Drug Week
Susan Hasty, Publisher
Table of Contents . . . July 23rd, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Drug Week | Other Publications
Cancer Therapy - Encouraging results from NCI-sponsored study with FK228 in T-cell lymphomas
Drug Resistance - Cell cycle promotion sensitizes lung cancer cells to paclitaxel
Immunology - PrP-GFP expression models analyze activity of Prnp gene during prion infections
Mesothelioma - CHMP positive opinion granted for two cancer indications
Thrombosis - Heparin does not affect graft thrombosis incidence in pediatric renal allografts
Urinary Tract Infection - Extended-release ciprofloxacin effectively treats UTI and combats resistance
Accreditation - Facility receives quality system certification to ISO 13485:1996
Acute & Chronic Pain - Clinical testing begins on RI 624 for acute and chronic pain
Adenocarcinoma - Pigment epithelium-derived factor favors pancreatic cancer patient survival
Adipogenesis - RNA knockdown of phospholipase inhibits preadipocyte differentiation
Adipogenesis - Sympathetic innervation of adipose tissue regulates fat cell number
Adolescent Health - Dieting among preadolescent and young adolescent females examined
Adolescent Health - School health councils promote health programs in U.S. schools
Adolescent Health - Weight-management practices among adolescents determined
Adverse Drug Effects - Erythema multiforme-like reaction to adalimumab reported
Adverse Drug Effects - Non-protein bound iron may be responsible for chemotherapy-induced toxicity
Adverse Drug Effects - Quetiapine-induced diabetes with metabolic acidosis reported
Adverse Drug Effects - Sirolimus-induced angioedema reported
Age-Related Macular Degeneration - Isis earns $1M milestone payment related to filing of Macugen NDA
Age-Related Macular Degeneration - SBIR grant to fund treatment of ocular neovascularization diseases
Alcohol-Related Diseases - NIH funding awarded for biomarker research in alcohol-related diseases
Alcoholism - Prickly pear cactus extract appears to reduce some hangover symptoms
Allergy & Immunology - IgG4-switched B cells may undergo secondary switch to IgE in allergen exposure
Allergy & Immunology - Malassezia enhances natural killer cell-induced dendritic cell maturation
Allergy Medicine - Grass pollen-specific marker allergens molecularly characterized
Allergy Medicine - Two out of three prescription antihistamine users don't have allergic disease
Alzheimer Disease - Genistein may be an alternative to estrogen for treatment of AD
Alzheimer Disease - Investigational treatment for Alzheimer disease to be tested in humans
Alzheimer Disease - North American phase III clinical trial on Alzhemed launched
Alzheimer Disease - Odyssey System being used for imaging animal models of AD
Alzheimer Disease - Polypeptide protects brain neurons in aluminum neurotoxicosis
Alzheimer Disease - Presenilin processes amyloid precursor protein in Drosophila
Angiology - Method devised for selective limitation of lumen diameter in corrosion casting
Animal Studies - Acid inhibition in male cotton rats creates gastric cancer models
Anthrax - Dutch company's anthrax products selected for testing by CDC
Anti-Infectives - Terbinafine resolves E. jeanselmei infection in heart transplant recipient
Antibiotics - License agreement announced for garenoxacin quinolone antibiotic
Antibiotics - Michael Marquard named president of company's branded sub
Anticancer Therapy - Cisplatin triggers CD95 redistribution to elicit cancer cell apoptosis
Antimicrobials - Antimicrobial cationic peptides effective against viruses
Antimicrobials - Mucosal antimicrobial peptide expressed by chinchilla airway identified
Apoptosis - ARC protects against cell death through interaction with Bax
Arthritis - Combination drug therapy sustains disease remission
Arthritis - Patients may be willing to exchange less effective drugs for fewer side effects
Assisted Reproduction - Anticoagulant heparin increases pregnancy rates
Atherosclerosis - Older people might need vitamin B-12 and folic acid supplements
Autoimmune Disease - Mutant NALP3 forms a highly active IL-lbeta-processing inflammasome
Bacillus - PhaQ regulates phasin expression in Bacillus megaterium
Bacillus Calmette-Guerin Vaccine - Guttate psoriasis-like lesions following BCG vaccination
Bacterial Endotoxin - A synthetic peptide derived from BPI: aa 148-161 neutralizes endotoxin
Bacteriology - L. pneumophila Philadelphia-1 magA expression developmentally regulated
Bacteriology - Rickettsia prowazekii Madrid E strain proteome analyzed
Bardet-Biedl Syndrome - Bardet-Biedl protein required for microtubule anchoring
Benign Prostatic Hyperplasia - FDA issues approvable letter for Cardura XL; OKs antibiotic ANDA
Bile Duct Cancer - Phase III trial of XL119 initiated
Bile Duct Cancer - Serum sFas/sFasL levels have prognostic value in bile duct cancer patients
Bioengineering - The synthetic molecule GFA-116 stifles angiogenesis and tumorigenesis
Biomaterials - "Packaging" proteins makes them more stable for shipping as drug products
Biotechnology - 3D optical photonic crystals with designed point defects generated
Bipolar I Disorder - Risperdal improves manic symptoms in bipolar I disorder study patients
Bladder Cancer - Clinical data presented from EOquin trial in superficial bladder cancer
Brain Injury - Progesterone attenuates inflammatory response to brain injury
Breast Cancer - Anastrozole recommended for first-line therapy for advanced disease
Breast Cancer - Innovative therapies expected to enter breast cancer therapeutics market
Breast Cancer - Radiation and tamoxifen after breast-conserving surgery reduce tumor recurrence
Breast Cancer - Response submitted to FDA approvable letter for Combidex
Breast Cancer - Somatic mutations in murine mammary cancer mirror human breast features
Breast Cancer - Trastuzumab combined with epirubicin and cyclophosphamide is safe for the heart
Breast Cancer - Utility of sentinel lymph node biopsy in breast cancer reviewed
Breast Cancer - p300/CBP-associated factor is a p53 target in breast tumors
Breast Cancer Vaccine - Breast tumor cell destruction by herpesvirus induces antitumor immunity
Burn Medicine - Novel allogeneic cultured dermal substitute system shows promise
Business & Finance - Biopharma to join Russell 3000 and Russell 2000
Business & Finance - Cellular-therapy company completes stock offering
Business & Finance - Foster City, California, company to join S&P 500 Index
Business & Finance - Incara announces 1-for-10 reverse split and name change
Business & Finance - Microencapsulation company taps Amper, Politziner & Mattia as auditors
Business & Finance - Pharmaceutical company reports highlights from stockholders meeting
Business Update - Agreement signed on the divestment of Campto colorectal cancer therapy
Business Update - Biopharmaceutical company elects directors at annual stockholders' meeting
Business Update - Biotech company appoints new president, CEO; company restructured
Business Update - Company reports on progress of Opterone and Econail
Business Update - Diagnostics company expands, relocates
Business Update - Millennium Pharmaceuticals reacquires European marketing rights for Integrilin
Cancer Proteomics - Peptide-based therapeutics are treatment alternatives for prostate cancer
Cancer Remission - The Wilms tumor gene screens for residual acute myeloid leukemia
Cancer Therapeutics - ADC technology licensed for antibody-based cancer treatment
Cancer Therapy - NCI selects SRI to qualify cancer drug candidates for clinical studies
Cancer Therapy - Phase II clinical trial with MDX-070 in prostate cancer announced
Cancer Therapy - Receptor tyrosine kinases offer targets for cancer therapy
Cancer Therapy - The treatment of cancer pain should involve neurosurgical treatments
Cancer Therapy - Tissue-specific promoters ensure oncolytic viruses target cancer tissues
Cancer Therapy - Treat the cancer, but take care to protect the heart, cancer cardiologists warn
Cancer Therapy - Utility of radiofrequency ablation of liver metastases reviewed
Cancer Trends - Monoclonal antibody therapies continue rapid growth in cancer market
Cancer Vaccine - Adoptive transfer of anti-idiotypic T cells cure B cell lymphoma
Cancer Vaccine - Dendritic cell vaccine prevents GI tumors based on mutation
Cancer Vaccine - Multiple antigens recognized by lymphocytes identified from individual
Cancer Vaccine - mRNA-transfected dendritic cells used for cancer immunotherapy
Candida Albicans - Biologists ID defense mechanism of leading fungal pathogen
Cardia Safety Monitoring - $1.2M awarded to study technology for cardiac safety monitoring
Cardiac Arrhythmia - Women more prone to develop Torsades de Pointes
Cardiology - ACE inhibition is an unexpected benefit of statin use
Cardiovascular Disease - Organosulfur compounds from alliaceae may protect against cardiovascular disease
Cardiovascular Disease - Parasympathetic cardiac nerve stimulation resolves atrial fibrillation
Cardiovascular Disease - Snoring induces massive pulmonary air embolism during pacemaker implantation
Cardiovascular Disease - Some patients are resistant to aspirin antiplatelet therapy
Charcot-Marie-Tooth Disease - Mutation linked to Charcot-Marie-Tooth disease with deafness
Charcot-Marie-Tooth Disease - Novel mutation in PMP22 gene associated with variable phenotype
Childhood Obesity - Low-back pain in adolescents linked to high body mass index
Chromosomes - New role defined for mitotic RAD21/SCC1 cohesin in chromosome cohesion
Chronic Lymphocytic Leukemia - CAMPATH B-CLL study fully enrolled; will evaluate prolonged survival
Chronic Lymphocytic Leukemia - Clinical trial to study Talabostat in advanced chronic lymphocytic leukemia
Chronic Lymphocytic Leukemia - FDA accepts HuMax-CD20 IND application for chronic lymphocytic leukemia study
Clinical Trials - Company awarded $1M for cardiac safety monitoring services
Clinical Trials - Enhanced Smart Trials service launched
Clinical Trials - Medical group encouraged by signs of support for national clinical trials registry
Clinical Trials - Receptor deficiency stalls the efforts of lung cancer gene therapy
Clostridium difficile-Associated Diarrhea - Enrollment completed for phase II trial of Ramoplanin for CDAD
Collaborations - Agreement signed to expand availability of high content screening
Collaborations - Companies to develop personalized dendritic-cell vaccines
Collaborations - Company to provide clinical trial support services
Collaborations - Generex announces joint venture and licensing arrangement for Oralin
Collaborations - Hovione enters drug-development alliance for potential new products
Collaborations - Human in vitro diagnostics PCR patent license executed
Collaborations - Immusol initiates collaboration to advance oncology drug-discovery efforts
Collaborations - MARtech under investigation for cell line development
Collaborations - Newton LIMS selected for quality control manufacturing facility in Spain
Collaborations - Research milestone achieved in antibody research deal
Collaborations - Strategic partnership signed for automated protein purification system
Colon Cancer - DNA lesion type defines death characteristics of colon carcinoma cells
Colon Cancer - Metalloproteinases exert differential expression in colon cancer tissue
Colon Cancer - Specialty reference laboratory collaborates in colon cancer research
Colon Cancer - The Cre/lox system helps Wnt-targeted gene therapy destroy colorectal cancer
Complementary & Alternative Medicine - Chinese herbal medicine is popular among breast cancer patients
Complementary & Alternative Medicine - Ribosome inactivating protein isolated from Trichosanthes kirilowii
Complementary & Alternative Medicine - SBIR grant awarded to study feverfew for migraine prevention
Complementary & Alternative Medicine - The weight loss supplement usnic acid may lead to liver failure
Congenital Ichthyosis - Liarozole receives FDA orphan drug status
Contraception - Benefits of oral contraceptives far outweigh potential risks
Contraception - Emergency contraception is efficacious and therapeutic across the board
Contraception - Male hormonal contraception looks promising
Contraception - Transdermal contraceptive system reviewed
Contraceptive Vaccine - Chitosan-plasmid DNA nanoparticles used for contraceptive vaccine
Coronary Artery Bypass - Phase III CABG trial evaluating edifoligide proceeding as planned
Coronary Artery Bypass - Type A dissection linked to aortic connector device reported
Coronavirus - SARS-CoV proteinase inhibitors may be developed from existing drugs
Cough - U.S. FDA approves 12-hour Codeprex
Craniofacial Surgery - Improved pediatric cranioplasty technique developed
Crohn Disease - Bacterial flagellin is dominant antigen in Crohn disease
Crohn Disease - Galileo discovers new gene candidate regions in whole genome study
Cryptosporidium - Cryptosporidium antibodies detected using multiplex bead assay
Cystic Fibrosis - Metabolism of P2 receptor agonists aids cystic fibrosis research
Cystic Fibrosis - tgAAVCF to enter phase IIb clinical trial for cystic fibrosis
Cytotoxicity - Cytokine regulation paves the way for arsenite-induced cancer destruction
DNA Research - Accelerated MDM2 auto-degradation is required for p53 activation
DNA Vaccine - Antigens with stress protein-capturing domain improve immunogenicity
DNA Vaccine - Processing of antigens delivered as DNA vaccines reviewed
Dendritic Cell Vaccine - Antibodies modulate interactions of adenovirus with dendritic cells
Dendritic Cell Vaccine - Dendritic cells and immunity to cellular antigens reviewed
Depression - E.U. "Newmood" research investigating genetic aspects of depression
Depression - Grant will fund intervention trial for depression over job loss
Dermatology - Loss of keratinocyte VEGF-A delays wound healing and blocks tumor growth
Diabetes - Islet-cell transplantation studies in primates to be conducted at UC Davis
Diabetes Complications - Sorbitol pathway plays role in dysfunction of oocytes in diabetes
Diabetes Genomics and Genetics - Mutation in AKT2 causes severe insulin resistance and diabetes
Diabetes Pathogenesis - Chemical modification of muscle protein occurs in diabetes
Diabetes Pathogenesis - E2F1-/- mice exhibit impaired beta cell mass and function
Diabetes Pathogenesis - Neomycin prevents glucose transport in 3T3-L1 adipocytes
Diabetes Survival & Mortality - Hyperglycemic crises and lactic acidosis in diabetes reviewed
Diabetes Therapy - Glumetza NDA accepted by FDA
Diabetes Therapy - Lipoic acid is therapy for diseases linked to oxidative stress
Diabetes Therapy - Sulfonylurea treatment of type 2 diabetes reviewed
Diabetes Therapy - Triple therapy fights type 2 diabetes without weight gain
Diabetic Nephropathy - High glucose concentration stimulates intracellular renin activity
Diabetic Neuropathy - Hyperglycemia plays role in early hyperalgesia in diabetic rats
Diabetic Neuropathy - Lipoic acid and evening primrose oil prevent diabetes-induced changes
Diabetic Neuropathy - Polyneuropathy after Campylobacter infection mimics mononeuritis
Diabetic Neuropathy - Role of human ANP gene in type 1 diabetic nephropathy investigated
Diabetic Retinopathy - High levels of insulin-like growth factor lead to diabetes-like eye disease
Diagnostic Imaging - Microvessel density is not essential for scintigraphic imaging of brain tumors
Diagnostics - Cardiac MRI safe in rats with implanted pacemakers
Diagnostics - Chromosomal deletions in frozen glioma samples aid sterotactic analysis
Diagnostics - High-throughput LC-MS-MS ketamine screen developed
Diagnostics - ICD electrograms useful for estimating pre-arrythmic repolarization alternans
Diagnostics - Proteomics-based screen identifies disease-associated humoral antigens
Diagnostics - The high affinity phage PHH2 will improve hepatitis B virus screening
Diagnostics - Tool for analyzing structural classification of protein data developed
Diagnostics - X-ray scatter correction algorithm devised for cone beam CT imaging
Diarrhea - Risk and protective factors for diarrhea in Brazilian children reported
Diet & Nutrition - Method to derive dietary patterns in nutritional epidemiology developed
Dieting - Public health groups warn about risks associated with low-carb diets
Drug Delivery - Fibrin-sealant matrices containing taurolidine blanket brain tissues
Drug Delivery - Implanted doxorubicin localizes at healing tissues in ablated rat livers
Drug Delivery - Lactide/glycolide monomers can improve PLGA gentamicin release
Drug Delivery - Liposomal encapsulation of nisin and lysozyme enhances anti-Listeria efficacy
Drug Delivery - Liposome-associated drugs exploit the presence of tumor vessels
Drug Delivery - Method for direct treatment of intestinal illnesses wins prize
Drug Development - Atelocollagen leads small interfering RNA to vascular growth factor
Drug Development - Bacteria spill their guts to aid researchers in quest for new antibiotics
Drug Development - Bacterial protein recycling factor possible key to new class of antibiotics
Drug Development - Beta-diketones boost apoptotic activity in human tumor cells
Drug Development - Coumarin derivatives act as TNF-alpha inhibitors
Drug Development - Drug regulation reexamined from perspective of innovation policy
Drug Development - Drugs that target hypoxia inducible factor-1 alpha curtail cancer
Drug Development - NIH grant to support development of therapeutics for Orphan indications
Drug Development - New body will boost clinical trials in U.K., says industry group
Drug Development - Novel anti-Leishmania immunotherapies show promise
Drug Development - Novel lipid-based cochleates drive gene uptake into mammalian cells
Drug Development - Orally bioavailable inhibitors of cathepsin K developed
Drug Development - Proteins discovered that regulate antioxidant defense
Drug Development - S-(2-(Acylamino)phenyl)2,2-dimethylpropanethioates are CETP inhibitors
Drug Discovery - Collaboration to develop novel genetic controls for diagnostic assays
Drug Importation - Florida offers to license storefronts that handle Canadian drugs
Drug Overdose - Acetadote launched for aspirin overdose
Drug Resistance - Over-the-counter pediculicides leading to treatment-resistant head lice
Drug Resistance - TtgV represses transcription of promoter for multidrug extrusion pump
Endocrinology - Complementary drugs slow the onset of androgen independence in prostate cancers
Endocrinology - Food packaging materials disrupt androgen activity in breast cancer cells
Endocrinology - Interleukin-6 stimulates VEGF autocrine loops in prostate cancer cells
Endocrinology - Poor glycemic control encourages VEGF-related diabetic vascular complications
Endocrinology - Role of the calcium-sensing receptor in parathyroid gland physiology
Environmental Health - Bioassays for measurement of herbicide toxicity evaluated
Environmental Health - Immunologic response to inhaled endotoxins clarified
Environmental Health - LC-MSMS multiresidue method to quantify pesticides in urine developed
Enzymology - Protein kinase C isozymes modulate mitochondrial Ca2+ signals
Erectile Dysfunction - Ardana to manufacture, market Invicorp erectile dysfunction treatment in E.U.
Exercise - Exercise suppresses NPY in hypothalamus of food-deprived rats
Exercise - Physical activity reduces coronary heart disease risk in childhood
Exercise - S100-beta increases in marathon runners reflect extracranial release
Female Sexual Dysfunction - Phase II trial for LibiGel completed
Fibromyalgia - AT-101 provides relief in fibromyalgia, chronic fatigue syndrome
Fibromyalgia - Phase II milnacipran data presented at meeting in Paris
Filtration - Polyacrylonitrile-based ultrafiltration membranes retain hepatitis A virus
Finance - Bertek's parent company declares quarterly cash dividend
Finance - Biopharmaceutical company to reduce operating expenses by more than $25M
Finance - Device company completes public offering of $600M
Finance - Device firm closes oversubscribed $27.5M round of private financing
Finance - Drug discovery company closes $50M Series E private placement financing
Finance - Elan's holdings of stock clarified
Finance - Gastric retention system maker to be added to Russell 2000 and 3000 indexes
Finance - Pharmaceutical company completes common stock sale
Finance - Pharmaceutical company reports net revenue increase in first quarter 2004
Finance - Pharmaceutical development company raises $37M in Series B financing
Finance - Simulation software developer reports preliminary financial estimates
Finance - Telik downgraded to HOLD by independent researcher
Food Safety - RNA extraction via oligo cellulose simplifies hepatitis A virus detection
Food-Borne Disease - Covalent mix ELISA suitable for swine Salmonella screening
Food-Borne Disease - Real-time PCR detection of Vibrio from mussels developed
Fungal Infection - Clinical factors predict fluconazole resistance/Candida blood infection survival
Gastric Cancer - Interleukin-8 marks Helicobacter pylori status in treated ulcer patients
Gastric Cancer - Microarray analysis reveals NOL8 overexpression in diffuse gastric cancer
Gastric Reflux - Reflux recurrence after surgery for Barrett syndrome precedes adenocarcinoma
Gastroenterology - H. pylori causes chronic gastritis in p53-knockout mice
Gastroenterology - HSC-39 cells capture the significance of Epstein-Barr virus in gastric cancer
Gastroenterology - Neurokinin receptors are targets for treating GI disorders and pain
Gastroenterology - Triple therapy tackles metastasis in human colon cancer xenografts
Gastroenterology Vaccine - Apical membrane receptors in intestine are targets for vaccine delivery
Gastrointestinal Disorder - Approval granted to market generic versions of lansoprazole in Spain
Gene Expression Systems - External heat treatment controls gene activation in muscle cells
Gene Regulation - Ets gene PEA3 assists beta-catenin-Lef-1/c-Jun in OPN transcription regulation
Gene Transfection - Hyperthermia augments lipofection-mediated transduction in lung cancer cells
Gene Transfer - Branched polymer guides plasmids into brain-derived cells
Generic Drugs - FDA approves two products as Levoxyl bioequavalent
Generic Drugs - Lannett announces the approval of its levothyroxine sodium product
Genetic Engineering - Mutant insulin-like growth factor receptor reduces tumor growth and invasion
Genomics - Hepatitis C virus type 2a subgenomic replicons thrive in human liver cells
Genomics - ICOS enters chemogenomics collaboration
Genomics - Microarray detection of transcription factor-binding motifs enhanced
Genomics - Novel approach improves automation of antibody microarray analysis
Genomics - Polymorphic GATA site in IL-12R beta 2 promoter region affects transcription
Genomics - SARS Coronavirus siRNA inhibitors achieve prophylactic and therapeutic effects
Genomics - Spatial genome organization reviewed
Genomics & Genetics - Gene guns useful for cellular delivery of lipophilic dyes
Genomics & Genetics - Mixture modeling can improve quality of DNA microarray data
Genomics & Genetics - Rare point mutation found in Han population of Guangdong China
Genomics & Genetics - Transcription factor essential in promoting Tomm70 gene expression
Genomics & Genetics - Ultraconserved elements in the human genome reviewed
Germ-Cell Tumors - Herv-K(HML-2) Gag/Env antibodies may indicate treatment response
Global Health - WHO: Target for HIV treatments will be reached
Glycemic Control - Diabetes management program improves patient outcomes at modest cost
Gout - Cardiome receives FDA approvable letter on oxypurinol for gout
Group Purchasing - Premier Purchasing to offer Prospera brachytherapy sources
Gynecologic Cancer - Alfa-epoietin can improve anemia in patients with gynecological cancer
Gynecology - Vascular endothelial growth factor levels rise in ovarian cancer patients
HIV Diagnosis - FDA approves OraQuick HIV-1/2 test to detect HIV-2 in oral fluid
HIV/AIDS - P24 tag useful tool for purifying and detecting recombinantly expressed scFvs
HIV/AIDS Prevention - CDC awards $2.2 million for study of topical microbicide
HIV/AIDS Research - Antigen-specific T cells migrate away from CXCR4-binding HIV-1 gp120
HIV/AIDS Research - Association not found between CCL3-L1 absence and HIV-1 infection susceptibility
HIV/AIDS Research - Furin processing likely mechanism for inactivating extracellular HIV-1 Tat
HIV/AIDS Research - Grant to fund assessment of HIV replication capacity
HIV/AIDS Research - HIV-1 RT and integrase proteins interact during viral replication
HIV/AIDS Research - HIV-1 immune response differs in exposed seronegative and seropositive partners
HIV/AIDS Research - Integrase plays important role during the RT step of the HIV life cycle
HIV/AIDS Research - Potential protective effect of HLA DQB1*06 alleles on course of HIV disease
HIV/AIDS Research - Structural/thermodynamic escape mechanism found from HIV-1 protease mutation
HIV/AIDS Research - Subtype D HIV-1 isolated from untreated individual highly resistant to NNRTIs
HIV/AIDS Research - TARTAR dimer therapeutic target for treatment of HIV-1 infection
HIV/AIDS Therapy - ART efficacy after protease inhibitor failure better in NNRTI-naive patients
HIV/AIDS Therapy - Atazanavir is a new option for treatment of HIV infection
HIV/AIDS Therapy - Compassionate use program expanded for Tipranavir
HIV/AIDS Therapy - Enfuvirtide safe and effective for adult and pediatric HIV-1 infection
HIV/AIDS Therapy - HAART effects survival and surrogate markers in vertically HIV-infected children
HIV/AIDS Therapy - Methadone plus HAART can be implemented with good results in HIV-infection
HIV/AIDS Therapy - New Drug Application submitted to FDA for Invirase 500-mg tablet formulation
HIV/AIDS Transmission - HLA-DRB1 and -DQB1 variants associated with HIV-1 transmission events
HIV/AIDS Transmission - South Africa: Nevirapine still dispensed to prevent vertical transmission
HIV/AIDS Treatment - Alabama may get funds to help AIDS patients get medicines
HIV/AIDS Treatment - CC-chemokine levels lack correlation with HIV-1 stage and response to treatment
HIV/AIDS Treatment - Combination therapy reduces mother-to-child transmission rate to below 2%
HIV/AIDS-Related Disease - CdCSH1p may have a role in adhesion of C. dubliniensis to fibronectin
HIV/AIDS-Related Disease - Chemokine-induced signaling pathways may mediate cell growth in Kaposi sarcoma
HIV/AIDS-Related Disease - Novel therapies developed for treatment of AIDS-related Kaposi sarcoma
HIV/AIDS-Related Disease - Prevalence of P. carinii mutations increased in the United States
HIV/AIDS-Related Disease - QTD PCR of oral-wash samples accurate and noninvasive for diagnosis of PCP
Head & Neck Cancer - Olfactory neuroblastomas are genetically distinct entities
Head & Neck Cancer - Sequential therapy stimulates apoptosis in human oral cancer cells
Health Education - Company releases multilanguage hepatitis B educational materials
Healthcare Coverage - Medicare-approved U Share Prescription Drug Discount Card announced
Heart Disease - Cardiac monitoring essential in patients with blood disorder
Heart Transplantation - Cardiac xenotransplantation may be feasible in the future
Hematology - Multiple myeloma patients require screening before receiving thalidomide
Hematology - Stimulated CD40 ligand stops mantle cell lymphoma proliferation
Hemodialysis - Diagnostic model helps detect cardiomegaly in dialysis patients
Hepatitis B Therapy - Phase II/III hepatitis B trial initiated
Hepatitis C Therapy - Nonexclusive HCV license granted to Prosetta
Hepatitis Transmission - Viral hepatitis transmission in ambulatory health settings reviewed
Hepatitis Virus - Novel class of phosphonate nucleosides potent and selective anti-HBV agent
Hepatotoxicity - Plasma tests for Ser-249 TP53 mutations disclose liver cancer status
Herpes Vaccine - Dendritic cell vaccine transfers herpes resistance to naive mice
Herpesvirus - Theta defensins protect cells from HSV by inhibiting viral adhesion/entry
Herpesvirus Research - Kaposi sarcoma-associated herpesvirus protease highly specific
High Blood Pressure/High Cholesterol - Caduet available for treatment of high blood pressure and high cholesterol
Hypothyroidism - Pharmaceutical company begins shipping generic Levothyroxine sodium tablets
Immunoassays - AxSYM diagnostic testing menus expanded in U.S.
Immunogene Therapy - Immunoporters permit tumor-specific targeting
Immunology - Antiviral cytokines induce granzyme B inhibitor/PI-9/SPI-6 hepatic expression
Immunology - B cells may trigger intestinal inflammation in inflammatory bowel disease
Immunology - BAFF dependence underlies reduced survival of autoantigen-engaged B cells
Immunology - C-terminal Src kinase regulates acute inflammation and granulocyte adhesion
Immunology - CD8 cells have unique secretory compartment for RANTES storage
Immunology - CGRP down-regulates IL-2 and IFN-gamma and up-regulates IL-4 production
Immunology - Complement-derived peptides regulate mast cell activation
Immunology - Costimulatory receptor programmed death-1 characterized
Immunology - CpG DNA redirects class-switching towards Th1-like Ig isotype production
Immunology - Cryo-electron tomography used to characterize individual IgG molecules
Immunology - Cutaneous immune sensitization is enhanced by antigen-independent IgE effects
Immunology - Dendritic cell expression of Ig-like transcripts characterized
Immunology - Epitope-specific cells don't lead hepatic injury in hepatitis B patients
Immunology - Granzyme M mediates a novel form of perforin-dependent cell death
Immunology - HDAC6 deacetylase links tubulin cytoskeleton with immune synapse
Immunology - I175E substitution converts Newcastle disease virus HN to an F-interactive form
Immunology - IFN-alpha priming results in a gain of proinflammatory function by IL-10
Immunology - IL-18 may affect B-cells through paracrine actions
Immunology - IL-4 uses IL-13Ralpha1 to induce Th1 cell apoptosis in neonates
Immunology - IL-8 complexes may be involved in lung inflammation pathogenesis
Immunology - Invariant Valpha 14 NK cell activity elucidated
Immunology - LC cysteine proteases limit cartilage derived CII-reactive T cell presentation
Immunology - Ly6Chi helper T cells regulate plasma cell production
Immunology - Notch 1 signals regulate peripheral T-cell activation
Immunology - Notch inhibition biases rat thymocytes towards NK cell lineage
Immunology - Notch ligands differentially instruct Th cell fate
Immunology - Phage protein confers resistance to lactococcal abortive mechanism
Immunology - Poly(I:C) may be one of the most appropriate agents to generate stable mature DC
Immunology - Potential uses of RapidMist technology in transmucosal vaccines discussed
Immunology - Pre-B cell receptor checkpoint function reviewed
Immunology - Pro- and anti-inflammatory cytokines differentially regulated by PKC isoforms
Immunology - Probabilistic regulation of IL-4 production in Th2 cells characterized
Immunology - Regulatory CD38 activity clarified
Immunology - RhoA and zeta PKC control different modes of chemokine-induced LFA-1 activation
Immunology - Role of ICOS signaling elucidated
Immunology - Salbutamol has specific effects on IFN-gamma, IL-10, and TGF-beta
Immunology - Somatic antibody mutations can alter superantigenic and polyreactive binding
Immunology - Somatic hypermutation occurs in immature murine B cells
Immunology - Sts-1 and -2 proteins regulate TCR signaling
Immunology - T-cell CD154 expression reduced in autoimmune thyroid disease
Immunology - TLR3 isoform cloned and characterized
Immunology - TPPII trims proteasomal degradation products for MHC-I presentation
Immunology - Toll-like receptor ligands directly promote activated CD4+ T cell survival
Immunology - p38 MAPK pathway critical for CD40L-mediated up-regulation of CD83
Immunosuppression - Therapy combining cyclosporin and sirolimus causes thrombotic microangiopathy
Infection - Neulasta lowers infection rate in myelosuppresive chemotherapy study patients
Infectious Disease - Lactobacillus-induced aortic endocarditis reported
Infectious Disease - Brugia Rapid test detects filaria-specific IgG4 antibodies in endemic areas
Infectious Disease - Cryptococcocis often causes death in liver transplant candidates
Inflammation - IL-6 mediates hypoferremia of inflammation by inducing hepcidin
Inflammation - VP015 reduces markers of inflammation in the brain, published data shows
Inflammatory Bowel Disease - Role of defensins in inflammatory bowel disease pathogenesis outlined
Influenza Vaccine - Organization advocates improving worker influenza immunization rates
Influenza Virus - Activity of analogs of influenza hemagglutinin fusion peptide described
Information Technology - Company announces advance in on-line access to clinical-trial information
Information Technology - Company launches unified platform for eCDM: RAVE 5.0
Information Technology - Company unveils product registration, submission lifecycle-management solutions
Information Technology - LifeSignals platform to include Enterprise ECG data warehousing solution
Insulin - Insulin under amyloidogenic conditions indicates protein-folding
Interventional Cardiology - European scientific panel recommends approval of Angiox
Joint Replacement - Wear patterns of UHMWPE hip liners characterized
Keratoconjunctivitis Sicca - Microvascular submandibular gland autotransfer effective
Kidney Disease - Statins may stave off kidney problems in patients with heart disease
Labeling - USP seal intented to help consumers locate quality supplements
Legal Issues - Biopharmaceutical company announces favorable ruling in antitrust case
Legal Issues - Brewery, Geron settle lawsuit
Legal Issues - Group seeks to block enforcement of title II of DC Access Rx act
Legal Issues - Judge acquits two TAP Pharmaceutical employees in bribe case
Legal Issues - Three in Rite Aid scandal begin prison terms
Leucoplakia - Expression of heat shock protein elevated in oral leucoplakia
Leukemia - Differentially expressed molecules in adult T-cell leukemia cells identified
Leukemia Diagnostics - Annexin A1 screen useful for hairy cell leukemia diagnosis
Licensing Agreement - Company moves forward with flu virus yield-enhancement technology
Lipid Studies - Infrared methodologies for trans fat determination reviewed
Lipid Studies - LDL apheresis can attenuate acute anterior ischemic optic neuropathy
Lipid Studies - Silver-ion HPLC improves identification of linoleic acid isomers
Lipogenesis - Rat liver lipogenesis is modulated by interleukin-15
Lipoprotein - The Rosuvastatin GALAXY Program studies cardiovascular risk reduction
Liver Cancer - Genetic profiles of liver cirrhosis nodules disclose valuable information
Liver Regeneration - Beta-2-GPI is growth regulated and plays role as survival factor for hepatocytes
Low Birth Weight - Early exposure to dexamethasone has long-lasting effects on neurodevelopment
Lung Cancer - FISH analysis of p53 and chromosome 17 has limited prognostic value
Lymphoma - Recurrent syncope can mark Burkitt lymphoma at carotid bifurcation
Malaria - Plasmodium linked to severe childhood malaria expresses PfEMP1
Malaria - CLAG 9 is located in rhoptries of Plasmodium falciparum
Malaria Vaccine - Progress in DNA-based immunization strategies for malaria reported
Market Analysis - Between 25% and 50% of pharmaceutical companies' revenue comes from licensing
Market Analysis - Biocompatibility to widen the scope of biomaterial applications
Market Analysis - Clinical trials consume 37% of pharmaceutical R&D spending
Market Analysis - Greater usage of disc technology for back pain predicted
Measles Vaccine - Serological response to early measles vaccination described
Medical Devices - Polyimide hollow-fiber oxygenator developed
Melanoma - Soluble EphB4 staunches tumor growth and angiogenesis in murine models
Melanoma Vaccine - Dendritic cell vaccine needs IL-2 for melanoma metastasis efficacy
Menopause - Dentists turn to ERT to promote bone healing around dental implants
Mergers & Acquisitions - Agreement signed for acquisition of Concorde Microsystems
Mergers & Acquisitions - Australian anti-infectives business to be demerged
Mergers & Acquisitions - Closing date of offer on Aventis postponed
Mergers & Acquisitions - Division of Matria Healthcare to be acquired
Mergers & Acquisitions - Firm enters orthopedic, spinal surgery arena through acquisition of NeuColl
Mergers & Acquisitions - Life science company acquires Tetrionics to expand fine chemicals capabilities
Mergers & Acquisitions - Merger agreement with Chromos announced
Mergers & Acquisitions - Merger creates genomics-driven global biotechnology company
Mergers & Acquisitions - Sample-management systems developer acquired
Metastasis - Aclacinomycin reduces tumor cell invasion
Metastasis - Flt-1 gene transfer suppresses gastric cancer peritoneal metastasis
Microarray Technology - CustomArray product line expanded with introduction of CustomArray12K
Microencapsulation - Microparticles for delivery of DNA vaccines developed
Molecular Targets - Polo-like kinase 1 suppression arrests the growth of pancreatic cancer cells
Molecular Toxicology - Toxicology grant awarded from NIH
Molecular Virology - JC virus genotyping offers new paradigm in the study of human populations
Monoclonal Antibody - CNTO 95 blocks alpha(v) integrins to suppress tumors in mice
Morbid Obesity - Anesthetic assessment of morbidly obese patients reported
Mosquito-Borne Disease - Metabolic fate of protein amino acids in mosquitoes determined
Multiple Myeloma - Methylation epigenetically regulates tumor-suppressing genes
Multiple Sclerosis - Cytosolic phospholipase A2 plays a key role in EAE pathogenesis
Multiple Sclerosis - Multiple sclerosis associated with neurofibromatosis type I
Multiple Sclerosis - Taxol induces nitric oxide production in astrocytes
Muscle Relaxant - Anectine short-acting muscle relaxant now available
Muscular Dystrophy - Spinal and bulbar muscular atrophy linked to myotonic dystrophy type 1
Mutagenesis - Dihydropyrazines induce mutagenesis in Escherichia coli
Mutagenesis - Metastatic lesions from head and neck cancers often lose chromosome Y
Mutagenesis - Novel lung cancer cell lines shed light on LKB1 protein activity
Mycobacteria Vaccine - Mycobacterium avium cell fractions used for vaccine development
Myocardial Infarction - Endostatin inhibition would aid collateral vessel growth after heart attacks
Nausea - FDA grants approval for dimenhydrinate injection
Nephropathy - Decoy nucleotides mitigate the formation of diabetic kidney disease
Neurology - Ethanol superior to formalin for mRNA preservation in tissue
Neurology - N-acetylcysteine administration after focal cerebral ischemia protects brain
Neuroprotection - Cysteine prodrugs may be useful neuroprotectors in Parkinson disease treatment
Neuroprotection - Local neurotrophic factor expression rescues motoneurons in study animals
Neuroscience - -RFamide peptides and effects on feeding behavior reviewed
Neuroscience - Brain emboli dissemination after captive bolt stunning can spread BSE in animal
Neuroscience - Cortical and subcortical GABA function may be compromised in schizophrenia
Neuroscience - Delayed genomic responses to murine brain ischemia characterized
Neuroscience - Malignant peripheral nerve sheath tumor cells will advance drug research
Neuroscience - PSD-95 protein involved in psychostimulant-induced plasticity
Neuroscience - Tyrosine phosphorylated disabled 1 recruits Crk family adapter proteins
Neuroscience - Utility of auditory brainstem implants reviewed
Neuroscience - Utility of upper extremity neuroprosthetics reviewed
Non-Hodgkin Lymphoma - Barriers to uptake associated with radioimmunotherapies may hinder market
Non-Small Cell Lung Cancer - Safety issues identified in study of Pivanex in non-small cell lung cancer
Nutritional Supplements - Survey: Consumers confused about the right combination of supplements
Obesity - Ozone hyperresponsiveness observed on airway mechanics in obese mice
Obesity Genomics & Genetics - Candidate genes for obesity reviewed
Obesity Pathogenesis - Gene expression in adipose tissue determined by differential display
Obesity Pathogenesis - Mechanism underlying mature-onset obesity proposed
Obesity Pathogenesis - Proopiomelanocortin neuron inhibition is desensitization in ob/ob mice
Obesity Pathogenesis - Transferase expression liver of transgenic mice causes obesity
Obesity Surgery - Controversies in laparoscopic adjustable gastric banding outlined
Obesity Survival & Mortality - High body mass index improves chronic kidney disease outcome
Ocular Cancer - Ultrasonic 2-D spectrum analysis useful for ocular tumor characterization
Oncogenesis - Hepatitis C virus infection associates with the risk for Hodgkin disease
Oncogenesis - Minimal deleted region clusters locate links to hepatocellular carcinoma
Oncology - Iron ions modify the cytotoxicity of hydroxyketones
Oncology - Kringle 1-5 requires cell surface ATP synthase to stop angiogenesis
Oncovirus - Double-stranded RNA-activated protein kinase declines in HBV-related cancers
Oral Mucositis - Biologics License Application submitted for FDA approval of Palifermin
Oral Mucositis - Preclinical data presented on CG53135
Oral Surgery - Endosseous implant-induced rhino-sinusitis reported
Oral Surgery - Onlay bone grafts with implants effective for severely resorbed maxillae
Orthopedic Surgery - Suture anchor failure in anterior shoulder instability repair reported
Osteoporosis - Are you less likely to be truthful about your weight, age, or height?
Osteoporosis - Floride and bisphosphonates make a nice cocktail for the bones
Osteoporosis - Ibandronate injections must be adequately dosed to provide good therapy
Osteoporosis - Phase I human study initiated for parathyroid hormone osteoporosis product
Osteoporosis - Study finds higher-dose ibandronate regimen effective and safe
Osteoporosis - Teriparatide is expensive but effective against bone loss
Osteoporosis - Zinc-containing beta-tricalcium phosphate has primarily local effect on BMD
Overactive Bladder - Extended-release tolterodine is an effective first-line treatment
Overactive Bladder - Health Canada approves OXYTROL for the treatment of overactive bladder
Pain Medicine - Neurotrophic factors sensitize recombinant vanilloid receptor-1
Pain Medicine - Routine MRI recommended for patients with facial pain
Pain Therapy - Nitric Oxide-enhancing COX-2 inhibitor advanced to phase II testing
Pancreatic Cancer - Phase III trial to study PANVAC-VF in advanced pancreatic cancer
Papillary Thyroid Cancer - JNK activation may play role in pathogenesis
Papillomavirus - All-trans retinoic acid suppresses transcription of HPV16
Parasitology - S. mekongi discovery has implications for schistosomiasis-control strategies
Parasitology - Protozoan gene expression outcomes correlate with regulation mechanism
Parasitology - Type I signal peptidase from Leishmania is a target of the immune response
Parasitology Vaccine - Immunogenicity of novel Theileria parva antigens improved
Parkinson Disease - Guilford licenses U.S. rights to GPI 1485
Parkinson Disease - Nitrosylation of parkin compromises parkin's protective function
Patents - European patent granted for technology to treat gene abnormalities
Patents - FDA applies Duragesic 6-month period of pediatric exclusivity
Patents - Genomics company expands patent portfolio
Patents - ICU Medical announces court order in patent infringement lawsuit
Patents - New patent issued for cell-cycle inhibitor "composition of matter"
Patents - Two patents awarded for applications of electroporation therapy
Pediatrics - Studies reveal high levels of anabolic steroid use by teenagers
Personalized Medicine - Data mining, predictive modeling provided for personalized medicine models
Personnel - Adrian Arima named vice president, general counsel of biotech company
Personnel - Alexander Cappello retires from board of directors at biotech company
Personnel - Australian fellowship to support neurodegenerative disease research
Personnel - Bioactive products developer announces election of board of directors
Personnel - Biopharmaceutical company names new chief scientific officer
Personnel - Biotechnology company names vice president of clinical research
Personnel - Byron Long joins pharmaceutical company as director of oncology research
Personnel - David Walshaw appointed as head of production planning at biocatalysis company
Personnel - Drug discovery company names new member to scientific and medical advisory board
Personnel - Gene-focused biopharma names Gregory M. Landes, PhD, as VP, biotherapeutics
Personnel - Healthcare company announces new board member
Personnel - Ion-channel-target focused company taps Mark J. Suto, PhD
Personnel - Jerry McMahon named chairman of cancer therapeutics company
Personnel - Jesus Leal named president of pharma subsidiary
Personnel - John Greisch named senior VP, chief financial officer at pharma company
Personnel - John Ratliff appointed CFO of pharmaceutical services organization
Personnel - Joseph J. Villafranca, PhD, joins board of cancer-therapy company
Personnel - Laboratory services provider announces retirement of board member
Personnel - Mattingly named VP of business development, marketing for genomics firm
Personnel - Neonatal products company names two board members
Personnel - Oncology company names biotech industry leader as president, CEO
Personnel - Ophthalmology company names Michael J. Regan to the board of directors
Personnel - Pharmaceutical company announces appointment of VP, business development
Personnel - Pharmaceutical company announces new members of oncology advisory board
Personnel - Pharmaceutical company appoints Patricia Allen as VP of finance
Personnel - Pharmaceutical company appoints senior VP, research and development
Personnel - Pharmaceutical company names first chief scientific officer
Personnel - Stephen Chang joins board of directors at cell line production company
Pharmacogenetics - Electrochemical sensor for the uncomplicated detection of "hits" on DNA chips
Pharmacology - Isolates from Aglaia silvestris exhibit potent cytotoxicity
Pharmacy Management - MedGuard bar-code medication-use process solutions showcased at meeting
Physical Activity - Childhood sports involvement predicts participation in sports as adult
Physical Activity - Regular physical activity reduces health care costs among employees
Pneumocystis Carinii Pneumonia - Positive efficacy results reported for DB289 phase II trial for PCP
Pneumonia - Cytokines involved in Mycoplasma pneumoniae infections reviewed
Prescription Drugs - Biotech developing hard-to-abuse version of painkiller Oxycontin
Prescription Drugs - Elan shares jump on possible 'accelerated approval' for MS-fighting drug
Prescription Fraud - Nebraska state senator arrested, accused of prescription fraud
Prostate Cancer - KOS-862 trial in prostate cancer planned, colorectal cancer trial terminated
Prostate Cancer - MMP-13 is androgen-regulated in prostate cancer
Prostate Cancer - Polymer-peptide conjugate targets prostate cancer tumor vessels in study
Prostate Cancer Risk Factor - Diabetes increases risk of prostate cancer
Proteomics - CIEF-RPLC-MS protein analysis system developed
Proteomics - Cellular small ubiquitin-related modifier substrate proteins identified
Proteomics - Der1p required for degradation of proteins of endoplasmic reticulum
Proteomics - Double chip protein array using recombinant scFv fragments developed
Proteomics - Method to assign chemical shifts of aromatic side chains developed
Proteomics - Murine lactoferrin receptor characterized
Proteomics - Novel subcellular extraction procedure facilitates protein analysis
Proteomics - Role of oligomerization domains in thrombospondins outlined
Psoriasis - CHMP gives positive opinion to psoriasis product Raptiva
Psoriasis - Infliximab shows promise for treatment of refractory pustular psoriasis
Rabies Vaccine - Prevention, and treatment of rabies reviewed
Receptor Studies - A Paeonia lactiflora root derivative compromises angiogenic growth
Receptor Studies - Angiotensin receptor inhibits ERK-2 activity via signaling pathway
Receptor Studies - Mutation delineates role of melanocortin-4 receptor in humans
Receptor Studies - Ras-GRFs play couple NMDA glutamate receptors to Ras, Erk, and CREB
Refractory Cancer - Davanat with 5-FU well tolerated in study patients with advanced solid tumors
Renal Disease - Utility of testosterone replacement therapy in ESRD patients reviewed
Respiratory Medicine - Novotizer dry powder inhaler superior to Turbuhater
Restenosis - Vein grafts remain patent following adenovirus-mediated gene delivery
Retroviral Infection - CD4+ regulatory T cells contribute to viral persistence
Retrovirology - Lentiviral and MLV based retroviral vectors for gene transfer elucidated
Retrovirology - Luciferase-based assay rapid and sensitive for detection of retrovirus entry
Rheumatoid Arthritis - Indications for etanercept reviewed
Rheumatoid Arthritis - Remicade approved in European Union for treatment of early rheumatoid arthritis
Rheumatology - Chondrosarcomas lack tumor-specific chromosome changes
Salmonella - Large pathogenicity island in Salmonella enterica excised
Salmonella - RpoA contribution to stimulation of Salmonella promoter outlined
Schizophrenia - Abilify launched in Europe
Schizophrenia - Dysbindin-1 reduced in hippocampus of schizophrenia patients
Sex Chromosome - XY body is a specialized meiotic chromatin domain
Sexual & Reproductive Health - Parental supervision may reduce the risk for certain STDs in adolescents
Sexual & Reproductive Health - Test chemical increases sexual appetite in female rats
Sickle Cell Anemia - LifeShirt System used in study of sickle cell anemia and nocturnal hypoxia
Sjogren Syndrome - GRAP gene may be involved in Sjogren syndrome pathogenesis
Skin Cancer - Basal cell carcinomas in xeroderma pigmentosum patients have distinct mutations
Smallpox Vaccine - Mass smallpox vaccination does not increase cardiac death rate
Smallpox Vaccine - Ring vaccination for smallpox control outlined
Snake Venom - Kininogen inhibits metalloproteinases of Bothrops jararaca venom
Solid Tumors - Canstatin-C arrests endothelial cell-associated tumor growth
Sports Medicine - Heart medication may significantly reduce shoulder pain
Squamous Cell Cancer - Dynamic contrast-enhanced MRI depicts the early effects of DC101 on tumors
Stem-Cell Research - E2A-deficient hematopoietic progenitors are pluripotent after long-term culture
Stem-Cell Research - Genetically modified stem cells reverse neurodegenerative symptoms in mice
Stem-Cell Transplantation - Heart allografts from donors lacking Flt3 ligand exhibit prolonged survival time
Stem-Cell Transplantation - RAG-1 is a suitable mouse model for mitochondrial DNA disease
Streptococcus Vaccine - PADRE-ASREAK peptide induces mucosal immune response to Streptococcus
Stroke - Panel releases expert report to improve treatment of acute stroke
Thalidomide - Evolving indications for thalidomide reported
Thrombosis - MATCH trial results: Adding aspirin to clopidogrel does not reduce stroke risk
Thyroid Cancer - Galectin-3 immunoassay facilitates diagnosis of occult papillary thyroid carcinoma
Thyroid Cancer - Genetic markers for malignant thyroid tumors identified
Thyroid Cancer - Insular phenotypes suggest unfavorable outcomes for thyroid carcinoma patients
Tibial Fixation - Bio-Intrafix launched for ACL repair
Transfusion-Transmitted Virus - TT virus can replicate in bone marrow as well as in the liver
Transplant Medicine - Graft dysfunction may lead to hepatic steatosis after islet transplantation
Tuberculosis Vaccine - Tuberculosis immunology in children reviewed
Tumor Suppression - Flavopiridol sensitizes cells to apoptotic stimuli
Tumorigenesis - Akt and hypoxia-inducible factor-1 activate tumor growth independently
Tumorigenesis - SPARC glycoprotein regulates host tissue response to tumor growth
Type 1 Diabetes - Activation-induced cell death in T cells reduced in diabetic patients
Type 2 Diabetes - Israel-based pharmaceutical company receives FDA approval for Metformin HCl
Type 2 Diabetes - Pharmaceutical company receives approval to market metformin hydrochloride
Urge Incontinence - Transdermal therapy for urge incontinence approved for marketing in E.U.
Urology - COX-2 inhibitors have little effect against renal and urological cancers
Urology - Darifenacin improves quality of life for those with overactive bladder symptoms
Vaccine Adjuvant - New model of NK cell deficiency provides insight into role of adjuvant
Vaccine Development - Antigen-immunostimulatory oligonucleotide conjugates reviewed
Vaccine Development - CD8+ T cell cross-priming occurs via transfer of proteasome substrates
Vaccine Development - Expression library immunization can improve vaccine antigens
Vaccine Development - Preventing HLA-A2-restricted peptide modification enhances antigenicity
Vector Development - Cutaneous gene transfer widens options for systemic gene delivery
Venous Stasis Ulcers - Clinical trial to test TB4 for the treatment of venous stasis ulcers
Venous Thromboembolic Events - Oral and injectable Exanta launched in Germany for prevention of VTE
Ventilator-Associated Pneumonia - Iseganan trial stopped for safety reasons
Viral Infection - DoD awards additional $2.18M for development of norovirus vaccine, therapeutics
Virology - 3' untranslated region of swine fever virus influences RNA synthesis
Virology - Amino acid variations in CTL epitopes can affect virus-specific CTL response
Virology - E.U. research fights killer viruses' stubborn resistance to drugs
Virology - Heat shock protein 60 is important for hepatitis B virus protein activity
Virology - Herpesvirus protein degrades MHC-I peptide loading complex
Weight Loss - Adiponectin acts in the brain to decrease body weight
Weight Loss - Glycyrrhetinic acid exerts differential effects in obese and lean rats
West Nile Virus - West Nile virus control dependent on animal monitoring and disease research
Wilms Tumor - SIOP trials and studies evaluate the prognosis of Wilms tumor patients
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