Drug Week
Susan Hasty, Publisher
Table of Contents . . . April 30th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Drug Week | Other Publications
Autism - Scientists in France announce discovery of an autism disease gene
Cancer Therapy - Data demonstrate IMO compounds inhibit tumor growth
Drug Development - New software predicts promising ingredients for new drugs
Obesity, Diabetes Therapies - Phase II trial of diabetes drug, phase I study of obesity therapy initiated
Psoriasis - U.S. phase II clinical trial initiated for Psoraxine
AIDS/HIV Vaccine - Finding epitopes of HIV-1 that induce protective antibodies remains a challenge
AIDS/HIV Vaccine - MVA-HIV-1 nef vaccine elicits T-helper cell responses in HIV patients
Abdominal Infections - Doripenem clinical trials begin in complicated intra abdominal infections
Acne - FDA approval granted for ANDA for erythromycin/benzoyl peroxide
Adverse Drug Events - Fewer allergic-like events seen following second prescription of penicillin
African Trypanosomiasis - Trypanosome microtubule-associated protein p15 is vaccine candidate
Allergy Medicine - Novel MRI method used to measure efficacy of MAP kinase inhibitor
Allergy Medicine - STI571 inhibits mast cell growth and adhesion in vitro
Alzheimer Disease - A-beta-peptide neurodegeneration in Alzheimer disease brain reviewed
Alzheimer Disease - E318G substitution in PSEN1 gene not linked to Alzheimer disease
Alzheimer Disease - Melatonin protects neuroblastoma cells from neurotoxicity
Angina - Application filed for European marketing approval of ranolazine
Angina - Cardiovascular drug combinations offer improved treatment options
Angiology - Anti-angiogenic agents could affect healing after surgery
Anthrax - Adefovir selectively inhibits factor key to anthrax pathogenesis
Anthrax Infection - IND application submitted to FDA for ToxBlox anthrax infection treatment
Anti-Infectives - Ciprofloxacin can prevent infection in pediatric cancer patients
Anti-Infectives - Linezolid effective against nosocomial VREF in premature infant
Antiangiogenics - Apicidin seen to inhibit new vessels in human vascular endothelial cells
Antibiotics - Letter of Intent entered for garenoxacin quinolone antibiotic
Anticancer Therapy - Preclinical data presented at AACR on anticancer agent
Antimicrobials - New steroidal dimers are antifungal and inhibit human oral and breast cancer
Apoptosis - Golgi fragmentation during apoptosis linked to rapid loss of GM130
Apoptosis - LIM kinase 1 overexpression makes PC12 cells resistant to apoptosis
Arthritis - Arthritis topical cream reduces symptoms in clinical study
Asthma - Identification of new asthma genes demonstrates model for improved patient care
Asthma - Most leukotriene-modifier use in managed-care plan doesn't follow guidelines
Atrial Fibrillation - Cardiac surgery clinical study initiated for RSD1235
Attention Deficit Hyperactivity Disorder - Study links ADHD drugs to growth delays, though permanent effects not known
Attention Deficit Hyperactivity Disorder - Zinc supplements could help treat ADHD
Bacteriology - University of Hawaii student dies of mysterious bacterial infection
Barrett Esophagus - European approval granted for Photobarr
Biomanufacturing - Electroporation technology to be developed for avian transgenic biomanufacturing
Biomanufacturing - Microbia expands partnership to improve biomanufacturing processes
Biomaterials - PHBHHx has good affinity with bone marrow stromal cells
Bladder Cancer - Studies: NMP22 BladderChek detects bladder cancer missed by conventional test
Blood Testing - Anti-Mullerian hormone levels used to investigate prenatal abnormal genitalia
Bone Fractures - Clinical trial initiated in Spain for bone grafting
Brain Cancer - New clues for glioma treatment found
Breast Cancer - APC8024 immunotherapy shows long-term disease stabilization
Breast Cancer - Anticancer effects, single-dose bioavailability reported with Neugene
Breast Cancer - Association found between primary, contralateral breast cancers
Breast Cancer - Drug development company selects chair for breast cancer trial
Breast Cancer - First 1000 patients enrolled in MammoSite patient registry
Breast Cancer - Partners to develop breast cancer gene expression database
Breast Cancer Risk Factor - Management of women at increased risk for breast cancer reviewed
Breast Cancer Therapy - Hellenic Cooperative Oncology Group HE 10/92 study results released
Business & Finance - Biopharmaceutical company announces listing on NASDAQ SmallCap Market System
Business & Finance - Biotechnology company raises $40.9M in Series B venture financing
Business & Finance - Blending of branded and generic pharmaceutical industries expected to continue
Business & Finance - Company completes private placement to advance NanoInvasive surgery
Business & Finance - Functional genomics company reports net loss during "rebuilding" year
Business & Finance - North Carolina officials deny drug company donations affect policy
Business & Finance - Novartis to pay $42.75M to satisfy remaining funding obligation
Business & Finance - Pfizer terminates NAALADase license agreement
Business & Finance - Pharmaceutical company to be included in Dow Jones Industrial Average
Business & Finance - Strategic alliance formed for technology acquisition opportunities
Business Update - Genencor sells its therapeutic vaccine program in multimillion dollar deal
Business Update - Pharma company opens satellite consulting office in Burlingame, California
Campylobacter Vaccine - Campylobacter jejuni strains analyzed for vaccine candidates
Cancer - Biotechnology company announces monoclonal antibody candidate
Cancer - PT-100 with chemotherapy agents shows preclinical anti-tumor activity
Cancer - Partnership plans to target cancer cells through the E2F pathway
Cancer - Pharmaceutical company summarizes cancer research data presented at meeting
Cancer - Positive pre-clinical results announced for OXi4503 in cancer models
Cancer - TLR9 agonist enhances tumor response to radiotherapy in animal model
Cancer Metastasis - Mounting evidence that Ezrin promotes tumor metastasis
Cancer Pathogenesis - IGF-binding protein-4 inhibits colony formation of cancer cells
Cancer Prognosis - Laminin-5 gamma 2 predicts oral lesions at risk for tumor development
Cancer Research - Ceretek drug discovery intellectual property assets acquired
Cancer Therapy - Biotech firm reports progress in soluble T cell antigen receptor programs
Cancer Therapy - Bruceantin is active against tumors in culture and in xenograft models
Cancer Therapy - Cancer-causing HDAC isoforms discussed at 2004 AACR meeting
Cancer Therapy - Company presents data from PARP inhibitor program
Cancer Therapy - Data demonstrate vaccine technology's potential to treat/prevent cancer
Cancer Therapy - Data provide rationale for KOS-862 combination clinical trials
Cancer Therapy - Data: INGN 241 continues to demonstrate broad utility as anticancer agent
Cancer Therapy - Data: Investigational MEK inhibitor AZD6244 combats cancer growth
Cancer Therapy - Dual action anticancer drug presented at AACR conference
Cancer Therapy - Early, high-dose chemotherapy with HPCS effective for poor prognosis GCT
Cancer Therapy - INO-1001, novel inhibitor of PARP, enhances radiation sensitivity
Cancer Therapy - Moffitt teams with genomics company to predict chemotherapy response
Cancer Therapy - NIH awards phase II SBIR grant for antioxidant research
Cancer Therapy - National Cancer Institute awards discodermolide-related grant
Cancer Therapy - New data provided on GRN163L, a telomerase inhibitor drug
Cancer Therapy - Positive preclinical results reported for novel pyrazole compound
Cancer Therapy - Preclinical data for oncolytic virus therapy released
Cancer Therapy - Preclinical results presented for vascular targeting agent MX116407
Cancer Therapy - Scientists overcome immune resistance in dendritic cell vaccines for cancer
Cancer Therapy - Studies initiated for PBI-1402 - results expected in 2004
Cancer Therapy - Studies: Phenoxodiol produces response and restores chemosensitivity
Cancer Treatment - University of Nebraska helps set new standards for treating cancer patient nausea
Cancer Vaccine - Designer glycopeptides for elimination of carcinomas developed
Cancer Vaccine - Exosomes transfer functional MHC class I/peptide complexes to dendritic cells
Cancer Vaccine - ISCOM-based vaccines show promise for cancer immunotherapy
Cancer Vaccine - Kunjin virus replicon vaccine protects against HPV-expressing tumor
Cancer Vaccine - New antigenic peptide encoded by several MAGE genes identified
Cancer Vaccine - Peptide that mediates tumor cell lysis induces cytotoxic T lymphocytes
Cancer Vaccine - Peptide vaccination induces CD4+ T cells reactive to class I tumor peptide
Cardiac Safety Monitoring - Studies awarded for cardiac safety monitoring, information distribution services
Cardiovascular Lesions - Enrollment in Taxus V clinical trial concluded
Cell Biology - Bcl-2 proteins at the endoplasmic reticulum reviewed
Cell Biology - Control of mitochondrial permeability by Bcl-2 family members reviewed
Central Nervous System - Agreements announced for co-development of CNS compounds
Chagas disease - Trypanosoma cruzi antigen and CpG-ODN protect against trypomastigotes
Chemotherapy - Cumulative etoposide doses prognostic factor for transplant-related mortality
Chlamydomonas - Chlamydomonas cells with outer dynein arm mutations characterized
Chronic Pain - Second phase III study with Oxytrex initiated for chronic pain
Clostridium - Clostridium perfringens characterized using DNA microarray chip
Colitis - The expression and role of Fas ligand in intestinal inflammation
Colitis Therapy - Trefoil peptide reduces VCAM-1 expression in intestinal inflammation
Collaborations - Adjuvant license, supply agreements signed with Aventis
Collaborations - Agreement with Innogenetics on hepatitis vaccine programs extended
Collaborations - Anti-epileptic drug Zonegran acquired from Elan
Collaborations - Biotech firm signs broad teaming agreement with DynPort Vaccine
Collaborations - Deal signed for copromotion of Aralast in pulmonology arena
Collaborations - Deal signed to study cervical cancer marker
Collaborations - Deal signed with Southern Cross University for epilepsy, anxiety R&D
Collaborations - Fulcrum Pharma named preferred provider of drug development services
Collaborations - GlaxoSmithKline enters strategic alliance
Collaborations - HP enters partnership to further genomic discovery in life science
Collaborations - Joint research program signed with H. Lee Moffitt Cancer Center
Collaborations - Lab company announces 5-year contract with NY prisons
Collaborations - Lilly enters partnership to combat digestive conditions
Collaborations - Manufacturing agreement extended with Lonza Biologics
Collaborations - Marketing, distribution deal signed to expand line of kinase assays, enzymes
Collaborations - Nanotechnology company announces deal with Fort Dodge Animal Health
Collaborations - Partnership to deliver tools to accelerate information-based medicine
Colon Cancer - C-1311 shows preclinical anticancer activity for colon cancer treatment
Colon Cancer - Calculator provides more accurate estimates of colon cancer survival
Colon Cancer - Interim results released from phase II study of CF101
Colon Cancer - Mucin-2 protein antibody combinatorial TX1TX2T peptide mixtures
Colorectal Cancer - Data reported for new class of cancer therapeutics
Colorectal Cancer - Loss of insulin-like growth factor imprinting linked to colon cancer
Complementary & Alternative Medicine - Attitudes toward alternative therapies differ by gender and onocology profession
Complementary & Alternative Medicine - Company secures patents for gut-based uremia therapy products
Complementary & Alternative Medicine - Intake of antioxidants in coffee, wine, and vegetables add to plasma carotenoids
Complementary & Alternative Medicine - Nutraceutical company launches ProAlgaZyme
Complementary & Alternative Therapy - In Norway, few oncologists are keen on complementary/alternative medicine
Congestive Heart Failure - Information about heart enzymes could lead to better treatments
Contraception - Immune responses to GnRH-based anti-fertility immunogen examined
Coronary Artery Disease - Update provided on coronary artery bypass graft clinical trials
Correctional Healthcare - Methamphetamine use takes major toll on inmates' dental health
Cytokine Analysis - Proteoplex 16-Well Human Cytokine Array Kit launched
Cytomegalovirus - Phase I clinical trial with cytomegalovirus vaccine initiated
Cytomegalovirus - Targets identified for T cell response in cytomegalovirus infection
DNA Repair - Grape seed procyanidin extract prevents DNA lesions in hepatocytes in vitro
DNA Vaccine - Peptides have enhanced, multivalent immunogenicity when bound to DNA vaccines
Dengue Fever - Policymakers' views on dengue fever and need for dengue vaccines outlined
Depression - Antidepressants are not safe for children
Depression - Dangerous interaction reported between the fluvoxamine and tizanidine
Depression - Elderly get tips to beat back the blues
Depression - Improving treatment creates long-lasting improvements for minority patients
Depression - Late-stage molecule licensed for the treatment of depression
Depression - More than half of surveyed antidepressant drug users still feel depressed
Depression - Preschoolers lead growth of antidepressant use
Diabetes - Pre-IND meeting on diabetic peripheral neuropathy formulation announced
Diabetes - Prefilled insulin doser introduced
Diabetes Genomics & Genetics - Susceptibility loci for type 2 diabetes found on chromosomes 6, 11, 14A
Diabetes Genomics & Genetics - Type 2 diabetes onset maps to chromosome 12p and locus on 12q24
Diabetes Genomics & Genetics - Type 2 diabetes susceptibility genes found in West Africans
Diabetes Pathogenesis - Expression of potassium channels in pancreatic islets described
Diabetes Pathogenesis - Onset of type 2 diabetes delayed in patients with prediabetes
Diabetes Therapy - Activin A and betacellulin improves glucose metabolism
Diabetic Nephropathy - Molecular profiling reveals novel genes linked to glomerular disease
Diabetic Nephropathy - Rat model of diabetic nephropathy characterized
Diabetic Neuropathy - Impaired pressure-induced vasodilation in type 1 diabetes reported
Diabetic Neuropathy - Pre-germinated brown rice prevents diabetic vascular complications
Diabetic Retinopathy - Role of caspase-1 in inflammation and apoptosis reviewed
Diagnostics - Data on disease-specific inflammatory diagnostics reported at cancer meeting
Diagnostics - Field-enhanced sample injection method developed for protein analysis
Distribution Agreement - LAM signs distribution agreement with Chinese firm
Divestiture - Nanobac sells practice-management software subsidiary
Drug Delivery - "Tandem technology" delivers two drugs simultaneously into cancer cells
Drug Delivery - Bandage could change lives
Drug Delivery - Company completes research on sublingual spray for pain relief
Drug Delivery - Novel, small peptide, GA3, has potential as drug delivery ligand
Drug Delivery - PVD-conjugated superoxide dismutase potential renal drug carrier
Drug Delivery - Study suggests insect-derived peptides could be used for vaccines
Drug Development - Anti-inflammatory agents isolated from Schinus molle fruit
Drug Development - Indazole-derived SAH/MTA nucleosidase inhibitors have antimicrobial activity
Drug Development - Lavendamycin analogues show promise as HIV reverse transcriptase inhibitors
Drug Development - Plant-derived liminoids exhibit potent antiretroviral activity
Drug Development - Turkish anise species yield antimicrobial agents
Drug Discovery - Company launches IMAP Substrate Finder
Drug Discovery - Geron announces telomerase licensing agreement
Drug Importation - Drug companies say imported prescription drugs unsafe and expensive
Drug Overdose - Florida mother charged with giving daughter fatal dose of methadone
Drug Research Safety - NIOSH for issues alert to prevent occupational exposure to hazardous drugs
Drug Resistance - Multidrug-resistance-associated protein inhibitors synthesized
Drug Resistance - Pheophorbide is specific probe for measuring ABCG2 function and inhibition
Drug Resistance - Structure of drug resistance transporter from E. coli identified
Drug Screening - U.S. patent granted for high throughput drug screening using zebrafish
Drug Treatment - Vermont seeks provider for mobile methadone clinic
Dyslipidemia - Increasing the body's good cholesterol may be a pill away
ECG Monitoring - GMP Cos. announces availability of Lifesync Wireless ECG System
Emotional Lability - Patient enrollment completed for Neurodex phase III trial
Epidemiology - Data augmentation helps estimate Legionella subclinical infection rate
Erectile Dysfunction - Oral medications are preferred for treating most cases of erectile dysfunction
Exercise - Physical training reduced antilipolytic action of catecholamines
Finance - $2.5M financing to fund company's launch into pain relief market
Finance - $20M financing reported by Canadian pharmaceutical firm
Finance - Allergy drug maker reports loss of $18M
Finance - Bertek parent declares quarterly cash dividend
Finance - Biopharmaceutical company reports 2003 financial results
Finance - Biotech firm reports 2.3% increase in revenue
Finance - Biotech firm reports loss of $0.33 per share
Finance - Cancer-therapeutics company files shelf registration statement
Finance - Chinese pharmaceutical firm closes private placement
Finance - Genomics company announces 2003 fourth quarter and full year financial results
Finance - Healthcare products distributor reports $13.5M private placement
Finance - Isotopes company reports drop in sales
Finance - Nutraceuticals company announces increased operating revenue for 2003
Finance - Oncology products developer completes $45M Series C financing
Finance - Ophthalmic company obtains initial $2M of $16.5M private placement
Finance - Pharmaceutical company announces offering of convertible senior notes
Finance - Pharmaceutical company reports 2003 financial results
Finance - Pharmaceutical company's performance outpaces the market
Finance - Pharmaceutical distributor announces increase in net sales
Finance - Pharmaceutical firm announces $63.5M private placement
Finance - Pharmaceutical firm raises $43M; updates progress on AP23573
Finance - Pharmacogenomics firm closes series A financing round
Finance - Small-molecule drug company raises $33.5M in series B financing
Finance - Supplement/pharmaceutical developer announces 2003 financial results
Finance - Tripos reports revenue growth in 2003
Finance - Venture capital fund closes $475M in life sciences funds
Gastric Cancer - Endoscopic mucosal resection for gastric epithelial neoplasms described
Gastroenteritis - Waterborne norovirus outbreak in Sweden described
Gastroenterology - Disruption of TRPM6/TRPM7 complex causes hypomagnesemia, hypocalcemia
Gene Medicine - Methods for production and purification of rAAV-2 vector reviewed
Generic Drugs - Pharmacy to launch Promethazine Plain syrup
Genetic Engineering - Biotech firm wants to grow genetically engineered rice as medicinal supplements
Genetic Variation Analysis - Varia introduced for high-throughput genetic variation analysis
Genital Warts - Positive phase III clinical results achieved with Polyphenon E Ointment
Genomics - Company to provide Merck with genetic rat models
Genomics & Genetics - Comparison of keratin-associated protein gene clusters reported
Genomics & Genetics - Prevalence of B3Delta27 in South Pacific islanders determined
Genomics & Genetics - p21-activated kinase 4 has direct interaction with PDZ-RhoGEF
Genotyping - Hepatitis B virus genotypes compared in Japan
Gift Awards - Eli Lilly gives $6 million to group that sued a year ago
Graft-Versus-Host Disease - LPAM integrin is important in graft-versus-host disease development
Growth Factors - ADAM10 and ADAM17 crucial in ectodomain shedding of six EGFR ligands
Guillain-Barre Syndrome - C. jejuni infection risk factors in Curacao identified
HIV DNA Resarch - HIV integrase can process a 3'-end crosslinked substrate
HIV Therapy - Canadian trial investigates Remune as a drug-sparing therapy in HIV
HIV-Associated Wasting - Serostim improves lean body mass in HIV-associated wasting, study shows
HIV/AIDS - Cheaper AIDS drugs to be available in U.N.-supported nations
HIV/AIDS - Discovery agreement inked regarding AIDS-related dementia
HIV/AIDS - FDA Advisory Panel recommends, with conditions, approval of Sculptra
HIV/AIDS - IPM will take over the development of microbicide TMC120
HIV/AIDS - Pharmaceutical company announces development milestones in HIV products
HIV/AIDS - Role of monocytes in latent HIV infection reviewed
HIV/AIDS Animal Models - M-tropic chimeric SHIV strains in CD4 cell-depleted macaques characterized
HIV/AIDS Cancer - Nadir B-cell counts correlated with Kaposi sarcoma risk
HIV/AIDS Cancer - Serum samples preferable for PCR-based Kaposi sarcoma diagnosis
HIV/AIDS Dementia - Mitochondrial glutaminase augments glutamate output by HIV-infected macrophages
HIV/AIDS Enzymology - Intracellular transport of HIV integrase elucidated
HIV/AIDS Immune Control - Role of CD40L dysregulation in HIV-induced APC dysfunction reviewed
HIV/AIDS Immune Control - Serum inactivation of SDF-1 prevents inhibition of HIV infection
HIV/AIDS Opportunistic Infection - C. albicans epithelial adhesion gene identified
HIV/AIDS Opportunistic Infection - Borna disease virus infection confirmed in HIV patients
HIV/AIDS Opportunistic Infection - Epidemiology of Aspergillus terreus at university hospital described
HIV/AIDS Opportunistic Infection - Hemolysin production by M. avium strains determined
HIV/AIDS Opportunistic Infection - Noninvasive assay for P. carinii pneumonia monitoring developed
HIV/AIDS Opportunistic Infection - Oral CMV therapy superior to intravenous treatment
HIV/AIDS Pathogenesis - DC-SIGN not sole determinant of macrophage HIV transmission
HIV/AIDS Pathogenesis - HIV Nef uses soluble factors to activate macrophage STAT3
HIV/AIDS Pathogenesis - Novel mechanism of naive T-cell anergy induction by HIVenv identified
HIV/AIDS Pathogenesis - Roles of uPA and uPA receptor in HIV infection reviewed
HIV/AIDS Proteomics - Nuclear targeting activities of HIV Rev transport signals characterized
HIV/AIDS Proteomics - Phosphorylation motif of HIV Vpu bound to beta-TrCP described
HIV/AIDS Receptor Studies - Opioid-induced CCR5 desensitization reduces R5 HIV infectivity
HIV/AIDS Therapy - Anti-NeoR6 resistance mutations suggest anti-HIV mechanisms
HIV/AIDS Therapy - Anti-nanobacteria phototherapy ameliorates HIV- and diabetes-related neuropathy
HIV/AIDS Therapy - Doctors likely to delay prescribing antiretrovirals for women, minorities
HIV/AIDS Therapy - Fludarabine-loaded RBCs can clear HIV macrophage reservoir
HIV/AIDS Tuberculosis - Epidemiology of MDR-TB in HIV patients in Peru described
HIV/HCV Coinfection - Risk factors for severe liver fibrosis identified
Haemophilus Vaccine - Haemophilus influenzae protein complex induces cytokine production
Head and Neck Cancer - Advexin Clinical Data presented at AACR
Head and Neck Cancer - Radiation impacts quality of life in head and neck cancer patients
Headache & Migraine - North American rights to Frovatriptan reacquired from Elan
Heart Disease - Cypher sirolimus-eluting coronary stent approved for marketing in Japan
Heart Disease - Enrollment concluded in Taxus V trial; FDA clears Contour SE
Heart Disease Risk Factor - Control of apolipoprotein A-I expression in diabetes reviewed
Heart Transplantation - LF15-0195 inhibits NF-kappaB signaling via IKK suppression
Heart Transplantation - Lepromatous leprosy in heart transplant recipient described
Helicobacter - H. pylori glutamyltranspeptidase upregulates peptide expression
Helicobacter - Gene profiles in mucosa identified during H. pylori infection
Hematological Cancer Therapy - Risedronate prevents and reverses bone loss in stem-cell graft recipients
Hematology - Effect of gamma radiation on hemoglobin clarified
Hematology - Munc13-4 regulates dense core granule secretion in platelets
Hemochromatosis - New mutation in hepcidin linked to juvenile hemochromatosis
Hemolytic Anemia - Compound mutations cause hemolytic anemia and severe rhabdomyolysis
Hepatitis - Cell culture and animal models for human viral hepatitis reviewed
Hepatitis C Epidemiology - Prevalence of hepatitis C high among homeless of Oxford, England
Hepatitis C Treatment - Synergy of antiviral effects seen when INF-alpha and ribavirin are combined
Hepatitis C Vaccine - Envelope protein-based vaccine enhances delays hepatitis C virus infection
Hepatitis C Virus - Synthetic RNA act as templates for hepatitis C virus NS5B polymerase
Herpes - Drug-delivery company to provide development services for herpes therapy
Hormone Therapy - Caution urged on testosterone therapy
Human Papillomavirus Vaccine - Immunogenicity against HPV enhanced by Salmonella enterica phenotype
Idiopathic Pulmonary Fibrosis - Results published from Actimmune IPF trial
Illegal Drug Distribution - Iowa druggist who lost license managing Michigan drug store
Illegal Drug Use - Heroin use among Massachusetts youth jumps sharply
Immune System Disorders - Cathepsin S research program designates candidate drug
Immunology - Activity of cord blood T cells characterized
Immunology - Acute immune response to filarial parasites characterized by Th1 cytokines
Immunology - CD59 acts as co-receptor in natural killer cell activation
Immunology - Cytotoxic T cells inactivated by HSV-infected cells
Immunology - Divergent selection of marginal zone B and B1a cells reported
Immunology - Expression of beta-adhesin part of HRgpA induces antibody response
Immunology - Genetic background affects role of TLR proteins
Immunology - Idiopathic thrombocytopenic purpura therapy reviewed
Immunology - Influence of aqueous humor on immunity reviewed
Immunology - Interaction between mannose receptors and C. albicans clarified
Immunology - Key Ig-like domain identified in IL-18R-alpha
Immunology - Morphine upregulates lymphocyte KLF7
Immunology - TLR2 and TLR4 have distinct roles in immune response to mycobacteria
Immunology - Whole blood samples may produce low FACS antigen-specific T-cell counts
Infectious Disease - Did West Nile virus infection fell Alexander the Great?
Infertility - FDA approves new presentations of Gonal-f to treat infertility
Influenza Vaccine - Influenza vaccination changes lymphocyte distribution in tonsils
Information Technology - New cheminformatics software development tools released
Information Technology - Target Informatics platform pilot licensed by Boehringer Ingelheim
Insomnia - Study demonstrates long-term efficacy with indiplon modified release
Insulin Resistance - Malonyl-CoA decarboxylase expression reverses insulin resistance
Insulin Sensitizer - Plans finalized for launch of Sucanon diabetes drug in Mexico
Kidney Disease - Activation of toll-like receptor-9 induces progression of renal disease
Legal Issues - Internal investigation finds no evidence of wrongdoing by BioBalance or parent
Legal Issues - Prison sentence upheld in drug diluting case
Leishmaniasis - Leishmania induce Myd88-dependent maturation of splenic dendritic cells
Leishmaniasis Therapy - Treatment of cutaneous leishmaniasis among travelers reviewed
Leukemia - Company completes NDA for clofarabine
Leukemia - Hematopoietic reserve evaluated in B-CLL patients
Leukemia - Molecular analyses of leukemia patients suggest strategies for better treatments
Leukemia - Phase II trial of BCX-1777 initiated in T cell leukemia
Leukemia - Study expands on effectiveness of AP23464, in Gleevec-resistant leukemia cells
Leukemia Therapy - Post-HSCT dendritic cell recovery kinetics determined
Licensing Agreement - P&GP to develop RDP58 for gastrointestinal disorders
Lipid Studies - Exercise and postprandial lipid metabolism reviewed
Lipid Studies - Oxidizability of LDL similar under good and poor glycemic control
Listeria - Listeria monocytogenes blood agar effective for microorganism isolation
Listeria - Chemokine receptor 5 dispensable response to Listeria monocytogenes
Listeria - Riboprint analysis of applied to Listeria monocytogenes isolates
Liver Cancer - Liver adenomatosis associated with diabetes phenotype
Lung Cancer - Positive results reported from phase IIb BLP25 liposomal vaccine trial
Lung Cancer - Telcyta phase III registration trial initiated in NSCLC
Lyme Disease - OspA/B plays essential role in life cycle of Lyme disease spirochete
Lyme Disease - Outer-surface protein C of Lyme spirochete induced in ticks
Lymphoma - Complete remission feasible in HIV NHL patients
Macular Degeneration - NDA submitted for SnET2-PDT to treat wet AMD
Malaria - Co-ligand complex anchors malaria merozoites to erythrocyte invasion receptor
Malaria Enzymology - Novel E. coli expression system provides functional plasmodial fp2
Malaria Therapy - Artemisinin can augment effects of anti-leukemia drugs
Malaria Vaccine - Activity of Plasmodium rhoptry-associated protein peptides reported
Malaria Vaccine - Antibodies to malaria peptide mimics inhibit invasion of erythrocytes
Malaria Vaccine - Erythrocyte-binding antigen of P. falciparum not promising vaccine candidate
Malaria Vaccine - Merozoite surface proteins differ in ability to protect against malaria
Malaria Vaccine - Sulphadoxine-pyrimethamine pretreatment not recommended for malaria vaccine
Market Analysis - Biotech endures through choppy month
Market Analysis - Branded drug-makers prepare for the inevitable
Marketing - Lupin enters collaboration to promote Zymar to pediatricians
Marketing Agreement - Labopharm inks agreement for once-daily formulation of tramadol
Mass Spectrometry - Liquid chromatography-mass spec used to study antiangiogenic drug in rat model
Medicaid - Loophole lets drug companies avoid Medicaid program's restriction list
Medicaid - Nonprofits get $138 million in West Virginia program funds annually
Medicare - CMS adds to list of outpatient services eligible for additional payments
Medicare - Inspector general warns against pharmacy kickbacks
Melanoma - CancerVax announces presentation of phase II data on Canvaxin
Melanoma - Scientists discover SSX, a new family of cancer vaccine targets
Melanoma Therapy - New treatments for melanoma at distant metastases being developed
Melanoma Vaccine - gp100209-2M peptide vaccine induces immune response in melanoma patients
Meningitis - Novel RT-PCR assay can aid diagnosis of EV-related meningitis
Meningococcal Vaccine - Mimics of capsular polysaccharide protect against group B meningococci
Mergers & Acquisitions - Biopharmaceutical company to acquire Kinetek Pharmaceuticals Inc.
Mergers & Acquisitions - Genaissance closes merger with genomics company
Mergers & Acquisitions - ISP acquires microencapsulation business
Mergers & Acquisitions - Invitrogen Corp. acquires microarray company
Mergers & Acquisitions - Japanese pharmaceutical firm now a subsidiary of Merck
Mergers & Acquisitions - Tularik to be acquired for $1.3B
Mergers & Acquisitions - Wyeth St. Louis biopharmaceutical facility to be acquired
Molecular Diagnostics - PGP9.5 mRNA contributes to medullary thyroid carcinoma molecular-based diagnosis
Mosquito-Borne Disease - Anopheles funestus gene markers identified
Mosquito-Borne Disease - Light-traps are alternative method for sampling adult anophelines
Mucosal Immunization - IgA against Shiga toxin-binding subunits produced by mucosal immunization
Mucosal Immunization - Mucosal vaccination increases expression of MAdCAM-1 in GI tract
Multiple Myeloma - Phase III pivotal trial for STR begins
Myelodysplastic Syndromes - Results reported from Dacogen phase III study in myelodysplastic syndromes
Myeloid Leukemia - Cloretazine studied for acute myeloid leukemia or myelodysplastic syndromes
Nanotechnology - Quantum dot conjugates being produced for biological research
Narcolepsy - Xyrem marketing authorization application accepted for review in Europe
Neurodegeneration - Role of cyclin-dependent kinase-5 in neurodegeneration reviewed
Nosocomial Infection - Antimicrobial resistance on the rise in American hospitals
Obesity Genomics & Genetics - Obesity-related locus found in chromosome region 12q23-24
Obesity Surgery - Gastric bypass surgery for morbid obesity decreases bone mass
Obesity Therapy - Growth hormone used as adjuvant therapy for obesity
Obesity and Diabetes - Adiponectin production increased in obesity and insulin resistance
Ophthalmology - Requirements for leukocyte passage across blood-retina barrier described
Oral Cancer - Overexpression of COX-2 is associated with radioresistance in oral SSC
Osteoporosis - Positive phase III data reported for PREOS
Outbreaks - Enterotoxin-producing E. coli O169:H41 outbreaks summarized
Ovarian Cancer - Agreement signed for phase III Xyotax trial
Ovarian Cancer - Dendritic cell stimulation restores ovarian-tumor-specific cytotoxicity
Pain - Initial commercialization of Oxycodone 80 mg announced
Pain Medicine - PPAR-gamma mediates NSAID-induced upregulation of TFF2 expression
Pain Medicine - Role of endothelin in inflammatory hyperalgesia in mice described
Pain Medicine - Ultracet effective and well tolerated for postsurgical pain
Pain Therapy - Details reported from FDA meeting on oxymorphone NDAs
Pain Therapy - Results of meeting with FDA on bicifadine reported
Pancreatic Cancer - FDA accepts Orathecin New Drug Application for filing
Parvovirus B19 - Persistent parvovirus B19 infection without chronic anemia reported
Patents - Appeals court upholds Genentech patent victory
Patents - Australian patent issued covering use of Cyanocobalamin for allergies
Patents - Company acquires broad rights from European Transfluor patent
Patents - Kos files suit for infringement of new Niaspan patent
Patents - Mylan loses patent infringement suit
Patents - New European patent granted for naltrexone
Patents - Patent awarded on quantitative analysis of nucleic acid amplification reaction
Patient Privacy - University of Kansas reports hacking of health center computers to FBI
Patient Safety - Adverse drug interactions program launched
Pediatric Eye Surgery - FDA grants orphan drug designation for microplasmin in pediatric eye surgery
Pediatric HIV/AIDS - Children may have enhanced responses to anti-HIV immunotherapy
Peripheral Arterial Disease - Patient enrollment completed for Deltavasc phase II trial
Peripheral Neuropathy - Elderly fall rate cut by 96% using anodyne therapy
Peripheral Vascular Disease - Early closure of patient recruitment in Liprostin trial reported
Personnel - Biopharmaceutical company appoints interim chief financial officer
Personnel - Biopharmaceutical company names new senior VP of clinical development
Personnel - Biotechnology company appoints new chairman of scientific advisory board
Personnel - Biotechnology company appoints new member to the board of directors
Personnel - Business strategy firm names new chief executive officer
Personnel - Clinical pathologist named corporate medical director at stem cell banking firm
Personnel - Drug discovery company names interim chairman of the board
Personnel - Jeffrey S. Williams named senior VP of pharmaceutical company
Personnel - Kirk Ways appointed VP, chief development officer at pharmaceutical firm
Personnel - Management consulting company announces new clinical operations associate
Personnel - Pharmaceutical company announces vice president, research, metabolic diseases
Personnel - Pharmaceutical company names new member to board of directors
Personnel - Pharmaceutical company nominates new member to board of directors
Personnel - Pharmaceutical firm appoints Abdalian as chief financial officer
Personnel - Pharmaceutical firm appoints Richard B. Brewer to board of directors
Personnel - Prominent chemical biologist joins biotech firms' advisory boards
Personnel - Robert W. Makuch, PhD, named chief scientific advisor of consulting firm
Personnel - Senior management team strengthened with additions at device firm
Personnel - Tollefson named to board of directors at pharmaceutical firm
Plague Vaccine - Novel vaccine candidates against Yersinia pestis generated
Polio Vaccine - Developing country perspective on vaccine-associated paralytic polio released
Polio Vaccine - Inactivated poliovirus vaccine produced in vero-cells is safe and effective
Prescription Drug Importation - County in North Carolina offers employees chance to buy drugs in Canada
Prescription Drug Importation - New Hampshire governor unveils state Internet link to Canadian pharmacy
Prescription Drug Importation - Wisconsin city studies getting prescription drugs from Canada
Product Licensing - Agreement inked for development of pharmacogenomic diagnostic assays
Product Licensing - Newtech negotiates to acquire rights to diabetes treatment
Prostate Cancer - Prostate tumors treated with antiandrogens can become hormone refractory
Prostate Cancer - Taxane-based therapy reduces pain and increases survival in HRPC
Prostate Cancer Therapy - Delivery system for leuprolide developed to treat prostate cancer
Proteomics - In vitro targeting reveals intrinsic histone tail specificity
Proteomics - Role of ClpX AAA+ ATPase in engagement of protein substrates described
Proteomics Research - TrueClone Collection acquired for structural proteomics program
Psoriasis - Phase II clinical trial initiated in U.S. for novel psoriasis treatment
Pulmonary Fibrosis - Coalition announces partnership to advance national advocacy programs
RNA Research - Fisher Scientific completes acquisition of RNAi technology company
Rabies Vaccine - Rabies vaccine for humans recalled in 24 countries
Radioimmunotherapy - Trivalent fusion protein for radioimmunotherapy developed
Receptor Studies - Agonist-induced Ca2+ entry determined by inositol recognition
Receptor Studies - Melanocortin-5 receptor deficiency reduces aggression in male mice
Regulatory Issues - Unethical promotion of medicines is rife in India
Renal Cell Cancer - Positive rhLF cancer results presented at AACR meeting
Respiratory Infections - FDA approval granted for Ketek (telithromycin) tablets
Respiratory Syncytial Virus - BBG2Na respiratory syncytial virus vaccine requires further testing
Respiratory Syncytial Virus - Vaccinia virus expressing RSV genes does not predispose for immunopathology
SARS - Distinctive radiological features of SARS identified
SARS - NCI collaboration to investigate role of ACE2 in SARS
SARS - Research response for severe acute respiratory syndrome outlined
SARS Diagnostics - Novel real-time PCR assay enhances detection of SARS coronovirus
Salmonella - Liver dendritic cells present antigens upon Salmonella encounter
Schizophrenia - Four neuroscience compounds to be co-developed and co-commercialized
Septic Shock - Adjunctive G-CSF enhances treatment of meliodosis septicemia
Sexually Transmitted Disease - Sexually transmissible infections other than HIV reviewed
Shigellosis Vaccine - Shigella flexneri 2a vaccine protects against shigellosis symptoms
Skin Cancer - Fresh apple peel extract may have potential chemoprotective effects
Solid Tumor Cancers - Novel anti-cancer drug data presented at cancer research meeting
Solid Tumors - Phase I trial of XIAP initiated
Spongiform Encephalopathies - Researchers make major gain in understanding how prions jump species
Staph Infection - Safety review of endocarditis/bacteremia data for Cubicin complete
Stem-Cell Research - CD41 expression defines hematopoiesis onset in the murine embryo
Stem-Cell Research - IL-21 induces rapid maturation of natural killer cell precursors
Stem-Cell Research - M1 muscarinic receptors expressed by neuronal progenitors
Stem-Cell Research - MEK-1/ERK signals have differential effects on erythroid progenitor self-renewal
Stem-Cell Research - Matrigel effective for neuronal differentiation of MSCs in culture
Stem-Cell Research - Murine and human ES cell hematopoiesis models reviewed
Stem-Cell Research - NF-kappaB/Rel-mediated apoptosis regulation reviewed
Stem-Cell Research - Neurogenesin-1 induces neurogenesis in adult hippocampus
Stem-Cell Research - Retinoic acid suppresses LIF signaling in murine embryonic stem cells
Stem-Cell Transplantation - Novel regimens allow mixed chimerism with T-cell depletion in mice
Stents - Hemolysis test produces successful results for Hap technology
Strep Throat - Newer drugs more effective at curing strep throat than penicillin
Streptococcal Infection - Novel system enables expression, purification of GAS Sic
Stroke - Antiplatelet pill key to preventing surgery complications
Structural Biology - Company introduces a new chip to grow diffraction-quality crystals
Sudden Cardiac Death - New drug prevents arrhythmias that cause sudden cardiac death
Systemic Lupus Erythematosus - Lupus group announces $6.7M in research grants
Systemic Sclerosis - Testicular protein overexpressed in SSc fibroblasts is autoantibody target
T Cell Lymphoma - HuMax-CD4 gets fast track status
Tick-Borne Encephalitis - Viral fusion protein from tick-borne encephalitis virus characterized
Tinnitus - New animal model of hearing disorder developed
Tissue Culture - Generation of 3-D pannus-like tissues in vitro show differentiation in arthritis
Tourette Syndrome - Brain activity, including memory-processing, changes in Tourette syndrome
Transfusion Medicine - C. perfringens alphaNAG converts type A2 blood cells to type O
Transplant Medicine - Risk factors and recurrence of primary biliary cirrhosis
Transplant Medicine - Study offers new insights into the mechanisms of rapamycin
Transplantation Medicine - Blood test useful for monitoring immunosuppressant interactions
Traumatic Brain Injury - Grant to fund development of dexanabinol for traumatic brain injury
Tremors - Agreement received from FDA on phase III protocol for Altropane
Tuberculosis - Mycobacterium tuberculosis cultures may represent cross contamination
Tuberculosis Enzymology - Crystal structure of M. tuberculosis PPAT determined
Tuberculosis Epidemiology - Beijing genotype linked with high TB relapse risk in Vietnam
Tuberculosis Epidemiology - Genetic distance useful as measure of ongoing TB transmission
Tuberculosis Epidemiology - Molecular features of extrapulmonary TB in San Francisco determined
Tuberculosis Immune Control - CD4+CD57+ activated memory T cells expanded in TB patients
Tuberculosis Immune Control - Novel CTL-mediated mechanism limits mycobacterial macrophage infection
Tuberculosis Risk Factor - IFN-gamma autoantibodies may raise mycobacterial infection risk
Tuberculosis Vaccine - Mycobacterium bovis BCG plus novel adjuvant protects against tuberculosis
Tuberculosis Vaccine - Aerosol immunization with M. bovis BCG results in paucibacillary TB
Tuberculosis Vaccine - BCG vaccination not associated with positive tuberculin test
Tumors - Oncology compounds identified for further development
Type 2 Diabetes - Dissociation found between insulin resistance and insulin signaling
Type 2 Diabetes - Reduced lipid oxidation in type 2 diabetes may be of genetic origin
Type 2 Diabetes - Repaglinide plus Rosiglitazone improves type 2 diabetes blood glucose control
Type 2 Diabetes Pathogenesis - Activated innate immunity implicated in pathogenesis of type 2 diabetes
Type 2 Diabetes Risk Factor - Inflammatory markers predict risk of type 2 diabetes in women
Ulcerative Colitis - Suspected role of Helicobacter in colitis studied
Urinary Retention - European urology meeting hears data on Xatral OD
Vaccine Safety - Adverse events of aluminum-containing DTP vaccines reviewed
Virology - HIV finds new way to play hide and seek
Virology - Interferon antagonist proteins of viruses suppress RNA silencing
Virology - Research offers intriguing clues to "Trojan horse" gene in HIV infection
Von Willebrand Disease - PltGPs do not affect clinical expression of von Willebrand disease type I
West Nile Virus - Drug maker may drop research on West Nile virus
Wound Care - Utility of fibrin glues for wound repair reviewed
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