Published in Drug Week, September 26th, 2003
"In vitro screening of thiacetazone derivatives indicated that two derivatives, SRI-286 and SRI-224, inhibited a panel of 25 Mycobacterium avium complex (MAC) isolates at concentrations of 2 microg/mL or lower," according to L.E. Bermudez and colleagues at Oregon State University.
"In mice, SRI-224 and thiacetazone had no significant activity against the MAC in livers and spleens, but treatment with SRI-286 resulted in significant reduction of bacterial loads in livers and spleens," they reported.
"A combination of SRI-286 and...
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