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Medulloblastoma

Cancer research center reports that retinoids kill childhood brain tumor cells

Published in Drug Week, September 5th, 2003

Previous U.S. Food and Drug Administration (FDA) approval for use of retinoids to treat a form of childhood cancer, neuroblastoma, will mean clinical trials in pediatric medulloblastoma patients will begin with minimal delay.

Researchers find that vitamin A derivatives may be highly effective and minimally toxic treatments for medulloblastoma, the most common form of childhood brain cancer. Clinical trials of the drugs, known as retinoids, are being planned for children who are at high risk for tumor relapse following standard therapy.

A study led by Fred Hutchinson Cancer Research Center researchers, Drs. Andrew Hallahan and James Olson, showed that...

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