Huntington Disease
Huntingtin and associated proteins stimulate NeuroD activity
Published in Drug Week, October 10th, 2003
"NeuroD (ND) is a basic helix-loop-helix transcription factor important for neuronal development and survival. By using a yeast two-hybrid screen, we identified two proteins that interact with ND, huntingtin-associated protein 1 (HAP1) and mixed-lineage kinase 2 (MLK2), both of which are known to interact with huntingtin (Htt)," scientists in the United States report.
"Htt is a ubiquitous protein important for neuronal transcription, development, and survival, and loss of its function has been implicated in the pathogenesis of Huntington's disease, a...
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Source: Drug Week (2003-10-10)
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