Published in Drug Week, February 6th, 2004
"Endothelin-1 is a vasoconstrictor peptide playing an important role in the pathophysiology of heart failure," cardiologists in France explained. "Endothelin-1 acts after fixation to two specific receptors: type A, responsible for vasoconstriction and type B, at the start of transient vasodilation and participating in clearance of the hormone."
"The experimental results in various animal models have demonstrated beneficial hemodynamic and clinical effects of the mixed or specific antagonists of the type A receptor," noted P. de Groote and colleagues at the...
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