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Drug Week

Susan Hasty, Publisher

Table of Contents . . . July 2nd, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Drug Week | Other Publications

Anemia - Special protocol assessment agreed on for approval-enabling study of Ranexa

Breast Cancer - Application filed for European marketing approval of RSR13 (efaproxiral)

Cancer Therapy - Ceplene 36-month malignant melanoma survival data published

Depression - Study links chromium picolinate supplementation, reduced carbohydrate cravings

Acute Bipolar Mania - Risperdal reduces acute bipolar mania symptoms as early as day 3 of treatment

Acute Coronary Syndrome - Millennium, partner begin trial with INTEGRILIN (eptifibatide) Injection

Acute myeloid leukemia - Fusion proteins overcome the hurdle of leukemia cell chemoresistance

Addiction Medicine - Liver function test results for naltrexone patients may be misleading

Adenovirus - Actin and its C-terminal peptide act as cofactors with adenovirus proteinase

Age-Related Macular Degeneration - SnET2 NDA accepted by FDA with priority review designation

Age-Related Macular Degeneration - Study will investigate safety, efficacy of PFTA as adjunct to Visudyne therapy

Allergy Medicine - Allergy vaccine disrupts structure of calcium-binding allergen

Allergy Medicine - Cytochrome P450 isoforms involved in oxatomide metabolism identified

Allergy Medicine - Lung proteome within airway mucosa following allergen challenge investigated

Allergy Medicine - Nanocrystalline silver cream potentially therapeutic for skin inflammations

Allergy Medicine - Total IgE measurement is valid surrogate for antigen-specific IgE

Alzheimer Disease - AApoAII amyloidosis induced by various heterogeneous amyloid fibrils

Alzheimer Disease - CD36 overexpression correlates with A-beta, not with Alzheimer disease

Alzheimer Disease - Neurodegeneration and amyloid plaques occur in transgenic Drosophila

Alzheimer Disease - Olfactory dysfunction occurs in mice overexpressing human tau protein

Alzheimer Disease - Oxidative stress and mitotic changes necessary for Alzheimer disease progression

Alzheimer Disease - Seeding specificity in amyloid growth induced by heterologous fibrils

Amyotrophic Lateral Sclerosis - Link suspected between soccer and amyotrophic lateral sclerosis

Angiographic Imaging - Study initiated for ferumoxytol under company's agreements with NCI

Angiology - Platelet-derived growth factor stimulates pericyte recruitment to tumors

Anthrax - NIH supports phase I clinical trial of DNA-based anthrax vaccine

Anthrax - Public-private partnership extends Dutch-American cooperation in biodefense

Anthrax Vaccine -  B. anthracis antigens for testing anthrax immunity identified

Anti-Infectives - Antimicrobial drug development declining

Anti-Infectives - Thyroliberin controls murine candidosis

Antibiotics - Development and marketing agreement signed for novel formulation of amoxicillin

Antifungal Agents - New antifungal agents offer prospects for treatment

Apoptosis - PIDDosome activates caspase-2 in response to genotoxic stress

Arthritis Therapy - Short-stemmed modular shoulder prosthesis safe and effective

Artificial Heart - Diaphragm patch facilitates placement of AbioCor implantable replacement heart

Attention Deficit/Hyperactivity Disorder - Strattera provides full-day relief from ADHD symptoms in systematic study

Attention-Deficit Hyperactivity Disorder - Strattera now available in the United Kingdom

Autoimmune Disease - Link between vaccinations and autoimmune disease reviewed

Autoimmune Disease - MFG-E8 mediates removal of apoptotic germinal center B cells

Awards - Biotechnology company named on list of technology industry's top 100 companies

Bacillus - Mosquito-larvicidal toxin produced by Bacillus sphaericus crystallized

Bacteria - Viral Antigens enters strategic collaboration

Bartonella - Diversity of Bartonella in rodents of Thailand determined

Bioengineering - Collagenous matrices release exogenous growth factors for tissue regeneration

Biotechnology - Albumin-containing sol-gel glasses developed

Biotechnology - Four pH-dependent formation constants for free PSA elucidated

Biowarfare - Vaccines for the prevention of diseases caused by potential bioweapons

Bipolar Disorder - Seroquel combined with mood stabilizer may improve mania symptoms

Blood Glucose - Accuracy of blood glucose estimation by children with diabetes studied

Blood Vessel - Company announces new intravenous gene-delivery method

Bone Repair - Calcium and thrombin trigger factors that spark endothelial cell proliferation

Bowel Incontinence - Secca clinical patient registry for bowel incontinence treatment

Brain Injury - Relation between stress and circulating levels of S100B protein reported

Breast Cancer - Follow-up data presented on autologous hemoderivative vaccine

Breast Cancer - Nanoparticle form of paclitaxel is active in patients who failed taxane therapy

Breast Cancer - Researchers develop better understanding of tamoxifen resistance

Breast Cancer - Survivin, Bcl-2, p53 and bax expression increased in breast carcinoma

Breast Cancer - Vaccine containing multiple antigens generates higher immune response

Breast Cancer - Women treated for breast malignancies receive poor postoperative education

Breastfeeding - FDA warns against women using domperidone to increase milk production

Business Update - Bridge Pharmaceuticals Corporation launched

Business Update - Company acquires rights to novel proteasome inhibitors and related technology

Business Update - Company opens new preclinical pharmaceutical inhalation facility

Business Update - Company to acquire controlling interest in HBBenda

Business Update - Drug discovery company announces completion of two validation milestones

Business Update - Hospira expands manufacturing capacity

Business Update - ImClone shares jump on favorable data on cancer drug

Business Update - Integrated BioPharma delivers update on paclitaxel API

Business Update - Nutraceutical/pharmaceutical company selects Central American distributor

Business Update - Pharmaceutical firm announces move to new facility

Business Update - Pharmaceuticals firm acquires two new drugs for ADHD, completes financing

Business Update - SEC finds Schering-Plough unit made bribes through charity

Business Update - Stem cell company announces plans for new facility

Business Update - Strategic Alliance formed for pulmonary delivery technologies

Cachexia - Lipid-mobilizing factor protects tumor cells from oxidative damage

Caffeine - Mechanism of caffeine as psychomotor stimulant proposed

Cancer Biomarker - Epidermal growth factor receptor and Cerb-B2 fail to predict tongue cancer

Cancer Epidemiology - Men with vitamin D receptor polymorphisms are at risk for prostate cancer

Cancer Genomics and Genetics - Role of hMLH1 and HPP1 in adenocarcinomas determined

Cancer Prevention - Cancer risk lowered in those taking statins to prevent heart attacks

Cancer Prevention - Warfarin does not prevent bladder cancer formation

Cancer Prognosis - Calcitonin gene hypermethylation marks the progress of leukemia

Cancer Risk Factor - Familial tooth agenesis signals the risk for colorectal cancer

Cancer Risk Factor - Genetic shifts emerge during hepatitis C virus-linked carcinogenesis

Cancer Screening - U.S. National Cancer Institute in vitro drug screening has expanded

Cancer Suppression - Disrupted STAT3 signaling opens the door to tumor cell invasion

Cancer Therapy - ADVEXIN and INGN 241 featured at international scientific conference

Cancer Therapy - Alternating electric fields have potent antitumor activity

Cancer Therapy - Biomarker predicts response of colon cancer patients to chemotherapy regimen

Cancer Therapy - CMS and NCI collaborate to bring new drugs, better treatment to cancer patients

Cancer Therapy - Celecoxib is a potent chemopreventive agent

Cancer Therapy - Clinical safety, efficacy data of Advexin featured at scientific meeting

Cancer Therapy - Companies end Genasense expanded-access program in melanoma

Cancer Therapy - Drug treatment first big improvement in brain cancer in decades

Cancer Therapy - Endothelial cell-specific human antibodies might retard tumor growth

Cancer Therapy - Gene therapy tested to protect bone marrow during chemotherapy

Cancer Therapy - Hsp90 inhibitors enhance complement-induced tumor cell lysis

Cancer Therapy - Liver cancer expert presents new data on SIR-Spheres

Cancer Therapy - Loco-regional interferon after tumor irradiation regresses metastatic melanoma

Cancer Therapy - M2BP-derived CTL epitopes with possible use in cancer immunotherapy identified

Cancer Therapy - Near-infrared labeled endostatin localizes at tumors in animal models

Cancer Therapy - PTK/ZK completes enrollment for phase III metastatic colorectal cancer trial

Cancer Therapy - Patients' genes may influence how they experience fatigue and quality of life

Cancer Therapy - Phase I trial for anticancer compound Xl647 initiated

Cancer Therapy - Preclinical drug studies in rodents can predict phase I starting dose

Cancer Therapy - Researchers show potential of fighting angiogenesis

Cancer Therapy - Some drugs effective in rodent tumor models fail to perform clinically

Cancer Therapy - When combining new oral agents with standard chemotherapy, timing may be crucial

Cancer Treatment - Genetic differences explain severity of chemotherapy side effects

Cancer Vaccine - Antitumor immunity determined by the tumor not vaccine

Cancer Vaccine - B7-2 expression elicits anti-tumor immunity in B-cell lymphoma

Cancer vaccine - Cross-talk between dendritic and NK cells examined

Carcinogenesis - DNA methylation of integrin alpha 4 gene supports gastric cancer formation

Cardiac Monitoring - U.S. patent issued for methods and systems for processing ECGs

Cardiac Safety Monitoring - $1M study awarded for cardiac safety monitoring, information distribution

Cardiovascular Disease - Implantable defibrillator effective against hypertrophic cardiomyopathy

Cell Biology - Bead-based assay is a poor model of apoptotic cell phagocytosis

Central Nervous System - Regulation of myelin proteolipid protein gene expression reviewed

Cervical Cancer - SOC1 inhibits HPV-E7-mediated transformation via degradation of E7 protein

Charcot-Marie-Tooth Disease - New locus for Charcot-Marie-Tooth disease type 2 maps to chromosome 12q24

Chemotherapy - Oral RDP58 permits CPT-11 dose escalation and relieves gastric tract toxicity

Chronic Hepatitis C - Cellular compartmentalization is a trait of hepatitis C virus-host interactions

Chronic Liver Disease - A four-step model outlines the progress of non-alcoholic steatohepatitis

Clinical Studies - Company initiates Diquafosol phase III dry eye trial

Clubfoot - Clubfoot with survival of motor neuron 1, telomeric gene deletion reported

Collaboration - Collaborative services agreement expanded by microarray company

Collaborations - Agreement signed for development of phase I HDAC inhibitor for cancer

Collaborations - Agreement signed with Althea Technologies for gene expression technology

Collaborations - Biotech firms conclude agreement regarding manufacturing of cancer drug

Collaborations - Company begins exploratory collaboration with Novartis Institutes

Collaborations - Contract signed with Lockton Companies to control healthcare costs

Collaborations - Development of a Centocor therapeutic protein candidate advances

Collaborations - Distribution deal signed for Aeroneb Professional Nebulizer System

Collaborations - Dutch biopharma enters collaborative agreement with NMRC

Collaborations - Iconix announces chemogenomics collaborative relationship

Collaborations - Joint venture to target cardiac repair

Collaborations - License agreement completed for worldwide rights to hepatitis B product

Collaborations - Manufacturing, commercial rights to trandolapril acquired from Aventis

Collaborations - Sports medicine/exercise group joins Indiana's life sciences initiative

Collaborations - Systems biology company enters licensing agreement with Invitrogen Corp.

Colon Cancer - Eloxatin study demonstrates benefit over standard colon cancer therapy

Colorectal Cancer - Avastin study shows extended survival in metastatic colorectal cancer patients

Colorectal Cancer - Cytochrome C depletion intensifies the immunogenicity of colon cancer cells

Complementary & Alternative Medicine - Salicin derivatives from H. cochinchinensis have antiviral activity

Complementary and Alternative Medicine - Many cancer patients turn to complementary therapies for healing

Constipation - SennaPrompt introduced for overnight relief of constipation

Coronary Angioplasty - FDA does not approve application to amend existing Angiomax label

Coronary Artery Bypass Surgery - Fatal complications after symmetry aortic connector use described

Coronary Artery Bypass Surgery - Pre-op IgG therapy facilitates off-pump CABG in ITP patient

Coronary Artery Disease - Clinical trials of invasive coronary interventions have unanswered questions

Cosmeceutical Trends - Merging health and beauty trends drive cosmeceutical growth

Critical Care Medicine - Detector-induced acute endotracheal tube occlusion reported

Critical Care Medicine - Management of postintubation stenoses in children reviewed

Crohn Disease - Diffuse alveolar hemorrhage reported after infliximab therapy

Cytomegalovirus - CMV viral load can guide clinical management of transplant recipients

Cytomegalovirus - Human cytomegalovirus large terminase subunit pUL56 characterized

DNA Damage - Attenuated p53 response in preneoplastic lesions growth advantage under stress

DNA Manufacturing - Company announces DNA fermentation breakthrough

DNA Repair - DNA double-strand break repaired by homologous recombination

DNA Research - Melatonin protects against oxidative stress in Chinese hamster B14 cells

DNA Research - XPC protein plays key role in cell cycle regulation during cisplatin treatment

Dendrites - Dendritic guidance reviewed

Dengue Fever - IgG1 antibody for neutralization of dengue type 4 virus identified

Dengue Virus - Neugene antisense shows inhibition of tropical virus

Depression - Study: Brain monitoring predicts treatment response in depressed patients

Diabetes Epidemiology - Prevalence of diabetes in the province of Girona, Spain reported

Diabetes Genomics and Genetics - IRS1 variant linked to type 1 diabetes in families from U.S. and U.K.

Diabetes Pathogenesis - Deficiencies in gut NK cell number and function precede diabetes onset

Diabetes Pathogenesis - Helper requirements for effector CTL to beta cell antigens outlined

Diabetes Pathogenesis - Insulin-like growth factors and pancreas beta cells reviewed

Diabetes Pathogenesis - Transcriptional networks controlling beta cell function identified

Diabetes Pathogenesis - pdx1 and HNF6 play roles in proliferation of endocrine precursors

Diabetes Therapy - Alliance to identify factors important to stem cell differentiation

Diabetes Therapy - Diabetes care and complications in remote health care setting described

Diabetes Therapy - Diabetes prevention using transgenic plants requires GAD and IL-4

Diabetes Therapy - Oral amino acids constitute metabolic therapy in patients with diabetes

Diabetes Therapy - Regenerated islets to be used to create supply for diabetes treatment

Diabetes Therapy - Sucanon marketing agreement signed for Mexico

Diabetes Therapy - Ticlopidine beneficial for hypercoagulability in diabetic patients

Diabetes Therapy - Treatment of type 1 diabetes by preserving insulin secretion reviewed

Diabetic Nephropathy - Glucose regulates glomerular endothelial cell proteoglycans

Diabetic Nephropathy - Streptozotocin injections cause early onset of glomerulosclerosis

Diagnostics - ELISA for glial fibrillary acidic protein developed

Diagnostics - Human urine contains colorectal cancer detection markers

Diagnostics - Novel immunoassay devised for HM-1 killer toxin measurement

Diagnostics - Reactivity of yeast phase lysate Blastomyces antigens compared

Diagnostics - Synthetic peptide ELISA for rubella virus neutralizing antibodies effective

Diet and Nutrition - Effect of fiber types on digestibility of nutrients in cats reported

Diet and Nutrition - Food restriction reduces age-related sensitivity to oxidized lipids

Disease-Management Trends - Report explores adoption of pharma company's disease management programs

Drug Addiction - Probuphine effective in clinical trial as opiate addiction treatment

Drug Benefits - Even among those who need them most, statin prescriptions go unfilled

Drug Compliance - Improving patient adherence integral to expanding antipsychotic market

Drug Delivery - Budesonide precipitation conditions affect aerodynamics

Drug Delivery - Carrageenan-based delivery of ophthalmic drugs shows promise

Drug Delivery - Degarelix-loaded PLGA microparticles may enhance prostate cancer treatment

Drug Delivery - Endothelial proteins accessible to drugs injected intravenously

Drug Delivery - Flow cytometry useful for measuring PLG microsphere protein loading

Drug Delivery - New polymer technologies introduced for site-specific drug delivery

Drug Delivery - Percutaneous intra-arterial catheter implantations transport liver cancer drugs

Drug Delivery - Researchers win Kaye prize for gastro-retentive sustained-release system

Drug Delivery - Uniform microspheres for drug delivery devised

Drug Development - Bispecific antibody shows promise as lymphoma therapy

Drug Development - Immunomodulatory activity of FIP-fve protein characterized

Drug Development - Immunomodulatory flavone glucosides isolated from Pleioblastus amarus

Drug Development - Immunomodulatory oxazolone derivatives synthesized

Drug Development - Multicellular tumor spheroids model HSVtk/ganciclovir systems in vitro

Drug Development - Puupehenone and associated compounds are angiogenesis inhibitors

Drug Development - Recombinant anti-MUC1 scFv has improved stability

Drug Discovery - FLIPR Tetra launched; offers 1536 kinetic measurements simultaneously

Drug Manufacturing - Pharmaceutical firm commences cGMP manufacturing of Thiovir

Drug Resistance - Bleomycin resistance stems from faulty transport mechanisms

Drug Resistance - Downregulated Bcl-2 or xIAP enhances the efficacy of breast cancer chemotherapy

Drug Resistance - Wild-type p53 polymorphisms anchor chemotherapeutic response

Emergency Medicine - University awarded patent for "date rape" drug test

Employee Health - ThedaCare, pharma, collaborate on employee health and productivity initiative

End-stage Liver Disease - De novo liver cancer in liver transplant candidates warrants list advancement

Endocrinology - Aldosterone signals modify bone marrow endothelial cell organization

Endocrinology - Hypothalamic glutamate decarboxylase expression cuts rodent feeding behavior

Endocrinology - Selenoprotein SelS is novel glucose-regulated protein

Endocrinology - Synthetic hormone in contraceptives, HRT causes negative effects in monkeys

Endocrinology - Vitamin D-mediated prostate cancer inhibition requires androgen signals

Environmental Health - MS method to measure toxaphene congeners in human serum developed

Environmental Health - Novel assay provides rapid detection of 2,4-D and simazine pesticides

Enzyme Stabilization - Water-based buffer for enzyme stabilization, storage available

Enzymology - Histone deacetylation is involved in ras-induced suppression of RECK

Enzymology - Nitric oxide is a negative regulator of endothelial cell migration

Epidermolysis Bullosa - Thymosin Beta 4 receives Orphan Drug designation for Epidermolysis Bullosa

Epilepsy - Anti-epilepsy drugs can increase rate of bone loss in older women

Epilepsy - Study confirms that Keppra provides opportunity for patients to be seizure free

Erosive Esophagitis - Prevacid IV for Injection approved by the FDA for erosive esophagitis

Eye Cancer - New laboratory model can be used to test new treatments for pediatric eye cancer

Fibrinolysis - Plasma D-dimer identifies lymph node metastasis in breast cancer patients

Finance - American Stock Exchange lists common stock of islet transplantation firm

Finance - Antimicrobial-drug company announces exercise of over-allotment option

Finance - Cancer immunotherapies company announces closing of public offering

Finance - Cancer vaccine maker reports $1M net loss

Finance - Chinese biotech firm issues update on AMEX listing

Finance - Company focused on lipids announces sale of real estate assets totaling $5.4M

Finance - Diagnostics company files secondary registration statement

Finance - Disposables supplier reports record fourth quarter net income

Finance - Drug discovery firm completes series D financing

Finance - Eye-disease focused company completes secondary public offering

Finance - Increase in number of authorized shares of stock approved at pharmaceutical firm

Finance - MRI pharmaceuticals company prices $75M offering

Finance - Milestone payment issued from Amgen as part of drug R&D deal

Finance - Ophthalmics company's stockholders approve $16.5 million financing

Finance - Ophthalmology company increases stockholders' equity through debt reduction

Finance - Oral insulin developer retains financial advisory firm

Finance - Pain therapy device firm announces stock repurchase plan

Finance - Pharmaceutical R&D company completes $55M Series D financing

Finance - Pharmaceutical company reports loss of $0.69 per share

Finance - Transfusion company announces 3-for-2 stock split and stock repurchase program

First Aid - SEAL-ON launched; designed to stop bleeding fast

Food-Borne Illness -  E. coli O157:H7 outbreak linked to salami in British Columbia

Food-Borne Illness - Bioassay suitable for screening of enrofloxacin residues in chicken

Food-Borne Illness - LC/MS analysis of brevetoxin metabolites in Eastern oyster reported

Fungal Infection - Voriconazole may prevent fungal relapse during at-risk periods of leukemia

Gastroenterology - Aurora-2 is a potential target for the treatment of pancreatic cancer

Gastroenterology - Clofazimine in lipiodol diminishes liver tumors in rodent cancer models

Gastroenterology - Diagnosis of gastroesophageal reflux disease reviewed

Gastroenterology Vaccine - Progress in enteric vaccine development outlined

Gastroesophageal Reflux Disease - Stretta procedure highly effective for GERD in obese patients, data shows

Gene Expression - Heterochromatin protein-1 affects dynamics of heterochromatin maintenance

Gene Therapy - New research on the progress of gene therapy presented at meeting

Gene Transfer - A new quantitative method measures the magnitude and volume of transgenes

Gene Transfer - NK4 transfection generates several modes of antitumor activity

Generic Drugs - Metronidazole Cream 0.75% introduced

Genetic Disorder - Aminoglycoside rescues disease-causing mutation in vasopressin receptor gene

Genetic Engineering - Administration route shapes the effects of IL-12-expressing dendritic cells

Genetic Mutation - Germline mutations in Chernobyl cleanup workers' offspring are modest

Genetics - Company adds cell-based knockins to its vector application services

Genomics - FDA, NIH drive clinical genomics: Is widespread application in the near future?

Genomics - Pharmacogenomic profiling of PI3K/PTEN-AKT-mTOR pathway in tumors elucidated

Genomics and Genetics - 5' nuclease assay with minor groove binder probes effective

Genomics and Genetics - Cryptic 6q subtelomeric deletion characterized

Genomics and Genetics - Myc-associated zinc finger protein activates murine RAG-2 promoter

Genomics and Genetics - Stress-induced cellular gene expression characterized

Geriatrics - Plasmid-based hormone therapy could improve disease or age-induced wasting

Growth-Hormone Deficiency - Companies agree to discontinue commercialization of Nutropin Depot

Guillain-Barre Syndrome - Mutations in CD14 or TLR4 not linked to GBS risk

Gynecology - Bikunin plus paclitaxel trims tumor burden and ascites in ovarian cancer models

HARS - Phase III trial to study Serostim as treatment, maintenance therapy for HARS

HIV & Cancer - EBV may play role in pathogenesis of head and neck cancers in HIV infection

HIV/AIDS - Co-administration of lopinavir decreases amprenavir concentration

HIV/AIDS - RNAi is gene-specific therapeutic option to control HIV-1 replication

HIV/AIDS Genetics - Mutations at position 184 of HIV-1 RT affect virus titer and viral DNA synthesis

HIV/AIDS Pathogenesis - HIV-1 Vpr promotes ubiquitination and turnover of Vpr mutants

HIV/AIDS Prevention - Misconceptions regarding condom use have implications for HIV prevention

HIV/AIDS Research - Atazanavir and tipranavir quantified in plasma by HPLC plus MS/MS

HIV/AIDS Research - Conserved bulky hydrophobic residues help stabilize HIV gp120-gp41 complex

HIV/AIDS Research - Major 5' site mutation renders CMV-driven HIV-1 proviral clone Tat-dependent

HIV/AIDS Research - Unusual ''senseless'' 2',5'-oligoribonucleotide has potent anti-HIV activity

HIV/AIDS Therapy - Research agreement renewed for development of novel HIV entry inhibitors

HIV/AIDS Therapy - Single-dose phase I trial of first-in-class HIV maturation inhibitor completed

HIV/AIDS Treatment - Antiretroviral therapy adherence issues are elucidated

HIV/AIDS Treatment - Drug interactions occur between opioids and antiretroviral medications

HIV/AIDS Treatment - Sociocultural barriers impede complementary and alternative medicine use for HIV

HIV/AIDS Treatment - Vif-resistant mutant APOBEC3G may provide gene therapy approach to HIV infection

HIV/AIDS Virology - Virologic failure in HIV patients associated with poor adherence to NNRTIs

Head and Neck Cancer - STK15 polymorphism correlates with esophageal squamous cell cancer occurrence

Healthcare Coverage - ACCC calls on CMS to allow for exceptions to ASP reimbursement

Healthcare Market - Survey reflects positive outlook for healthcare industry for remainder of 2004

Hearing Loss - Ceptor Corporation receives grant for hearing loss study

Heart Attack - Genetic markers linked to increased risk of heart attack

Heart Surgery - Bivalirudin superior to heparin for thrombosis prevention

Heart Surgery - Expanded pouch enables safe intra-abdominal placement of Novacor device

Heart Surgery - Novel technique devised for pediatric mitral valve annuloplasty

Heart Surgery - Stenting can enhance treatment for cervical artery dissection

Helicobacter -  H. pylori-specific antibodies counteract resistance against infection

Hematology - 1,8-Anilinonaphthalene sulfonate binds to central cavity of human hemoglobin

Hematology - Low-molecular-weight heparins may interfere with tumor growth and metastasis

Hemophilia - Foundation says it's not deterred by Avigen gene-transfer therapy announcement

Hemophilia - Immunosuppressive therapy can rapidly resolve acquired postpartum hemophilia

Hemorrhagic Fever - West Nile virus trial expands to include additional lethal viruses

Hepatitis B Virus - Low-level viremia of hepatitis B found in antibody-positive blood donor

Hepatitis C - Genetic vaccine promising against chronic hepatitis C

Hepatitis C Vaccine - Vaccine encoding hepatitis C antigens elicits specific immune response

Hepatocellular Carcinoma - Selective resection margins attempt to contain liver cancer micrometastases

Hepatology - Cancer drugs and irradiation combine to overcome liver cancer proliferation

Hepatology - Expression of CYP3A4 mRNA correlates with metabolic activity in human liver

Hereditary Angioedema - FDA permission granted to resume DX-88 clinical trials

Hip Replacement - Bone sialoprotein-coated femoral implants subject to loosening

Hip Replacement - Creep is main component of fatigue damage at cement-bone interface

Hip Replacement - Taper-design uncemented femoral stem may reduce bone loss

Hodgkin Disease - B7-2 protein levels reduced in HD tumor cells

Hormone Replacement Therapy - Long-term tibolone therapy appears to benefit lipid profile

Hypercholesterolemia - U.S. FDA grants tentative approval to market fenofibrate tablets

Hypertension - North American licensing strategy outlined for Thelin

Hypogonadism - Misrouted cell surface GnRH receptors contribute to hypogonadism

Idiopathic Thrombocytopenic Purpura - ITP study finds Gamunex safe and efficacious for patients

Immune Thrombocytopenic Purpura - Rituximab safe and effect for ITP treatment

Immunology - 4-1BB signaling plays key role in regulatory T-cell function

Immunology - Actin cytoskeleton suppresses basophil signaling

Immunology - Alpha-actinin recruits SPA-1 to immunological synapse

Immunology - Antibodies against enterococcal bacteriocin enterocin P evaluated

Immunology - CD28 costimulation triggers tumor recognition by modified T cells

Immunology - CD45 isoform expression compared in T-cell subsets

Immunology - CXC chemokines forge a link between inflammation and angiogenesis

Immunology - Cell-line company adds Dr. Stephen Chang to scientific advisory board

Immunology - Cytosolic phospholipase A2 alpha targets the phagosome membrane

Immunology - Dihydropyridine receptors are selective markers of Th2 cells

Immunology - Fc receptor aggregation has inhibitory effect on pre-B cells

Immunology - Generation of distinct CD8+ memory T cell subsets is CD40L-dependent

Immunology - Hepatitis C virus clears despite immunosuppression after liver transplantation

Immunology - Immunoenhancing effects of bovine glycomacropeptide characterized

Immunology - Impaired IL-18 release activated with protein I/II

Immunology - Interferon-gamma attenuates interferon-alpha activity in liver cells via STAT1

Immunology - Interleukin-6 obstructs T cell-mediated hepatitis

Immunology - Mannose 6-phosphate receptors not involved in granzyme-mediated cytotoxicity

Immunology - Maternal IgG appears phenotypically in offspring as non-genetic inheritance

Immunology - NIH awards phase II SBIR to develop zebrafish apoptosis drug-screening assays

Immunology - Novel assay detects different forms of IFN-gamma in single NK cells

Immunology - Results on electroporation-enhanced DNA vaccine delivery presented at meeting

Immunology - Role of IL-10 in skin disease pathogenesis and/or treatment reviewed

Immunology - StcE may protect E. coli O157:H7 and host cell from complement-mediated lysis

Immunology - T cells from elderly adults respond to stimulation with IL-2 production

Immunology - TRX and MIF/GIF proteins have cysteine-dependent immune regulatory activity

Immunology - There are two sides of the antitumoral activity of imiquimod

Immunotherapy - Lorus announces European patent to protect unique tumor suppressor

Immunotherapy - R&D company licenses rights to proinflammatory cytokine receptor antagonists

Infection - Antimicrobial impregnated catheters demonstrate efficacy and cost effectiveness

Infectious Disease -  C. parvum enterocyte infection may affect expression of defensins

Infectious Disease - Candidemia documented in wide range of patient populations

Infectious Disease - Early NO inhibition augments HSV-1 intranasal infection

Infectious Disease - IFN-gamma production during RSV infection is not associated with IL-12 or -18

Infectious Disease - Incidence of methicillin-resistant S. aureus infection high in prison population

Inflammation - Enzyme linked to inflammation reduced in mouse study

Inflammatory Bowel Disease - 4-ASA enemas well-tolerated by patients with 5-ASA-induced pancreatitis

Inflammatory Bowel Disease - DSS load affects colitis severity in mice

Influenza Vaccine - Influenza A vaccine based on M2 domain provides weak protection

Influenza Vaccine - Splenectomized patients have normal response to influenza vaccine

Influenza Virus - Fate of 130 hemagglutinins from different influenza A viruses determined

Insulin - EU approves Levemir, a long-acting insulin analog

Insulin Delivery - In vitro degradation of insulin-loaded nanoparticles reported

Insulin Delivery - Nanoparticle-based oral insulin study data published

Kidney Cancer - Treatment shows promise for aggressive kidney cancer

Kidney Transplantation - TGF-beta1 production is activated in kidney transplant recipients

Knee Replacement - Image-based and non-image-based navigation systems compared

Knee Replacement - Revision total knee arthroplasty safe and effective

Knee Replacement - Total knee replacement alters knee and hip joint kinematics during stair climbing

Leber Congenital Amaurosis - Abolished interaction of NUB1 with AIPL1 linked to Leber congenital amaurosis

Legal Issues - $272,000 released to Pennsylvanians for Taxol and paclitaxel purchases

Legal Issues - Is GSK guilty of fraud?

Legal Issues - Pharmaceutical company reaches agreement with Texas Attorney General's Office

Leptin Studies - Leptin released within brain at increased rate in obese humans

Leptin Studies - Leptin-leptin receptor interactions have 1:1 stoichiometry

Leukemia - FDA begins priority review of NDA for clofarabine in pediatric acute leukemia

Leukemia - Hydroxyurea may cause acute leukemia in patients with sickle cell disease

Liver Metastases - Hepatic artery infusion has high partial response but no longevity benefit

Lung Cancer - The 5-fluorouracil derivative UFT foils non-small cell lung cancer angiogenesis

Lung Transplantation - Diagnostic utility of Platelia Aspergillus galactomannan antigen determined

Lymphoma Therapy - T-cell dysfunction characterized in chemotherapy-treated lymphoma patients

MMR Vaccine - Economic analysis of two-dose MMR vaccination program in U.S. reported

MMR Vaccine - Measles-mumps-rubella vaccination recommended at 12 to 15 months of age

Market Analysis - 38% of pharma companies involve thought leaders in clinical trial kick-offs

Market Analysis - Benchmarks the pharmaceutical market research function analyzed

Market Analysis - Biological response modifiers' image dominates arthritis therapies despite price

Market Analysis - Biotech loses ground in May as the economy stalls and the IPO market softens

Market Analysis - New product planning, strategic alliances drive pharmaceutical success

Measles Epidemiology - Epidemiology of measles in the United States from 1997-2001 reported

Measles Epidemiology - Minimum investigation rate for evaluating measles monitoring proposed

Measles Epidemiology - Surveillance is adequate to detect endemic measles in the U.S.

Measles Survival and Mortality - Acute measles mortality in the United States during 1987-2002 reported

Measles Survival and Mortality - Measles hospitalizations during 1985-2002 in U.S. reported

Measles Vaccine - Disparity in measles vaccine coverage in minority children eliminated

Measles Vaccine - Vaccination levels associated with lack of measles in preschoolers

Measles Vaccine - Vaccine-induced antibodies to measles persist 26 to 33 years

Measles Virus - Genetic analysis of measles viruses in U.S. performed

Measles Virus - Measles elimination in U.S. aids global measles elimination efforts

Measles Virus - Measles virus shedding does not occur with inapparent measles infections

Medical Devices - Utility of several differet types of latex immunoassay particles compared

Medical Ethics - Ethics of vaccine research reviewed

Medicare - Initiative helps low-income beneficiaries sign up for drug discount card

Medication - Brand medications preferred over generics for serious conditions, survey shows

Melanoma - FDG-PET not suitable for lymph node metastasis testing

Melanoma - Topical imiquimod immunotherapy effective for amelanotic lentigo maligna

Melanoma Vaccine - Targeting melanoma inhibitor of apoptosis protein destroys tumors

Meningitis - Unique variant of disease-causing meningococci characterized

Meningitis Vaccine - New Neisseria meningitidis candidate vaccine identified

Mergers and Acquisitions - Advanced Bionics acquired for $740M in cash

Mergers and Acquisitions - Agreement in principle signed to acquire MJ Research

Mergers and Acquisitions - Biotechnology companies enter definitive merger agreement

Mergers and Acquisitions - Genesis Bioventures enters into strategic agreement

Mergers and Acquisitions - Genomics Collaborative acquired through stock deal

Mergers and Acquisitions - IVAX acquires Peruvian pharmaceutical company

Mergers and Acquisitions - Majority interest acquired in $10M Chinese company

Mergers and Acquisitions - Merger produces pipeline of products for serious infectious diseases

Mergers and Acquisitions - Merger to develop advanced molecular diagnostics for personalized medicine

Metastasis - Hyperthermic antiblastic perfusion curtails locoregional limb melanoma

Metastasis - SIKVAV retro and retro-enantio analogues take aim at metastatic events

Metastasis - The aggressive nature of insular carcinoma calls for total thyroidectomy

Metastatic Cancer - MGB1 differentiates metastasized breast cancer from primary lung lesions

Microencapsulation - Particle characteristics affect transcutaneous vaccine delivery

Migraine - FDA issues not-approvable letter for MT 100 migraine treatment

Monoclonal Antibody - Monoclonal antibodies captured using hydrophobic interaction chromatography

Mucopolysaccharidosis VI - Positive phase III data reported on Aryplase for MPS VI

Multiple Myeloma - Thalidomide Pharmion application to be resubmitted to EMEA for multiple myeloma

Multiple Myeloma - Thalidomide Pharmion approved in Turkey for multiple myeloma

Multiple Sclerosis - Application submitted to European Medicines Agency for Antegren approval

Multiple Sclerosis - Bone marrow and CNS parenchymal iNOS have similar role in EAE

Multiple Sclerosis - Influence of HLA-DRB1 alleles on MS risk elucidated

Multiple Sclerosis - Integrin gene expression reduced in MS patients responding to IFN-beta treatment

Multiple Sclerosis - Peripheral blood microarrays provide valuable information on MS pathology

Multiple Sclerosis - Study: MS patients in personalized nurse program adhere to Betaseron treatment

Multiple Sclerosis - Trial tests diabetes drug in treatment of multiple sclerosis

Mutagenesis - Telomere length is maintained during early tumorigenesis

Mycobacterium - Multiple polymorphic loci used to type strains of Mycobacterium leprae

Myelodysplastic Syndromes - First component of Dacogen New Drug Application submitted to FDA

Nasopharyngeal Cancer - Nasopharyngeal carcinomas and Epstein-Barr virus reviewed

Nephrology - Cat scratch disease may lead to IgA nephritis

Neuroblastoma - Prognostic marker candidates for neuroblastoma identified

Neurodegeneration - Ubiquitin proteasome system involved in synaptic and axonal degeneration

Neuroscience - Exercise induces BDNF and synapsin I to separate hippocampal areas

Neuroscience - GPI-1046 attenuates ischemic brain damage in rats

Neuroscience - KA-induced neuronal death in immature OHCs region-specific and irreversible

Neuroscience - Lymphocyte dopamine receptor expression linked to persistent personality

Neuroscience - Peripheral olfactory ensheathing cells augment healing after spinal cord injury

Neuroscience - Proteins associate with tau mRNA and HuD protein in neuronal cells

Neurotoxicity - The advent of ifosfamide-related encephalopathy is unpredictable

Obesity - Recruitment complete for phase IIb AOD9604 obesity trial

Obesity Risk Factor - Occupational factors affect weight change among men in Danish cohort

Obesity Risk Factor - Socioeconomic status affects attitudes toward eating and weight

Obesity Surgery - Intestinal bypass syndrome presents as erythema nodosum

Obesity Therapy - Agents have different effects on behavioral satiety sequence in rats

Obesity Therapy - CCK-8 response changes after MC3/4-receptor blockade reported

Obesity Therapy - Capsaicin changes neuropeptide Y and cholecystokinin expression

Obesity and Diabetes - PCK1 is a candidate diabetes and obesity gene

Obesity and Diabetes - Short-term weight loss improved metabolic syndrome in overweight adults

Obstetrics - Intravenous nitroglycerin studied in preterm labor

Obstetrics - LMW heparin helps prevent venous thromboembolism in pregnancy

Oncogenesis - Novel PMS2 pseudogenes conceal the true genomics of pediatric cancer

Oncogenesis - The Niban gene is a candidate marker for renal cancer formation

Oncogenesis - Unique genes or gene products profile hepatocellular carcinomas

Oncology - Cancer therapy combining cisplatin and WR-2721 doesn't prolong patient response

Oncology - New models offer insight into the mechanics of thalidomide analogues

Oncology - XIAP is key modulator of TRAIL-mediated apoptosis in tumor cells

Oral Cancer - S100A4 expression prognostic indicator in invasive and metastatic oral SCCs

Oral Mucositis - L-glutamine formulation helps prevent, treat common chemotherapy side effect

Orthopedic Surgery - Nonstoichiometric hydroxyapatite granules effective in orthopedic surgery

Orthopedics - Periostin may play key role in early fracture healing

Osteoarthritis - Osteoarthritis patients report improved function in collagen hydrolysate study

Osteoporosis - Calcitonin reduces acute bone loss in patients with pertrochanteric fractures

Osteoporosis - Dietary fermented soybean may improve bone formation in premenopausal women

Osteoporosis - PAI complete for nasal-spray facility

Osteoporosis - Study finds dietary supplement increases bone mineral density

Outbreaks - Model for disease outbreaks in realistic urban networks developed

Ovarian Cancer - Gemcitabine yields favorable results vs. recurrent epithelial ovarian cancer

Ovarian Cancer - Generex prepares for trials in patients with Her-2/neu positive ovarian cancer

Ovarian Cancer - Tumor grade correlates with fluorodeoxyglucose uptake in ovarian cancer

Overactive Bladder - Company announces FDA approval of SANCTURA

Overactive Bladder - U.S. FDA approves Sanctura for treatment of overactive bladder

Pain Management - Vertebroplasty and kyphoplasty ameliorate cancer-derived fracture pain

Pain Therapy - Refinement of topical ENT-103 formulation begins

Pain Therapy - Report discusses effective ways to manage pain

Parkinson Disease - Specialty distributor provider chosen for Apokyn Parkinson therapy

Patents - China patent granted for Cyclosporin Neuroprotection

Patents - Company wins patent for Filled Canister apparatus related to bone repair

Patents - Company wins patents for genetically enhanced antigens for vaccine development

Patents - Gene therapy may be useful in cancer treatments

Patents - U.S. patent granted for asthma, allergy treatment

Pediatric Oncology - Neuroblastoma cells express Olf/EBF transcription factors

Peripheral Arterial Disease - Combination therapy to treat acute blocked peripheral arteries evaluated

Personnel - Alan Barber named chief financial officer at biotech firm

Personnel - Andrew P. Aromando named senior VP at biopharmaceutical firm

Personnel - Biopharmaceutical R&D company names vice president, business development

Personnel - Biopharmaceutical company appoints VP, preclinical and basic research

Personnel - Biopharmaceutical company names vice president, process development

Personnel - Biotechnology company announces appointment of new board member

Personnel - CRO appoints Lyon Gleich as director, medical affairs

Personnel - David Busam named VP of finance/administration, CFO at genomics firm

Personnel - David MacDonald promoted to president, CEO at biotech firm

Personnel - David S. Tierney named to board of directors at generic drug firm

Personnel - Development team formed for Axenohl silver dihydrogen citrate technology

Personnel - Donald W. Kufe elected to board of directors at oncology drug firm

Personnel - Dr. Michael Fons tapped as executive director, corporate development

Personnel - Dr. Wilfred Sylvain Nambei joins biotech as member of scientific committee

Personnel - Drug discovery company announces new board member

Personnel - Duu-Gong Wu joins drug development firm as senior director

Personnel - Edward Kenney named EVP, chief business officer of cancer therapeutics company

Personnel - Herbert Michael Pinedo joins board of oncology company

Personnel - John Cardis elected to board at cardiovascular disease company

Personnel - Joseph E. Smith elected to board of directors of pharmaceutical company

Personnel - Katherine High named president of gene therapy group

Personnel - Lead director of cancer therapy systems manufacturer passes away

Personnel - New member added to board of directors of biotech

Personnel - Nickel named business development, marketing VP at hematology firm

Personnel - Pharmaceutical company announces new appointments

Personnel - Pharmaceutical company appoints new vice president, clinical development

Personnel - Pharmaceutical firm announces changes to its board of directors

Personnel - Research products maker firm elects new member to board of directors

Personnel - Software/strategic services provider announces senior VP, business development

Personnel - Stem cell company announces management appointments

Pharmaceutical Companies - Drug company influence under microscope at annual AMA meeting

Pharmaceutical Drugs - Ann Arbor company closing in on production of eggs that carry drug ingredients

Pharmaceutical Drugs - FDA accuses maker of antiretroviral of misleading promotions

Pharmaceutical Sales - j-forceNET helps enhance pharmaceutical field force productivity in Japan

Pharmaceutical Settlement - Arkansas agencies get refunds from drug antitrust case

Pharmacogenomics - Patients in Japan, U.S. react differently to the same chemotherapy regimen

Pharmacology - HepDirect prodrugs deliver nucleoside-based therapy to the liver

Physical Fitness - BMI affects aerobic fitness during incremental exercise

Phytotherapy - The plant alkaloid sanguinarine suppresses angiogenesis

Pneumococcal Vaccine - Pneumococcal vaccine not cost-effective for all elderly adults

Pneumococcal Vaccine - Pneumococcal vaccine prevents pneumococcal disease but not pneumonia

Pneumococcal Vaccine - Responses to pneumococcal vaccine in IgA deficient patients studied

Polio Vaccine - Vaccine-derived poliovirus isolated from sewage in Estonia

Postoperative Ileus - Second portion of NDA submitted for Entereg

Practice Guidelines - ADA issues new advice to doctors on lowering diabetes-heart disease risks

Prion Disease - Cu(II) binding modes of mammalian normal prion protein examined

Prion Disease - Scrapie protein degraded by cysteine proteases in dendritic cells

Prion Disease - Tolerance to prion protein broken by prion protein peptides and ODN-CpG

Product Licensing - Hemosol completes agreements to license Cascade technology

Prostate Cancer - Common bone complications in advanced prostate cancer patients lead to increased medical costs

Prostate Cancer - Estrogen boosts memory in men with prostate cancer

Prostate Cancer - Estrogen patches lower cholesterol in men with prostate cancer

Prostate Cancer - Hormone treatment less effective for younger men with higher-grade tumors

Prostate Cancer - Marketing authorization granted for cancer products in Latin America

Prostate Cancer - Pill may stave off disease and ease pain

Prostate Cancer - Positive phase IIb data reported for ACAPODENE

Prostate Cancer - Tools needed to reliably report side effects in chemotherapy clinical trials

Proteomics - WNT signals encourage multiple myeloma cell proliferation

Pulmonary Medicine - Facial deposition of aerosol-delivered drugs characterized in children

Radiation Therapy - Researchers seek clues to healing radiation scars

Radiotherapy - Boron neutron capture therapy kills oral squamous cell carcinoma in mice

Receptor Studies - Eph receptor-ephrin bidirectional signals that target Ras and Rho proteins

Receptor Studies - Hapten receptors bear selective delivery of imaging and therapeutic agents

Receptor Studies - Melanocortin-4 receptor agonist effect on energy homeostasis assessed

Receptor Studies - Photoaffinity scanning useful for mapping of the peptide receptor interfaces

Receptor Studies - Promoter of mouse melanin-concentrating hormone receptor 1 characterized

Receptor Studies - Transforming growth factor-beta superfamily of receptors reviewed

Reconstructive Surgery - Failed scalp replantation can induce dangerous psychological sequelae

Reconstructive Surgery - Free vascularized osteocutaneous fibular graft to tibia effective

Reconstructive Surgery - Immediate mandibular reconstruction serves oral cavity cancer patients well

Reconstructive Surgery - Novel dysvascular lower extremity reconstruction technique devised

Reconstructive Surgery - Prophylactic plating not cost-effective after radial osteocutaneous flap harvest

Rectal Cancer - Functional nuclear MRI is applied to in vivo anticancer research

Recurrent Gliomas - Phase II trial to study Cloretazine in adult patients with recurrent gliomas

Regulatory Issues - FDA rejects Illinois drug import pilot program

Renal Cell Carcinoma - Renal cancer tumor vessels express a member of the RGS superfamily

Renal Failure - AGE-modified materials may underlie prurigo in dialysis patients

Renal Failure - Rasburicase mitigates the nephropathic effects of tumor lysis syndrome

Reproductive Health - Human antisperm antibody response in SCID mice is complex

Reproductive Medicine - Microarray analysis reveals putative spermatogenesis genes

Reproductive Medicine - SerW3 cell assay useful for identification of reproductive toxins

Restenosis - Ultrasound-augmented nucleotide transfer harnesses neointimal growth

Rotavirus - Simple method for storage of rotavirus RNA in stool samples developed

SARS Vaccine - DNA vaccines target nucleocapsid protein of SARS coronavirus

Salmonella -  Salmonella enterica Javiana infections linked to amphibian contact

Salmonella -  Salmonella epitopes for CD8+-T-cell recognition identified

Schizophrenia - Drink can improve effectiveness of psychosis drugs, lessen side effects

Seizure Disorder - Inhibition of delayed induction of p38 protein kinase reduces neuronal loss

Sexually Transmitted Disease - Guide to sexually transmitted disease resources on Internet released

Sjogren Syndrome - Anti-cerebral mAChR antibodies involved in cognitive dysfunction

Skin Cancer - Evidence of increased apoptosis/reduced proliferation in tazarotene-treated BCC

Skin Cancer - Multicenter melanoma vaccine study demonstrates promising results

Skin Care - Kinerase product line to expand in 2004

Smallpox - Smallpox as biological weapon reviewed

Smoking Cessation - Generic Zyban launched under supply agreement

Smoking Cessation - Teva commences commercial launch of generic Zyban

Staphylococcal Vaccine - Opsonic antibodies target fibrinogen binding protein of Staphylococcus

Stem Cell Research - Stem cell transplants reactivate resolved hepatitis B virus infections

Stem-Cell Research - BCR-ABL has distinct biological effects in primary human hematopoietic cells

Stem-Cell Research - Fas may function as mediator of growth rather than death in neural stem cells

Stem-Cell Research - Glycine cleavage system abundantly expressed in embryonic neural stem cells

Stem-Cell Research - HSC mobilization-associated granulocytosis severely worsens acute renal failure

Stem-Cell Transplantation - AFLP accurately identifies Candida colonization in children undergoing SCT

Stem-Cell Transplantation - Allogeneic HSCT has favorable outcome in early CML in younger patients

Stem-Cell Transplantation - Functional evidence for single endodermal origin for thymic epithelium

Stem-Cell Transplantation - Lower doses of lymphocytes increase survival in myeloid leukemia

Stem-Cell Treatment - Fetal BM-derived Flk1+ CD34- stem cells are ideal as treatment source

Streptococcus - Mutant of response-regulator homologue from Streptococcus crystallized

Streptococcus - Residues 18-230 of PhtA protein from Streptococcus pneumoniae characterized

Stroke - U.K. study shows substantial reduction in stroke over past 20 years

Surgical Technology - Cyanoacrylate adhesive superior to sutures for microvascular anastomosis

Sydenham's Chorea - Chemokines linked to Sydenham's chorea pathogenesis identified

Testicular Cancer - Laparoscopic lymph node dissection is feasible for some testicular cancers

Thrombosis - New Arixtra indications: Acute deep venous thrombosis, acute pulmonary embolism

Toxicology - Trivalent arsenic stimulates proangiogenic signals

Transcriptional Regulation - Agents that activate NRIF3 coregulators would target breast cancer cells

Transduction - Electric field-induced molecular vibration forges DNA transfer

Transplant Medicine - Hepatitis C contributes to persistent ascites after liver transplantation

Transplant Medicine - Steatosis isn't linked to recurrent HCV in the year after liver transplantation

Tuberculosis Vaccine - Aerosolized IFN-gamma helpful for drug-resistant pulmonary tuberculosis

Tuberculosis Vaccine - Pantothenate auxotroph of M. tuberculosis protects guinea pigs

Tumor Suppression - Modified thrombospondin-2 cDNA transduction stops tumor growth and angiogenesis

Urinary Tract Infection - Ciprofloxacin therapy is efficacious for UTI treatment

Urothelial Cancer - Immunohistochemistry provides reliable determination of HER-2/neu status

Vaccine Development - Climate for funding of vaccine research reviewed

Varicella Vaccine - Varicella vaccine stabilizer without animal-derived components developed

Vector Development - Folate receptors ensure correct delivery of tumor-selective gene therapy

Vector Development - Hybrid LTR retroviruses seek and transfect tumor endothelial cells

Vector Development - PLL-modified silica nanoparticles transport antisense oligonucleotides

Vibrio - Lipase and lipase activator protein from Vibrio vulnificus CKM-1 cloned

Viral Genomics and Genetics - Purine ribonucleosides rely on unique relationships for hepatitis C inhibition

Virology - Adenoviruses D and E diagnosed by phylogeny-based classification method

Virology - Alternatively spliced soluble CARs inhibit coxsackievirus infection

Virology - Human T-cell leukemia virus type 1 displays preferential genomic integration

Virology - Molecular bases of Ad41 enteric tropism stem from its physicochemical properties

Virology - Priming deficient polymerase in HBV core particle allows for oligomer synthesis

Virology - Proteasome inhibition boosts viral replication in an HBX-dependent manner

Virology - Viral cocktails afford efficient gene transfer in animal models

Weight Loss - Weight loss decreased FT4 levels in experimental obese beagle dogs

West Nile Vaccine - Dow, federal lab to collaborate on plant-based vaccine for horses

West Nile Virus - Company receives approval for WNV protocol with Alferon N treatment

Wound Care - Chemokine receptor up-regulated after skin injury but unneeded for healing

Wrinkled Skin - Test results shows Dermagenetics reverses signs of aging

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