amyloidosis - DSMB recommends continuation of clinical trial for Fibrillex

Anti-inflammatory Drugs - Companies sign agreement for transdermal version of ketoprofen

Anticancer Drugs - Anticancer drug mithramycin is associated with H1-depleted chromatin

Antitumor Drugs - A disaccharide anthracycline, MEN 10755, can binds 2 DNA helices simultaneously

Aortic Constriction - Colchicine preserves cardiac function of aortic-constricted rats

Asthma - Agreement reached to codevelop Asmanex and Foradil combination product

Asthma - Airozin launched

Asthma Supplement - Panel of experts concludes Airozin safe

Atherosclerosis - Vascular tissue fragility occurs in surface areas with thrombolysis

Atopic Eczema - Consensus on atopic dermatitis treatment stresses long-term management

Bioengineering - Size-exclusion reaction chromatography is new technique for protein PEGylation

Bipolar Disorder - Ziprasidone demonstrates fast onset of action in significantly reducing symptoms

Birth Control - Generic Microgestin oral contraceptive launched

Breast Cancer - Caelyx - a novel agent in the fight against metastatic breast cancer

Breast Cancer - Percutaneous 4OHTam may be a useful alternative to tamoxifen

Cancer Therapy - Clinical evaluation of lead antisense drug, OGX-011, expanded

Cancer Therapy - New findings published on diagnostic applications of HAAH Oncology Program

Cancer Therapy - Novel dihydroartemisinin ethers cytotoxic to tumor cells

Cardiology - NHE1 inhibitor cariporide prevents the detrimental effects of DOCA/salt

Chemotherapy - Tetrathiomolybdate prevents bleomycin-induced pulmonary fibrosis

Chemotherapy Fatigue - Supplement reduced chemotherapy induced fatigue

Clinical Trials - Icodextrin effects volume status, blood pressure, and echocardiographic parameters

Coagulation Therapy - Recombinant FVIIa limits dental blood loss in Glanzmann thrombasthenia patients

Cognitive Impairment - Company begins dosing patients in brain protection indication for dexanabinol

Collaboration - Drug discovery agreement involves supply of assay system

Collaboration - Lead discovery alliance focused on assay development

Collaborations - Standstill period ended; alliance moves forward

Complementary and Alternative Medicine - Hypothyroidism induced by an over-the-counter fat loss supplement

Diabetes Therapy - 3,3-Diamino-sulfonylacrylonitriles are novel inhibitors of insulin secretion

Diabetic Neuropathy - Nimodipine exerts antinociceptive effect on diabetic neuropathic pain

Drug Analysis - Capillary electrophoresis used for chiral and non chiral determination of Dopa

Drug Delivery - NovaDel Pharma enters license and development agreement

Drug Production - beta-Lactam selection pressure in culture disappears surprisingly quickly

Drug Resistance - Erythromycin and amphotericin B together may elevate Candida's tolerance

Dyslipidemia - New data suggest rosiglitazone may also lower cardiovascular disease risk

EMEA Compliance - Company is prepared for new EMEA electronic reporting regulations

Electronic Data Capture - Israeli company to use software to expedite clinical trial

Endocrinology - Thiazolidinediones inhibit Id2 expression in human aortic smooth muscle cells

Epilepsy - Study results on harkoseride presented at meeting

Erectile Dysfunction Therapy - Vardenafil effective for treatment of erectile dysfunction

Escherichi coli - Clinical trial to combat complications from EHEC

Finance - BI Nutraceuticals not part of bankruptcy

Finance - Drug maker reports 9.3%s sales increase

Finance - RxBazaar announces 2002 year end results

Finance - Stockholder approval of proposed financing recommended

Generics - Statement released on reported ANDA filing for a generic Enoxaparin

HCV Treatment - Positive hepatitis C, hepatitis B treatment results released

HIV/AIDS Therapy - Indinavir suppresses glycogen synthesis in HepG2 hepatoma cells

Heart Failure - Nitric oxide-like drug could revive a failing heart

Heart Surgery - Fibrinolysis rises significantly during low-dose aprotinin treatment

Hemostasis - Moore Medical enters multiyear distribution agreement for QuikClot

Hepatitis C Virus - FDA grants priority review to Rebetol

Hypertension - ACE inhibitors have effect on myocardial uptake, biochemistry, hemodynamics

Hypertension - Different dihydropyridines have effects on sympathetic and baroreflex function

Hypertension - Myocardial PKC beta 2 and Na/K-ATPase sensitivity to MBG reduced by cicletanine

Idiopathic Pulmonary Fibrosis - Phase II results evaluating Actimmune to be released

Innovative Research Grants - Drug discovery, development research grant program announced

Iptakalim Hydrochloride - Novel antihypertensive drug reverses cardiovascular remodeling

Legal Issues - Pfizer subsidiary found liable in Rezulin case

Legal Issues - Resolution reached regarding CEA antibody technology

Leukemia - Fludarabine accumulation in CLL is mostly mediated by ENT-type transporters

Malaria Therapy - Beta-cyclodextrin-artemisinin complex effective at low doses

Malaria Therapy - Plasmepsin I and II protease inhibitors developed

Marine Science - Cholestyramine shows protective effects for marine toxin poisoning

Mergers and Acquisitions - Pfizer-Pharmacia merger stirs debate over company's size

Metastatic Melanoma - Fotemustine plus whole brain irradiation works better than fotemustine alone

Metastatic Melanoma - IFN-alpha, verpamil, and dacarbazine combination can be effective

Milestone - Update provided on Pfizer collaboration

Multiple Myeloma - New data reported on Xcytrin

Multiple Sclerosis - Meta-analysis shows Copaxone slows accumulated disability

Natural Antifungals - Ubiquitin has several antifungal activities

Neutraceuticals - Neptune Technologies & Bioressources products now available in Quebec

Non-Hodgkin Lymphoma - Some prescription medications reduce risk in women

Non-Hodgkin Lymphoma - Study: Biomarkers may determine responsiveness to Ganite

Nutritional Supplementation - Research reveals key role of chromium picolinate in insulin resistance

Overactive Bladder - Study: Prelief may improve quality of life

Pain Medicine - Organon, Ligand confirm full, on-schedule start of Avinza copromotion

Patents - Canada issues patent to protect invention of antisense antimicrobial drugs

Patents - Key patents issued for antibiotics, antivirals

Patents - Patent issued for compounds defining new platform technology

Personnel - Cardiovascular experts join drug development company

Personnel - Clinical diagnostics executive added to board of biotech company

Personnel - Farr promoted to senior VP, chief scientific officer of drug delivery company

Personnel - Gabriel named president, CEO at genomics company

Personnel - Gilbert nominated to dermatology company's board of directors

Personnel - Increased responsibilities announced for key senior management

Personnel - Lankau named president, chief operating officer

Personnel - New advisory board members named to Canadian biotech company

Personnel - Rautsola named as CEO at Danish biotech company

Personnel - Summers named director at CRO

Personnel - Unither Pharma announces promotion of Yu-Lun Lin to president and CEO

Pneumococcal Meningitis - France's commitment to vaccines will help to save children from health risks

Pneumonia - Efficacy results of DB289 in pneumonia trial released

Prostate Cancer - Sequence matters when using novel agent

Regulatory Review - Sucanon regulatory response announced for insulin sensitizer

Safety - Enrollment closes for Hemolink trial

Schizophrenia - UNC expands historic study to incorporate newest antipsychotic drug

Severe Acute Respiratory Syndrome - New products to address SARS

Sickle Cell Anemia - ICA-17043 prevents erythrocyte dehydration in mice

Skin Cancer - Phase II trial approved for oral phenoxodiol at Royal North Shore Hospital

Stimulants - Are Americans finally ready to give up ephedra diet pills?

Stock Market - NASDAQ delisting notification to be appealed

Systemic Lupus Erythematosus - Open-label safety study of Riquent closed

Telik, Inc. - TRAP drug discovery collaboration announced

Topical Drugs - Trials for drug-absorption enhancer, SEPA, now cleared to resume

Transplant Medicine - Aerosol cyclosporine improves lung function in transplant patients

Trypanosomiasis - Itraconazole protects better against development of new ECG abnormalities

Tuberculosis Therapy - Low quality packaging can lead to drug degradation

Tuberculosis Therapy - Novel ethambutol analogs show improved efficacy

Tuberculosis Therapy - Treatment restores normal neutrophil function in HIV-negative patients

Tumor Growth - Inhibitors of novel cancer target attack tumor on two fronts

Ulcerative Colitis - Additional phase II trial of Alicaforsen planned

Ulcerative Colitis - Studies of RDP58 show peak response of 77% and a 71% remission rate in patients

Viral Encephalitis - NEOUCOM shares $1.1 million U.S. grant for development of CEL-1000

Virology - HIV vaccine candidate taken by into phase I trial in U.S., Africa

Vitreous Hemorrhage - FDA issues an approvable letter for Vitrase

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