Cancer Therapy

Sphingosine kinase inhibitors may hold key to halting growth of some tumors

Published in Drug Week, October 10th, 2003

Penn State College of Medicine researchers have identified compounds that could wipe out an enzyme responsible for tumor growth.

"These compounds our team found are the first 'drug-like' agents that have been shown to inhibit an enzyme called sphingosine kinase," said Charles D. Smith, PhD, professor of pharmacology, and director of the Drug Discovery Core, Penn State College of Medicine. "Since sphingosine kinase is involved in growth regulation and certain other biological processes that are important in tumor growth, these compounds have potential use for the treatment of many types of cancer."

This study, titled, "Discovery and evaluation of...

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Source: Drug Week (2003-10-10)

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