Published in Drug Week, March 26th, 2004
"Chronic diabetic ulcers are characterized by elevated levels of pro-inflammatory cytokines and proteases, which are thought to impair wound healing by degrading essential molecules. There is a need for an inexpensive, safe, and simple-to-use agent that promotes healing by selectively reducing levels of pro-inflammatory cytokines and proteases. Doxycycline, a member of the tetracycline family of antibiotics that inhibits metalloproteinases, was evaluated in vitro for inhibition of tumor necrosis factor-alpha (TNF-alpha) converting enzyme (TACE) and for inhibition of protease activities in human chronic...
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