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Drug Week

Susan Hasty, Publisher

Table of Contents . . . June 25th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Drug Week | Other Publications

Asthma - Clinical trial to evaluate Xolair in pediatric allergic asthma patients

Breast Cancer - Chemotherapy including epirubicin may improve survival for some patients

Non-Hodgkin Lymphoma - FDA accepts Onco TCS new drug application

Pneumonia - FDA approves Avelox (moxifloxacin HCI) for community-acquired pneumonia

AIDS Vaccine - Volunteers needed as more AIDS vaccines move into clinical trials

Adverse Drug Effects - Lupus-like syndrome linked to simvastin therapy

Allergies - Full enrollment reported in phase II/III AIC trial

Allergy & Immunology - PAR-2-mediated activation enhances airway inflammation

Allergy Medicine -  Dermatophagoides atopy patch tests are highly reproducible

Allergy Medicine - Allergy to ovalbumin induces lymphocyte migration to intestinal mucosa

Allergy Medicine - PAF responsiveness in subjects with plasma PAF acetylhydrolase deficiency

Allergy Medicine - Test methods evolving for newly emerging allergy epidemics

Alzheimer Disease - Beta-secretase modulates processing of APLP2 in vivo

Alzheimer Disease - Carboxyl-terminus of amyloid protein precursor needed to activate MAPK

Alzheimer Disease - Deactivation of two genes could be the cause of AD

Alzheimer Disease - Diffusion tensor imaging detects white matter changes in mouse model

Alzheimer Disease - Hypoxia remodels Ca2+ homeostasis in type I cortical astrocytes

Anemia - Successful cord blood stem cell transplant reported

Anesthesia - Cox-2 inhibitors reduce complications after laparoscopic surgery

Angiology - Endovascular management effective for iliac vein occlusive disease

Angiology - Nitric oxide and GABA mediate adrenomedullin's hypotensive effects in brain

Angiology - Study of decellularized carotid artery vascular grafts released

Angiology - TAL-1 stimulates endothelial cell migration and morphogenesis

Anorexia - Megestrol acetate improves appetite and weight gain in cancer and AIDS patients

Anti-Infectives - Polycomplexes of poly(acrylic acid) and streptomycin sulfate characterized

Antibacterial Research - NMR evidence found for independent domain structures in zoocin A

Antibiotics - Antibiotic activity of field-collected Streptomycetes characterized

Antibiotics - Biopharmaceutical company announces additions to fungicide patent portfolio

Antibiotics - FDA approves amoxicillin and clavulanate potassium for oral suspension

Antidepressants - Serotonin increases neurotrophic factor release in glioblastoma cells

Antimicrobials - Structural motif of alpha-helical antimicrobial peptides identified

Apoptosis - Caspase-mediated cleavage of syntaxin 5 and giantin occurs in apoptosis

Apoptosis - Granzyme B encoded by RAH allele retains pro-apoptotic activity

Apoptosis - TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis

Aspergillus - Method for purification of Aspergillus niger xylanase developed

Aspergillus - Production of melanin by Aspergillus fumigatus reviewed

Assisted Reproduction - Low-dose luteinizing hormone boosts ovulation but mitigates hyperstimulation

Asthma - Alvesco (ciclesonide) has no effect on HPA-axis function

Asthma - FDA approves ANDA for Terbutaline Sulfate Injection

Asthma - Gene at root of urban air pollution's lung effects

Asthma - Xopenex improves FEV1 more than racemic albuterol in study patients

Atherosclerosis - PAD patients should be aggressively treated for atherosclerotic risk factors

Atherosclerosis - Vulnerable atherosclerotic plaque identified with novel texaphyrin compounds

Atherosclerotic Disease - Vitamin E in dialysis fluid may reduce endothelial damage

Autoimmune Disease - ELISA for detection of autoantibodies to BP230 developed

Autoimmune Disease - Mice made to express liver cell osteopontin model human autoimmune hepatitis

Avian Influenza - Biotech firm to make flu vaccine for U.S. National Institutes of Health studies

Avian Influenza - NIAID announces contracts to develop vaccine against H5N1 strain of bird flu

Awards - 2004 Analytical Instrumentation Company of the Year named by Frost & Sullivan

Bacterial Meningitis - Choroid plexus involved in host defense

Bacteriology - Histopathologic changes in kidney and liver correlate with SPE B production

Bardet-Biedl Syndrome - Oligogenic properties of Bardet-Biedl syndrome reviewed

Benign Prostatic Hyperplasia - FDA warning letter clarified by biotech firm

Bioengineering - 2'-O-methyl- groups stabilize the binding of phosphorothioate antisense ODNs

Bioengineering - Cell matrix-modified implants stimulate new vessel growth in animals

Biomarker Discovery - Advanced multiplexed protein labeling technology described

Biotechnology - Glassy carbon microchip developed for electrospray mass spectrometry

Bladder Cancer - Carbonic anhydrase IX predictive of outcome in bladder cancer

Blood Banking - Autologous FG by CryoSeal FS System suggestive for hypothetical blood saving

Blood Screening - Consensus determines principles of screening and prevention of vCJD

Blood Vessel Formation - Phase I trial of ATN-224 initiated in patients with solid tumors

Brain Cancer - Bispecific immunotoxin effective in murine model

Brain Cancer - Microspheres developed for 5-FU delivery to brain

Brain Cancer - RNAi delivery system crosses blood-brain barrier to target brain tumors

Breast Cancer - Adding Herceptin to chemotherapy regimen boosts response rates in early disease

Breast Cancer - Aromasin after Tamoxifen lessens breast cancer recurrence in study

Breast Cancer - Concordance between HER-2 testing methods determined

Breast Cancer - Drug shrinks tumors or slows growth in up to half of women

Breast Cancer - Epirubicin and paclitaxel activity independent of adjuvant therapy

Breast Cancer - FDA grants approval for Gemzar in combination with Taxol

Breast Cancer - Gemcitabine/paclitaxel combination extends patients' overall survival

Breast Cancer - Gene expression ratio identifies recurrence risk in patients receiving tamoxifen

Breast Cancer - Gene mutation, use of certain antidepressants may decrease tamoxifen's effects

Breast Cancer - Overview of neoadjuvant endocrine therapy for breast cancer published

Breast Cancer - RT-PCR for mammaglobin genes detects sentinel lymph nodes micrometastases

Breast Cancer - Tamoxifen stimulates tumor growth following alteration of estrogen receptor

Breast Cancer Survival and Mortality - CD105 identifies node-negative breast cancer patients with poor prognoses

Breast Cancer Therapy - Radiation and subsequent TRAIL/Apo-2L quells breast tumor xenografts in mice

Breast Cancer Vaccine - Electroporated DNA vaccine clears breast cancer in transgenic mice

Business & Finance - Biopharmaceutical company achieves second milestone of license agreement

Business & Finance - Biopharmaceutical company announces participation in NASDAQ Biotechnology Index

Business & Finance - Biopharmaceutical company reports loss of $0.02 per share

Business & Finance - Biotechnology company receives first success-based milestone payment

Business Update - Collaboration to develop various dosage forms of cephalosporin antibiotics

Business Update - Drug developer to realign product development strategy

Business Update - Genetic manufacturing company relocates

Business Update - Pharmaceutical company announces new name and ticker symbol

Business Update - Portfolio of OTC and personal care brands acquired from Pfizer

Business Update - Pozen shares plummet after migraine drug rejected

Business Update - U.K. pharmaceutical company to establish U.S. headquarters in Pennsylvania

Cancer - Life sciences research and information company launches new publication

Cancer - Ligand-based VTA technology presented at international conference

Cancer - Phase II clinical studies to study Pivanex in leukemia and melanoma

Cancer - Scope of breast duct to be distributed in the Middle East

Cancer Cell Biology - Researchers pinpoint unlikely ally in cancer fight

Cancer Diagnosis - Immunomagnetic separation depicts esophageal cancer micrometastasis

Cancer Diagnostics - S100C staining may aid diagnosis of thyroid lesions

Cancer Prognosis - High levels of serum VEGF predict poor outcomes after liver cancer therapy

Cancer Recurrence - The management of recurrent cancer after prostatectomy is not clear cut

Cancer Research - CEACAM6 crosslinking leads to increased extracellular matrix component adhesion

Cancer Screening - Prostatic adenocarcinomas can be detected in men with low PSA values

Cancer Therapy - Algal toxin may disrupt the tumor fighting functions of E-cadherin

Cancer Therapy - Amifostine does not protect lungs from carmustine-containing chemotherapy

Cancer Therapy - Cannabis may help nausea, pain, and spasticity

Cancer Therapy - Electrochemotherapy may be a new treatment for solid tumors

Cancer Therapy - Genetically engineered virus targets "selfish" cancer cells

Cancer Therapy - Marine sponge Homaxinella sp. yields new cytotoxic metabolites

Cancer Therapy - Radiotherapy toxicity linked to abnormal transcriptional responses to DNA damage

Cancer Therapy - Scientists block cellular enzyme activity involved in cancer progression

Cancer Therapy - The thalidomide analogue CC-5013 uses T-cell induction to fight cancer

Cancer Vaccine - Melanoma cells expressing CD83 induce antitumor immunity

Cancer Vaccine - NY-ESO-1 protein protects against NY-ESO-1+ tumors

Cancer Vaccine - Researchers turn tumor cells in situ into tumor epitope-presenters

Candida Vaccine -  Candida albicans strain protects against systemic candidiasis

Carcinogens - Exposure route dictates lung cancer type after arsenic contact

Carcinogens - New animal models show the carcinogenic synergy of UV radiation and arsenic

Cardiology - 30-day safety data available for coronary stent

Cardiology - Cardiology imaging and information company to manage stent trial

Cardiology - Cigarette smoking predicts reduced maximal FEV1 level in males but not females

Cardiology - Heparin coating protects blood during open-heart procedures

Cardiology - Intrinsic implantable cardioverter-defibrillator now available in Europe

Cardiology - L-type calcium channel subunit expression clarified in developing heart

Cardiology - Medtronic launches InSync cardiac resynchronization therapy system in Japan

Cardiology - New clinical data on stent performance announced

Cardiology - New report shows diagnostics driving cardiovascular market

Cardiology - Potential treatment for aortic aneurysm repair surgery given FDA fast track status

Cardiology - Recreation of published results may confirm nanobacteria in arteries and valves

Cardiology - Technology company invests in catheter-based technology for heart valve repair

Cardiovascular Disease - Heat-inactivated C. pneumoniae is not atherogenic

Cardiovascular Disease - Impaired apoptotic cell clearance enhances atherogenesis and autoimmune disease

Cardiovascular Disease - Metabolic syndrome positively associated with cardiovascular disease

Cardiovascular Disease - Moderate hepatic impairment has limited effect on azimilide pharmacokinetics

Cell Biology - Nck and Crk adaptor proteins modulate VEGF-controlled cell migration

Cervical Cancer - HPV oncoproteins expressed by foreskin cells alter the angiogenic environment

Childhood Obesity - After school activities can reduce obesity among inner city youth

Chirality - Method to determine chirality determination of amino acids developed

Chlamydia - Glycosaminoglycans protect against Chlamydia infection in vitro

Cholesterol - Cholesterol regulates GCase activity/stability in Niemann-Pick disease type C

Chronic Bronchitis - Avelox promotes rapid remission of chronic bronchitis symptoms in study

Chronic Constipation - Zelnorm demonstrates safety and efficacy in chronic constipation studies

Chronic Hepatitis C - Diligence is important for managing patients with hepatitis C virus infections

Chronic Lymphocytic Leukemia - Rituximab called most promising emerging drug for chronic lymphocytic leukemia

Chronic Myeloid Leukemia - A few questions remain concerning chronic myeloid leukemia

Chronic Obstructive Pulmonary Disease - Tiotropium Bromide Inhalation Powder recommended for COPD in ATS guidelines

Cochlear Implant - Effects of pulse rate on Clarion cochlear implant performance determined

Cochlear Implants - Cochlea is surgically accessible through middle cranial fossa

Cognition - Cognitive performance varies after radiation therapy for brain tumors

Collaborations - Exclusivity rights to 150mg generic Zyban relinquished

Collaborations - FTC clears reacquisition of intranasal influenza vaccine products

Collaborations - Licensing agreement signed to develop, market Lumigan in Japan

Collaborations - Option granted for rights to blood platelet modification technology

Collaborations - Pandemic influenza vaccine agreement signed

Collaborations - Pharmaceutical firm gets $21M award under expanded agreement

Collaborations - Rights acquired to retinoid portfolio

Colon Cancer - Multiple local IL-2 treatments effective in mice

Colon Cancer - Nitric oxide rules colon carcinoma angiogenesis markers differentially

Colorectal Cancer - Bio-pathological profile is prognostic in colorectal adenocarcinomas

Colorectal Cancer - Expression of p185 protein has prognostic value

Colorectal Cancer - Flavaglines induce apoptosis in colorectal cancer cells

Colorectal Cancer - Oral PSK with UFT reduced recurrence in colorectal cancer

Colorectal Cancer - Treatment options for liver metastases from colorectal cancer outlined

Complementary & Alternative Medicine - Licorice extract significantly improves learning and memory

Compliance - Many don't get full dose of chemo

Congestive Heart Failure - Data published on study of blood volume measurement

Constipation - Constipation treatment has no rebound effect after discontinuation

Coronary Artery Bypass Surgery - Intraoperative metoprolol does not improve beta-adrenergic receptor function

Coronary Artery Disease - ABT-578-eluting stents may inhibit restenosis

Coronary Artery Disease - Carvedilol may reverse MDR1/P-glycoprotein-mediated multidrug resistance

Coronary Blockage - Diabetic patients benefit from Cypher Sirolimus-eluting coronary stent

Critical Care Medicine - Factors predictive of postextubation stridor identified

Critical Care Medicine - Radiologic-assisted endotracheal intubation described

Crohn Disease - Antegren to be submitted for approval in Europe

Cutaneous Melanoma - Altering the limb perfusion schedule of cutaneous melanoma does not alter response

Cystic Fibrosis - Patent application filed for potential cystic fibrosis treatment

DNA Research - 53BP1 links DNA damage response to Ig heavy chain class-switch recombination

DNA Vaccine - Inoculation of plasmid DNA induced expression of LacZ gene

Dengue Fever - IgG avidity test can distinguish primary from secondary dengue infections

Dermatology - Nephrogenic fibrosing dermopathy characterized

Detection - RAPD analysis useful for genotyping clinical Candida spp. isolates

Diabetes Pathogenesis - B cell selection defects promote diabetogenic antigen-presenting cells

Diabetes Pathogenesis - Bovine serum albumin in cow's milk not likely cause of diabetes

Diabetes Pathogenesis - Cytokine disruption shared by macrophages from diabetic and lupus mice

Diabetes Pathogenesis - IL-10-resistant PGS2 expression found in type 1 diabetic monocytes

Diabetes Pathogenesis - Increased islet antigen presentation leads to type1 1 diabetes

Diabetes Pathogenesis - Prior 5-HT exposure on rat islet insulin responses investigated

Diabetes Research - New DNA technology used by tissue-banking firm to study diabetes

Diabetes Therapy -  Fraxinus excelsior and Silybum marianum are hypoglycemic

Diabetes Therapy -  Syzigium cumini seeds are antidiabetic and antihyperlipidemic

Diabetes Therapy - Diabetes in older adults reviewed

Diabetes Therapy - K+ stimulates proinsulin biosynthesis in rat pancreatic islets

Diabetes Therapy - Language used in relation to diabetes may undermine therapy efforts

Diabetic Nephropathy - Rapid change in glucose level aids mesangial cell proliferation

Diagnostic Imaging - PET may become invaluable for diagnosing and treating brain tumors

Diagnostics - Adaptive mechanical index can shorten color blooming in Doppler flow imaging

Diagnostics - Agreement adds positron emission tomography to medical center's imaging menu

Diagnostics - Automated schistocyte counting method evaluated

Diagnostics - FDA requests and approves new name for infection imaging product

Diagnostics - In vivo bioluminescence imaging reveals tumor elements in animal models

Diagnostics - Method to minimize interference of silver staining with MS developed

Diagnostics - Molecular assay detects RSV, influenza, and parainfluenza viruses

Diagnostics - New ClinProt products launched for proteomics, biomarker discovery

Diagnostics - Radioiodinated MMP inhibitor tracers may enhance tumor imaging

Diet and Nutrition - Arabinogalactan offers no long-term benefits on serum lipids or glucose

Diet and Nutrition - Dietary proteins in regulation of food intake and body weight reviewed

Diet and Nutrition - S-adeno-syl-L-methionine in dietary supplements characterized

Diet and Nutrition - n-3 Fatty acid supplements raise exercise levels in pancreatic cancer patients

Disease Diagnostics - New agreement will help develop diagnostic tests in oncology and other diseases

Drug Access - New campaign against reimportation launched

Drug Advertising - FDA warning letter issued on promotional materials for Advate

Drug Approval - New survey highlights FDA's successes and failures

Drug Delivery - Behavior of drug-loaded "microballoons" in stomach characterized

Drug Delivery - Biodegradable thermoplastic depot maintains camptothecin stability

Drug Delivery - Chitosan membrane shows promise for transdermal dosing

Drug Delivery - Crystallization of NEA in transdermal patch characterized

Drug Delivery - Gel-entrapped tamoxifen offers sustained drug release at tumor sites

Drug Delivery - New drug delivery system allows for combination of drugs

Drug Delivery - Optimal conditions determined for impinging jet-based drug dispersal

Drug Delivery - PLGA microspheres suitable for ocular peptide delivery

Drug Delivery - Scientists smuggle drugs into tumors

Drug Delivery - Transdermal Delta8 -THC system developed

Drug Development - Advances in understanding autism may lead towards effective treatment

Drug Development - Chitosan microspheres potential carrier for drugs

Drug Development - Class-action suit filed over brain cancer drug

Drug Development - Collaboration to develop pegylated formulation of Zadaxin

Drug Development - Conditionally replicating adenoviruses with short hairpin RNAs silence genes

Drug Development - Endotoxin testing not needed for inhalation grade lactose

Drug Development - Han fangji extract inhibits granulocyte activity in rheumatoid arthritis

Drug Development - Hepatitis C virus NS3 protease inhibitors need select elements for efficacy

Drug Development - Isoflavone metabolite inhibits ERK-1 activity in vascular smooth muscle cells

Drug Resistance - Different mechanisms produce VX-950 and BILN 2061 resistance

Drug Resistance - Short-term morphine exposure doesn't subdue multidrug resistance

Drug Resistance - Topoisomerase II alpha foils the effectiveness of etoposide in myeloma cells

Drug Resistance - c-Jun NH2 -terminal kinase opposes prostate cancer apoptosis

Drug Safety - Study will use bioinformatics to examine genetic causes of adverse drug reactions

Endocrinology - Androgens work through prohibitin to steer prostate cancer growth

Endocrinology - Breast cancer cell CD36 expression ebbs in response to estradiol

Endocrinology - Human glucose transporter-like protein-9 characterized

Endocrinology - Intestinal secretion regulation involving neurotransmitters reviewed

Endocrinology - Metabolic products measured by NMR analysis of one glucose derivative

Endocrinology - Noradrenaline and neuropeptide Y from hypothalamus high in diabetes

Endocrinology - Researchers design potent retinoid X receptor alpha agonists

Endometrial Cancer - Recurrent disease with a molecular alteration may respond to targeted therapy

Endometriosis - Mouse model developed as tool for drug testing, gene target validation

Environmental Health - Immunologic effects of perinatal PCB, dioxin exposure persist into school age

Environmental Health - Insulin-like growth factor 1 increased in people exposed to pollutants

Enzymology - ELISA methods for enzymes in cancer tissues developed

Enzymology - Evans Blue acts as protein tyrosine phosphatase inhibitor

Enzymology - High-throughput screening detects heat-shock protein 90 ATPase inhibitors

Enzymology - Seprase encourages tumor and microvessel growth in breast cancer models

Epilepsy - Distribution agreement announced for epilepsy treatments

Expression Analysis - Mouse genome microarray launched

Fatty Liver Disease - Nonalcoholic steatohepatitis histologically resembles alcoholic liver disease

Fertility - Positive phase II data reported on Cetrorelix

Fibrosis - Syndecan-2 regulates transforming growth factor-beta signaling

Finance - Biopharmaceutical company announces pricing of IPO

Finance - Biopharmaceutical company announces subsidiary's bridge debt financing

Finance - Biotech company announces pricing of initial public offering

Finance - Biotech company complete $4 million funding arrangement

Finance - Biotech company delisted by Nasdaq

Finance - Biotechnology company approved for American Stock Exchange listing

Finance - Diagnostic products firm announces $1M private placement

Finance - Information management company reports first quarter results

Finance - Japanese company receives $600,000 investment from two Far East distributors

Finance - Life sciences company delists from Berlin stock exchange

Finance - Medical device company announces fourth quarter results

Finance - Medical information company in danger of NASDAQ de-listing

Finance - NASDAQ biotechnology index adds new company

Finance - New biotech public offering

Finance - Ophthalmology company announces secondary offering

Finance - Pharmaceutical company completes first phase of investor conferences

Finance - Pharmaceutical firm announces $25M underwritten stock offering

Finance - Pharmaceutical firm raises $51M in series C financing

Finance - Pharmaceuticals announces initial public offering

Finance - Pharmacy benefit and health care company announces annual results

Finance - Psychiatric drug maker reports loss of $0.36 per share

Gastric Cancer - Results of phase II study of G17DT vaccine reported

Gastroenteritis - Efficacy results announced for gastroenteritis-causing rotavirus vaccine

Gastroenteritis - Licensing agreement will further research into norovirus treatments

Gastroenteritis - New license agreement for norovirus detection technology

Gastroenterology - ABCG2 may be involved in the evolution of colon cancer drug resistance

Gastroenterology - Etodolac staunches colitis-induced tumors in rodent models

Gastroenterology - Promising therapies available for the treatment of Crohn disease

Gastrointestinal Disease - FDA approves gastrointestinal selective antibiotic

Gene Delivery - Novel imaging assesses non-viral transfer systems

Gene Induction - Inducible promoters aid gene expression in head and neck cancer cells

Gene Silencing - Epigenetics may offer new approach to aging, cancer

Gene Transfer - 2-Amine is major bystander metabolite when CB 1954 is activated by NTR in tumors

Gene Transfer - High-capacity hybrid viral vectors garner transduction stability

Genetic Engineering - Stem cell factor gene-modified natural killer cells overwhelm tumor cells

Genomics - FBI awards contract for DNA analysis

Genomics - Gene encoding C. stercorarium beta-xylosidase Xyl43B in E. coli sequenced

Genomics - Genetic differences in ethnic groups affect the chronicity of hepatitis C

Genomics - Loss of heterozygosity on chromosome 12 concurs with lung cancer induction

Genomics and Genetics - ChromoViz software graphically maps genomic data onto chromosomes

Genomics and Genetics - Estrogen-related genes identified in murine uterus

Geriatrics - Amide molecular clocks in Drosophila proteins may regulate aging

Ginkgo Biloba -  Ginkgo biloba protects liver against diabetes and hypoxia damage

Graves Ophthalmopathy - Role of cytokines in pathogenesis elucidated

Gynecology - Polycystic ovary follicular excess may be main culprit for follicular arrest

HIV Diagnosis - HIV-1/2 oral fluid rapid tests under development

HIV/AIDS - (+)-Inophyllum B and (+)-calanolide A candidates for anti-HIV therapy

HIV/AIDS - AIDS-related NHL is treated traditionally as supportive care improves

HIV/AIDS - Ezrin/CD95 linkage key role regulating susceptibility to CD95-mediated apoptosis

HIV/AIDS - New protease inhibitors offer improved clinical effectiveness

HIV/AIDS - Pharmaceutical company launches second wave of Global Health Fellows Program

HIV/AIDS Gene Therapy - TAT-pK/DNA complex useful way to package therapeutic genes for cell transduction

HIV/AIDS Progression - Timed ablation of regulatory CD4+ T cells prevents AIDS progression

HIV/AIDS Research - Central domain of HIV-1 matrix protein influences virus infectivity

HIV/AIDS Research - Channels formed by Vpu result from the self-assembly of monomers

HIV/AIDS Research - FIV env-mediated fusion mechanism and kinetics are similar to HIV env

HIV/AIDS Treatment - Cell surface targets identified for HIV-1 therapeutics using genetic screens

HIV/AIDS Treatment - New protease inhibitors offer improved tolerability and safety

Haemophilus Vaccine -  Haemophilus influenzae meningitis in immunodeficient girl reported

Head & Neck Cancer - Docetaxel is active against squamous cell carcinoma of the head and neck

Head and Neck Cancer - The loss of RASSF1A expression propels nasopharyngeal cancer proliferation

Health and Fitness - Multiple myeloma patients commit to exercise based on a number of factors

Healthcare Access - "VA-style' prescription drug benefit won't work in Medicare, pharmacy group says

Healthcare Access - Significant increases in co-payments may reduce patients' use of needed drugs

Healthcare Coverage - Midwest bank and patient assistance program to offer loans for hospital bills

Heart Disease - Data demonstrate cardiovascular impact of weight loss with sibutramine

Heart Disease - Enrollment in Taxus registry completed

Heart Disease - Positive results presented from PISCES stent trial

Heart Failure - AbioCor replacement heart implanted in 14th patient

Hematology - Bfl-1/A1 is a potent antiapoptotic stimulant in myeloma cells

Hematology - Cryoprecipitate-removed plasma is factor IX source for treatment of hemophilia B

Hematology - Updated results presented from phase III study of Dacogen in MDS

Hepatitis - Hepatitis A virus cDNA-transfected Ltk-cells might reveal viral pathogenesis

Hepatitis - Hepatitis C virus NS3 and NS4A interactions modulate RNA unwinding activity

Hepatitis - New Phase II trial slated for chronic hepatitis C

Hepatitis A Vaccine - Immunogenicity data on Aventis Pasteur hepatitis A vaccines compiled

Hepatitis B Vaccine - Mechanism of hepatitis antigen adsorption by Al(OH)3 elucidated

Hepatitis C - African Americans respond poorly to hepatitis C treatment

Hepatitis C - Oral prodrug selected for front-line treatment of chronic hepatitis C

Hepatitis C Therapy - Hepatitis C patient study to measure A4+L liver product QOL results

Hepatitis C Therapy - Phase I/II trial to study R803 for the treatment of hepatitis C

Hepatitis C Therapy - Trial studies merimepodib in hepatitis C non-responders to peg-IFN and ribavirin

Hepatitis C Virus - Hepatitis C virus E2 glycoprotein mutations examined

Hepatocellular Carcinoma - Molecular markers evolve early in hepatitis B virus-related liver cancer

Hepatology - The transcription factors Snail and SIP1 heighten liver cancer invasion

Hereditary Angioedema - DX-88 placed on clinical hold pending review

Herpesvirus - HHV-8 vFLIP essential for survival of infected lymphoma cells

Hip Replacement - Bone cement reduces acetabular cup wear

Hormone Replacement Therapy - Estradiol-chemical delivery systems considered

Hormone Replacement Therapy - Options other than CEE and MPA are available

Human Antibodies - Lymphoma treatments receive EU orphan drug designation

Human Genome - Genomics company publishes DNA sequence of human chromosome 10

Hypercholesterolemia - Thrombocyte activity is marker of LDL-apheresis intensity

Hypertension - Alagebrium demonstrates benefits on heart, kidney in preclinical studies

Hypertension - Ambrisentan phase II results presented at ATS 2004

Hypertension - Blood pressure drugs cut death rate in half

Imaging - Nanoparticles illuminate brain tumors for days under MRI

Immune Mediated Diseases - Clinical trial of new immunomodulatory agent set to begin

Immunology - $100,000 invested in software modeling systems for inflammatory diseases

Immunology - A single class II myosin modulates T-cell motility

Immunology - Angiotensin II receptors modulate murine macrophage activity and phagocytosis

Immunology - Anti-inflammatory activity of retinoids elucidated

Immunology - CD11b levels predict risk of pollution-induced airway inflammation

Immunology - Crystal structures of IL-2 tyrosine kinase characterized

Immunology - E2A protein regulates marginal zone B-cell development

Immunology - Effects of glucocorticoids on renal epithelial cells clarified

Immunology - HIV infection impairs immunity to malaria in pregnant women

Immunology - Influence of phosphoinositide 3-kinase on T-cell activity reviewed

Immunology - Interleukin receptor kinase deficiency linked to bacterial infections

Immunology - Modified interferon-beta protein may one day help multiple sclerosis patients

Immunology - New phase I cancer trial planned

Immunology - Novel polymorphism in cytoplasmic region of IgA Fc receptor gene found

Immunology - Protection against infection may depend upon healthy host-microbe interactions

Immunology - RIP1 plays key role in TLR3-induced NF-kappaB activation

Immunology - S1P receptor activation by FcepsilonRI trigger required for mast cell function

Immunology - Selected peptides functionally represent the Fc-gammaRII-binding part of IgG1

Immunology - Serum factor I mediates C3b cleavage on S. aureus surface

Immunology - Stable immunological synapse not needed for efficient T-cell killing

Immunology - Structural basis for ICAM-1 dimerization elucidated

Immunology - TOX plays calcineurin-dependent role in CD8 cell lineage commitment

Immunology - Toll-like receptor signaling regulates phagosome maturation

Immunology - Triad3A regulates Toll-like receptor signaling

Immunology - Ubi-L suppresses cAMP-induced p38 MAPK activation in Th2 cells

Infectious Disease - Additional results from Europe available for TB test; kits shipped to China

Infectious Disease - Modes of hantavirus transmission inferred from mitochondrial DNA analyses

Infectious Disease - Multiplex PCR effective for Salmonella typing

Infectious Disease - Treatment of long-term catheter-related Brevibacterium described

Influenza - Positive progress reported on powder vaccine delivery technology

Influenza Vaccine - Influenza viruses isolated in 1997 and 2003 have antigenic differences

Information Technology - New tool released to improved protein identification

Kidney Cancer - Bispecific antibody works against micrometastatic renal cell carcinoma

Kidney Failure - Zemplar (Paricalcitol Injection) receives FDA approval for pediatric use

Kidney Transplantation - Immunosuppressants may hasten oncogenesis in patients with p53 mutations

Kidney Transplantation - Immunosuppression without calcineurin inhibitors safe, effective

Kidney Transplantation - Tacrolimus-associated myositis reported in renal graft recipient

Kidney Transplantation - Two-hour postdose levels optimal for pediatric cyclosporine monitoring

Knee Replacement - CT-guided knee replacement system improves accuracy

Laser Technology - Distribution agreement reached for laser system treatment for enlarged prostate

Legal Issues - Pharmaceutical company to seek rehearing of court ruling in diet drug trials

Legal Issues - Taxol settlement brings Coloradans $430

Legal Issues - Tennessee cancer patients get $265,000 in Taxol settlement

Legionnaire Disease - FDA grants 510(k) clearance for Legionella pneumophila test

Legislation - Pharmaceutical company reports higher revenue, earnings

Leptin Studies - Features of leptin-induced hypertension described

Leptin Studies - Leptin and membrane fluidity of erythrocytes in hypertension studied

Leukemia Therapy - Effective rituximab treatment of B-cell PLL reported

Leukemia Therapy - High CD33-antigen levels limit gemtuzumab efficacy

Lipid Studies - Lipoprotein profiles under varied androgen blockade conditions reported

Lipid Studies - New class of lipid absorption inhibitor from sage discovered

Lipogenesis - IL-1 and LPS downregulate PPAR-gamma in brown adipocytes

Lipogenesis - Liver X receptors stimulate adipocyte differentiation via PPAR-gamma

Lipogenesis - Notch target gene plays dual roles in differentiation of preadipocytes

Liposuction - Hemodynamics and organ histology of large-volume liposuction reported

Liver Cancer - Novel PCR-array system useful for gene expression profiling

Liver Cancer - Utility of cryotherapy as ablative treatment evaluated

Liver Cancer Therapy - Quadruple therapy battles liver cancer on several fronts

Liver Disease - Nonalcoholic fatty liver disease encompass benign steatosis and steatohepatitis

Liver Failure - Treatment options vary for acute liver failure

Liver Metastasis - Epirubicin levels in liver metastases after administration reported

Lung Cancer - Enrollment completed in pivotal trial of Xyotax

Lung Cancer - Lung screening test may prove useful as first line of lung cancer testing

Lung Cancer - Matrix metalloproteinase-2 encourages pulmonary adenocarcinoma invasion

Lung Cancer - Variations in DNA repair genes may predict survival in lung cancer patients

Lyme Disease -  B. burgdorferi saliva inhibits neutrophil activity

Lymphoma - Contract research organization to help develop monoclonal antibody for lymphoma

Lymphoma - FDA issues special protocol assessment for phase III trial of FavId

Malaria - MS analysis of P. falciparum protein variants reported

Malaria - Proteomics in malaria reviewed

Malaria Vaccine - Merozoite surface protein antibodies inhibit malaria antibody responses

Managed Care - New research shows Miami as most competitive HMO market

Management - Biopharmaceutical company names new board chair

Management - Generic pharmaceuticals developer appoints new board member

Management - New board member announced

Management - Tennessee pharmaceuticals company expands into New Jersey

Mangement - Biopharmaceutical company names new board director

Market Analysis - Drug price increases in 2003 nearly triple

Measles Outbreak - Largest U.S. outbreak of measles in 1999 characterized

Measles Outbreaks - Measles outbreak control in adult populations discussed

Measles Risk Factor - Risk of measles transmission low after exposure on airline flight

Measles Vaccine - Clinical significance of measles reviewed

Measles Vaccine - Evolution of measles elimination strategies in the United States

Measles Vaccine - Progress toward measles eradication in the Americas updated

Medical Devices - Aortic Starr-Edwards ball valve prosthesis replaced after 28 years

Medical Devices - Femoral nerve catheter knotting reported

Medical Devices - Immunoassay for detection of irradiated prawns developed

Medical Devices - TIPS stent-grafts do not prevent liver transplantation

Medicare - Prescription drug discount cards show significant, sustained discounts

Medicare - Unclassified, FDA-approved drugs administered to outpatients will be reimbursed

Medicare Reform - Beneficiaries with chronic conditions still face high costs under new drug law

Medicare Reform - New study identifies leading Medicare reform factors

Medication Compliance - Many patients diagnosed with chronic illness stop taking medicines

Melanoma - MART1/MelanA stains have high false-positive rate

Melanoma Vaccine - Melanoma vaccine based on vector of membrane fusogenic liposomes

Melanoma Vaccine - Reproductive death delayed in progeny of irradiated melanoma cells

Meningococcal Vaccine - Integrity assay for meningococcal type B conjugate vaccine developed

Menopause - Bio-identical hormone replacement therapy is alternative treatment for menopause

Mental Health - 5-HT2C receptors contribute to actions of central serotonin systems

Mental Health - Federal program focuses mental health program in state of Florida

Mental Health - Publication highlights link between antidepressants and increased risk of suicide

Mergers & Acquisitions - Acquisition of Novocure completed

Mergers & Acquisitions - Agreement signed to acquire Chinese state-owned pharmaceutical firm

Mergers & Acquisitions - Business information provider Medtech Insight acquired

Mergers & Acquisitions - Ophthalmic device firm commences offer to acquire Drew Scientific Group

Mergers & Acquisitions - Renal Care Group acquires dialysis programs in Iowa

Metabolism - Scientists discover way to regulate the body's energy expenditure

Metapneumovirus - Human metapneumovirus recovered from cDNA

Metastases - Researchers identify a novel target for cancer therapy

Metastasis - Antisense oligonucleotides diminish breast cancer cell migration

Metastasis - Breast metastases from extramammary malignancies are rare

Metastasis - Vitamin E succinate abates human prostate cancer cell invasiveness

Metastatic Solid Tumors - Patient treatment begins in Reolysin trial for metastatic solid tumors

Microbial Testing - FDA approves ues of microbiological test as part of drug quality control process

Microfluidics - New technology introduced to replace liquid chromatography columns

Molecular Diagnostics - Molecular typing techniques are useful for detecting pathogenic fungi

Mucosal Immunization - Intestinal villous cells allow antigen entry site in mucosal epithelium

Multiple Sclerosis - Effects of glatiramer acetate on blood-brain barrier inflammation clarified

Multiple Sclerosis - Fibrin augments neuroinflammatory demyelination

Multiple Sclerosis - Leptin modulates inflammation in relapsed patients

Mutagenesis - PTEN gene alterations don't appear to impact synovial sarcoma prognosis

Myelodysplastic Syndromes - FDA approves Vidaza (azacitidine for injectable suspension) for MDS

Myocardial Infarction - Calcium antagonists are effective after acute MI in Japanese subjects

Nanotechnology - International nanotechnology shores up European shareholder base

Neurodegeneration - Autoimmunity may be immune defense against degenerative processes

Neurodegeneration - Role of IGF-I signaling in neurodegenerative diseases explored

Neurology - Myelin protein impairs neurological function after spinal cord injury

Neurology - Study shows restless legs syndrome under-diagnosed

Neuromuscular Disorders - Is chemogenetherapy the next step in gene therapy?

Neuroscience - Alterations in tau transcripts correlate with sporadic tauopathy neurofilament

Neuroscience - CXCL12 supports the angiogenesis and cellular cross-talk of glioma

Neuroscience - Enzyme signals help interferon-beta stimulate glioma cell apoptosis

Neuroscience - MRI can locate ataxia-inducing lesions in Miller Fisher syndrome patients

Neuroscience - Oxidative stress elicits differential MnSOD and HO-1 expression

Neuroscience - Retrovirally mediated gas1 expression restricts glioma cell proliferation

Neuroscience - proNGF exhibits neurotrophic activity but is less active than mature NGF

Non-Hodgkin Lymphoma - Extranodal non-Hodgkin lymphoma can occur in the sinonasal tract

Non-Small Cell Lung Cancer - Patients with locally advanced lung cancer benefit from chemoradiotherapy

Obesity - Company acquires rights to the patent for nasal spray treatment for obesity

Obesity - Nastech highlights PYY nasal spray development program

Obesity - Positive safety data presented for obesity treatment

Obesity - Xenical more effective than lifestyle changes alone in overweight adolescents

Obesity Epidemiology - Increasing obesity rates will lead to higher disability rates

Obesity Pathogenesis - Gastrointestinal satiety signals reviewed

Obesity Surgery - Minimally invasive surgery for morbid obesity reviewed

Obesity Therapy - Leptin induces patterns of immediate early gene expression in the brain

Obesity Therapy - Non-imidazole histamine receptor antagonist has anti-obesity effects

Obesity and Diabetes - Weight loss significantly improved metabolic syndrome in obese Koreans

Oncogenesis - Bcl-2 suppresses senescence and programmed cell death

Oncogenesis - Cyclin-dependent kinase 4 may foster liver cancer formation

Oncogenesis - Epithelial metaplasia may be involved in antitumor immunity

Oncogenesis - Many genes synergize with Cbfb-MYH11 to produce acute myeloid leukemia

Oncology - Human prostaglandin F synthase reigns in respiratory and digestive tract tumors

Oncology - Thalidomide treats multiple myeloma by targeting bone marrow angiogenesis

Oncolysis - Peroxisome proliferator activated receptor response elements block cell death

Ophthalmology - Research suggests aspirin helps combat cataracts

Ophthamology - Ocular inflammation treatment on file with FDA

Opioid-Induced Constipation - Methylnaltrexone to move on to phase II trials for opioid-induced constipation

Oral Cancer - Synthetic and natural agents can cause apoptosis in oral cancer cells

Oral Medicine -  Fusobacterium nucleatum serine protease identified

Orthopedic Surgery - Prevention of deep vein thrombosis reviewed

Osteoporosis - Gene therapy reverses established osteopenia in ovariectomized mice

Osteoporosis - Risedronate preserves bone architecture in osteoporotic postmenopausal women

Osteoporosis - Website helps parents raise strong daughters

Osteoporosis - sNDA submitted to FDA for once-monthly dose of Boniva

Osteosarcoma - Apo2L/TRAIL and doxorubicin increases sensitivity to bone sarcomas

Ovarian Cancer - Anti-tumor responses induced by ovarian cancer protein characterized

Ovarian Cancer - Chemotherapy after cytoreductive surgery for ovarian cancer beneficial

Pain - Combination liquid pain reliever provides low-level acetaminophen

Pain - Publication urges caution for women seeking OTC pain relief

Pain Management - FDA gives approval for generic morphine doses

Pain Medicine - New developments in treatment of cancer pain reviewed

Pain Medicine - Pre-emptive morphine may contribute to neonate brain damage

Pancreatic Cancer - Clinical trial to study Panvac-VF in advanced pancreatic cancer

Pancreatic Cancer - Inactivation of Men1 gene causes pancreatic and pituitary tumorigenesis

Pancreatic Cancer - Pancreatic islet cell tumors have non-islet origin

Parasitology - Functional genomics for parasitic nematodes and platyhelminths reviewed

Parkinson Disease - Parkinson disease mutations affect axonal transport in cultured neurons

Patent Litigation - Court rules in favor of surgical device company's patent

Patents - Eight U.S. patents granted for high-speed cell analysis platform

Patents - U.S. patent granted for its Immunogene therapy for cancer

Pediatric Cancer - Parental pesticide exposures may be linked to pediatric lymphoma cases

Pediatric Vaccine - Vaccine against six diseases is safe and effective in children

Periodontal Disease - TaqMan PCR assay detects six species of periodontopathic bacteria

Personnel - Biopharmaceutical company announces re-election of board members

Personnel - Biopharmaceutical company appoints new member to board of directors

Personnel - Biopharmaceutical company names new board member

Personnel - Biotech company announces new chairman of the board

Personnel - Dale A. Stringfellow joins biotech company's board of directors

Personnel - Dentist fined for over prescribing medicine leads antidrug group

Personnel - Diagnostics/research company names chief financial officer

Personnel - Immunotherapeutics company appoints Peter Thornton as chief financial officer

Personnel - James Rouse appointed as medical officer at nutraceutical firm

Personnel - Medical advisory board assembled to guide development of CDAD treatment

Personnel - Molecular oncology research company names new board member

Personnel - Orthobiologics company appoints new board member

Personnel - Pharmaceutical company announces resignation of chief development officer

Personnel - Pharmaceutical company appoints new member to scientific advisory board

Personnel - Pharmaceutical company names three new leaders to U.S. executive team

Personnel - Pharmaceutical company names vice president, global sales and marketing

Personnel - Pharmaceutical company's chairman and chief executive officer to retire

Personnel - Specialty pharmaceutical company names vice president and general counsel

Pharmaceutical Development - Generic versions of two drugs receive FDA approval

Pharmaceutical Development - New conference to focus on American and Asian partnerships

Pharmaceutical Development - New report shows that expiring patents may cost pharmaceutical industry $80 billion

Pharmaceuticals - U.S. senior population using Internet for health and pharmaceutical information

Pharmacogenomics - Pharmacogenomics could lower health care costs, investigators report

Pharmacokinetics - Method to measure kinetics of penicillin thermal decomposition reported

Pharmacokinetics - Time-resolved X-ray data can identify protein intermediate structures

Pneumonia - Phase II study results of pulmonary delivery of amikacin presented

Pneumovirus - Molecular genetics and pathogenesis of animal pneumoviruses reviewed

Polio Vaccine - Seroprevalence of poliovirus antibody among children in Korea reported

Polymerase Chain Reaction - Short PNA molecular beacons discriminate nucleotide polymorphisms

Prescription Drugs - Canadian drug plan advances in Oak Creek, Wisconsin

Prescription Drugs - FDA rejects petition on Illinois pilot program to buy Canadian medicine

Prescription Drugs - Few Oklahoma seniors apply for card

Prescription Drugs - Low-income enrollments lagging for Medicare drug cards, Thompson

Prescription Drugs - Meetings to help Medicare beneficiaries choose discount cards

Prescription Drugs - New Hampshire Governor signs preferred drug list bill

Prescription Drugs - West Virginia customers experience prescription delays

Prion Disease - Prion protein undergoes alpha- and beta- cleavages of amino-terminus

Product Launch - Pharmaceutical companies increase staffing between phase III and launch

Prostate Cancer - Androgen deprivation affects thyroid function tests in prostate cancer

Prostate Cancer - Array CGH superior to standard CGH for detection of DNA loss

Prostate Cancer - Choosing hormone therapy for prostate cancer depends on several factors

Prostate Cancer - Epidemiology of prostate cancer outlined

Prostate Cancer - Researchers advocate adjuvant therapy in high-risk prostate cancer

Prostate Cancer - Xanafide clinical trial commences in patients with prostate cancer

Prosthodontics - Diagnostic and surgical template for dental implants developed

Prosthodontics - Utility of conversion partial dentures reviewed

Protein Kinase C - Protein kinase C potentiates duodenal mucosal bicarbonate secretion

Protein Regulation - von Hippel Lindau-hypoxia inducible factor controls COX-2 in the injured liver

Proteomics - Kaposi sarcoma-associated herpesvirus K1 protein stimulates invasion factors

Proteomics - Search for folded proteins in vitro and in silico described

Proteomics - Technique enables efficient production of microchip microdialysis membranes

Proteomics - Transforming growth factor-beta 1 regulates several endothelial cell proteins

Protozoal Infection - CTLA-4 blockage increases resistance to infection with Trypanosoma cruzi

Pulmonary Function - Reduced airway function in infancy associated with persistent wheeze at age 11

Pulmonary Medicine - Downregulated dipeptidyl peptidase IV lets non small cell lung cancer flourish

Quality Assurance - Report shows FDA inspectors found quality-control problems at Wyeth plant

RNA Research - RNA interference-based microarray developed

Radiation Therapy - Quinoxaline 1,4-dioxides potentiate the effects of ionizing radiation

Radiotoxicity - COMP-Ang1 protects endothelial cells from radiation-induced apoptosis

Receptor Studies - Melanocortin 4 receptor behavior characterized

Recombinant Therapy - Newly designed COMP-Ang1 outpaces angiopoietin-1 in angiogenesis assays

Reproductive Medicine - Sperm factor that activates eggs is novel phospholipase C:PLC zeta

Respiratory Disease - New studies focus on overproduction of mucus

Respiratory Medicine - Drug-device combo improves efficiency of pediatric inhalation therapy

Retrovirus - FIV replication in activated CD4+CD25+T cells independent of cell proliferation

Rheumatoid Arthritis - European Union approves Enbrel for expanded use

Rheumatoid Arthritis - Matrix metalloproteinases are targets during experimental arthritis

Ribosome - Decreased repeat lengths encourage transgene stability after transfection

Rotavirus Vaccine - Background risk of intussusception in children reported

Rubella - Rubella virus P90 associates with cytokinesis regulatory protein

Saccharomyces - ESF1 required for 18S rRNA synthesis in Saccharomyces cerevisiae

Salmonella -  Salmonella has poor survival but high immunogenicity in resistant mice

Salmonella Vaccine - Immunogenic properties of Salmonella atypical fimbriae determined

Schizophrenia Therapy - Nutrition affects outcome of schizophrenia therapy

Seborrheic Dermatitis - Phase III trial of Sebazole initiated

Skin Cancer - More UVA than UVB fingerprint mutations in basal layer of human squamous tumors

Sleep Disorders - PD-6735 granted Orphan Drug Status for sleep disorders in blind patients

Smallpox - Data supports efficacy of LC16m8 smallpox vaccine candidate

Smallpox Vaccine - Mouse neurotoxicity test for vaccinia-based smallpox vaccines developed

Smallpox Vaccine - Smallpox DNA vaccine protects primates against lethal monkeypox

Staphylococcus Vaccine - Staphylococcal enterotoxin B mutant protein protective in C3H/HeJ mice

Stem Cells - Preclinical studies show that stem cells may reverse diabetes in mice

Stem-Cell Biology - From lung to gut - the Wnt signaling pathway transforms cell fate

Stem-Cell Research - Activated neural stem cells contribute to stroke-induced neurogenesis

Stem-Cell Research - Allogeneic PBSCT is feasible for children with beta/beta and beta/E

Stem-Cell Research - Cord blood stem cells plus fibrin platelet glue used for wound repair

Stem-Cell Research - Developing neonatal rabbit appendix is seeded by immature blood-borne B cells

Stem-Cell Research - Dopaminergic neurons generated from embryonic stem cells

Stem-Cell Research - Embryonic stem cells are an alternate marrow donor source

Stem-Cell Research - GAMT deficiency causes biochemical adaptations in brain and skeletal muscle

Stem-Cell Research - Large defect bone reconstruction using BM-derived SSC not proven for non-union

Stem-Cell Research - Mesenchymal stem cells from adult mouse bone marrow isolated and characterized

Stem-Cell Research - Novel DZIP gene expressed in embryonic stem cells and germ cells is identified

Stem-Cell Research - Nucleosome remodeling defect prevents IL-12(P35) transcription in neonatal DC

Stem-Cell Research - Poly(NiPA-co-AAc) gel may provide optimal chondrocyte propagation 3D environment

Stem-Cell Research - Skeletal muscle differentiation potential of adult BM cells may lead to therapy

Stem-Cell Transplantation - Allogeneic hematopoietic stem cell transplant for lymphoma should be selective

Stem-Cell Transplantation - Predictors of outcome identified in patients with metastatic rhabdomyosarcoma

Streptococcus - Streptococci from infants with invasive disease characterized

Streptococcus Pneumoniae - 99.9% of S. pneumoniae isolates susceptible to Ketek, per surveillance study

Stroke - Protein may identify tPA bleeding risk in ischemic stroke patients

Stroke Prevention - Angiotensin II provides cerebroprotection against stroke

Survival and Mortality - Older breast cancer patients in Canada benefit from early detection

Thrombosis - Pinokinase reduces thrombosis in high-risk individuals on long flights

Tissue Engineering - Cartilage tissue regenerated by serum-free cultured chrondrocyte implantation

Tissue Engineering - Nanocolumns produced for cell culture using colloidal lithography

Tissue Regeneration - FDA issues special protocol assessment approval

Toxicology - Cream may ward off jellyfish stings

Toxoplasmosis -  T. gondii-specific recombinant antigens useful for serodiagnosis

Transfusion Medicine - GB virus C/hepatitis G virus infections are rare and self-limiting in India

Transgenics - New transgenic system produces bulk protein

Trypanosomiasis - Cytokine response to T. brucei infection characterized

Tuberculosis Vaccine - Inactivated Mycobacterium bovis BCG vaccine protects against TB

Tumor Development - Neuroblastomas exposed to hypoxia undergo genetic shifts

Tumor Suppression - Adenoviruses bearing gfp-zeocin fusion cassettes select p53-deficient cells

Tumor Suppression - p16 Plasmids control telomerase activity in human gliomas

Tumorigenesis - Acquired periostin expression promotes breast cancer angiogenesis

Type 1 Diabetes - Esophagus stiffens in experimental type 1 diabetes

Type 1 Diabetes - Insulin detemir lessens blood glucose variability in study

Type 2 Diabetes - Repaglinide outperforms nateglinide in type 2 diabetes study

Ultrasonography - Ultrasound affects structure and function of proteins of PPSB complex

Urology - The benefits of radical prostatectomy extend beyond cancer control

Vaccine Adjuvant - Cell death induced by vaccine adjuvants containing surfactants

Vaccine Development - Inflammatory cytokines overcome age-related defects in T-cell responses

Vaccine Development - Tumor necrosis factor autovaccination eliminates melanoma metastasis

Vaccine Research - New licensing agreement to create therapeutic vaccine platform

Vaccines - DNA system to support research on vaccine devlivery

Vascular Development - p68RacGAP interactions modulate the formation of capillaries

Vascular Treatments - Medical device manufacturer receives two FDA marketing clearances

Vector Development - Adenovirus vector targets cells expressing junctional adhesion molecule

Vector Development - Amphiphilic cyclodextrins enhance transgene expression

Vector Development - Bone cancer cells respond to HSV thymidine kinase-ganciclovir gene therapy

Vector Development - T-cell response to adenovirus hexon and DNA-binding protein in mice

Viral Disease - Biotech company testing possible antidote for bioterrorism viruses

Viral Genomics & Genetics - Two subtypes of hepatitis B virus genotype B flourish in Japan

Viral Genomics and Genetics - New hepatitis C virus models will expand research possibilities

Virology - Hepatitis C virus suppression of IRE1-XBP1 promotes viral persistence

Virology - Human Coronavirus 229E in nasal specimens detected by RT-PCR hybridization assay

Virology - Viruses appropriate apoptotic and NF-kappa B signaling pathways

Vitiligo - Efficacy of 308-nm xenon-chloride excimer laser clarified

Vulvovaginal Candidiasis - Positive results reported from CZEN-002 trial for vulvovaginal candidiasis

Wound Care - Insulin-like growth factor-I alters the effects of thermal trauma in rats

Wound Treatment - LAM Pharmaceutical accelerates Central American product launch

Yersinia - Nuclear targeting signal in YopM from Yersinia species identified

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