Published in Drug Week, July 23rd, 2004
According to recent research from France, "Expression of the cellular prion protein (PrPc) by host cells is required for prion replication and neuroinvasion in transmissible spongiform encephalopathies. As a consequence, identification of the cell types expressing PrPc is necessary to determine the target cells involved in the cerebral propagation of prion diseases."
"To identify the cells expressing PrPc in the mouse brain, the immunocytochemical localization of PrPc was investigated at the cellular and ultrastructural levels in several brain regions. In...
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