Umbilical Cord Blood

Senescent T-cell subpopulation characterized

Published in Drug Week, July 18th, 2003

The origins of a senescent T-cell subpopulation in umbilical cord blood have been determined.

According to published research from Poland, "during replicative senescence either in vivo or in vitro," a growing "subpopulation of CD8+CD28- cells is observed".

To characterize this group of cells, A. Brzezinska and colleagues at the Polish Academy of Sciences "compared replicative senescence of T cells derived from mononuclear cells of peripheral blood (PBMC) of adults with those from cord blood (CBMC)," which did not yet contain CD8+CD28- cells.

"In PHA-stimulated and IL-2-dependent cultures, T cells from both cord blood and...

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Source: Drug Week (2003-07-18)

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