Published in Drug Week, February 13th, 2004
According to recent research published in the journal Mutagenesis, "due to the very limited transduction capacity of hitherto available vectors, the success of gene therapy of tumors by means of suicide genes has so far essentially depended on the transfer of toxic drug metabolites from transduced (metabolizing) cells to adjacent non-transduced cells via gap junctions (bystander effect).
"Most experimental systems for the detection of a bystander effect yield net data of cell losses and cannot differentiate between killed transduced versus killed bystander cells. Here...
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