Immunology
LC cysteine proteases limit cartilage derived CII-reactive T cell presentation
Published in Drug Week, July 23rd, 2004
According to recent research published in the journal International Immunology, "Development of type-II collagen (CII)-induced arthritis (CIA) is dependent on activation of CII-reactive T cells. Dendritic cells (DCs) are believed to play a crucial role in antigen-specific priming of T cells but it is still unclear how the CII-reactive T cells are primed since Langerhans cells (LCs) are poor antigen-presenting cells for CII."
"In the present study we show that LCs, treated with cysteine protease inhibitors, are able to process and present CII to...
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Source: Drug Week (2004-07-23)
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