Infectious Disease Therapy
Novel carbapenems show promise for treatment of drug-resistant pathogens
Published in Drug Week, September 26th, 2003
"SM-197436, SM-232721, and SM-232724 are new 1beta-methylcarbapenems with a unique 4-substituted thiazol-2-ylthio moiety at the C-2 side chain," researchers in Japan explained.
"In agar dilution susceptibility testing these novel carbapenems were active against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (MRSE) with a MIC90 of {{<=}}4 microg/mL," according to Y. Ueda and colleagues at Sumitomo Pharmaceuticals.
"Furthermore, SM-232724 showed strong bactericidal activity against MRSA, in...
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Source: Drug Week (2003-09-26)
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