Drug Week
Susan Hasty, Publisher
Table of Contents . . . April 2nd, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Drug Week | Other Publications
HIV/AIDS Proteomics - HIV Vif protein post-translationally modified by ubiquitin
HIV/AIDS Proteomics - Protease activity regulates Env-mediated membrane fusion
HIV/AIDS Proteomics - Tat from HIV subtype C has impaired chemotactic ability
HIV/AIDS RNA Research - Perinuclear HIV RNA release mediated by hRIP
HIV/AIDS RNA Studies - Antisense oligonucleotide scanning arrays reveal novel HIV leader RNA foldings
HIV/AIDS Therapy - Emtricitabine is option for once-daily antiretroviral therapy
HIV/AIDS Therapy - Protease inhibitors can induce lactic acidosis
HIV/AIDS Transmission - Medical injections do not spread HIV in rural Uganda
HIV/AIDS Vaccine - HIV-1 Nef delivery to dendritic cells may stimulate immune response
HIV/AIDS Vaccine - HIV-neutralizing antibody fragment isolated from lupus library
Head & Neck Cancer - Angiogenic protein marks oral squamous cell carcinoma prognosis
Head & Neck Cancer - Interim data announced for Xcytrin and concurrent chemoradiation trial
Head & Neck Cancer - TNP-470 diminishes tongue cancer growth and lymphatic invasion in study models
Healthcare Economics - Prescription drugs inflation down from 6.2% to 2.2% in just over 2 years
Healthcare Practice - General practitioners are more likely to prescribe technical aids to women
Heart Disease Risk - Microalbuminuria is marker of heart and kidney disease risk in diabetes
Heart Disease Therapy - At-home device would check blood thinning
Heart Disease Therapy - Baseline data from heart protection trial reveal dramatic shift in treatment
Heart Failure - Elevated LVEDP may induce myocardial cytokine release
Heart Failure - Interstitial purine metabolites elevated during post-MI LV remodeling
Heart Failure Therapy - Biventricular pacing may induce electrical remodeling
Hematological Malignancies - Dacogen shows activity in hematological malignancy patients, study shows
Hematology - Antisense knockdown in zebrafish models mammalian prothrombin deficiency
Hematology - Hepatic infiltration of leukemia cells leads to non-alcoholic steatohepatitis
Hematology - Mechanisms downstream of P2Y12 ADP-receptor described
Hematology - Prostaglandin E1 enhances inhibition of platelet aggregation
Hematology - Protein 4.2 critical to CD47-membrane skeleton attachment in red cells
Hematology - Therapy containing adeno-associated virus type 8 corrects murine hemophilia A
Hemophilia A - Marketing authorization granted from EC for Advate
Hepatitis C Virus - Study shows highest sustained response rates reported in hepatitis C patients
Hepatitis E Vaccine - Hepatitis E virus-like particles protect monkeys against HEV infection
Hepatitis Vaccine - Hepatitis B surface antigenemia occurs after hepatitis A and B vaccination
Hepatology - Balanced cytochrome P4502E1 activity is key to treating steatohepatitis
Hereditary Antithrombin Deficiency - Company presents ATryn safety and efficacy data
Hunter Syndrome - Patient enrollment completed in Hunter syndrome clinical trial
Huntington Disease - CRE-mediated transcription increased in Huntington disease
Hypercholesterolemia - Group seeks ban of anticholesterol drug
Hypercholesterolemia - Study: Lower cholesterol helps save lives
Hypertension - Alagebrium chloride approved as generic name for ALT-711
Hypertension - Angiotensin II increases tyrosine hydroxylase production in rat adrenal medulla
Hypertension - Study looks at cost of high blood pressure therapy
Hyperthyroidism - Propylthiouracil is preferred therapy for pregnant women with thyroid disease
Hysterectomy - Study reports the standard of care for radical hysterectomy in Europe
Immune System Disorders - Regulatory approval granted in Germany for Gamunex
Immunology - CD4+CD25+ TR cells control anti-HIV, CMV T-cell activity
Immunology - Interleukin 3 modulates etoposide toxicity on mouse macrophages
Immunology - Interleukin-1 beta stimulates persistent liver inflammation
Immunology - Patient demographics influence granulocytic surface antigen markers
In Vitro Fertilization - Study supports move toward single births
Infectious Disease - CIEF-WCID may enhance norovirus testing
Infectious Disease - Epidemiology of human M. bovis infection in U.K. characterized
Infertility Treatment - European Commission approves Gonal-f Filled-by-Mass prefilled pen
Inflammation - Rosiglitazone reduces acute inflammation
Influenza - Targeted treatment could contain pandemic influenza
Influenza Vaccine - Children with nephrotic syndrome have adequate response to influenza vaccine
Information Technology - IASIS awards McKesson solutions $30 million IT contract
Information Technology - Network to allow electronic exchange of prescription information
Information Technology - Web-based retail pharmacy network enrolls with RxScan to minimize errors
Insomnia - Company begins trial for extended release formulation of Sonata
Insomnia - FDA issues approvable letter for ESTORRA
Insomnia - Study: Indiplon effective in treating elderly patients with difficulties maintaining sleep
Insulin - Momordica charantia fruit suppresses blood glucose
Insulin - Pfizer and Aventis seek approval to market Exubera in Europe
Insulin - Phase II trial of insulin sensitizer MBX-102 begins
Insulin Resistance - Research: Lower chromium levels linked to increased risk of disease
Interstitial Cystitis - New drug combinations manage the symptoms of a painful bladder disorder
Invasive Aspergillosis - Zadaxin demonstrates anti-fungal efficacy in invasive aspergillosis study
Ischemia - Effects of tPA and PAI-1 on blood vessel tone described
Kidney Disease - New treatment may help patients with kidney failure
Legal Issues - Pennsylvania sues drug makers over pricing practices
Legal Issues - Pharmaceutical dosage division transfers operating revenues to joint venture
Leishmaniasis - Sesquiterpenes inhibit multidrug-resistance in Leishmania tropica
Leptin Studies - Cocaine transcript stimulates lipid metabolism to control body fat accrual
Leptin Studies - Leptin resistance in obesity related to defects in leptin signaling pathways
Leukemia - Bone marrow transplant from partially mismatched family donor is feasible
Leukemia Pathogenesis - E2a/Pbx1 triggers proliferation of SCF-dependent pro-T cells
Leukemia Therapy - Effects of class I HLA NK epitopes on haploidentical SCT outcome determined
Leukemia Therapy - Unrelated cord blood transplantion feasible for adult AML patients
Licensing Agreement - Endo enters agreement to codevelop new drugs for pain
Lipid Studies - Lipoproteina levels respond to life-style changes in obese adults
Lipid Studies - Negative energy balance and exercise improves lipid profiles
Liver Disease - Hepatitis C virus carriers need access to quality, continuous care
Local Anesthetics - Company reports results of ENT-103 expanded preclinical testing
Lung Cancer - Adenovirus-mediated p53 expression uses other genes to stimulate apoptosis
Lung Cancer - Translational research seeks ways to avoid radiotherapy-induced lung toxicity
Lupus Nephritis - New medicine offers hope to lupus patients with kidney disease
Lymphoid Cancer - European approval granted for once weekly NeoRecormon
Lymphoma Therapy - Post-SCT immunological recovery similar in CLL, NHL patients
Lymphoproliferative Disease - Reduced-intensity BEAM-alemtuzumab SCT effective
Malaria Drug Resistance - Crt and Mdr1 orthologues not involved in P. chabaudi chloroquine resistance
Malaria Therapy - ACT adherence low for pediatric patients in Zambia
Malaria Therapy - Mefloquine-artesunate effective for treating uncomplicated malaria
Malaria Transmission - No Plasmodium infection found in donated blood from Turkey
Male Pattern Baldness - Homspera deemed dermally nontoxic
Manufacturing Agreement - Ligand inks agreement for manufacturing and packaging of AVINZA
Market Analysis - Americans might be getting better deal on pharmaceuticals than Europeans
Market Analysis - Biotech was up nearly 2% in February
Market Analysis - Twenty-two year analysis shows overall media coverage of HIV/AIDS decreasing
Market Trends - Report: Key opinion leaders trend toward specialization
Medical Errors - New Mexico doctors face license loss
Medical Ethics - Research ethics and placebo use debated
Medicare - Health insurance plans moving forward on drug discount card for beneficiaries
Menopausal Symptoms - Research validates efficacy of herbal remedy MenoCare
Menopause - Many variables affect hair thickness and its other properties in aging women
Menopause - Ovarian failure changes reproductive mechanisms, not energy balance
Menstruation - Prostacyclin plays a pivotal role in normal and dysfunctional menstruation
Mergers & Acquisitions - Assets of Hematronix purchased by diagnostics services company
Mergers & Acquisitions - Assets of biotech firm involved in immune regulation, hepatitis acquired
Mergers & Acquisitions - Fisher completes acquisition, expands its portfolio of proprietary products
Mergers & Acquisitions - National Health Services, Inc., acquisition completed
Mergers & Acquisitions - Neutron Enterprises, Inc., completes merger; retains legal, accounting firms
Mergers & Acquisitions - Pure Encapsulations acquired for $50 million in cash
Metastatic Breast Cancer - CNS metastases from breast cancer can occur after trastuzumab treatment
Migraine - Off-label use of drug gives children relief
Myelodysplastic Syndrome - Protein 4.1 deficiency linked to acquired elliptocytosis
Myelodysplastic Syndrome - Revlimid receives orphan drug designation by the European Commission
Myocardial Infarction - Beta blockers usage low despite insurance
Myocardial Infarction - MCIP1 overexpression preserves post-infarction cardiac function
Myocardial Infarction - State-required CME: No effect on heart attack care, boosts use of branded drugs
Neurobiology - Neuroscience company raises $19.4 million in private equity financing
Neuroscience - A novel technique highlights the elements of early neuronal development
Neuroscience - Dopamine neurons mediate excitatory signals via glutamatergic synapses
Neuroscience - Erythropoietin cDNA protects rodent brains against hypoxia-ischemia
Neuroscience - Gender influences interhemispheric interconnectivity in the corpus callosum
Neurotoxin - Trimethyltin induces apoptosis via caspase activation in PC12 cells
Non-Hodgkin Lymphoma - Long-term chemotherapy in children with NHL adversely affects teeth
Non-Hodgkin Lymphoma - Pivotal trial initiated for Pixantrone
Nuclear Medicine - Company announces commercial availability of lutetium, rhenium
Nutrition - FDA to consider petition for more extensive health claims for calcium
Obesity Epidemiology - Obesity, diet, and physical activity in college students assessed
Obesity Epidemiology - Prevalence of obesity in southeast Spain increasing
Obesity Therapy - 5-Hydroxy-L-tryptophan suppresses food intake in stressed rats
Obesity Therapy - Exercise augments CB1-receptor inverse agonist effects on weight loss in mice
Obstetrics - Fetal short femur length identifies babies at risk for skeletal dysplasias
Obstetrics - Mother-to-child transmissions of HTLV type I have fallen in Japan
Obstetrics - When lactation ends bones regenerate to prepare mothers for more reproduction
Oligodontia - Missense mutation in PAX9 causes non-syndromic oligodontia
Oncogenes - Researchers find a protein that controls cell growth
Oncogenesis - Protein tyrosine phosphatase gamma is a tumor suppressor gene in breast cancer
Oncology - Signals for c-erbB-2 and VEGF combine to assess breast cancer prognosis
Ophthalmology - Biochemical inhibitors may be able to prevent diabetic retinopathy
Orthopedics - Body composition associates with type of hip fracture among elderly women
Osteoarthritis - Clinical study confirms efficacy of Lyprinol in treating osteoarthritis
Osteomyelitis - Acceptable treatment failure rates of osteomyelitis in diabetes listed
Osteoporosis - Assessments of medieval bones show activity mitigates osteoporotic fracture
Osteoporosis - Estrogen receptor genotypes explain perimenopausal bone loss rates
Osteoporosis - Hydrocortisone increases the differentiation rate of human osteoblasts
Osteoporosis - MMP-9 gene changes associate with bone mineral density in men but not women
Osteoporosis - Premenopausal women show specific chromosomal links to bone mineral density
Osteoporosis - Research services company announces osteoporosis contract
Osteoporosis - Risedronate reduces nonvertebral fracture risk within 6 months of initiation
Osteoporosis - When combined, alendronate and HRT have no added benefit for gaining bone mass
Ovarian Cancer - Combo paclitaxel/carboplatin is effective as second-line ovarian cancer therapy
Pain Medicine - Drug safe and effective for the elderly
Parainfluenza Vaccine - Parainfluenza type 3 vaccine safe and effective in children
Parkinson Disease - Disposition of 1,2,3,4,-tetrahydroisoquinoline in rat brain reported
Patents - Additional patent granted on phenotype microarray technology
Patents - Company receives third ISA247 patent
Patents - Donation of patents may accelerate new treatment for global health problem
Patents - Preliminary injunction relating to Tannate 12d S will delay initial shipments
Patents - Tissue engineering company announces approval of Canadian patent
Pediatric Epidemiology - Community issues diminish the effects of IMCI on infant mortality in India
Pediatric HIV/AIDS - HLA-A2-restricted anti-Nef CD8 cell response limited in children
Pediatrics - Most preterm infants in Brazil need preventive antimicrobials
Peripheral Neuropathy - Sensory impairments from peripheral neuropathy improve in Anodyne study
Personnel - Aetna chief financial officer joins ophthalmology company board of directors
Personnel - Andrew M. Clarkson and J. Kenneth Glass join board of men's health company
Personnel - Ashley Bush signs 10-year consultancy agreement with biotech firm
Personnel - Biomaterials company announces new vice president of sales
Personnel - Bioscience company appoints new chairman
Personnel - Biotech company reports board changes, new governance structure
Personnel - Biotechnology company elects Eric H. Bjerkholt to board of directors
Personnel - Canadian biotech company announces CFO change
Personnel - Carroll named chief business officer at firm developing nanofluidic systems
Personnel - Chief financial officer John McCarthy leaves genomics firm
Personnel - Device company names new board member
Personnel - Drug-discovery company names new CEO
Personnel - Genomics company appoints Paulette Dillon chief business officer
Personnel - Genomics company appoints financial expert to board of directors
Personnel - Glycoprotein company makes development appointment, opens new office
Personnel - Joseph C. Connors, general counsel, plans to leave company.
Personnel - Joseph Harris named to board of EndoVenous laser treatment maker
Personnel - Leon E. Rosenberg, MD, joins biopharma's board
Personnel - Montgomery named VP of business development at pharmaceutical firm
Personnel - Papadopoulos named to board of directors at genomics firm
Personnel - Pharmaceutical company announces new members of scientific advisory board
Personnel - Pharmaceuticals company announces new scientific advisory board members
Personnel - Plattner named head of research at anti-infectives pharmaceutical firm
Personnel - Promotion, appointment of regulatory affairs post reported at drug firm
Personnel - Protein therapeutics company adds to senior management team
Personnel - Research-based startup names first chief executive officer
Personnel - Spitz named marketing and sales VP at drug delivery firm
Pharmaceutical & Drug Development - Intestinal solute carriers improve oral drug absorption
Pharmaceutical & Drug Development - Microwave accelerated oligonucleotide labeling expands research possibilities
Phytohormone - Newly discovered 8-prenylnaringenin is a strong angiogenesis inhibitor
Prescription Drug Benefits - United Methodist Church offers discounts on prescription medications
Prion Disease - Fibroblast cell lines susceptible to TSE agents
Prostate Cancer - Finasteride adversely affects the early diagnosis of prostate cancer
Prostate Cancer - Peptide vaccine helpful for HLA-A2-positive patients with prostate cancer
Prostate Cancer - VEGF plays a fundamental role in the promotion of osteoblastic metastasis
Protein Expression - Multi-affinity tag system to produce proteins in E. coli developed
Protein Mapping - Protein-protein interaction map of virulence-related genes published
Proteomics - Formin induces nucleation of actin filaments
Proteomics - Gene structure new member of Tieg family of proteins reported
Proteomics - Integrated lysis and affinity purification plates introduced
Proteomics - Ku86 deficiency reduces intrachromosomal homologous recombination
Proteomics - Tumor endothelial marker 8 interactions mediate tumor angiogenesis
Pulmonary Medicine - Excess placenta growth factor exacerbates pulmonary emphysema
Pulmonary Medicine - VEGF and proteolytic enzyme show a strong correlation with pleural effusions
Rankings - Diagnostics company named best in people development by Training magazine
Receptor Studies - G-protein coupled receptors in neuroendocrine pathways are oligomeric
Receptor Studies - ORL1 receptor modulation of calcium channels is agonist-independent
Renal Disease - HCV elicits abnormal immunology in a patient with kidney disease
Reproductive Medicine - Transcription factor required for lamina propria differentiation
Respiratory Medicine - LTB4 promotes neutrophil recruitment to inflamed pleural space
Restenosis - FDA approval granted for Taxus Express2 paclitaxel-eluting stent system
Rheumatoid Arthritis - Lipid peroxidation decreased in patients with rheumatoid arthritis
Rheumatology - Interleukin gene therapy expands options for treating osteoarthritis
Rotavirus Vaccine - HIV-1 Tat peptide-rotavirus enterotoxin protein stimulates immune response
SARS - Company announces discovery of compound for the potential SARS treatment
Schistosomiasis - IL-12 enhances immunity of Schistosoma mansoni fatty acid-binding protein
Schizophrenia - Impaired AKT1-GSK3 beta signaling plays role in schizophrenia
Sepsis - Inhibition of myocardial cytochrome C oxidase involved in sepsis
Sexual & Reproductive Health - Patient demographics and provider differences affect abortion outcomes
Sexual & Reproductive Health - Previous Chlamydia trachomatis infections adversely affect male fertility
Skin Cancer - Topical celecoxib treatment can inhibit acute oxidative tissue damage
Small-Cell Lung Cancer - Vinorelbine plus doxorubicin in relapsed small-cell lung cancer is highly toxic
Smallpox - Clinical trial of smallpox vaccines to be conducted in St. Louis
Smallpox - New inoculations show promise
Smallpox - Recommendations issued on development of drugs for vaccine side effects
Smoking Cessation - New drug helps smokers quit while limiting post-cessation weight gain
Sports Medicine - Hormone supplement used by athletes may not increase testosterone
Staph Infections - Altastaph receives FDA fast track designation
Stem-Cell Research - Endothelial progenitor cells are detected in infantile hemangioma
Stem-Cell Research - Four-color immunofluorescence enables mesenchymal stem cell identification
Stem-Cell Research - OLIG2 inhibits astrocyte differentiation
Stem-Cell Research - Olfactory bulb neural stem cells lack hematopoietic potential
Stem-Cell Research - PU.1 supports proliferation of immature erythroid progenitors
Stem-Cell Research - SOCS3 negatively regulates granulopoiesis and G-CSF receptor signaling
Stem-Cell Research - TRAIL regulates erythroid maturation via ERK signaling
Stem-Cell Research - Verotoxin and IFN-alpha have synergistic effect on erythropoiesis
Stem-Cell Transplantation - Fetal cytokine production during MLRs determined
Stem-Cell Transplantation - RIC SCT feasible for patients with advanced solid tumors
Stem-Cell Transplantation - Treosulfan-fludarabine conditioning regimen safe and effective
Stomach Ulcers - New 10-minute test for ulcer screening introduced
Stroke - Association tools help hospitals improve stroke care
Stroke - Early treatment confirmed as key to stroke recovery
Stroke - Lack of awareness about stroke hinders use of life-saving drugs
Tick-borne Disease - Antibodies to tick salivary antigens detected in patients from Spain
Tick-borne Disease - Cases of spotted fever rickettsioses in U.S. travelers summarized
Transfusion Medicine - Effects of cryopreservation on cord blood cell immunogenicity determined
Transplant Medicine - Depression is less common among married transplant recipients
Transplant Medicine - Living donor liver transplantations face technical challenges
Tropical Medicine - Congenital Trypanosoma cruzi abounds in Bolivia despite reduced poverty
Tuberculosis - Biotechnology company licenses gene target identification technology
Tuberculosis - TB often underlies cervical lymphadenopathies in Mexican women
Tuberculosis - Unique proteins identified in Mycobacterium tuberculosis
Tuberculosis Diagnostics - Bactec MGIT 960 provides accurate TB drug resistance profiles
Tuberculosis Enzymology - Structural features of M. tuberculosis AKmt identified
Tuberculosis Enzymology - Structure of M. tuberculosis RpiB characterized
Tuberculosis Epidemiology - Factors linked to TB clustering in Spain identified
Tuberculosis Pathogenesis - STAT1 plays key role in defense against pulmonary TB in mice
Tuberculosis Proteomics - Structure of M. tuberculosis MPT51 protein characterized
Tuberculosis Therapy - Fast-flow EPR spectroscopy enables observation of isoniazid hydrazyl radical
Tuberculosis Therapy - Location of M. tuberculosis KatG radical formation identified
Tuberculosis Vaccine - Prospects for new tuberculosis vaccines reviewed
Type 2 Diabetes Pathogenesis - Reducing oxidative stress improves glycemic control in type 2 diabetes
Type 2 Diabetes Therapy - Protein tyrosine phosphatase inhibitor acts as antihyperglycemic agent
Urinary Incontinence - Bladder neck mobility increases the odds for post-pregnancy stress incontinence
Vaccine Development - Acetyl and phosphate groups quantified in vaccine polysaccharides
Vaccine Efficacy - Diphtheria-tetanus-pertussis vaccine booster effective in adults
Vector Development - Expression of exogenous genes in Trypanosoma cruzi improved
Vector Development - Lentiviral vector encoding NY-ESO-1 induces effective CTL response
Vector Development - Silk-elastin-like hydrogels convey genes to human cancer cells
Virology - A new continuous nonradioactive assay monitors RNA polymerase activity
Virology - Human TT virus variants may be associated with pathology
Virology - Key steps optimize the propagation of gene deleted Sendai virus vectors
Virology - Two-step purification confirms that RNA viruses replicate within RNP complexes
Weight Reduction - Group calls for comprehensive solutions to help reduce obesity
Women's Health - AHA responds to findings from Women's Health Initiative
Wound Care - Skin substitutes and wound healing reviewed
siRNA Targeting - siGENOME siRNA targets entire human genome
HIV/AIDS Proteomics - Effects of P-TEFb on HIV transcription elucidated
HIV/AIDS Perinatal Medicine - HIV coreceptor expression determined in exposed but uninfected infants
HIV/AIDS Proteomics - Assembly properties of HIV CA protein determined
HIV/AIDS Pathogenesis - HIV matrix serine phosphorylation in early postentry replication clarified
HIV/AIDS Immune Control - TRIM5alpha restricts HIV infection in Old World monkeys
HIV/AIDS Epidemiology - Ottawa HIV "superinfection" case did not carry superinfection
HIV/AIDS Gene Therapy - Novel anti-HIV lentiviral vector efficiently selects transduced stem cells
HIV/AIDS Epidemiology - HIV test interval information useful in progression studies
HIV/AIDS Dementia - Cocaine-enhanced gp120-induced neurodegeneration mediated by iNOS
HIV/AIDS Diagnostics - Incomplete peptide dissolution can lead to false-positive ELISPOT results
HIV/AIDS Cancer - AIDS-associated oral plasmablastic lymphomas linked to HHV8, EBV infection
HIV/AIDS Dementia - CXCR4 mediates gp120 neurotoxicity in cerebellar granule cells
HIV/AIDS - Serostim decreases visceral adipose tissue in HARS patients, study shows
HIV/AIDS - FDA authorizes a clinical study with Alferon LDO for HIV
HIV Therapy - IND filed with FDA for phase Ib/IIa trials for HIV viral entry inhibitor
Gynecology - Tumor angiogenesis has no predictive value for epithelial ovarian cancer
Gynecology - Sublingual misoprostol is better than oral delivery for cervical priming
Gynecology - Steroid hormones are strong regulators of vaginal tissue contractility
Geriatrics - Researcher reports on key antioxidant to slow aging
Gynecology - Ovarian cancer cells regain more normal phenotypes with simultaneous therapy
Geriatrics - Clinicians need better tools for identifying people at risk for fracture
Genomics Toolkit - Collection of functional gene knockouts in a multicellular organism published
Genomics & Genetics - X-linked gene elements leave women vulnerable to primary biliary cirrhosis
Genomics & Genetics - Gene for vitamin K epoxide reductase identified
Genomics & Genetics - Cardiac troponin I mutation linked to idiopathic dilated cardiomyopathy
Gene Silencing - DNA-delivered RNAi products launched for research applications
Generic Drugs - FDA approves generic version of Claritin-D 24-Hour
Gene Expression Analysis - RNAi, siRNA educational website launched
Gastroenterology Vaccine - Progress made in vaccines against gastrointestinal helminth parasites
Gastric Ulcer - Prevacid NapraPAC available in U.S.
Gastric Cancer - Gastric cancer patients benefit from combined, intermittent chemotherapy
Food-borne Illness - Method to determine putrescine and cadaverine in shrimp developed
Fraser Syndrome - Link found between the protein GRIP1 and Fraser syndrome protein Fras1
Food-borne Illness - Method to confirm chloramphenicol in seafood validated
Food-borne Illness - Indicator organisms for safety and quality reviewed
Food-borne Illness - Fresh garlic, semi-dried tomatoes linked to Salmonella Virchow spread
Finance - Therapeutics company announces closing of $57.7M common share offering
Finance - Specialty pharmacy completes $150 million credit facility
Finance - Specialty pharmaceutical company reports net loss
Finance - Specialty pharmaceutical company closes $25.8M round of financing
Finance - Schroder leads $10.2M venture capital financing
Finance - Record revenues for fourth quarter produce first quarter of profits in company
Finance - Proposed offering of convertible senior notes announced
Finance - Pharmaceutical company reports loss of $0.85 per share
Finance - Pharmaceutical company reports annual sales increase of 103%
Finance - Pharmaceutical company reports 2003 financial results
Finance - Pharmaceutical company files registration statement for IPO
Finance - Pharmaceutical company announces series A preferred financing
Finance - Pharmaceutical company files for initial public offering
Finance - Pharmaceutical company announces 2003 financial results
Finance - Pain relief company closes on $5 million financing
Finance - Pharmaceutical company announces $34M private placement
Finance - OTC pharmaceuticals firm reports 15% increase in sales
Finance - NIH grant awarded to expand development of antianthrax antibodies
Finance - Lifestyle-drug-focused biotech announces 3-for-2 forward split
Finance - Generics company completes sale of $400M of 1.5% senior convertible notes
Finance - Immunotherapy company announces net losses for quarter, year
Finance - Generic drug maker reports earnings of $0.32 per share
Finance - Factive maker reports net losses for fourth quarter and fiscal year 2003
Finance - Drug-delivery company raises $1.764 million through private placements
Finance - Drug delivery company's revenues up 61%
Finance - Drug delivery company reports improved financial results
Finance - Device firm reports 13% increase in revenues
Finance - Biotechnology company completes sale of convertible debenture offering
Finance - Cancer diagnostics company closes round A funding
Finance - Cancer vaccine maker reports quarterly loss of $11.1M
Finance - Biotech company announces exercise of underwriters' over-allotment option
Finance - Biotech company received Nasdaq delisting notice
Finance - Biotech company reports fourth quarter earnings per share of $0.24
Finance - Biosciences company reports $6.2M private equity placement
Finance - Biotech board approves conditional stock split
Finance - Australian biotech company receives second U.S. $3M milestone payment
Finance - American Stock Exchange lists common stock of generic drugs company
Finance - 22% increase in revenues reported by lab services company
Female Sexual Arousal Disorder - Viagra clinical studies in women do not support regulatory filing
Female Sexual Arousal Disorder - Company to launch Femprox clinical study in China
Eye Cancer - Rb protein's role in retina development is key to understanding retinoblastoma
Atrial Fibrillation - Studies reinforce potential benefits of new stroke-prevention drug
Crohn Disease - Drug can heal, reduce recurrence of fistulas
Diabetes - Company to advance LY519818 into phase III studies for type 2 diabetes
Erectile Dysfunction - Drug appears safe for some men with congestive heart failure
HIV/AIDS Drug Resistance - Crystal structures of NNRT-resistant HIV RT characterized
Heart Disease - Study: Cholesterol lowering with atorvastatin halts progression of heart disease
Pharmaceutical & Drug Development - Peptide ester conjugates for ester prodrug stability developed
Abortion - Ultrasounds are advised for all women who request pregnancy termination
Actinic Keratosis - FDA approval granted for immune response modifier for precancerous skin lesions
Acute Coronary Syndrome - Analysis from TACTICS-TIMI 18 trial published
Addiction Medicine - GABAB receptor agonists exert bidirectional effects on dopamine
Addiction Medicine - Study: Alcohol treatment meds, behavioral therapy effective for cocaine addiction
Addiction Medicine - Women, drinkers, and older people are at risk for prescription drug misuse
Adipose Tissue - Beta-adrenergic receptor agonists increase apoptosis of adipose tissue
Adipose Tissue - Preadipose cell changes into smooth muscle-like cells investigated
Age-Related Macular Degeneration - Macugen data presented at Aspen Retinal Detachment Society meeting
Alcoholism - Alcoholism and obesity may involve overlapping neuropeptide pathways
Allergy Medicine - Increased thrombin activity occurs after allergen challenge
Allergy Medicine - Phase II/III trial initiated for ragweed allergy immunotherapy
Alzheimer Disease - A-beta antibody levels not changed in patients with Alzheimer disease
Alzheimer Disease - ACE gene polymorphism linked to damage in Alzheimer disease
Alzheimer Disease - Common bacteria linked to brain disease
Alzheimer Disease - Physiological role of beta-amyloid peptide explains Alzheimer disease
Alzheimer Disease - Vaccine shows promise in animal model
Amyotrophic Lateral Sclerosis - Studies support role of glutamate, RNA processing in muscle-wasting disease
Angiology - Matrix metalloproteinase-9 is needed for revascularization after ischemic injury
Angiology - Polymorphism in gene promoter linked to increased bilirubin and HDL levels
Angiotensin - Angiotensin II attenuates caspase-3 activation in cortical neurons
Anthrax Vaccine - FDA-licensed anthrax vaccine supplied to Taiwan
Anthrax Vaccine - Phase I clinical trial results of anthrax vaccine candidate reported
Antibiotics - Major determinants of activity of antibiotic peptide described
Antibiotics - Partnership to develop novel formulation of amoxicillin
Artificial Blood - Progress in development of blood substitutes reported
Asthma - Inhaled steroid therapy does not reduce fetal growth
Atherosclerosis - Endothelial catalase overexpression attenuates oxidant-mediated injury
Attention Deficit Disorder - Better driving by teens with ADHD may be due Concerta
Awards - Technology company receives award for pharmaceutical automated sales tool
Bacillus - Method to identify protease genes from B. thuringiensis developed
Bacteriology - Acyl-homoserine lactone binding in Vibrio fischeri is reversible
Bacteriology - YefM antitoxin family carries novel antibacterial target
Benign Prostatic Hyperplasia - Uroxatral marketed in U.S. for benign prostatic hyperplasia
Bioengineering - The biosurfactant MEL-A cultivates vigorous liposomal transfection
Biotechnology - Peptide array used to identify Ang II inhibitory peptide
Biotechnology - SdFFF system aids study of PFC emulsion particle stability
Body Composition - A large-sample QTL study in mice examined body composition
Bone Loss - Low vitamin B-12 levels linked to bone loss in older women
Brain Cancer - IL-2-activated NK cells enhance effect of tumor vaccine in brain cancer
Brain Tumors - Proton therapy offers advantages for children with brain tumors, study shows
Breast Cancer - Estrogen interacts with estrogen receptor and SP proteins to control VEGF
Breast Cancer - Fulvestrant gains E.U. marketing approval
Breast Cancer - Patients switched from tamoxifen to exemestane more likely to stay cancer-free
Business & Finance - Antibody company files for initial public offering
Business & Finance - Biosciences company updates stock plan, gets patent
Business & Finance - Dermatology company emerges from Chapter 11 protection with new owners
Business & Finance - Drug development company announces reduced loan principal
Business & Finance - Drug development services provider expands facility and increases credit line
Business & Finance - Pharmaceutical company announces vitamin E contract
Business & Finance - Pharmaceutical company enters agreement to sell MVI product business
Business & Finance - Pharmaceutical company makes significant strides in 2003
Business Update - Firm combines gene expression, proteomics and reagents businesses
Business Update - Wellbutrin maker provides updated 2004 guidance
Cancer - Biopharmaceutical companies announce antibody collaboration
Cancer - Pharmaceutical company provides update on second-generation TAPET vectors
Cancer Metastasis - Platelet-activating factor boosts the activation of proangiogenic cytokines
Cancer Prevention - Advocacy group to accelerate the attack on cancer
Cancer Research - Movies of cells capture transmission of messages that control genes
Cancer Therapy - Decoy receptor 3 can be suppressed to staunch tumor angiogenesis
Cancer Therapy - First KOS-862 phase Ib chemotherapy combination trial begins
Cancer Therapy - Higher doses would make taxane-mediated antiangiogenesis more effective
Cancer Therapy - Polo-like kinase 1 is a viable target for the treatment of prostate cancer
Cancer Therapy - Semaphorin-3F curtails tumor angiogenesis
Cancer Therapy - Spacer-containing doxorubicin prodrugs limit tumors without systemic toxicity
Cancer Vaccine - CG motifs in virus-like particles induce cytotoxic T cell responses
Candidiasis - New peptide derived from protein in saliva may be promising antifungal agent
Candidiasis - Protease-inhibitor cocktail protects, increases antimicrobial action of new peptide
Cardiology - AT2 -receptor antagonists block Ang II effects on atrial noradrenaline release
Cardiology - High heart rate reduces arterial distensibility
Cardiovascular Disease - AT1 receptors linked to insulin resistance-induced vascular dysfunction
Cardiovascular Disease - Angiotensin II causes oxidative stress in hypertension patients
Cardiovascular Disease - Antioxidant therapy helps manage diabetic cardiovascular disease
Cardiovascular Disease - Apolipoprotein risk factors for CVD reviewed
Cardiovascular Disease - CAC deposits linked to elevated LV mass in African-Americans
Cardiovascular Disease - GATA-4 transcription factor regulates cardiac myocyte apoptosis
Cardiovascular Disease - GP Ialpha genotype affects CHD risk
Cardiovascular Disease - Hypertension-induced cardiac remodeling reviewed
Cardiovascular Disease - Leukocyte counts may have prognostic value in acute CVD
Cardiovascular Disease - Myocardial perfusion not linked to peripheral endothelial function
Cardiovascular Disease - PET can help determine regional sympathetic function during heart disease
Cardiovascular Disease - Post-revascularization contractile recovery in LV dysfunction patients evaluated
Cardiovascular Disease - Rate of LV hypertrophy progression to heart failure evaluated
Cardiovascular Disease - T wave alternans predicts mortality in congestive heart failure patients
Cardiovascular Disease - Urinary N-BNP suitable for heart failure diagnosis
Cardiovascular Disease Diagnostics - Biomarkers of acute coronary artery disease reviewed
Cardiovascular Disease Therapy - Atorvastatin and fluvastatin have plasma antioxidative activity
Cardiovascular Disease Therapy - Tedisamil has multiple cardioprotective effects
Cell Biology - Core 1-derived O-glycans command successful angiogenesis
Cell Biology - Integrin-linked kinase regulates VEGF-induced vascular morphogenesis
Chronic Hepatitis B - Humanized anti-HBs Fab fragment may neutralize hepatitis B surface antigen
Collaboration - Agreement signed for Chagas disease blood screening technology
Collaborations - Agreement reached for development of biodefense pathogen, filtration device
Collaborations - Agreements inked to develop novel molecular imaging agents
Collaborations - Aventis provided with early access to high-throughput GeneChip platform
Collaborations - Biotech firm grants non-exclusive license on its DPD-process to Roche
Collaborations - Cardiovascular discovery collaboration signed with DMI BioSciences
Collaborations - CatchMabs enters commercial bacteriophage production collaboration
Collaborations - Deal signed for development of therapeutic antibodies for cancer
Collaborations - IT service contract signed by biotech firm
Collaborations - Imaging company announces agreement with GlaxoSmithKline
Collaborations - Partner selected for Amoxicillin Pulsys product candidate
Colon Cancer - Panel recommends testing system for colon cancer metastatic to the liver
Colorectal Cancer - Close postoperative follow-up is needed following colorectal cancer resection
Colorectal Cancer - Pharmaceutical company announces in-licensing of colorectal cancer drug
Colorectal Cancer - Promising new trial investigates colorectal cancer
Complementary & Alternative Medicine - Many women find homeopathic remedies resolve menopause-related symptoms
Congestive Heart Failure - Multicenter trial compares three medications in patients with heart failure
Contraception - Antimycotics won't compromise the efficacy of contraceptive vaginal rings
Contraception - Essure approved for use by Planned Parenthood Federation of America
Contraception - Licensing agreement for fentanyl patch inked
Contraception - Nestorone-releasing implants offer women contraceptive protection
Contraception - Progestins mitigate thrombotic risk of contraceptive estrogens
Correction - Nebraska aims to protect children from methamphetamine labs
Cosmetic Surgery - Positive results reported in phase III autologous cellular therapy study
Cytokines - Interleukin-4 inhibits preadipocyte proliferation
DNA Vaccine - Altering conditions of DNA immunization allows control of immune response
Dengue Fever - Epidemiology of dengue virus in French Guiana elucidated
Dengue Virus - Dengue virus receptor molecules isolated by affinity chromatography
Device Trends - Report: Coating technology is a key in the growth of the medical device sector
Diabetes - Pharmaceutical companies seek approval to market Exubera in Europe
Diabetes Pathogenesis - Apoptosis of insulin-secreting cells investigated
Diabetes Pathogenesis - Biotin enhances ATP synthesis in rat pancreatic islets
Diabetes Therapy - Hypoglycemic substance in Capsicum frutescens isolated
Diabetes Therapy - Sucanon production set to start
Diabetes Therapy - Vasopeptidase inhibition normalizes diabetic endothelial dysfunction
Diagnostic Imaging - Integrated analyses of tumor vessels and metabolism yield better data
Diagnostics - Recovery of radioactively labeled proteins from gels investigated
Diet &Nutrition - High-fiber Mexican-style diet improves dyslipidemia in type 2 diabetes
Diet &Nutrition - Vitamin D effects seasonal changes in serum 250HD levels in older women
Distribution Agreement - LSBC enters biomanufacturing and commercial distribution agreement
Distribution Agreement - Longport announces receipt of $525,000 distribution rights payment
Drug Delivery - Company announces application for CE Mark for Prometra pump
Drug Delivery - New type of vesicle could approach capabilities of biological structures
Drug Development - N6-substituted adenosine derivatives have antimalarial activity
Drug Development - N,N'-spacer-linked oligomeric ergolines have antimalarial activity
Drug Development - Wikstroemia indica biflavonoids active against drug-resistant Plasmodium
Drug Development - Agents derived from Central American medicine plants have antiprotozoal activity
Drug Development - Antimicrobial diflunisal hydrazide-hydrazones synthesized
Drug Development - Approval period for biopharmaceutical products comparable in U.S. and E.U.
Drug Development - Commercialization in drug development stage drives product success, study shows
Drug Development - Novel arylsulfonamides active against drug-resistant HIV
Drug Development - Novel piperidine-based CCR5 antagonists synthesized
Drug Development - Pertussis toxin B-oligomer is pleiotropic HIV Tat inhibitor
Drug Development - Resonance energy transfer monitors the delivery of angiogenic proteins
Drug Development - Selective inhibitors of mitochondrial F1 F0 ATP hydrolase synthesized
Drug Development - Thiolactomycin analogues show promise as antimalarial, antitrypanosomal agents
Drug Discovery - Biopharmaceutical company announces successful drug discovery collaboration
Drug Discovery - Drug discovery company announces expansion of strategic alliance
Drug Discovery - Harvard Bioscience completes acquisition
Drug Resistance - N. gonorrhoeae protein mutant allows entry of antimicrobials
Drug Resistance - Staphylococcus lentus gene encodes resistance to chloramphenicol
Drug Resistance - First VanB vancomycin-resistant Enterococcus faecium isolated in Spain
Drug Resistance - Ribosomes contribute to bacterial resistance against antibiotic
Dyslipidemia - Phase I trials for dyslipidemia drug commence in Canada
Edema - Dyrenium diuretic drug to be marketed to physicians online
Electroporation Therapy - Head-and-neck cancer study to advance commercialization of the MedPulser
Endocrinology - Atypical protein kinase C is target of TC10 signaling pathways
Endocrinology - Lipid profiles are significantly related to bone mass in women and men
Endocrinology - Maternal melatonin is a selective regulator of fetal and neonatal cortisol
Endocrinology - Parathyroid hormone production diverges with surgical versus natural menopause
Environmental Health - Adsorption and clay-catalyzed degradation of erythromycin A reported
Enzymology - C-terminal Src kinase facilitates angiogenic sprouting and vascular remodeling
Enzymology - Protein kinase C negatively modulates integrin expression
Enzymology - The VEGFR 2 inhibitor SU1498 stimulates ERK kinase accumulation and inhibition
Epidemiology - Hepatitis C virus type 1 is the most prevalent genotype in central Italy
Erectile Dysfunction - Study shows use of Testim improves symptoms of ED, low libido
Esophageal Variceal Bleeding - New drug application submitted for Sanvar IR
Evolution Research - Brains of chimps, humans closely related in gene expression
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