HIV/AIDS Proteomics
Protease activity regulates Env-mediated membrane fusion
Published in Drug Week, April 2nd, 2004
Evidence has been presented "for a direct interaction between the matrix (MA) domain of the human immunodeficiency virus type 1 (HIV-1) Gag protein and the cytoplasmic tail of the transmembrane envelope (Env) glycoprotein gp41," virologists in Japan explained. "In addition, it has been postulated that the MA domain of Gag undergoes a conformational change following Gag processing, and the cytoplasmic tail of gp41 has been shown to modulate Env-mediated membrane fusion activity."
"Together, these results raise the possibility that the interaction between the gp41 cytoplasmic tail and MA is...
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Source: Drug Week (2004-04-02)
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