Enzymology
Nitric oxide is a negative regulator of endothelial cell migration
Published in Drug Week, July 2nd, 2004
According to a study from Taiwan, "nitric oxide (NO) has been shown to inhibit migration of cells in which various matrix metalloproteinases (MMPs) are involved. The underlying molecular mechanisms of this inhibition remain elusive. Endothelial cells (ECs) constitutively produce MMP-2."
"The effect of NO on MMP-2 expression was examined. A dose-dependent inhibition of MMP-2 mRNA level was demonstrated in ECs treated with NO. ECs infected with adenovirus carrying endothelial NO synthase (Ad-eNOS) reduced MMP-2 expression. The inhibitory effect of NO on MMP-2 expression was a...
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Source: Drug Week (2004-07-02)
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