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Type 2 Diabetes Pathogenesis

Conjugated linoleic acid promotes beta-cell viability

Published in Drug Week, August 1st, 2003

Conjugated linoleic acid promotes beta-cell viability, helping to prevent the development of type 2 diabetes.

"To determine whether dietary fatty acids affect pancreatic beta-cell function, the INS-1 beta-cells and the pancreatic islets isolated from Zucker obese (fa/fa) rats were cultured with stearic acid and conjugated linoleic acid (CLA)," researchers in South Korea report.

"As a result, DNA fragmentation laddering was substantially decreased in the INS-1 beta-cells and the isolated pancreatic islets cultured with 2 mM CLA compared to those cultured with stearic acid," stated I. S. Jang and colleagues at Jinju National University. "To investigate...

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