Neurology
Ethanol superior to formalin for mRNA preservation in tissue
Published in Drug Week, July 23rd, 2004
"Although RNA can be retrieved from formalin-fixed, paraffin-embedded (FFPE) tissues, the yield is low, and the RNA is fragmented," scientists in the United States explained. "Recent advances in gene expression profiling underscore the importance of identifying a fixative that preserves histology and mRNA."
In a recent study, J.M.F. Su and colleagues at the Texas Children's Cancer Center found that, "for immersion fixation of brains, 70% ethanol is superior to formalin for mRNA preservation."
"RNA yield from ethanol-fixed tissues was 70% of the...
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Source: Drug Week (2004-07-23)
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