Malaria Pathogenesis
Interleukin-12 levels can predict disease progression
Published in Drug Week, August 1st, 2003
"The interaction between pro- and anti-inflammatory cytokines such as interleukin 12 (IL-12), interleukin 18 (IL-18) and transforming growth factor beta (TGF-beta) plays an important role in malaria pathogenesis and outcome, modulating the immuno response in Plasmodium falciparum malaria," researchers in Italy explained.
M. Musumeci and colleagues at the University of Sassari "analyzed the plasmatic levels of IL-12, IL-18 and TGF-beta in 105 African children with different degrees of malaria" and "correlated the production of these cytokines with the severity of the disease."
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Source: Drug Week (2003-08-01)
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