Enzymology
Cholesterol oxidases illustrate nature's approach to protein design
Published in Drug Week, November 28th, 2003
According to a study from the United States, "Cholesterol oxidases are important as clinical reagents, potential larvicides, and tools in cell biology, and they are implicated in bacterial pathogenesis."
"Here we review chemical aspects of their function," said Nicole S. Sampson and Alice Vrielink at the State University of New York-Stony Brook. "We describe our current structural and mechanistic understanding of the type I and II cholesterol oxidases, our identification of an NH-pi hydrogen bond motif for stabilization of reduced flavins, our structural...
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Source: Drug Week (2003-11-28)
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