Drug Delivery
Implanted doxorubicin localizes at healing tissues in ablated rat livers
Published in Drug Week, July 23rd, 2004
According to research from the United States, "in this study, we report the histological findings of a combined therapy using radiofrequency ablation and intratumoral drug delivery in rat livers, with special attention to wound-healing processes and their effects on drug transport in post-ablated tissue. Doxorubicin-loaded millirods were implanted in rat livers that had undergone medial lobe ablation. Millirods and liver samples were retrieved upon animal sacrifice at time points ranging from 1 hour to 8 days."
"Results demonstrate a clearly defined area of coagulative necrosis...
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Source: Drug Week (2004-07-23)
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