Receptor Signaling
Toll-like receptor 4 has MyD88-independent pathway for inducing interferons
Published in Drug Week, September 5th, 2003
"Toll-like receptors (TLRs) play an essential role in the detection of invading pathogens in the body. Individual TLRs recognize distinct components derived from pathogens, which is followed by cytokine production. The TLR family harbors extracellular leucine-rich repeat domains and a cytoplasmic domain that is homologous to that of the IL-1 receptor (IL-1R) family," scientists writing in the Journal of Infectious Diseases report.
"After stimulation, TLR recruits IL-1R-associated kinase via adaptor myeloid differentiation factor 88 (MyD88) and induces...
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Source: Drug Week (2003-09-05)
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