Drug Week
Susan Hasty, Publisher
Table of Contents . . . April 23rd, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Drug Week | Other Publications
Drug Delivery - B12 influences NF-kB survival signaling and antitumor activity of Apo2L/TRAIL
Drug Delivery - Researchers creating polymers that act like biomolecules
Anaphylaxis - Positive data presented for inhaled form of epinephrine
Heart Failure - Company reports preliminary results for EMOTE; doesn't reach primary endpoint
Ototoxicity - FDA issues orphan drug designation for sodium thiosulfate
Psoriatic Arthritis - Results of phase II study of Raptiva in psoriatic arthritis announced
AIDS - NIH grant to be used to develop novel anti-HIV therapeutics
Acne - Positive results reported from Velac phase III pivotal trials
Acute Coronary Syndrome - Improved treatments needed to prevent restenting in diabetic patients
Addiction Medicine - Adolescents at risk for drug abuse need to acquire self-control competencies
Adiposity - ASP/complement C3adesArg deficiency increases energy expenditure
Adverse Drug Effects - Alfacalcidol treats glucocorticoid-induced osteoporosis
Adverse Drug Effects - Flutamide produces liver toxicity and a death in Germany
Adverse Drug Effects - Tamoxifen might stimulate the growth of PCDGF/GP88-positive breast cancer
Aesthetic Medicine - Dallas plastic surgeon among the first in the U.S. to offer Restylane
Aging - Calorie restriction extends lifespan, reduces cancer
Allergies - Advances in treatment, diagnosis of food allergy, colic presented
Allergy Medicine - Allergy season can mean asthma trouble
Allergy Medicine - Kinetics of eosinophilopoiesis after allergen inhalation reported
Allergy Medicine - Lactic acid bacteria and allergen induce immune response in allergy model
Alliances - Pharma-biotech alliances prove to be good investments, states report
Alzheimer Disease - Brain amyloid imaging in Alzheimer disease with Pittsburgh Compound-B
Analgesia - Analgesic therapy may offer protection against bladder cancer
Anemia - Anemia among cancer patients can be treated with human erythropoietin
Angiology - Contrast agent concentration in mouse blood used to determine tumor vascularity
Angiology - Sinusoidal capillarization is distinct from angiogenesis in benign liver tumors
Angioplasty - Restenosis inhibited by tissue factor pathway inhibitor
Ankylosing Spondylitis - Lipid peroxidation increased in patients with ankylosing spondylitis
Anthrax Vaccine - Needle-free skin patch vaccination method for anthrax developed
Anti-Infectives - Chlorhexidine comparable to hexachlorophane for neonatal S. aureus control
Anti-Infectives - Low rate of enterococcal/staphylococcal resistance against oxazolidinone AZD2563
Antioxidant - Ascorbic acid inhibits oxidative modification of apolipoprotein E
Assisted Reproduction - FDA approves Follistim AQ Cartridge
Asthma - Clinical data reported on Alvesco and on its intranasal formulation
Asthma - Data supports benefits of second-generation immunomodulatory oligonucleotides
Atherosclerosis - Lipoproteins inhibit cholesterol efflux to apolipoprotein A1
Autism Risk Factor - Issues surrounding the MMR vaccine and autism discussed
Bacillus Calmette-Guerin - Immunogenicity of recombinant BCG vaccine strains investigated
Bacterial Endotoxin - FDA approval granted to manufacture Pyrotell products at new facility
Benign Prostatic Hyperplasia - Alfuzosin 10 mg shows beneficial effect in patients with urinary retention
Biological Therapy - Altered Rho GTPase signaling pathways potential target for breast cancer therapy
Biological Therapy - Silenced clusterin-apolipoprotein J gene causes cancer cells to implode
Biomaterials - Phosphobetaine-based copolymer coatings superior to sulfobetaine coatings
Biotechnology - "Infectivity PCR" enhances detection of replication-competent adenovirus vectors
Biotechnology - Novel protein A/nano-gold immobilization system improves antibody analysis
Bladder Cancer - Intra-arterial chemotherapy relieves symptoms of advanced bladder cancer
Bladder Cancer - New phase II/III Bexidem trial launched
Bladder Cancer - Vitamin E linked to lower risk of bladder cancer, according to study
Bone Marrow Transplantation - Biotechnology company announces breakthrough in cord blood stem cell expansion
Brain Cancer - Erthropoietin improves learning and memory impairment after brain irradiation
Breast Cancer - Androgen receptor polymorphism alters breast cancer risk in hormone therapy
Breast Cancer - Breast pain as the only presenting symptom is rarely associated with cancer
Breast Cancer - Circulating tumor cells in breast cancer reviewed
Breast Cancer - FDA clears to market breast cancer assessment applications
Breast Cancer - New findings published on treatment for late-stage breast cancer
Breast Cancer - Prune cAMP phosphodiesterase binds nm23-H1 and promotes breast cancer metastasis
Breast Cancer - Regulatory approval sought for use of Taxotere in early stage breast cancer
Breast Cancer Prognosis - Poor responsiveness of breast cancer to chemotherapy explained by profile
Breast Cancer Prognosis - p53 expression does not play role in recurrent breast cancer
Breast Cancer Therapy - Bispecific antibody MDX-H210 with filgrastim highly effective in early trials
Breast Cancer Therapy - Exemestane and aromatase inhibitors play role in breast cancer management
Bronchitis - Paroxetine effective as antitussive in opioid-resistant cough
Business & Finance - 89% of surveyed companies consider outsourcing a strategic tool
Business & Finance - Alliance Retail Management Group to represent O24 product line in Canada
Business & Finance - Biotechnology company receives $3M through private offering
Business & Finance - Drug discovery collaboration to develop novel small molecule therapeutics
Business & Finance - Pharmaceutical company announces discontinuation of operations
Business & Finance - Pharmaceutical company comments on potential spin-off
Business & Finance - Report announces leader in neurology drug market
Business & Finance - Research collaboration extended
Business & Finance - Specialty pharmaceutical company acquires Fosrenol patent rights
Business & Finance - Squalamine maker reports 2003 net loss of $12.5 million
Business & Finance - Supply and license agreements signed for NeoVisc and Uracyst in U.S. markets
Business & Finance - Therapeutics company announces reincorporation to Delaware
Business & Finance - Xopenex co-promotion agreement announced
Business Update - ANDA filings pending for Concerta; Wellbutrin marketing rights relinquished
Business Update - Company announces first results of antiwrinkle study; gets private financing
Business Update - Genomics company "sharpens" focus, announces layoffs; CEO to retire
Business Update - Hydroxyapatite coating technology passes key systemic injection test
Business Update - Proteomics company announces mission statement
Cancer - European patent grants claims covering vascular targeting agent technology
Cancer Risk Factor - Human papillomavirus infects all ages of women in Nigeria
Cancer Therapy - Chemotherapy of anaplastic oligodendroglial tumors outlined
Cancer Therapy - Company reports additional positive data from MBT-0206 phase I trials
Cancer Therapy - Conjugates containing HPMA copolymer and TNP-470 target tumor angiogenesis
Cancer Therapy - Multimodality therapy for rectal cancer led to massive iliac artery bleeding
Cancer Therapy - Thrombospondin-1 predicts how tumors respond to low-dose cyclophosphamide
Cancer Vaccine - Exosomes act as potent cell-free peptide-based vaccines
Cancer Vaccine - High efficiency of low-affinity epitopes in cancer therapy reported
Cancer Vaccine - Natural killer T-like cells induced by thymoma expressing alpha-fetoprotein
Cancer Vaccine - Peptide-based vaccines for cancer immunotherapy reviewed
Cardiology - Protein kinase C-alpha is a nodal integrator of cardiac contractility
Cardiology - Simvastatin employs VEGF in the regeneration of arterial endothelial cells
Cataracts - Calpain inhibitors show promise as targets of cataract prevention
Cerebral Malaria - Western neuropsychological tests can be modified to fit Kenyan children
Chemoresistance - Genomic alterations make cells more or less resistant to drug therapy
Childhood Obesity - Food stamp program linked to overweight in young children
Childhood Obesity - Soft tissue facial morphology different in obese adolescents
Cholestatic Hepatitis - Liver graft failure occurs despite antiviral prophylaxis
Chronic Hepatitis B - Interferon therapy restrains wild-type and precore mutated HBV equally
Chronic Lymphocytic Leukemia - Geldanamycin and herbimycin A make leukemia cells sensitive to chemotherapy
Chronic Myelogenous Leukemia Therapy - Cytogenetic CE alone does not reduce post-SCT imatinib efficacy
Chronic Obstructive Pulmonary Disease - Spiriva predicted to corner the COPD drug market
Clinical Trial - Company awarded $1.2M for cardiac safety monitoring and services
Clinical Trial - Positive results announced for pharmacokinetic trials with oral cladribine
Cognition - Cognitive dysfunction and subjective complaints of cancer patients studied
Cognition - Three variants of primary progressive aphasia described
Collaborations - Agreements signed for acquisition of rights to Loestrin oral contraceptives
Collaborations - Contract signed with pharmaceutical customer for assay development
Collaborations - Deal signed to develop bird influenza research program
Collaborations - Drug discovery technology licensed from Texas Tech University
Collaborations - Generex Biotechnology announces letter of intent for joint venture
Collaborations - Morton Grove signs exclusive agreement with company in India
Collaborations - NeoGenesis Pharmaceuticals announces drug-discovery collaboration
Colon Cancer - CPMP recommends approval of Erbitux
Colon Cancer - Existing therapies applied to new use in broader spectrum of cancer care
Colon Cancer - Study reveals 52 differences in protein expression using DIGE technology
Colonoscopy - Company begins phase II study of INKP-102, a purgative product
Complementary & Alternative Medicine - Ginkgo biloba extract stimulates endothelial progenitor cells
Complementary & Alternative Medicine - Efforts to standardize herbal supplement stymied by lack of research
Complementary & Alternative Medicine - Many Taiwanese homebound cancer patients use complementary therapy
Complementary & Alternative Medicine - Oriental medicine may inhibit mast cell activity in arthritis patients
Complementary & Alternative Medicine - U.S. government issues public briefing on safety of dietary supplements
Coronary Artery Bypass - Desmopressin does not reduce postoperative bleeding in patients taking aspirin
Coronary Artery Disease - New growth factor protein helps damaged hearts
Coronary Artery Disease - Phase II trials initiated for pharmacologic stress agent for heart studies
Coronary Stents - Company sells $42M in stent systems in 10 days
Crohn Disease - M. paratuberculosis infection common in patients
Cryptosporidium - Genetic diversity of Cryptosporidium species in reptile pets reported
Cystic Fibrosis - Diagnostics firm receives product of the year award
DNA Research - SCF component Skp2 degraded by anaphase-promoting complex
DNA Vaccine - Bacteria-mediated DNA transfer in gene therapy and vaccination reviewed
DNA Vaccine - Methylated CpG-containing plasmid activates immune system
Daytime Sleepiness - Enrollment complete for excessive daytime sleepiness trial
Dendritic Cell Vaccine - Activation of dendritic cells translates innate into adaptive immunity
Depression - Employees with depression view illness as roadblock to career success
Depression - Generic bupropion hydrochloride sustained-release 150 mg launched
Depression - Home-based program effective in treating minor depression in older adults
Dermatology - Anti-p200 pemphigoid autoantigen characterized
Dermatology - CD4+ and HLA-DR+ T cells reduced in vitiligo patients
Diabetes Epidemiology - Diabetes prevalence among Puerto Ricans affected by age, education
Diabetes Genetics & Genomics - PC-1 Q121 allele associated with type 2 diabetes
Diabetes Genetics & Genomics - Similarity in genomics of types 1 and 2 diabetes reported
Diabetes Pathogenesis - Protein tyrosine phosphatase alpha not involved in insulin signaling
Diabetes Therapy - National trial to study best treatment of type 2 diabetes in youth
Diabetes Therapy - Peptide allows successful allogeneic islet transplantation in mice
Diabetes Therapy - Researchers one step closer to creating oral insulin
Diabetes Therapy - Success of new drug that may halt progression of type 1 diabetes
Diabetes Therapy - Treatment for insulin resistance in diabetes accompanying obesity is patented
Diabetic Nephropathy - GFPT1 variations not linked to diabetic nephropathy
Diabetic Neuropathy - Axon reflexes are diminished in diabetic small-fiber neuropathies
Diabetic Neuropathy - Neuropathy in type II diabetes mellitus by multimodal evoked potentials
Diabetic Neuropathy - Poly(ADP-ribose) polymerase inhibitors may treat diabetic neuropathy
Diabetic Retinopathy - Hyperglycemia thwarts angiogenesis without diminishing VEGF activity
Diabetic Retinopathy - VEGF -460C polymorphisms predict diabetic eye disease
Diagnostic Imaging - Triple fusion reporter vectors identify gene expression in living subjects
Diagnostics - Highly specific probes detect hepatitis C virus in liver tissues
Diagnostics - Methods for HAV detection in shellfish compared
Diet & Nutrition - Dietary energy restriction may prevent skin carcinogenesis
Diet & Nutrition - Meat supplements make a favorable impact on the bone health of older people
Diet & Nutrition - Postprandial suppression of ghrelin does not predict intermeal interval
Drug Ban - Oklahoma to be first to ban over-the-counter pseudoephedrine
Drug Delivery - Consulting firm reports that transdermal drug delivery continues to grow
Drug Delivery - Patent issued for protein delivery
Drug Development - Anti-HIV activity of linear peptide gp120 inhibitors characterized
Drug Development - Company announces sale of Congers, New York, assets
Drug Development - Company reports advances in targeting Hypoxia-Inducible Factor
Drug Development - Definitive Phase 1 QT ECG trial required for drug safety assessment
Drug Development - Drug development provider inks multiyear contract with pharmaceutical company
Drug Development - Fatty acid pathway, glucose combine to produce triacetic acid lactone
Drug Development - Human anti-neuroblastoma antibody cloned
Drug Development - Lipophilic substitutions improve benzylpyrazole CCR5 antagonists
Drug Development - Novel C-10 non-acetal trioxane dimers show antimalarial, anticancer activity
Drug Development - Pharmaceutical firm awarded SBIR grant for antibody development
Drug Development - Targeting inactive RNA conformation effective drug design strategy
Drug Development - Technology company awarded fourth electronic data capture study
Drug Development - Timing of R&D/marketing efforts effect drugs' market performance, report shows
Drug Development - Transgenomic to provide manufacturing support for novel drug
Drug Discovery - Collaboration to develop and co-market focused libraries for kinase targets
Drug Discovery - Holding corporation reports 25% increase in 2003 revenues
Drug Discovery - Research collaboration to study matrix metalloprotease inhibitors
Drug Resistance - Cancer-altered apoptosis leads to tumor progression and therapy resistance
Drug Resistance - Interleukin-6 stimulates a protein known to cause chemoresistance
Drug Resistance - MUC1 transforming protein confers resistance to genotoxic anticancer agents
Eating Disorder - Simplistic explanations regarding women and body image neglect other factors
Endocrinology - Cholecystokinin stimulates aldosterone from adrenocortical cells
Endocrinology - Function of mitogen-activated protein kinases in ovarian cells reported
Endocrinology - Genetic mutations associate with spontaneous ovarian hyperstimulation syndrome
Endocrinology - Growth hormone has reduced ability to activate kinase pathway
Endocrinology - Hormonal regulation of atypical absence seizures investigated
Endocrinology - Japanese licensee obtains approval for drug delivery technology in Japan
Endocrinology - Parathyroidectomy improves depression in patients with hyperparathyroidism
Endocrinology - Role of CREB in CCAAT/enhancer-binding protein beta gene described
Endometriosis - Peritoneal fluid macrophages jumpstart endometrial inflammation
Environmental Health - Prenatal organochlorine exposure linked to low cord blood TNF-alpha levels
Enzymology - Aminopeptidase A is a functional vascular target
Epilepsy - Mutation in synapsin I reported in family with epilepsy
Erectile Dysfunction - Levitra refill rates three times higher than most recent entry in ED market
Erectile Dysfunction - Study: LEVITRA improved erectile function, reduced depressive symptoms
Ewing Sarcoma - Long-term follow-up necessary for non-metastatic Ewing sarcoma
Finance - Automated instrument reagent company fails to meet guidance
Finance - Biologics company raises financing for working capital
Finance - Biopharmaceutical company announces 2003 financial results
Finance - Biopharmaceutical company announces sale of common stock
Finance - Biopharmaceutical company reports 2003 financial results
Finance - Biotechnology company completes $5.5M equity private placement
Finance - Blood-products company reports improved 2003 income
Finance - Cardiac device maker reports a $1.1M expense adjustment
Finance - Cell-therapy company raises $10.7 million in series B financing
Finance - Company reports financial impact of U.K. judicial decision
Finance - Device company announces $21M private placement of common stock
Finance - Flavin Ventures announces start-up for life sciences company
Finance - Hepatitis drug developer announces initial public offering
Finance - Hepler appointed to board of directors at biotech firm
Finance - KRX-101 maker reports decreased net loss for year
Finance - Maker of neurological/psychiatric drugs announces $250M financing
Finance - Medical supply distributor reports increase in net loss
Finance - Neuroscience pharmaceutical firm reports 4Q loss of $0.25 per share
Finance - Oncology company raises $12.8M in private placement
Finance - Pharmaceutical company files statement for common stock offering
Finance - Pharmaceutical company renews revolving term credit facility
Finance - Pharmaceutical company reports loss of $0.68 per share
Finance - Pharmaceutical firm announces pricing of common stock offering
Finance - Pharmaceuticals company reports quarterly loss of $0.19 per share
Finance - Revenue guidance of $40-50M given for skin disorders drug Cubicin
Finance - Rule 10b5-1 stock trading plans announced
Finance - Theranostics company completes $750,000 private financing
Finance - Valve maker reports revenue up 42% through third quarter fiscal year 2004
Finance - Wound-healing company notified that its shares will be delisted
Food-Borne Illness - Acid exposure improves enrichment of enterohemorrhagic E. coli
Forecast - Study: CerAxon will corner the neuroprotectant drug market in 2013
G Lymphatic Insufficiency - Stanford inks Fractal Genomics Modeling agreement
Gastric Cancer - Second-line chemotherapy contributed to favorable outcome in gastric cancer
Gastroenteritis - Novel PCR assay enables norovirus genotyping
Gastroenterology - Inducible nitric oxide synthase sensitizes colorectal cancer to radiation
Gene Analysis - Altered caveolin and thrombospondin reveal liver cancer vessel status
Gene Expression - Single rat array launched for whole-genome expression analysis
Gene Expression - Study validates first universal microarray RNA expression system
Gene Therapy Vectors - Sheep retrovirus Env efficiently pseudotypes HIV-based lentiviral vectors
Gene Transfer - A new cleavage product gives real-time information about transgene activity
Gene Transfer - Vectors encoding for angiostatin and endostatin surpass single-encoded vectors
Generic Drugs - Company receives FDA approval and 180-day exclusivity for nitrofurantoin
Generic Drugs - Company receives tentative approval for Felodipine ER
Generic Drugs - FDA approves generic versions of Declomycin, Wellbutrin
Generic Drugs - FDA approves hydrocodone bitartrate and ibuprofen tablets 5/200 mg tablets
Genetic Disorder - Neuroretinal dysfunction found in heterozygote for CLN3 defect
Genetic Disorder - Prevalence of hypercholesterolemia mutation in Quebec reported
Genetic Engineering - Genetically altered mice predict toxicity for individual targeted cancer therapy
Genomic Biomarkers - Company contributes drug signatures to promote biomarker research
Genomics - Direct analysis of single molecules without amplification announced
Geriatrics - Scientists develop new drug treatment for memory loss in old age
Gestational Diabetes - Glucose values improve throughout gestation in triplet pregnancies
Glanzmann Thrombasthenia - Factor VIIa restores aggregation of platelets
Gynecology - Angiostatic agents look promising for treating endometriosis
Gynecology - The ceruloplasmin promoter shows an affinity for ovarian tumors
HIV Prevention - FDA accepts IND for unique HIV vaccine
HIV/AIDS - Cambodian sex workers turn down Bill Gates-funded HIV drug
HIV/AIDS - Companies receive European positive opinion for Telzir
HIV/AIDS - Efforts to get AIDS medications to developing countries may be near breakthrough
HIV/AIDS Diagnosis - Doubly indeterminate HIV Western blot results are negative
HIV/AIDS Drug Resistance - Fitness loss caused by HIV resistance mutations may account for low viremia
HIV/AIDS Drug Resistance - Prevalence of HIV resistance mutations in Brazil determined
HIV/AIDS Genomics and Genetics - "Somatic hypermutation" hypothesis for HIV R5-X4 switch proposed
HIV/AIDS Genomics and Genetics - Mutation rates of HIV genomes clarified
HIV/AIDS Immune Control - IL-15 levels elevated in patients with discordant response to treatment
HIV/AIDS Immune Control - Scavenger function of CCR5Delta32 protein involved in protection from HIV
HIV/AIDS Opportunistic Infection - Aeration augments Aspergillus fumigatus gliotoxin production in vitro
HIV/AIDS Opportunistic Infection - Antisera-based immunoassay effective for aspergillosis diagnosis
HIV/AIDS Pathogenesis - Ability of HIV LysRS to bind tRNA determines virion packaging efficiency
HIV/AIDS Pathogenesis - Expansion of tumor antigen-specific T cells in transgenic mice reported
HIV/AIDS Protein Research - Chimeric HIV/SIV provides stable trimeric HIV Env for study
HIV/AIDS Therapy - Enfuvirtide is new fusion inhibitor for HIV infection treatment
HIV/AIDS Therapy - MALDI-TOF MS assay provides improved NRTI monitoring
HIV/AIDS Vaccine - Assays with extended incubation phases needed to monitor HIV vaccine trials
HIV/AIDS Vaccine - HIV-1 infection blocked via CCR5 and CXCR4 receptors
HIV/AIDS Vertical Transmission - Girls may have heightened risk of intrauterine HIV infection
HIV/AIDS Vertical Transmission - Mortality from formula use and vertical HIV transmission comparable
HIV/HCV Coinfection - Undetectable HCV viremia and normal liver enzyme levels may not mark cure
Head and Neck Cancer - High rates of mitochondrial DNA instability mark squamous cell carcinoma
Head and Neck Cancer - RASSF1A hypermethylation is an early sign of thyroid cancer tumorigenesis
Headaches - Company receives purchase order from Eckerd for OTC migraine therapy
Heart Attack - Blood-forming stem cells fail to repair heart muscle
Heart Disease - Drug delivery firm completes trial for optimization of paclitaxel stent
Heart Disease - PPAR-gamma role in cardiovascular disease reviewed
Heart Disease Risk - Repeated treatment of gum disease reduces levels of inflammatory factors
Heart Disease Risk Factor - Evolving targets for cardiovascular risk reduction in diabetes reviewed
Heart Disease Risk Factor - Signs of cerebral amyloid angiopathy-related inflammation reported
Heart Disease Therapy - Antarctic fish study may aid cardiac research
Heart Failure - Positive results reported in preclinical trial of Anginera
Hematology - Central role of the P2Y12 receptor in platelet activation
Hematology - Cynomolgus macaques model the effects of hemophilia B gene therapy
Hematology - Mediators of cytokine-induced stem-cell survival identified
Hematology - New therapies help patients beat cancer-related anemia
Hematology - Stem cells in the spleen rely on neoangiogenesis for relocalization
Hematology - Thalidomide helps endothelial cells escape doxorubicin-induced apoptosis
Hematology - Thrombin can predict response to tissue factor challenge
Hematology - Unrelated bone marrow transplants treat patients with non-Hodgkin lymphoma
Hemorrhagic Fever - Study to assess WinRho as treatment for widespread tropical disease
Hepatitis C Therapy - Forty-eight weeks of therapy may not be long enough for treating HCV type 1
Hepatology - Anti-Liv8 depleted bone marrow cells useful for liver regeneration
Hepatology - COX-2-independent mechanisms steer the growth of cholangiocarcinoma
Hepatology - Injured liver cells signal fibrosis in nonalcoholic fatty liver disease
Hepatology - Ticlopidine-induced cholestatic hepatitis diminishes slowly
Human Corneal Apoptosis - TB4 reported to inhibit human corneal apoptosis
Human Metabolism - Technology aids in study of human obesity, diabetes
Hyperbilirubinemia - Fetoprotein not adequate to screen for neonatal hyperbilirubinemia
Hypertension - Primary endpoints met in PW2101 hypertension study
Hypertension Pathogenesis - Endothelin-1 plays role in regulating blood pressure in obese rats
Hypothyroidism - Relationships among thyroid, adrenal and gonadal hormones studied
Idiopathic Pulmonary Fibrosis - Pirfenidone granted U.S. orphan drug designation for IPF treatment
Immunology - A new immunoassay monitors HCV-infected patients for treatment response
Immunology - ATG and CYA treatment effective for hemophagocytic syndrome
Immunology - Age-related P-glycoprotein loss linked to reduced CD4/CD8 cell activity
Immunology - CD24 ligation induces TCR- and caspase-independent apoptosis
Immunology - CD37 has key regulatory role in T-cell proliferation
Immunology - Changes in T-bet/GATA-3 expression determine neonatal immune response type
Immunology - Chemotherapy is enhanced when used in combination with OncoVEX
Immunology - Diacylglycerol mediates BCR activation of NFAT and NF-kappaB
Immunology - Divergent effects of TNF-RII on TCR-mediated T-cell activation described
Immunology - FDA requests additional study of Homspera
Immunology - Function of marginal zone B cells reviewed
Immunology - Gene therapy in a murine multiple sclerosis model corrects disease
Immunology - Hypomethylated CpG dsDNA activates autoreactive B cells
Immunology - Impaired anti-inflammatory responses reported in term and preterm neonates
Immunology - Loss of CD22 offsets B-cell defects in SLP65/BLNK-deficient mice
Immunology - Mast cells produce corticotropin-releasing hormone and urocortin
Immunology - Octreotide regulates CC-induced chemokine production in rat Kupffer cells
Immunology - Prognostic value of DC subsets in pediatric cancer patients determined
Immunology - Regulation of dendritic cell TLR4-MD2 expression elucidated
Immunology - SIGN-R1 mediates uptake of S. pneumoniae CPS in mouse spleen marginal zone
Immunology - Serglycin involved in neutrophil granular protein transport
Immunotherapy - Incomplete tolerance to the tumor-associated antigen MDM2 investigated
Immunotherapy - PD-L1/B7H-1 inhibits effector phase of tumor rejection by CD8+ T cells
Infection - Alvesco well tolerated in mild-to-moderate asthma study patients
Inflammatory Bowel Disease - Inflammatory bowel disease agents show activity in clinical study
Inflammatory Breast Cancer - RhoC boosts the expression of genes involved in breast cancer metastasis
Influenza - Fatal human influenza A subtype H5N1 disease re-emerges
Influenza - New human influenza vaccine research and development project initiated
Influenza Vaccine - Universal influenza vaccination in children not yet justified
Information Technology - Intalio to provide BPMS to business services provider
Insomnia - Study demonstrates positive results with indiplon immediate release
Insulin Resistance - Indices useful to estimate insulin resistance in type 2 diabetes
Invasive Aspergillosis - Anidulafungin combination regimen well tolerated in invasive aspergillosis
Irritable Bowel Syndrome - Enrollment complete for Sucampo phase II study
Kaposi Sarcoma - Activity of KSHV K8.1 late promoter characterized
Kaposi Sarcoma - KSHV-encoded vIRF-3 activates transcriptional activity of cellular IRF-3/IRF-7
Kaposi Sarcoma - Strong IgG antibody activity linked to high HHV-8 viremia
Kidney Disease - Swedish authorities approve FOSRENOL
Laryngology - Study evaluates various strategies for diagnosis and treatment of sore throat
Leptin Studies - Pituitary somatotropes are significant source of leptin
Leukemia - Aplidin enters phase I trials in pediatric solid tumors, leukemias
Leukemia - IL-18 increases invasiveness of myeloid leukemia cells via MMP-9 upregulation
Leukemia - Low-dose decitabine treats myeloid malignancies in a phase I trial
Leukemia - Researchers discover green tea component helps kill cancer cells
Leukemia - Researchers testing compounds that may stop replication of T-cell virus
Leukemia Diagnostics - Standardized protocols for RQ-PCR residual disease analysis developed
Leukemia Therapy - Specific T-cell replete haploidentical SCT feasible for pediatric ALL
Licensing Agreement - Forbes Medi-Tech signs Reducol licensing and distribution agreement
Lipid Studies - Proteins in fraction of human hepatocyte cell line HuH7 identified
Lipid Studies - Safflower phenolic compounds improve lipid profiles
Lipid Studies - Soybean beta-conglycinin helps maintain healthy lipid levels in women
Liver Cancer - IL-12 administration suppressed metastatic liver tumor unsusceptible to CTL
Liver Cancer - Methylated p16 may be a tumor marker for hepatocellular carcinoma
Liver Disease - Phase I pharmacokinetic trial of orally dosed histamine completed
Lung Cancer - ASCO accepts BLP25 liposomal vaccine phase IIB trial results for presentation
Lung Cancer - Cisplatin with vindesine not effective for non-small cell lung cancer
Lung Cancer - Drug offers hope for small-cell lung cancer patients
Lung Cancer - Molecular profiling provides insights into lung tumor progression
Lung Cancer - Primary pulmonary lymphoma presents as pulmonary mass with cavitation
Lymphoma - NHL-associated systemic AL amyloidosis characterized
Lymphoma - Ocular muscle paresis sign of toxic neuropathy associated with vincristine use
Lymphoma - Peripheral neuropathy in Hodgkin lymphoma caused by paraneoplastic syndrome
Lymphoma - Retroperitoneal lymphoma presenting as pancreatic tumor responds to chemotherapy
Malaria Drug Resistance - High rate of antifolate-resistant malaria in Guinea-Bissau children
Malaria Enzymology - P. falciparum delta-aminolevulinic acid dehydratase characterized
Malaria Pathogenesis - Function of P. falciparum DHPS clarified
Malaria Pathogenesis - Role of erythrocyte membrane proteins during malaria infection clarified
Malaria Vaccine - Adjuvant combination enhances protective effect of malaria vaccine
Malaria Vaccine - Live sporozoite vaccine under chloroquine therapy protects against malaria
Market Analysis - Drug companies connect R&D with marketing to enhance development efficiency
Medicare - U.S. HHS approves 28 private sponsors to provide drug-discount cards
Melanoma - Cancer/testis gene isoforms elicit cytotoxic T cell reactivity to melanoma
Melanoma - Proteasomal targeting improves presentation of melanoma tumor antigen
Melanoma - TNF-alpha linked to apoptotic cells favors cross-priming to melanoma antigens
Men's Health - Harvard Heart Letter urges caution on testosterone therapy
Menopause - Intravenous ibandronate is an alternative for postmenopausal osteoporosis
Mental Health - The reduction of select risk factors could prevent parental stress
Mergers & Acquisitions - China-based pharmaceutical firm to merge with Dragon Pharmaceuticals
Mergers & Acquisitions - Company agrees in principle to acquire Hydrogel Design Systems
Mergers & Acquisitions - Global Botanics, Inc., acquired
Mergers & Acquisitions - Lynx and Solexa jointly acquire company's assets
Mergers & Acquisitions - Nutraceuticals company announces sale of subsidiary
Mergers & Acquisitions - Pain relief company announces intent to acquire Denver Pain Management
Mergers & Acquisitions - Pharmaceutical distributor merges with and Familymeds Group
Mergers & Acquisitions - Remaining 30% stake in Ciphergen Biosystems K.K. purchased
Metastasis - Dynamic contrast-enhanced MRI models distinguish metastatic prostate tumors
Metastasis - Laminin-5 gene methylation corresponds with poor outcomes in cancer patients
Microbiology - The Nugent scoring system is reliable for diagnosing bacterial vaginosis
Microencapsulation - Anionic microparticles deliver antigens from Neisseria meningitidis
Molecular Biology - To stop cancer, keep your ICMT away from your RAS
Molecular Oncology - Cancer drug target Hsp90 susceptible to inhibition by 17AAG with cell activation
Mucosal Immunization - Bordetella pertussis acts as adjuvant and inhibitor of immune responses
Multiple Myeloma - SGN-40 phase I clinical trial initiated in multiple myeloma
Multiple Sclerosis - Antegren to be submitted for regulatory review in Europe
Multiple Sclerosis - Chemo could help treat multiple sclerosis
Mumps Epidemiology - Genetic diversity of mumps virus found in oral fluid specimens
Muscle Disease - Semicarbazide-sensitive amine oxidase overexpressed in human myopathies
Mutagenesis - Drugs targeting the FLT3 gene might treat acute myeloid leukemia
Mutagenesis - Molecular analysis of ductal fluid provides data about breast cancer markers
Mutagenesis - Mutated NBS1 gene increases susceptibility to prostate cancer
Mutagenesis - Mutation of hCDC4 leads to cell cycle deregulation of cyclin E in cancer
Mycobacteria - T-cell inhibition by M. intracellulare-infected Mphis is B7/CTLA-4-independent
Nanofluidics - Data released from study of genomic samples using through-hole array chip
Nasal Allergies - Clinical results released on new nasal allergy spray
Nephrology - Gene therapy shows promise for treating renal diseases
Neurodegeneration - Polyoma virus detected in brains of patients with leukoencephalopathy
Neurodegenerative Diseases - Alliance to develop non-embryonic stem cell therapies
Neurology - Company opens expanded facility for contract study services
Neuropathic Pain - Lyrica receives positive opinion from CPMP in Europe
Neuroscience - Epidural anesthesia for labor worsens symptoms in a Guillain-Barre patient
Neuroscience - Imaging studies quantify the vasculature of brain tumors
Neuroscience - White matter volume influences cognition in pediatric brain cancer survivors
Non-Hodgkin Lymphoma - Primary follicular lymphoma of the testis cured without adjuvant chemotherapy
Non-Small Cell Lung Cancer - Cyclooxygenase-2 uses angiogenic chemokines to launch lung cancer progression
Non-Small Cell Lung Cancer - Radiotherapy plus cisplatin improves survival in NSCLC patients
Nutrition - Group comments on high-fructose corn syrup, obesity connection
Obesity Epidemiology - Method for developing standards for BMI in Taiwanese children reported
Obesity Genomics and Genetics - Genetics of obesity in Mexican Americans explored
Obesity Survival & Mortality - Obesity increases risk of many cancers
Obesity Therapy - Obesity from different causes should be considered differently
Obesity Therapy - Prevention of obesity should be demedicalized
Obstetrics - Ginger supplement helps relieve pregnancy-related nausea, vomiting
Obstetrics - Pre-term labor drug sensitizes brain to pesticide injury
Obstetrics - Randomized controlled trials would clarify the merits of cesarean delivery
Obstetrics - Transient receptor potential canonical proteins foster labor mechanics
Obstetrics - VEGF and other angiogenic cytokines flourish at the fetal-maternal interface
Oncogenesis - Group of proteins can turn cancer on or off, depending on circumstances
Oncogenesis - Hypoxia circumvents hypoxia-inducible factor to rouse VEGF activity
Oncology - Angiogenesis biomarkers signal the prognosis of breast cancer
Oncology - Dihydromotuporamine C activates Rho protein to diminish breast cancer invasion
Oncology - Human leukocyte antigen alleles link hepatitis C virus to liver cancer
Oncology - Stromal enzyme uses pericyte recruitment to regulate neuroblastoma angiogenesis
Organ Transplant - 2003 deceased organ donation at highest rate in five years
Orthopedics - Hip fracture incidence in central Norway is regionally oriented
Osteoarthritis - Osteoarthritis and interstitial cystitis products licensed from Canadian firm
Osteoporosis - A new formula improves estimations of total intestinal calcium
Osteoporosis - Reduced procollagen N-terminal propeptide I marks raloxifene's efficacy
Outbreaks - Cats may be responsible for Rio de Janeiro sporotrichosis epidemic
Outbreaks - PFGE and AFLP equally useful for typing nosocomial enterococci
Outbreaks - U.S. legal response to SARS outbreak outlined
Outbreaks - West Nile virus found in Manitoba geese
Ovarian Cancer - COX-2 enzyme may promote development of ovarian tumors
Ovarian Cancer - Docetaxel and paclitaxel exhibit similar efficacy for ovarian cancer
Pain Management - Collaboration to develop novel controlled-release opioid product
Pain Management - Final FDA approval granted for Oxycodone extended-release tablets
Pain Management - Oxycodone Hydrochloride ER Tablets 80 mg receives FDA approval
Pain Medicine - Opioid tolerance may be a question of receptor internalization
Pain Medicine - Role of CCK2 receptors in homeostasis of opioid system reviewed
Pancreatic Cancer - New research sheds surprising results on potential sources of cancer risk
Parainfluenza Virus - Parainfluenza virus polymerase mutations provide varying attenuation
Parenteral Nutrition - Thiamin deficiency led to severe lactic acidosis in total parenteral nutrition
Parkinson Disease - Pael-R is accumulated in Lewy bodies of Parkinson disease
Parkinson Disease - Trinucleotide repeats associated with typical Parkinson disease
Paroxysmal Nocturnal Hemoglobinuria - Membranous glomerulopathy reported after allo-SCT in PNH patient
Patents - Additional patent granted on Phenotype MicroArray technology
Patents - Global patents for Fosrenol sold to Shire Pharmaceuticals
Patents - International patent application filed covering 496 angiogenesis targets
Patents - New nanobacteria patent announced
Patient Compliance - Pharmaceutical companies initiate aid programs for low-income consumers
Pediatric Cancer - Herpes simplex virus thymidine kinase genes diminish nearby neuroblastoma cells
Periodontal Disease - Dentin matrix proteins may regulate healing of periodontal tissues
Periodontal Disease - Periodontitis vaccine decreases local prostaglandin E-2 levels
Personnel - Biopharmaceutical company announces changes to board of directors
Personnel - Biotechnology company announces new member of board of directors
Personnel - Cancer diagnostics firm announces Donald Steen as new chairman
Personnel - Chemistry services firm announces restructuring of research departments
Personnel - Company announces senior appointment in corporate information technology
Personnel - Company focused on intranasal pharmaceuticals names John C. Carlisle as CEO
Personnel - Del Humphreys becomes senior VP, sales, for gastro-focused pharma company
Personnel - Dennis Langer named to board
Personnel - Donahue named VP of cardiovascular marketing at biotech firm
Personnel - Drug development company chairman and chief executive officer to retire
Personnel - Enzyme-focused company adds to management team
Personnel - Financial executive named to board of directors at drug delivery firm
Personnel - Lamontagne named president, CEO at drug discovery firm
Personnel - Life science company adds to management team
Personnel - Logica finance executive appointed as head of alliances, acquisitions
Personnel - Michael D. Casey appointed to board of pharmaceutical-systems company
Personnel - Neugene maker announces additions to board of directors
Personnel - Nicholas G. Moore joins board of biopharmaceutical company
Personnel - Pharmaceutical company announces new chief financial officer
Personnel - Pharmaceutical company announces resignation of chief financial officer
Personnel - Pharmaceutical company names Ryan as VP of regulatory affairs
Personnel - Ross Graham named non-executive director at vaccine company
Pharmaceutical Sales - Pharma-SalesAccelerator to help improve pharmaceutical sales productivity
Pneumococcal Vaccine - Revaccination with pneumococcal vaccine is effective in older adults
Polio Vaccine - Circulating vaccine-derived polioviruses reviewed
Polio Vaccine - Potential strategies for eradication of polio outlined
Polio Vaccine - Role of routine polio immunization in post-certification era reviewed
Premature Ejaculation - Company reports positive results for early ejaculation product
Prescription Drugs - Maryland Senate ready to approve bill calling for state mail-order drugs
Primary Care Medicine - Knowledge about osteoporosis management eludes some practitioners in Spain
Prion Disease - Present-day spread and epidemiology of BSE and prion diseases reviewed
Prostate Cancer - Short-term human prostate primary xenografts model cancer angiogenesis
Prostate Cancer - Tertiary scores of prostate adenocarcinoma specimens need to be reported
Prostate Cancer - Vinorelbine and estramustine are effective in patients with prostate cancer
Proteomics - CREB protein encourages the progression of hepatocellular carcinoma
Proteomics - HB autoantigen is the barrier-to-autointegration factor
Proteomics - Mechanism of AP-1 inhibition by 15d-PGJ2 characterized
Proteomics - Sorting of GPI-anchored proteins reviewed
Proteomics - Syndecan-2 is required for angiogenic sprouting in developing embryos
Psoriasis - Covance selected to advance clinical research of LI 313
Pulmonary Tuberculosis - Multifocal lupus vulgaris preceding pulmonary TB reported
Radiation Oncology - Effects of ionizing, UV radiation differ during development
Rankings - Pharmaceutical care provider named to FORTUNE 500 list
Receptor Studies - Expression of plasminogen activator receptors depends on their origin
Receptor Studies - Kinase RIP3 dispensable for normal signaling by immune cell receptors
Rectal Cancer - Management of stage IV primary rectal cancer reviewed
Rheumatology - Abnormal forms of HLA-B27 recognized by CD4+ T cells
Rheumatology - Non-antigen presenting effects of HLA-B27 reviewed
Rosacea - Periostat reduces rosacea inflammatory lesions in study patients
SARS - Company receives STTR research grant from NIH for a virion solvent treatment
SARS - SARS-associated cytokine dysregulation characterized
SARS - Tissue responses to SARS-CoV vary by organ
SARS - Ultrastructural characterization of SARS coronavirus completed
SARS Diagnosis - Real-time PCR assay developed for SARS-associated coronavirus
SARS Transmission - No SARS transmission occurs with U.S. SARS patient
SARS Transmission - Superspreading SARS events in Beijing, 2003, described
Schistosomiasis - DNA Vaccine protects against Schistosoma mansoni
Schistosomiasis - Peptide vaccine shows promise against schistosomiasis and fascioliasis
Schizophrenia - Patients don't take antipsychotic medications regularly
Sepsis - Antioxidants may increase sepsis survival
Sepsis - Company receives preclinical report on MDI-P
Sexual & Reproductive Health - Viagra may affect fertility
Sexual Dysfunction - Impotence has devastating effect on morale
Sickle Cell Disease - New therapeutic approach for blood disorder described
Skin Care - Kinerase product line extended with new intensive eye cream
Sleeping Sickness - IND submitted to FDA for DB289
Smallpox - Successful smallpox vaccine trial announced
Staphylococcus - Staphylococcus and lipopolysaccharide induce heterologous priming
Staphylococcus - Teichoic acids play role in Staphylococcus nasal colonization
Staphylococcus Aureus - FDA approves IDI-MRSA test
Stem-Cell Research - Autophagy gene beclin 1 is haploinsufficient tumor suppressor
Stem-Cell Research - Circulating CD14+ monocytes contain progenitors with mesenchymal cell differentiation
Stem-Cell Research - Influence of p38 MAP kinase isoforms on erythroid differentiation determined
Stem-Cell Research - Marrow stromal cells selected by serum deprivation express embryonic genes
Stem-Cell Research - Mesenchymal stem cells may be useful for hard tissue regeneration
Stem-Cell Research - Morphological and ultrastructural neurosphere features characterized
Stem-Cell Research - Pediatric brain tumors contain malignant stem cells
Stem-Cell Research - Wnt proteins promote neural stem-cell differentiation in vitro
Stem-Cell Research - Wnt signals control immature thymocyte proliferation, cell adhesion
Stem-Cell Transplantation - Benefits and drawbacks of umbilical cord blood transplantation reviewed
Stem-Cell Transplantation - Fatal post-SCT androgen-related hepatic adenoma described
Stem-Cell Transplantation - MURR enters into holmium-166 agreement
Stem-Cell Transplantation - Recipient CMV status should determine T-cell depletion
Stem-Cell Transplantation - Reservation of PBSCs for DLI at harvest improves postrelapse treatment efficacy
Stem-Cell Transplantation - Risk factors for posttransplant TB in South Korea identified
Stents - Company expands Endeavor trial program in Europe
Streptococcus Vaccine - Group B streptococcal protein rib and cholera toxin protect against infection
Substance Abuse - Long-lasting medication shows promise for treatment of heroin addiction
Surgery - New disposable implant cartridge for Salute Fixation System introduced
Thymic Carcinoma - Outcome of multimodality therapy for thymic carcinoma described
Thyroid Diseases - Company launches commercial sale of Iodine-131
Tobacco Use - Shifts in lung cancer histology may be attributable to filtered cigarettes
Tongue Cancer - Tumor-associated proteins in oral tongue carcinoma identified
Toxicogenomics - Company launches integrated toxicology outsourcing service
Transplant Medicine - Central pontine myelinolysis is a complication of liver transplantation
Transplant Medicine - Cotransplanted third-party cells improve double cord blood transplantation
Transplant Medicine - Cytokine genes are key to hepatitis C virus recurrence in liver graft patients
Trends - Report: Growth-factor inhibitors market to triple in coming years
Tuberculosis - Low number of new anti-TB drugs under development, says information provider
Tuberculosis Diagnostics - PRIMAGRAM assay useful with skin test for TB diagnosis in macaques
Tuberculosis Diagnostics - Skeletal tuberculosis can mimic seronegative spondyloarthropathy
Tuberculosis Drug Resistance - M. tuberculosis has multiple thioredoxin-mediated hydroperoxide detox routes
Tuberculosis Vaccine - Efficacy of tuberculosis DNA vaccine varies with method of DNA introduction
Tuberculosis Vaccine - Oral BCG vaccine in lipids protects against pulmonary tuberculosis
Tumor Growth - Protein critical in tadpole metamorphosis has role in human cancer
Tumor Marker - Soluble cytokeratin 18 in serum depicts cell death in some tumors
Tumorigenesis - Aurora kinase inhibitor VX-680 suppresses tumor growth in vivo
Type 1 Diabetes Risk Factor - Retrovirus K-18 polymorphisms linked to type 1 diabetes
Type 2 Diabetes - Pancreatic islet amyloid polypeptide fibrils characterized
Type 2 Diabetes Therapy - Cultural intervention developed for black women with type 2 diabetes
Uterine Cancer - Sentinel lymph node procedure in uterine cancers reviewed
Vaccine Adjuvant - Costimulatory ligand is efficient adjuvant for antiviral T cell responses
Vaccine Safety - DtaP vaccine causes hypersensitivity to aluminum in children
Vaccinia Virus - Protein kinases complement DNA-negative phenotype of vaccinia virus
Varicella Vaccine - Effectiveness of live varicella vaccines reviewed
Varicella Vaccine - Varicella skin test antigen best to monitor response to varicella vaccine
Virology - Mimicking viruses may provide new way to defeat them
Virology - Taq-generated products can give misleading information about RNA viruses
Vitamins - Company announces launch of Prenate Elite
Weight Loss - Fatty acid synthase inhibitor modulates protein kinase
Wound Healing - Chinese regulatory body approves wound gel
Wound Healing - FDA clears collagen sponge wound, film wound, and dental dressings
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