Published in Drug Week, October 10th, 2003
"The Dvl-1 gene on chromosome 1p36 belongs to a family of highly conserved secreted proteins which regulates embryonic induction, generation of cell polarity and specification of cell fate through activation of Writ signaling pathways. Wnt signaling activates the gene encoding DVL-1; the latter suppresses B-catenin by promoting its degradation through enhanced inactivation of glycogen-synthase-kinase 3 (GSK3)," scientists writing in the journal Oncology Reports report.
"Here we demonstrate increased expression of DVL-1 mRNA in...
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