Hematology
Bleeding disorder in fawn-hooded hypertensive rat characterized
Published in Drug Week, October 17th, 2003
"Release of platelet dense granule contents occurs in response to vascular injury, playing an important role in platelet aggregation and primary hemostasis. Abnormalities of the platelet dense granules results in a bleeding disorder of variable severity termed 'storage pool defect' (SPD). We have examined the fawn-hooded hypertensive (FHH) rat as a model of SPD in order to genetically map the locus (Bd) responsible for prolonged bleeding," investigators in the United States report.
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Source: Drug Week (2003-10-17)
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