Published in Drug Week, April 2nd, 2004
"Formins are proteins best defined by the presence of the unique, highly conserved formin homology domain 2 (FH2). FH2 is necessary and sufficient to nucleate an actin filament in vitro. The FH2 domain also binds to the filament's barbed end, modulating its elongation and protecting it from capping proteins," investigators in the United States report.
"FH2 itself appears to be a processive cap that walks with the barbed end as it elongates," wrote Sally H. Zigmond and colleagues at the University of Pennsylvania.
Zigmond and her coauthors published their study in Current Opinion in...
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