Stem-Cell Research
Autophagy gene beclin 1 is haploinsufficient tumor suppressor
Published in Drug Week, April 23rd, 2004
According to recent research from New York, the "biochemical properties of beclin 1 suggest a role in two fundamentally important cell biological pathways: autophagy and apoptosis."
Z.Y. Yue and coauthors at Rockefeller University found that "beclin 1-/- mutant mice die early in embryogenesis and beclin 1+/- mutant mice suffer from a high incidence of spontaneous tumors."
"These tumors continue to express wild-type beclin 1 mRNA and protein, establishing that beclin 1 is a haploinsufficient tumor suppressor gene," they reported. "Beclin...
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Source: Drug Week (2004-04-23)
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