Published in Drug Week, October 10th, 2003
According to recent research published in the Journal of Clinical Endocrinology and Metabolism, "low bone mineral density (BMD) in adolescents with anorexia nervosa ( AN) is associated with a low bone turnover state. Osteoprotegerin (OPG), a cytokine that acts as a decoy receptor for receptor activator of nuclear factor-kappaB ligand, decreases bone resorption by inhibiting differentiation of osteoclast precursors and activation of mature osteoclasts, and by stimulating osteoclast apoptosis. We compared OPG levels in 43 adolescent girls with AN with 38 controls and examined bone density,...
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