Susan Hasty, Publisher
Table of Contents . . . May 9th, 2003
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Drug Week | Other Publications
Acute Myeloid Leukemia - Compound triggers release of nitric oxide to fight leukemia and tumors
Weight Loss - Antiepileptic drug useful in obese adults
Community-Acquired Pneumonia - FDA approves Factive for treatment of respiratory tract infections
HIV/AIDS Therapy - High interlaboratory variability seen in drug level measurements
Heart Disease Risk - FDA announces labeling changes on cholesterol drug Zocor
Obesity Therapy - Herbal antiobesity agent possesses mechanism similar to fluoxetine
Type 2 Diabetes Therapy - Drugs promoting periodicity of insulin release show promise for diabetes therapy
AIDS Research - Stampidine first effective agent against FIV
AIDS Test - FDA clears Cobas Amplicor HIV-1 Monitor Test
AIDS Therapy - Virucort may slow development of HIV
Acute Childhood Diarrhea - Series of studies confirm action of homeopathy on childhood diarrhea
Acute Respiratory Distress Syndrome - Humanized lung surfactant exhibits anti-inflammatory properties
Addiction Research - Promiscuous enzyme could offer treatment for drug overdose, chemical exposure
Adverse Drug Events - Dangerous interaction between cholesterol-lowering drug and antidiabetic drug
Amyloidosis - DSMB recommends continuation of clinical trial for Fibrillex
Anti-inflammatory Drugs - Companies sign agreement for transdermal version of ketoprofen
Anticancer Drugs - Anticancer drug mithramycin is associated with H1-depleted chromatin
Antitumor Drugs - A disaccharide anthracycline, MEN 10755, can binds 2 DNA helices simultaneously
Aortic Constriction - Colchicine preserves cardiac function of aortic-constricted rats
Asthma - Agreement reached to codevelop Asmanex and Foradil combination product
Asthma - Airozin launched
Asthma Supplement - Panel of experts concludes Airozin safe
Atherosclerosis - Vascular tissue fragility occurs in surface areas with thrombolysis
Atopic Eczema - Consensus on atopic dermatitis treatment stresses long-term management
Bioengineering - Size-exclusion reaction chromatography is new technique for protein PEGylation
Bipolar Disorder - Ziprasidone demonstrates fast onset of action in significantly reducing symptoms
Birth Control - Generic Microgestin oral contraceptive launched
Breast Cancer - Caelyx - a novel agent in the fight against metastatic breast cancer
Breast Cancer - Percutaneous 4OHTam may be a useful alternative to tamoxifen
Cancer Therapy - Clinical evaluation of lead antisense drug, OGX-011, expanded
Cancer Therapy - New findings published on diagnostic applications of HAAH Oncology Program
Cancer Therapy - Novel dihydroartemisinin ethers cytotoxic to tumor cells
Cardiology - NHE1 inhibitor cariporide prevents the detrimental effects of DOCA/salt
Chemotherapy - Tetrathiomolybdate prevents bleomycin-induced pulmonary fibrosis
Chemotherapy Fatigue - Supplement reduced chemotherapy induced fatigue
Clinical Trials - Icodextrin effects volume status, blood pressure, and echocardiographic parameters
Coagulation Therapy - Recombinant FVIIa limits dental blood loss in Glanzmann thrombasthenia patients
Cognitive Impairment - Company begins dosing patients in brain protection indication for dexanabinol
Collaboration - Drug discovery agreement involves supply of assay system
Collaboration - Lead discovery alliance focused on assay development
Collaborations - Standstill period ended; alliance moves forward
Complementary and Alternative Medicine - Hypothyroidism induced by an over-the-counter fat loss supplement
Diabetes Therapy - 3,3-Diamino-sulfonylacrylonitriles are novel inhibitors of insulin secretion
Diabetic Neuropathy - Nimodipine exerts antinociceptive effect on diabetic neuropathic pain
Drug Analysis - Capillary electrophoresis used for chiral and non chiral determination of Dopa
Drug Delivery - NovaDel Pharma enters license and development agreement
Drug Production - beta-Lactam selection pressure in culture disappears surprisingly quickly
Drug Resistance - Erythromycin and amphotericin B together may elevate Candida's tolerance
Dyslipidemia - New data suggest rosiglitazone may also lower cardiovascular disease risk
EMEA Compliance - Company is prepared for new EMEA electronic reporting regulations
Electronic Data Capture - Israeli company to use software to expedite clinical trial
Endocrinology - Thiazolidinediones inhibit Id2 expression in human aortic smooth muscle cells
Epilepsy - Study results on harkoseride presented at meeting
Erectile Dysfunction Therapy - Vardenafil effective for treatment of erectile dysfunction
Escherichi coli - Clinical trial to combat complications from EHEC
Finance - BI Nutraceuticals not part of bankruptcy
Finance - Drug maker reports 9.3%s sales increase
Finance - RxBazaar announces 2002 year end results
Finance - Stockholder approval of proposed financing recommended
Generics - Statement released on reported ANDA filing for a generic Enoxaparin
HCV Treatment - Positive hepatitis C, hepatitis B treatment results released
HIV/AIDS Therapy - Indinavir suppresses glycogen synthesis in HepG2 hepatoma cells
Heart Failure - Nitric oxide-like drug could revive a failing heart
Heart Surgery - Fibrinolysis rises significantly during low-dose aprotinin treatment
Hemostasis - Moore Medical enters multiyear distribution agreement for QuikClot
Hepatitis C Virus - FDA grants priority review to Rebetol
Hypertension - ACE inhibitors have effect on myocardial uptake, biochemistry, hemodynamics
Hypertension - Different dihydropyridines have effects on sympathetic and baroreflex function
Hypertension - Myocardial PKC beta 2 and Na/K-ATPase sensitivity to MBG reduced by cicletanine
Idiopathic Pulmonary Fibrosis - Phase II results evaluating Actimmune to be released
Innovative Research Grants - Drug discovery, development research grant program announced
Iptakalim Hydrochloride - Novel antihypertensive drug reverses cardiovascular remodeling
Legal Issues - Pfizer subsidiary found liable in Rezulin case
Legal Issues - Resolution reached regarding CEA antibody technology
Leukemia - Fludarabine accumulation in CLL is mostly mediated by ENT-type transporters
Malaria Therapy - Beta-cyclodextrin-artemisinin complex effective at low doses
Malaria Therapy - Plasmepsin I and II protease inhibitors developed
Marine Science - Cholestyramine shows protective effects for marine toxin poisoning
Mergers and Acquisitions - Pfizer-Pharmacia merger stirs debate over company's size
Metastatic Melanoma - Fotemustine plus whole brain irradiation works better than fotemustine alone
Metastatic Melanoma - IFN-alpha, verpamil, and dacarbazine combination can be effective
Milestone - Update provided on Pfizer collaboration
Multiple Myeloma - New data reported on Xcytrin
Multiple Sclerosis - Meta-analysis shows Copaxone slows accumulated disability
Natural Antifungals - Ubiquitin has several antifungal activities
Neutraceuticals - Neptune Technologies & Bioressources products now available in Quebec
Non-Hodgkin Lymphoma - Some prescription medications reduce risk in women
Non-Hodgkin Lymphoma - Study: Biomarkers may determine responsiveness to Ganite
Nutritional Supplementation - Research reveals key role of chromium picolinate in insulin resistance
Overactive Bladder - Study: Prelief may improve quality of life
Pain Medicine - Organon, Ligand confirm full, on-schedule start of Avinza copromotion
Patents - Canada issues patent to protect invention of antisense antimicrobial drugs
Patents - Key patents issued for antibiotics, antivirals
Patents - Patent issued for compounds defining new platform technology
Personnel - Cardiovascular experts join drug development company
Personnel - Clinical diagnostics executive added to board of biotech company
Personnel - Farr promoted to senior VP, chief scientific officer of drug delivery company
Personnel - Gabriel named president, CEO at genomics company
Personnel - Gilbert nominated to dermatology company's board of directors
Personnel - Increased responsibilities announced for key senior management
Personnel - Lankau named president, chief operating officer
Personnel - New advisory board members named to Canadian biotech company
Personnel - Rautsola named as CEO at Danish biotech company
Personnel - Summers named director at CRO
Personnel - Unither Pharma announces promotion of Yu-Lun Lin to president and CEO
Pneumococcal Meningitis - France's commitment to vaccines will help to save children from health risks
Pneumonia - Efficacy results of DB289 in pneumonia trial released
Prostate Cancer - Sequence matters when using novel agent
Regulatory Review - Sucanon regulatory response announced for insulin sensitizer
Safety - Enrollment closes for Hemolink trial
Schizophrenia - UNC expands historic study to incorporate newest antipsychotic drug
Severe Acute Respiratory Syndrome - New products to address SARS
Sickle Cell Anemia - ICA-17043 prevents erythrocyte dehydration in mice
Skin Cancer - Phase II trial approved for oral phenoxodiol at Royal North Shore Hospital
Stimulants - Are Americans finally ready to give up ephedra diet pills?
Stock Market - NASDAQ delisting notification to be appealed
Systemic Lupus Erythematosus - Open-label safety study of Riquent closed
Telik, Inc. - TRAP drug discovery collaboration announced
Topical Drugs - Trials for drug-absorption enhancer, SEPA, now cleared to resume
Transplant Medicine - Aerosol cyclosporine improves lung function in transplant patients
Trypanosomiasis - Itraconazole protects better against development of new ECG abnormalities
Tuberculosis Therapy - Low quality packaging can lead to drug degradation
Tuberculosis Therapy - Novel ethambutol analogs show improved efficacy
Tuberculosis Therapy - Treatment restores normal neutrophil function in HIV-negative patients
Tumor Growth - Inhibitors of novel cancer target attack tumor on two fronts
Ulcerative Colitis - Additional phase II trial of Alicaforsen planned
Ulcerative Colitis - Studies of RDP58 show peak response of 77% and a 71% remission rate in patients
Viral Encephalitis - NEOUCOM shares $1.1 million U.S. grant for development of CEL-1000
Virology - HIV vaccine candidate taken by into phase I trial in U.S., Africa
Vitreous Hemorrhage - FDA issues an approvable letter for Vitrase
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