Drug Week
Susan Hasty, Publisher
Table of Contents . . . October 17th, 2003
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Drug Week | Other Publications
Peutz-Jeghers Syndrome - Could diabetes treatments fight cancer?
Thalassemia - Study confirms safety and efficacy of deferiprone
Acute Coronary Syndrome - Study: Early use of antiplatelet therapy reduces incidence of death
Drug Development - Surface cavities of alpha(1)-antitrypsin could be targeted for liver therapy
HIV/AIDS Therapy - Analysis comparing TDF to EFV reports high rate of virologic nonresponse in TDF arm
Oncogenesis - Lovastatin, cholestyramine or niacin alters K-ras membrane association
Streptococcus Pneumoniae - Telithromycin active, in vitro, against multidrug-resistant strains
AIDS Therapy - Research: FUZEON-based regimens provide significant durable response
AIDS Therapy - Study: Kaletra regimen shows viral suppression for patients new to therapy
AIDS Vaccine - HIV vaccine candidate trial begins in 18 cities around the world
Actinic Keratoses - Additional patent granted for 5-FU microsponge formulation
Addiction Medicine - Bupropion enhances properties of nicotine and food in rats
Advanced Solid Tumors - Cisplatin, irinotecan, and epirubicin have promising broad antitumor activity
Allergy Genetics - The IL-4 receptor alpha chain Q576R/R polymorphism is linked to allergic asthma
Allergy Medicine - Mouse allergen exposure common in low-income New York City apartments
Alzheimer Disease - A-beta42-lowering NSAIDs preserve cleavage of amyloid precursor protein
Alzheimer Disease - Amyloid beta 42 production not reduced by many NSAIDs
Alzheimer Disease - Amyloid precursor enzymes antagonistic toward beta-amyloid peptide production
Alzheimer Disease - ApoE4 blocks environmental stimulation of synaptogenesis and memory
Alzheimer Disease - Drug to treat late-stage disease takes step toward U.S. market
Alzheimer Disease - Lack of proteins in dentate gyrus linked to Alzheimer disease
Alzheimer Disease - NSAIDS decrease amyloid beta 42 by direct modulation of gamma-secretase
Alzheimer Disease - Ongoing Phenserine clinical program expanded
Alzheimer Disease - Presenilin-1 binds immature BACE1 for amyloid cleavage in cultured cells
Alzheimer Disease - Presenilin-1 mutation Y256S giving extremely early-onset AD and high Abeta
Alzheimer Disease - Rat model helps test new AD drugs
Alzheimer Disease - Relevance of amyloid precursor protein to Alzheimer disease reviewed
Amyloid Pathology - Amyloid classification important for determining treatment regimen
Androgen-Deprivation Therapy - Primary hormone induced meningiomas may result from prostate cancer therapy
Anemia - Red blood cells deficient in CD55 and/or CD59 may relate to hemolytic anemia
Anesthesia - Lymphatic system disorders may influence anesthesia in intensive care
Angina - Low-dose aspirin is best choice for cutting bleeding risks
Anthrax - Lethal factor from Bacillus anthracis assayed
Anthrax - Model predicts optimal antibiotic prophylaxis duration during anthrax outbreak
Anthrax - Pathology of inhalation anthrax in cynomoigus monkeys detailed
Anti-Infective Proteins - Subfractions of human milk lactoferrin have five different enzymatic properties
Anti-Infectives - Crotalus durissus terrificus venom inhibits measles virus growth
Anti-Infectives - Anti-infective tablet for oral suspension receives FDA approval
Anti-Infectives - New potential target for anti-parasite drugs reported
Antibacterial Immunity - Gram-positive bacterial cell walls are identified by innate immune sensors
Antibiotics - Bioadhesive gel ensures that drug sticks to the problem
Antibiotics - Company releases data on two novel antibiotic classes at ICAAC
Antibiotics - Molecule compounds identified that kill growth of disease-causing bacteria
Anticancer Drugs - Cancer cell chemosensitivity relates to rate of drug shedding in vesicles
Anticancer Drugs - Colorectal cancer may be treatable with 9-cis-RA, tamoxifen plus ciprofloxacin
Anticancer Drugs - Marine organisms may offer source of anti-cancer drugs
Anticancer Immune Response - Investigation of leukemia spontaneous remission cause may lead to cure
Anticancer Therapy - Thymosin alpha 1 may be an important component of anticancer therapy
Antifungal Therapy - Terbinafine safe, effective in children
Antigen Presentation - Lymphocyte migration, antigen presentation in lymphoid organs may be random
Antihistamine Activity - Macrophages may uptake histamine for clearance by L-histidine decarboxylase
Antimicrobial Resistance - Burkholderia cepacia is an increasing problem in CF, immunodeficient patients
Antipsychotic Effects - Drug manufacturer defends product against risk for diabetes
Antitumor Target - Phospholipase A2 expression in tumors may target it for therapy
Antiviral Therapy - Plant compounds from Stylogne cauliflora block hepatitis C virus protease
Apoptosis - Melatonin performs cell death functions related to healthy homeostasis
Arthritis Therapy - Glomerulonephritis, hypocomplementemia may result from RA therapy
Atherosclerosis - Aspirin reduces risk of first heart attack by one-third
Atherosclerosis - C-reactive protein testing for atherosclerotic risk can be done on plasma
Atherosclerosis - Phospholipid transfer protein is expressed by macrophages in atherosclerosis
Atopic Disease - Atopic diseases with and without elevated IgE should be treated differently
Autoimmunity - Xenogeneic proteins may lead the way to effective cancer vaccines
B-Cell Function - Activation induced cytidine deaminase may act as DNA, instead of RNA, editor
B-Cell Function - Immunoglobulin heavy chain genes in both alleles are transcribed
Bacteriology - Genome sequence of Yersinia pestis bacteriophage phi A1122 reported
Bacteriology - Phr peptide processing in Bacillus subtilis analyzed
Bladder Cancer - Usefulness of current bladder cancer tests reviewed
Blood Coagulation - Vitamin K-dependent gamma-glutamyl carboxylase gene has TATA-less promoter
Botulinum Toxin - Inhibition of neurotransmitter release by botulinum toxins studied
Brain Cancer - Antigen targeted in melanoma therapy also prompts response in brain tumor cells
Brain Metastases - Radiotherapy prognosis related to RPA class, extracranial metastases, KPS
Brain Tumors - Metastatic pilocytic astrocytoma may be treatable with imatinib mesylate
Breast Cancer - Antisense p21 ODN triggers breast cancer cell apoptosis
Breast Cancer - BRCA1 gene points way to targeting treatment
Breast Cancer - Brand name announced for ABI-007; national sales director named
Breast Cancer - CARP-1 is a novel regulator of retinoids that diminish cancer
Breast Cancer - Comparison study finds better overall response rate, survival with docetaxel
Breast Cancer - Exemestane demonstrates high tumor response rate
Breast Cancer - FTI and tamoxifen may increase the antitumor effect of either drug alone
Breast Cancer - First Canadian patient treated with site-specific radiation for breast cancer
Breast Cancer - Letrozole is better tolerated, provides better quality of life than anastrozole
Breast Cancer - New evidence eases some concerns about bone fracture risk with anastrozole
Breast Cancer - Novel taxane analogs could effectively kill MDR1-positive breast cancer cells
Breast Cancer - Women who use antihistamines are not at higher risk for developing breast cancer
Breast Cancer - Younger U.K. women prefer hormonal treatment for breast cancer
Breast Cancer Immunology - CD1a+ dendritic cell density may be linked to higher breast cancer survival
Cancer Pain - End-of-life cancer pain can be prevented
Cancer Prevention - COX inhibitors have potential in cancer prevention and therapy
Cancer Research - Hedgehog pathway implicated in human pancreatic carcinoma and other cancers
Cancer Risk Factor - Exercise intensity affects risks of cancer
Cancer Risk Factor - Obesity increases risk of some hormone-dependent tumors
Cancer Therapy - COX-2 inhibitors may be used as radiosensitizing agents for cancer therapy
Cancer Therapy - Canadian company gets patents protecting cancer and infectious disease programs
Cancer Therapy - FDA approves Ganite for treatment of cancer-related hypercalcemia
Cancer Therapy - FDA grants fast track designation for Advexin
Cancer Therapy - Third clinical trial with GTI-2040 to begin in cooperation with NCI
Cancer Therapy - Thrombogenic fusion proteins diminish the vascularity of tumors
Cancer Vaccine - Carbohydrate-specific antibodies make potential cancer vaccine for human use
Cancer Vaccine - Glycosylamino acids with tumor-associated carbohydrate antigens synthesized
Cancer-related Weight Loss - Nutritional product reverses weight loss in advanced cancer patients
Carcinoma - Nitric oxide synthase plays a role in the angiogenesis of bladder cancer
Cardiology - Gene transfer of IkappaBalpha limits infarct size in a murine model
Cardiopulmonary Bypass - Heparin-induced thrombocytopenia is manageable in bypass surgery
Cardiovascular Disease - Study supports broad indications for PhotoPoint PDT in atherosclerosis
Catheter-related Infection - Paired DTD values can differentiate catheter and non-catheter bacteremia
Catheters - LifeValve Platinum, company's newest central venous catheter, launched
Cell Signaling - Molecular mechanism underlying tumor selectivity of Hsp90 inhibitors identified
Chemotherapy - Davanat increases anticancer efficacy of 5-fluorouracil
Chemotherapy - New developments in drug delivery have implications for cancer care
Childhood Cancer - Chemotherapy decreases epiphyseal strength and increases bone fracture risk
Childhood Disease - Babies exposed to Kingella kingae are susceptible to disease after 6 months
Childhood Immunization - No relationship found between thimerosal and autism
Cholera - Dose-ranging study of CholeraGarde confirms immunogenicity
Chronic Bronchitis - Study shows positive clinical results for AECB patients on Avelox
Cognition - Altered expression of NCAM underlies learning deficits in diabetic rats
Collaborations - Agreement signed for BAY 73-6944/PTK 0796
Collaborations - New firm to focus on next generation of drug-eluting stents
Collaborations - Pain management partnership terminated
Collaborations - Regulatory affairs programs to be offered through cooperative agreement
Collaborations - Sublicense signed with Copernicus to develop drug delivery methods
Colon Cancer - Nordic collaboration gives new insights into adjuvant chemotherapy
Colorectal Cancer - Aminosalicylates may have chemopreventative value in IBD
Colorectal Cancer - FDA grants priority review to Eloxatin
Colorectal Cancer - Vioxx may be a chemopreventive in humans at risk for colorectal neoplasia
Congenital Heart Disease - FDA approves expanded label for Synagis use in children with CHD
Cornea Transplant - In corneal transplants, few immunosuppressants are options to prevent rejection
Coronary Artery Disease - Total plasma apoA-IV in coronary artery disease patients is lower than in controls
Coronary Lesions - Correlation found between lipid-rich plaques, heart attacks in cath lab patients
Cough Medicine - Hi-Tech Pharmacal to copromote Diabetic Tussin C to physicians
Creuztfeldt-Jakob Disease - CSF from CJD patients is high in pro-MMP-9 and active MMP-2, and TIMP inhibitors
Cytokine Receptors - New class II cytokines, receptors have antiviral and anti-inflammatory potential
Cytokines - Males with sexual dysfunction in multiple sclerosis have lower testosterone
DNA Vaccine - Topical delivery of DNA antigens reviewed
Dementia - Company to market animal model for Alzheimer disease
Dendritic Cell Vaccine - Dendritic cells respond to antigens through heat shock protein receptor
Dendritic Cells - Dendritic cells can cross-present virus-like particles
Dendritic Cells - Dendritic cells have defined subsets that are specialized; some fight viruses
Depression - Cost-effective, generic drug expected to make impact on antidepression market
Depression - FDA gives final approval for marketing of generic antidepressant
Depression - Study: Lexapro is as effective as Effexor XR, better tolerated
Dermatology - Cervicofacial actinomycoses are produced by various genera
Dermatology - Efficacy and safety of itraconazole use in children reviewed
Diabetes Survival & Mortality - Polymorphisms of aldose reductase gene linked to diabetic complications
Diabetic Nephropathy - Renin-angiotensin system role in diabetic nephropathy studied
Diagnostics and Therapeutics - Pharmaceutical company signs agreement for SF-25 oncology program
Dialysis - Company begins trial of noninvasive vascular blood clot treatment
Diet and Nutrition - High-protein diet produces metabolic adaptations in type 2 diabetes
Diet and Nutrition - Reduced basal hunger contributes to anorexia in older adults
Disease Epidemiology - Glomerulonephritis appears to be the most common renal disease in Macedonia
Drug Costs - Group comments on governor's proposal to buy prescription drugs from Canada
Drug Delivery - Intraject development program advances with Configuration trial results
Drug Development - Anti-HIV mechanisms of SPMG clarified
Drug Development - CCR5 antagonists derived from fungus
Drug Development - Caffeoyl naphthalenesulfonamide derivatives inhibit HIV integrase activity
Drug Development - Company wins NIST funding for a D-amino acid drug development platform
Drug Development - Development and approval time trends for drugs in the U.S. reviewed
Drug Development - Diasteromeric antimalarial agent developed
Drug Development - Dipeptidyl peptidase inhibitor shows promise for treatment of blood cell deficiencies
Drug Development - Emergent patterns in the regulation of pharmaceuticals reported
Drug Development - Genentech enters R&D collaboration
Drug Development - Jatrorrhizine shows promise as antifungal therapy
Drug Development - Kanamycin infusions are useful for identifying transgenic tobacco plants
Drug Development - Mycobacterial arabinogalactan linkage disaccharide analogs block cell wall biosynthesis
Drug Development - New system rapidly identifies antibody diagnostic, therapeutic candidates
Drug Development - New version of the Screener software system released
Drug Development - Novel plant-derived agents inhibit M. tuberculosis growth
Ebola Virus - Protection determined by innate immune response in Ebola virus mouse model
Elevated Cholesterol - Crestor now available nationwide
Embryonic Research - The cytochrome P450 system plays a key role in early vessel growth
Endocrinology - An autocrine loop controls angiogenic growth factors in pancreatic cancer
Endocrinology - Excess Bcl-2 production reverses programmed cell death in beta cells
Endocrinology - Growth hormone sensitivity is growth period and tissue type dependent
Environmental Health - Cadmium and lead content high in foods in Kuwait
Epidemiology - One in 10 adults of South Asian origin may have undiagnosed type II diabetes
Epithelial Differentiation - CD44v6 is involved in oral epithelial differentiation but not cancer
Epstein Barr Virus - Targeting therapy to virus is best way to selectively eliminate EBV cancers
Esophageal Cancer - Irinotecan and docetaxel shows some activity in extensively pretreated patients
Exercise - Obesity does not increase knee joint torque and power during walking
Eye Research - Lacrimal gland atrophy follows estrogen deprivation in study animals
Facilities - Biotech company purchases its Foster City Campus
Female Sexuality - In new study, testosterone patch improved sexual desire in women
Finance - $10M equity financing agreement reported; herpes data revealed
Finance - $20M secured for commercialization of whole genome sequencing technology
Finance - $30M financing closed by oncology company
Finance - Angiotech announces offering of common shares
Finance - Biotech company closes private placement; receives grant for ricin vaccine
Finance - Biotech firm announces $22.7M sale of common stock, warrants
Finance - Chemotherapy company raises in excess of $5M to develop Amplimexon
Finance - Company signs financing agreement; money to help fund ALS trial
Finance - Drug delivery company announces conversion of debt to equity; licensing agreement
Finance - Drugmaker reports increase in quarterly sales and net income
Finance - Epitopes-focused company completes private placement
Finance - Glycobiology company reports reduction in net loss in second quarter
Finance - Milestone reached in Amgen license agreement
Finance - New York City pharmaceuticals company announces asset sale and arbitration settlement
Finance - Pharmaceutical company announces public offering, sales agreement
Finance - Pharmaceutical company raises $2.5M through a private placement
Finance - Placement of preferred stock reported by biotech company
Finance - RNAi developer raises $8.7M in private placement of common stock
Finance - Sinusol maker receives commitment to raise $500,000
Finance - Supplement company begins trading on the New York Stock Exchange
Finance - Vaccine developer announces board change, provides corporate update
Financing - Pharmaceutical company raises $12.7M in private placement
Food Allergy - In food allergy, c-fos increased in brain emotion areas, anti-IgE resolved
Food Safety - Chicken rinse water can now be tested rapidly for Campylobacter jejuni
Food-borne Illness - Salmonella uses molecular "staples" to change structure of infected cells
Foot Ulcers - NIH funding to support trials of rhLF gel
Funding - NIH grant to fund Texas center for immunology and biodefense
Funding - Pharmaceutical company receives three research awards totaling $582,500
Fungal Infections - The newest antifungals are lipopeptides and pseudomycin-related compounds
Gastric Cancer - A phase II clinical trial evaluates effect of paclitaxel on ascites
Gastric Cancer - Taxanes may be useful for clinical application against gastric cancer
Gastrointestinal Cancer - There is a high degree of overexpression of COX-2 in upper GI cancers
Gene Transfer - Compacted DNA transfects arrested cells with better efficiency
Gene Transfer - NT-3 gene delivery elicits corticospinal axon growth following injury
Generic Anticonvulsant - Company asserts "first to file status" on gabapentin tablets in certain dosages
Genitourinary Parasites - Trichomonas vaginalis Hmp35 may be a new pore-forming protein
Genome Sequencing - MegaBACE DNA sequencing platform updated
Genomics - Chemogenomics company's library now consists of more than 250 drug signatures
Genomics - Tumor suppressor genes in hepatocellular carcinoma have aberrant profiles
Geriatrics - Activated macrophages in olfactory neurons in Alzheimers lower sensitivity
Geriatrics - The interrelation of cancer, depression, and aging may affect geriatric immunity
Gestational Diabetes - Serum C-reactive protein related to obesity in pregnant women
Glaucoma - FDA grants approval of generic glaucoma medication
Glycemic Control - Oral monotherapy solution for type 2 diabetes mellitus gains FDA approval
Gonorrhea - Neutrophil CEACAM3 receptor captures Neisseria gonorrhoeae by two mechanisms
Graft Failure - Enrollment completed for pivotal phase III trial studying E2F Decoy
Gram-Positive Bacteria - Company presents oritavancin data at ICAAC
Guillain-Barre Syndrome - Panel of leading neurologists announce best treatment
Gynecology - Interleukin-10 therapy stifles angiogenesis and ovarian cancer tumor growth
Gynecology - Intravaginal ring could be used in new approach to AIDS prevention
Gynecology - Postmenopausal women have rapid bone loss after withdrawal from long-term HRT
HIV/AIDS Drug Resistance - Non-parametric methods can predict HIV drug susceptibility from genotype
HIV/AIDS Neurology - Virological suppression in HIV patients linked to improved psychomotor speed
HIV/AIDS Pediatric - High IL-7 levels linked to CD4 cell recovery in pediatric HIV patients
HIV/AIDS Therapy - Antiretroviral drug interaction with lamivudine can affect its transport
HIV/AIDS Therapy - HIV protease inhibitor can be co-administered with Maalox TC, Zantac, or Lipitor
HIV/AIDS Therapy - Mutations in HIV gp41 linked to C-34 resistance
HIV/AIDS Therapy - Switch maintenance may prevent lipodystrophy in NNRTI-treated HIV patients
HIV/AIDS Therapy - Viramune or Efavirenz regimens demonstrate comparable viral decay rate
HIV/AIDS Vaccine - HIV-1 peptide protects mice against virus expressing HIV-1 antigen
HIV/AIDS Vaccine - Phthalocyanines may prevent sexually transmitted HIV infection.
HIV/AIDS Vaccine - Protein grafting used to create anti-HIV epitope
HIV/AIDS Vertical Transmission - Early antiretroviral treatment helps prevent vertical HIV transmission
HTLC Virus - HTLV-I-infected T-cell leukemia cells may not express Tax, may be immune evasion
Hantavirus - Causative Hantavirus genotype of hemorrhagic fever identified
Hearing Loss - Inserting steroids into tympanic membrane may help
Heart Disease Risk Factor - Reducing risk of congenital heart defects by vitamins debated
Heart Pump - Health Canada approves enhancements to Novacor LVAS
Helicobacter Pylori - H. pylori blocks T cell activation with vacuolating cytotoxin A
Hematology - Bleeding disorder in fawn-hooded hypertensive rat characterized
Hematology - Case of four factor deficiency described
Hematology - Coagulation factor VIIa binds to tissue factor to prevent apoptosis
Hematology - Competition for cofactor sites on thrombin determines its fate
Hematology - SU6668 uses a multifunctional approach for targeting myeloproliferation
Hematology - Thrombin activatable fibrinolysis inhibitor characterized
Hepatitis B Vaccine - Mosaic particles of hepatitis B virus protein are homo- and heterodimers
Hepatitis B Virus - UNICEF launches emergency vaccination campaign in Peru
Hepatitis C Virus - Duke, Johns Hopkins to lead first comparative trial of therapies
Hepatitis E Virus - Targeted cleavage of HEV RNA by hammerhead ribozymes blocks replication
Herpes Simplex - Cell membranes expressing gH as well as gD, but not gB or gL, stop HSV-1 entry
Human Papillomavirus - Anti-HPV16 IgA appears about a year postinfection, reverts sooner than IgG
Human Papillomavirus - HPV type 16 E5 protein is potential vaccine target
Hypertension - ALT-711 clinical development outlined
Hypoxia - Activator protein-1 plays role in down-regulation of CYP2J2 gene in hypoxia
Immunoglobulin Molecules - Cytoglobin is in the nucleus of all cells; neuroglobin is in brain, pancreas
Immunology - Antibodies help pediatric diabetic patients reduce daily insulin dose
Immunology - Antifungal in vivo efficacy data presented at ICAAC
Immunology - Bone marrow stem-cell transplants may be options for clearing hepatitis B virus
Immunology - Glycobiology company announces key appointments to board of directors
Immunology - Human trials begin of investigational HIV prime-boost vaccine candidates
Immunology - Memory T-cell generation needs costimulatory molecules from TNF receptor family
Infection - Anti-infective drugs highlighted at 43rd ICAAC
Infection Control - Antimicrobial biodegradable coating to reduce device infection risk
Infection Recognition - Toll-like receptors play a role in both antibacterial and antiviral responses
Infectious Disease - Europe produces guidelines for preventing worker to patient hepatitis infection
Influenza - Chimeric influenza A virus with influenza B virus neuraminidase created
Influenza - Influenza A virus load can be reduced the most by early oseltamivir therapy
Influenza - Positive results reported from human challenge study of FluINsure vaccine
Information Technology - AstraZeneca deploys j-forceNET sales channel
Information Technology - Medication safety system added to AmeriNet agreement
Infusion Services - Pact signed for full-line dual-source infusion contract
Initial Public Offering - Eye-focused pharmaceutical files IPO registration statement
Insulin Resistance - ELISA system for quantification of resistin developed
Interleukins and Clonality - T-cell clones don't appear to have monoallelic expression of interleukins
Kawasaki Disease - Pulmonary nodules with IgA plasma cells can occur in Kawasaki disease
Kidney Cancer - LABAZ1 is a new tumor model that complements the study of renal cell carcinoma
Kidney Disease - Thrombospondin-1 inhibition disables progressive renal disease
Kidney Stones - Kidney stone protein content used to investigate structure of organic matrix
Laboratory Automation - Production under way for PatchXpress drug-screening platforms
Lambert-Eaton Myasthenia - Patients and family members of those with LEMS have high serum IL-10, TNF-alpha
Legal Issues - Massachusetts attorney general sues 13 generic drug makers
Legal Issues - New patent covers restoring normal function to mutant proteins
Legal Issues - U.S. patent issued for high throughput gene expression analysis
Leishmaniasis - Protein kinase involved in flagellar-length control
Leishmaniasis - TNF-alpha regulates nitric oxide synthesis in macrophages, not neutrophils
Leptin Studies - Cerebral endothelial barrier not altered in diet-induced obesity
Leukemia - European phase II study commences in pediatric acute lymphoblastic leukemia
Leukemia - Specific targeted therapy of chronic myelogenous leukemia possible with imatinib
Leukemia Therapy - Novel assay detects low levels of STI-571 resistance mutations in CML patients
Leukocyte Activation - The conformation of lymphocyte CD69 needs calcium to bind carbohydrates
Liquid Handling - FDA issues four patents on applications of acoustic droplet ejection
Liver Protection - Liver ischemia-reperfusion damage may be decreased by tacrolimus therapy
Lung Cancer - Dolastatin 15 analogue LU 103793 is ineffective in treating advanced non-SCLC
Lung Cancer - It may be possible to predict response based on molecular signature
Lung Cancer - Lung cancer chemoprevention may be moving from concept to reality
Lung Cancer - No need to change postoperative treatment, says scientist
Lung Cancer - Patient enrollment in Targretin study concludes ahead of schedule
Lung Cancer - Phase I trial initiated for lung cancer vaccine
Lymphoproliferative Disorder - PTLD caused by Epstein Barr virus can be controlled with rapamycin
Macular Degeneration - U.S. FDA grants fast track review status for macular degeneration therapy
Malaria Pathogenesis - Erythrocyte protein target of plasmodial MESA identified
Malaria Therapy - Azadirachta indica derivatives not practical for malaria treatment
Malaria Therapy - C-2-symmetric inhibitors of Plasmodium falciparum plasmepsin II developed
Malaria Therapy - Cyclosporin-binding P. falciparum proteins identified
Malaria Therapy - Genetic basis of plasmodial drug resistance clarified
Malaria Therapy - Massive funding needed for artesunate-based malaria therapy in Africa
Malaria Therapy - Oxindole-based compounds inhibit Plasmodium protein kinases
Malaria Therapy - Plasmodial PfCRT expression modulates chloroquine resistance
Malaria Therapy - Plasmodial SAHH structure, function characterized
Malaria Vaccine - Plasmodium falciparum antigens identified
Malaria Vaccine - Plasmodium protein elicits antibodies that recognize conserved epitopes
Malignant Melanoma - SBIR award to aid development of melanoma peptide vaccine
Market Analysis - $20B growth factors market to expand in size, scope
Market Analysis - Average preclinical market research budgets 28% higher than phase I spending
Market Analysis - Current status reported for phase III trials of agents in oncology
Market Analysis - Drug market for type 2 diabetes will reach $20.5B in 2012
Marketing - I-Flow Corp. to copromote ON-Q Post-Surgical Pain Relief System
Measles Vaccine - Measles virus peptide recognized by T lymphocytes from human blood
Medicare - Industry-sponsored prescription drug savings program enrolls over 1 million
Medication Safety - Physicians encouraged to report adverse drug reactions in children
Melanoma - Interleukin 2 therapy helpful following surgery for metastatic bladder melanoma
Men's Health - Most infertility cases in men not caused by human FATE gene mutations
Meningitis - Platelet activating factor acetylhydrolase identified in meningitis CSF
Meningitis - Steroid treatment can reduce hearing loss, brain damage in children
Menopause - Ginkgo biloba causes modest cognitive improvements in postmenopausal women
Menopause - Twelve weeks of soy extract improves cognitive function in postmenopausal women
Mental Health - Obstetrical problems aren't linked to schizophrenia in the Caribbean population
Mental Health - Symptomatology in women with premenstrual disorders is wide-ranging
Mental Health - The burden of premenstrual dysphoric disorder resembles that of other disorders
Mergers and Acquisitions - Cephalon's revised acquisition proposal reviewed
Mergers and Acquisitions - Genzyme completes acquisition
Mergers and Acquisitions - Peptide suppler acquires reagents maker
Metastasis - Abnormal sugars present in many cancers could lead to new drug targets
Metastatic Cancer - During the last year of life, pain in many cases may be suboptimally treated
Metastatic Melanoma - Journal publishes Thalomid plus temozolomide study
Microarray - MWG Biotech strengthens U.S. market presence with partnerships
Migraine Relief - Imitrex found to provide migraine relief to patients with nausea or severe pain
Multifunctional Receptor - The mer receptor tyrosine kinase may be ubiquitous in immune cells
Multiple Sclerosis - Data support extremely early intervention
Multiple Sclerosis - Increased VLA-4, LFA-1alpha, MMP-9 occur at initiation of multiple sclerosis
Multiple Sclerosis - New oral MS drug successfully passes phase II
Multiple Sclerosis - New positive long-term results for Rebif presented at ECTRIMS
Myelodysplastic Syndrome - Patients with myelodysplastic syndrome lack natural killer T cell IFN-gamma response
Myocardial Infarction - Adjunctive therapy helps minimize damage to the heart
Myocardial Infarction - Trial results demonstrate safety of endovascular cooling after heart attack
Natural Killer Cells - NK cells depend on lysophosphatidic acid for chemotaxis, calcium mobilization
Nausea - Aloxi now commercially availability
Neisseria - Lipoprotein from Gram-negative bacterium identified
Neovascular Growth - High oxygen levels spark zone-wise obliteration of retinal capillaries
Nephropathy - Company announces first S.O.A.R. Program collaboration for KRX-101
Neuroblastoma - Anti-GD2 monoclonal antibody immunotherapy may prevent neuroblastoma relapse
Neuroblastoma - Retinoid therapy of high-risk neuroblastoma improved event-free survival
Neurodegeneration - Indomethacin protects against dopaminergic cell death in rat brain cultures
Neuroscience - Bisphosphonate clodronate prevents microglial cell activation upon CNS injury
Neuroscience - DAP12/TREM2 deficiency is linked to osteoporotic orientation
Neuroscience - Gene-modified cells correct Parkinson-like disease in animal models
Neuroscience - Rat pup calls model human problems associated with prenatal malnourishment
Nutrition - Healthy meal planning guides offered for people with HIV using Viracept
OTC Trading - Biopharmaceutical company's stock can now be traded electronically
Obesity Pathogenesis - Rise in cellular pH and sodium uptake greater in obese patients
Obstetrics - Bone loss occurs rapidly near the end of pregnancy
Obstetrics - Researchers urge caution over using ginseng in early pregnancy
Occupational Health - Workplace exposure to hepatitis C virus calls for timely management
Oncogenes - Identifying cancer genes - will it really lead to better treatment?
Oncology - Nonradioactive iodide stimulates apoptosis in genetically modified cancer cells
Oncology - Tetrathiomolybdate abridges NFkappaB signals to halt cancer metastasis
Open-Heart Surgery - Heart-stopping drugs described
Opportunistic Infection - IL-2 prevents MCMV retinitis by increasing intraocular perforin mRNA levels
Opportunistic Infection - Increased antimicrobial use by HIV patients may heighten MRSA risk
Oral Contraceptives - Generic Loestrin Fe 1/20 and 1.5/30 tablets approved
Orthopedics - Bone morphogenetic protein-4 gene therapy regenerates in vivo bone formation
Osteoporosis - Combination of PTH & bisphosphonates no better than either drug type alone
Osteoporosis - Etidronate cyclic therapy stems local osteoporosis after hip arthroplasty
Osteoporosis - Study shows risedronate sodium tablets helped preserve bone quality at 5 years
Otitis Media - Augmentin ES-600 more effective than Zithromax
Ovarian Cancer - Melphalan may be used for treatment of recurrent epithelial ovarian cancer
Ovarian Cancer - NIH grant to be used for dendritic cell vaccine research
Pain Medicine - Hyperbaric bupivacaine and intrathecal fentanyl prolong labor analgesia
Pain Medicine - Propofol half-life in fetuses is long after transplacental transfer
Pancreatic Cancer - Celecoxib added to gemcitabine and radiotherapy results in more toxicity
Pancreatic Cancer - First steps toward a vaccine described
Papillomavirus - Human papillomavirus type 45 can be neutralized by antisera to HPV45, HPV18 VLP
Parasitology - Hormones and drugs that control blood pressure also control malaria
Parkinson Disease - Deep brain stimulation offers benefits
Parkinson Disease - Interactions between biochemical deficits occur in model of Parkinson disease
Parkinson Disease - New treatment reduces "wearing off" effect of previous Parkinson disease drugs
Parkinson Disease - Protein mutated in early onset Parkinson's disease has been resolved
Patent Issues - Study: Generic drugs helping AIDS fight
Patents - European patent granted for chemical genetics technology for kinase drug discovery
Patents - Patent granted for non-contact method for pico-to-nano volume fluid transfer
Patient Care - Research suggests care of terminally ill patients improves through stabilized drug delivery
Pediatric Neurology - Multimodal therapy for neuroectodermal tumors may lead to future lymphoma
Pediatrics - Hydrochlorothiazide won't cause bone loss in youth with myelomeningocele
Pediatrics - Maturation tends to take care of voiding dysfunction in children
Personnel - Biotech company adds business, scientific leaders to its board of directors
Personnel - Biotech company forms scientific advisory board for potential cancer drug
Personnel - Biotech firm announces chairmanship transition
Personnel - Biotech promotes executives, names new VP, oncology sales and marketing
Personnel - Ettouati named chief business officer at oncology company
Personnel - Gene Mancino appointed to the board of immunotherapeutics company
Personnel - Guy Macdonald to direct operations and expand commercialization efforts
Personnel - Information technology company names Jim McLauchlan as CFO
Personnel - Jade R. Brown promoted to VP, marketing and business development
Personnel - Joseph L. Fischer named to board of directors
Personnel - Larry A. May named CFO of adult stem-cell company
Personnel - Pharmaceutical company announces new president and CEO, and chairman
Personnel - Pharmaceutical company appoints Nitin Kaushal to board of directors
Personnel - Scientific advisory board appointment announced by pharmaceutical firm
Personnel - Sullivan elected to board of directors
Physiogenomics - New company will apply genomics to disease prevention
Phytotherapy - Isoflavonoids from the rhizomes of Belamcanda chinensis arrest tumor growth
Plant Science - RAPD analysis used in genetic characterization of Echinacea medicinal plants
Platelet Activation - Epigallocatechin-3-gallate from green tea may inhibit platelet aggregation
Pneumonia - VAP-focused company reaches SPA agreement with FDA
Polio Vaccine - Poliovirus research in the vaccine era reviewed
Predictive Gene Function - Use of proteomics solutions demonstrated in cardiovascular disease
Pregnancy Complications - Macrophage inhibitory cytokine 1 is not an immune regulator in pregnancy
Prescription Drug Importation - As Minnesota looks into importing drugs to save money, pharma group balks
Prostaglandin - Human multidrug resistance protein acts as prostaglandin efflux transporter
Prostate Cancer - Celecoxib and nimesulide may be prostate cancer prevention/treatment agents
Prostate Cancer - Preliminary data from completed Provenge phase III trial D9901 reported
Prostate Cancer - U.S. deaths down one-third in men aged 50-74: Europe following?
Protein Kinase C - Zeta isoform of protein kinase C plays role in cancer cell movement
Proteomics - 'Top down' mass spectrometry used to identify intact proteins
Proteomics - E. coli DNA-binding protein mediates template recycling
Proteomics - A new human protein resembling zebrafish Sef modulates several functions
Proteomics - Key amino acids related to biological activity of huwentoxin-V reported
Proteomics - Migration inhibitory factor could be a therapeutic booster of cardiac repair
Proteomics - New look at beta-sheet structures using Raman optical activity reported
Proteomics - Proteins identified in cellular ubiquitin affinity extract
Pseudobulbar Affect - Data presented on late-stage drug candidate Neurodex
Pseudomonas - Pseudomonas tol-oprL gene products play role in solute uptake
Pseudorabies Virus - Changes in pseudorabies virus BUK-TK900 vaccine strain characterized
Pseudotumor - Bladder inflammatory pseudotumor can be distinguished histologically from cancer
RNA Interference - Research collaboration studies effects of siRNA-induced gene silencing
RNA Research - Interaction specifics of Bluetongue virus protein with viral RNA reported
Radiography - Signal detection in digital radiography investigated
Receptor Studies - Agonists for neuropeptide Y receptors stimulate different phases of feeding
Receptor Studies - Leptin- and orexin-receptors co-exist in feeding-regulating neurons
Reproductive Medicine - Repression of BMP-15 and GDF-9 mediates gamete regulation of female fertility
Respiratory Distress Syndrome - Lower protein C, higher thrombomodulin are found in acute lung injury, ARDS
Restenosis - Positive phase II results in restenosis trial of Neugene
Restenosis - Resorbable polymer drug-delivery stent now visible by X-ray
Restenosis - Results presented on CDS-TC-32 in inhibition of restenosis
Rheumatoid Arthritis - Novel proteins designed to block inflammation regulator discovered
Rheumatoid Arthritis - Treatment receives notice of allowance for patent
Rubella - Capsid protein responsible for complementation of deletion in rubella protein
Sales - Sixty-three percent of pharmaceutical companies employ contract sales organizations
Salmonella - Biogenesis of the Salmonella-containing vacuole explored
Salmonella - Iron-responsive genes in Salmonella enterica serovar typhimurium studied
Schizophrenia - Milestone reached in CARING study
Sexual Dysfunction - Removing the hurdles to adequate drug compliance will boost revenues
Shigella - Structural stability of Shiga toxin B-subunit analyzed
Sinusitis - Healthcare corporation acquires provider of chronic sinusitis therapies
Spinal Cord Injury - CD4, CD8 are differentially expressed on spinal cord, infiltrating macrophages
Spinal Muscular Atrophy - Drug safety studies in children with spinal muscular atrophy launch
Stem-Cell Transplantation - G-CSF-primed BM autografts improve hematopoietic recovery in some cancer patients
Stem-Cell Transplantation - Gemtuzumab ozogamicin increases VOD risk in myeloablative stem cell graft recipients
Stem-Cell Transplantation - Oral sirolimus shows promise as graft-versus-host disease prophylaxis
Stroke - Compound may provide estrogen's neuroprotective benefits without its risks
Stroke - Data on novel targets, compounds for stroke therapy presented
Substance Abuse - Epilepsy drug eyed for cocaine addiction
Systemic Lupus Erythematosus - Glomerular cells, infiltrating neutrophils undergo apoptosis in lupus nephritis
T-Cell Activator - Preproenkephalin production by immune cells boosts T-cell activation
Thoracic Cancer - Selective COX-2 inhibitors enhance tumor response to radiation
Thrombosis - PAR4 plays role in thrombin-induced thromboxane production in human platelets
Thrombosis - Pediatric lupus patients with anticoagulants have variable risk for thrombosis
Thymus Imaging - Different radiopharmaceuticals have distinct uptake patterns in the thymus
Toxicology - 1R4F reference cigarette smoke exposes smoking's effects in fetal animal models
Toxoplasmosis - Placental trophoblasts infected with Toxoplasma gondii don't rupture
Transfusion Complications - Transfusion-related acute lung injury is a risk factor for cardiac surgery
Transfusion Medicine - High MBL doses may be needed to preserve protective levels
Transfusion Medicine - Plasma-derived MBL safe for patients with MBL deficiency
Transgenics - Novel method of generating neuronal cell lines from knockout mice developed
Transplant Complications - Leukoencephalopathy due to polyomavirus may be a risk in lung, heart transplant
Transplant Medicine - Genetically predisposed kidney allografts may be at cancer risk
Transplant Medicine - Mycophenolate mofetil following kidney transplant may give risk of anemia
Trypanosomiasis - Enzymes essential to bloodstream form of African trypanosome identified
Tuberculosis Therapy - Genes encoding viomycin biosynthesis from Streptomyces vinaceus identified
Tularemia - Francisella tularensis causes proinflammatory changes in cells
Tumor Targeting - License obtained for heat-activated gene therapy
Type 1 Diabetes Pathogenesis - Linkage analysis of CTLA4 gene region in diabetic patients reported
Type 2 Diabetes Pathogenesis - Antioxidant deficiency present in type 2 diabetes
Type 2 Diabetes Therapy - Brain natriuretic peptide predictive of left ventricular dysfunction
Type 2 Diabetes Therapy - Glyburide/metformin provides better glycemic control than monotherapy
Type 2 Diabetes Therapy - Rosiglitazone increases ability of beta-cell to respond to glucose
Ulcers - Maintenance therapy not always necessary to prevent recurrence
Urinary Incontinence - New drug delivery system for treating incontinence developed
Vaccine Adjuvant - Recent advances in discovery and delivery of vaccine adjuvants reviewed
Vaccine Development - Researchers achieve in vitro infection by Ehrlichia ruminantium
Varicose Veins - Superficial vein thrombosis may lead to deep vein thrombosis, pulmonary embolism
Ventilator-Associated Pneumonia - Belfast research suggests way of reducing pneumonia in ITU patients
Viral Hepatitis - GB virus-B may be a viral surrogate for testing hepatitis C therapy
Virology - Liver inoculation with synthetic RNA causes GB virus B persistence in tamarins
Weight Gain - Postnatally overfed rats possess altered responses to neuropeptides
Weight Loss - Weight loss improves neurovascular and muscle metaboreflex control
West Nile Virus - Glycoprotein involved in West Nile virus infection characterized
Wilson Disease - Copper-binding sites regulate catalytic activity of Wilson disease protein
Wound Care - Erythropoietin stimulates major functions during wound repair
Wound Repair - Epiregulin is effective at ERK/MAPK activation, highly enhancing wound closure
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