Published in Drug Week, July 16th, 2004
"Numerous attempts to induce immunity against HCV core (HCV-C) by DNA immunization met serious difficulties in optimizing T-helper cell and antibody responses. Immunomodulatory properties of HCV-C could be blamed that seem to be dependent on the genotype of HCV source. Here, we characterized HCV-C gene from HCV lb isolate 274933RU," scientists writing in the journal Vaccine report.
"Eukaryotic expression of HCV-C was effectively driven by CMVIE, while human elongation factor I alpha promoter directed low levels of HCV-C expression," said...
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