Immunology
Optimal T-cell activation requires CD6/CD166 interaction
Published in Drug Week, June 11th, 2004
According to recent research from England, the "T-cell surface glycoprotein CD6 binds CD166 in the first example of an interaction between a scavenger receptor cysteine-rich domain and an immunoglobulin-like domain."
N.J. Hassan and coauthors at the University of Oxford found that "these proteins interact with a KD =0.4-1.0 microM and Koff {{>=}}0.4-0.63/s, typical of many leukocyte membrane protein interactions."
"CD166 also interacts in a homophilic manner but with around 100-fold lower affinity (KD =29-48 microM and...
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Source: Drug Week (2004-06-11)
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