Published in Drug Week, September 5th, 2003
The resistance is caused by hydrolysis of the b-lactam by a bacterial lactamase enzyme, but fortunately it can often be overcome by the use of a serine b-lactamase inhibitor in combination with the drug. This approach is successfully used already; for example clavulanic acid is used in combination with amoxycillin in Augmentin.
Unfortunately, various b-lactam drugs are also inactivated by metallo-b-lactamases, which cannot be overcome by the...
Want to see the full article?
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Drug Week
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.