Stem Cell Transplantation

High CD34 cell dose linked to heightened GVHD risk but improved survival

Published in Drug Week, August 1st, 2003

A high CD34 cell dose increases the risk of chronic graft-versus-host reactions but improves overall survival for patients receiving HLA-matched stem cell grafts.

In a study from South Korea, "the impact of the CD34+ cell dose on chronic graft-versus-host disease (cGVHD) and the clinical outcome was analyzed in 41 consecutive adult patients submitted to allogeneic peripheral blood stem cell transplantation from HLA-identical siblings."

"The patients were classified into 'low' or 'high' CD34+ cell dose groups based on whether they received less or more than a median CD34+ cell dose of 10.5 x 10⁶/kg, respectively," according to S.K. Sohn and...

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Source: Drug Week (2003-08-01)

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