Drug Week
Susan Hasty, Publisher
Table of Contents . . . August 6th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Drug Week | Other Publications
Allergy Medicine - Heat-sensitive method tests effectiveness of allergy meds
Alzheimer Disease - Enrollment closes in phase III trial with Phenserine
Hypogonadism - North American rights acquired for Andrin
Invasive Pneumococcal Disease - CDC recommends resumption of third dose of Prevnar
Periodontitis - Company reports positive results from Periostat + Atridox study
AIDS Therapy - Up-front cost for treating HIV-infected patient in Africa is US$30 per visit
Acute Lymphoblastic Leukemia - Novel FLT3 inhibitors may be considered to treat hyperdiploid or relapsed ALL
Acute Myeloid Leukemia - FLT3 mutations in AML adversely associate with CR with intensive chemotherapy
Acute Myeloid Leukemia - Factors affecting good and poor CD34+ cell mobilization in AML determined
Acute Myeloid Leukemia - Timed sequential therapy for AML patients over 60 tolerated but unsatisfactory
Addiction Medicine - G protein regulators play key role in cocaine seeking
Adipogenesis - Flow cytometric method used to assess lipid accumulation in fat cells
Adipose Tissue Tumors - Malignant adipose tissue tumors reviewed
Adverse Drug Events - University of Florida teams with Tufts on food and drug interactions
Allergies - Academy reacts to FDA alert on allergic reactions to pigment in permanent makeup
Allergy Medicine - FDA approves phase III study design for PreHistin
Allergy Medicine - Novel approach to specific allergy treatment developed
Allergy Medicine - Tentative approval granted for Allegra-D extended-release tablets
Alzheimer Disease - Effect of citalopram on lymphocyte gene expression characterized
Alzheimer Disease - Enoxaparin shows promise as therapy
Amyotrophic Lateral Sclerosis - Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor
Amyotrophic Lateral Sclerosis - Nerve cells' powerhouse "clogged" in Lou Gehrig disease
Anal Fissures - U.K. gives Cellegesic nod to treat chronic anal fissure pain
Angina - Agreement with FDA reached on clinical development program for diltiazem
Angiology - Pathway of platelet procoagulant activity is regulated by IQGAP1
Angiology - STI571 and taxol target skeletal compartment tumor-associated cells
Anti-Infectives - Meropenem lung penetration measured by microdialysis
Antibiotics - Pharmacists highlight antibiotic misunderstanding and overuse in public survey
Antimicrobial Resistance - Role of mhc polymorphism in anti-microbial resistance reviewed
Antioxidants - Antioxidants prevent exercise-induced lipid peroxidation
Antipsychotic Therapy - Antipsychotics upregulate bcl-2 mRNA/protein in frontal cortex and hippocampus
Antiretroviral Therapy - Styrylquinolines do not interfere with HIV entry but act before integration
Antisense Technology - New methods ease the separation of antisense oligonucleotide in plasma
Anxiety Disorder - Serotonin transporter gene variation correlates with social phobia severity
Apoptosis - Akt kinase activation blocks apoptosis in intestinal epithelial cells
Apoptosis - P300 regulates p53-dependent apoptosis in colorectal cancer cells
Arrhythmia - Effectiveness of ablation for atrial fibrillation has not been established
Arthritis - Roles of IL-18 in collagen-induced arthritis investigated
Arthritis - Vioxx in high doses causes hypertension
Arthritis Therapy - Bovine collagen peptide vaccine modulates severity of arthritis
Aspergillosis Therapy - Thymosin alpha 1 activates dendritic cells for antifungal resistance
Asthma - European approval sought for Xolair as treatment for severe allergic asthma
Asthma - Hundreds of athletes with asthma compete in Athens
Asthma - Physicians fail to prescribe proper medication for asthma patients
Atherogenesis - Oxidized lipids, antibodies may be markers for atherogenesis
Atherosclerosis - Low-density lipoprotein should be between 50 and 70 mg/dl
Atherosclerosis - Some lipid-lowering drugs can stabilize atherosclerotic plaque
Atherosclerosis - Statins promote collateral neovascularization without causing cancer growth
Australian Cancer Technology - U.S. pharmacy group to distribute nutritional supplement
Awards - Pharmaceutical innovation award program announced
Biochemistry - Non-electrophoretic assays screen for chemical inhibitors of DNA ligase
Biochemistry - Nucleoside insertions stabilize oligonucleotides
Biomarker - Oligonucleotides in human urine don't contain oxidized lesions
Biomedical Imaging - Imaging agent launched for preclinical computed tomography
Biotechnology - Biosensors identify DNA binding at the single molecular level
Bioterrorism - Congress OKs bill to create vaccines, antidotes to biological, chemical weapons
Bloom Syndrome - BLM and CAF-1 coordinate to promote survival in response to DNA damage
Bone Regeneration - Local gene therapy improves bone deposition during distraction osteogenesis
Bone Regeneration - PCL-TCP scaffolds seeded with osteoblasts sustains osteogenic expression
Bone Regeneration - PRDC is a potent BMP antagonist with a wide tissue expression pattern
Botulism Vaccine - Vaccination with botulinum neurotoxin fragments prevents botulism
Brain Cancer - Vaccine targeting cancer-related antigens appears to prolong survival
Breast Cancer - Cancer therapeutics development company files IND for metastatic breast cancer
Breast Cancer - ER codon 594/HER2 codon 655 polymorphisms not associated with breast cancer risk
Breast Cancer - Increased serum folate levels associated with reduced breast cancer risk
Breast Cancer - Novel phosphorylation sites in HMGN1 protein from breast cancer cells identified
Breast Cancer - Tamoxifen metabolite R-isomer forms more DNA adducts in liver cells
Breast Cancer Therapy - Slow release rate optimal for pegylated liposomal doxorubicin
Buruli Ulcer Disease - Buruli ulcer disease in Cameroon rediscovered
Business & Finance - Medical technology company lists on London AIM Exchange, reports on options
Business & Finance - Personal care products marketer applies for NASDAQ national market listing
Business & Finance - Pharma company announces exercise of over allotment option
Business & Finance - Pharmaceutical company added to Russell 2000 Index
Business & Finance - Pharmaceutical group announces that joint venture is operational
Business Update - Alprox-TD license, supply and distribution agreement signed with Schering
Business Update - Approval received to market Lyrica in Europe
Business Update - Biopharmaceutical company announces contract with GlaxoSmithKline
Business Update - Biosafety lab expansion, patent issuance and biodefense reagents sale announced
Business Update - Biotech firm establishes new international headquarters
Business Update - Certificate of Suitability granted for Cephradine
Business Update - Decapinol approved in EU; Aloclair Gel approved in U.S.
Business Update - Drug discovery company spins off peptide technologies business unit
Business Update - FDA approval granted for new biopharmaceutical production plant
Business Update - First payment made in Therapik multi-year agreement
Business Update - Licensing agreement forged for antiphospholipid therapy technology
Business Update - Ligand announces $1 million milestone payment
Business Update - London biotech company moves to The Stiller Centre for Biotechnology
Business Update - New contracts announced for biodefense-related contract work
Business Update - New health/pharmaceutical government staff directory launched
Business Update - Nine of top ten pharmaceutical companies attend user conference
Business Update - Pharmaceutical company announces E.U. regulatory approval for T-GO
Business Update - Pharmaceutical company enters license agreement for SubQ aesthetic product
Business Update - Pharmaceutical company seeks new independent auditor
Business Update - Pharmaceutical firm works to become advanced drug discovery chemistry provider
Business Update - Prudencia selects online pharmacy for mail order services
Business Update - UnitedHealth beats Street by a penny
Cancer Diagnosis - Early stage cancers could be predicted with accuracy by confocal laser endoscopy
Cancer Markers - Molecular markers useful to detect various stages of non-small-cell lung cancer
Cancer Pain - Biopharmaceutical company announces promotion agreement for Kadian
Cancer Therapy - Catalytic antioxidant inhibits tumor regrowth following radiation therapy
Cancer Therapy - DNABarrier cancer treatment licensed to Chinese biotechnology corporation
Cancer Therapy - Effects of P-glycoprotein inhibitors on paclitaxel uptake clarified
Cancer Therapy - First batch of cGMP paclitaxel produced by manufacturer
Cancer Therapy - Mechanics of girolline antitumor activity elucidated
Cancer Therapy - Nanomedicine global developments and growth opportunities explored
Cancer Therapy - National Cancer Institute grant received to develop multiplex cell assay
Cancer Therapy - Patent issued for method to predict effectiveness of chemotherapy
Cancer Therapy - Pharmaceutical company applies for European agency approval of oral cancer drug
Cancer Therapy - Potential of TOR pathway as cancer therapy target reviewed
Cancer Vaccine - Alloantigen presentation linked to CTL antigen response
Cancer Vaccine - Antennapedia transduction sequence promotes antitumor immunity
Cancer Vaccine - Autologous lymphoma vaccines induce T cell responses against epitopes
Cancer Vaccine - DNA fusion gene vaccines against cancer reviewed
Cancer Vaccine - NY-ESO-1-related HLA A2-restricted epitopes characterized
Cancer Vaccine - Reduced L-selectin expression identifies tumor-specific type 1 T cells
Cancer Vaccine - SSX-2 epitope presented by dendritic cells to CD4+ T cells identified
Cancer Vaccine - TCR DNA vaccine induces humoral response for lymphoma beta chain
Cancer Vaccine - Transfection of tumor antigens generates cytotoxic T lymphocytes
Candida - Method to quantify drug resistance gene expression in Candida developed
Carcinogens - Mechanism of benzene-induced leukemia elucidated
Carcinogens - VEGF is a mediator of PCB 104-induced breast cancer cell invasion
Cardiac Development - Disturbed lymphangiogenesis underlies fetal heart malformation
Cardiology - Gene therapy shows promise for treating cardiovascular disease
Cardiovascular Disease - AI-700 collaboration, license and supply agreement forged with Acusphere
Cardiovascular Disease - Tirofiban and ICT used to recanalize occluded coronary artery
Cardiovascular Disease Model - Cyclic nucleotides may be novel target for care of cardiovascular diseases
Cardiovascular Instability - Safe practices for spinal anesthesia during caesarian section given
Cardiovascular Surgery - Endothelial progenitor cell mobilization encourages aortic repair
Catabolism - Role of ghrelin in catabolism reviewed
Cataplexy - Prescriptions increase for cataplexy associated with narcolepsy
Cell Biology - Integrin alphav beta3 is involved in leukocyte-induced angiogenesis
Cell Biology - Store-operated calcium ion entry regulates vascular smooth muscle gene activity
Cell Biology - Tim50 suppression sensitizes human cells to death stimuli
Cell Regulation - Ectopic cyclin D1 expression blocks STI571-induced erythroid differentiation
Central Nervous System - Proteomic analysis of rat brain postsynaptic density fractions reported
Central Nervous System - Rho activated in injured axons following spinal cord injury
Chemotherapy - Low-dose metronomic cyclophosphamide offers advantages to cancer patients
Chemotherapy - MAX2 reproducibly estimates average per patient risk for chemotherapy toxicity
Chemotherapy - siRNA against NF-kappaB p65 subunit enhances sensitivity to chemotherapeutics
Cholesterol - OTC statin options discussed at inaugural meeting of Midwest Lipid Association
Chronic Hepatitis C - Key hepatitis C-virus proteins rule interferon resistance mechanisms
Chronic Lymphocytic Leukemia - Alemtuzumab effective therapy for CLL with p53 mutations and deletions
Chronic Muscle Pain - Mechanisms of transition from acute to chronic muscle pain
Chronic Myelogenous Leukemia - IL-11 may improve thrombocytopenia associated with imatinib therapy in CML
Clinical Cell Culture - GMP approval granted by Belgium authorities for CellSpray manufacture
Clinical Trial - Endo Pharmaceuticals announces agreement for Oxymorphone ER trial design
Clinical Trial - Process uses riboflavin and light to reduce pathogens in donated blood
Clinical Trials - Company reiterates guidance for STRIDE-2 trial enrollment
Coccidioidomycosis - Efficacy of lipid amphotericin B formulations compared
Cognition - Antisense knockdown of drebrin A produces cognitive function deficits
Collaborations - Agreement signed for Kadian in cancer pain
Collaborations - Agreement signed for glaucoma, ocular hypertension treatment
Collaborations - Agreement signed with Artemis Pharmaceuticals for transgenic mice
Collaborations - Agreement with Nycomed for development of Oxygent terminated
Collaborations - Alliance formed for point-of-care CD4 monitoring for HIV/AIDS patients
Collaborations - Alliance signed to market, distribute cholesterol assay, nutrients
Collaborations - Companies agree to discontinue codevelopment of abciximab in Japan
Collaborations - Crucell, alliance partner, report protein-production milestone
Collaborations - Exclusive license agreement signed to commercialize Tostrex gel in Europe
Collaborations - Five-year agreement signed for manufacture of cell cassettes
Collaborations - Genomics application licensed from Stanford University
Collaborations - Microarray platform licensed to University of Nottingham
Collaborations - New development program signed with Innovata Biomed
Collaborations - Perrigo named as U.S. pharmaceutical firm in licensing agreement for Tabwrap
Collaborations - Research deal signed to study epilepsy animal models
Collaborations - Tech company signs agreement with cell signaling products maker Upstate
Colonoscopy - Positive phase II study results reported for INKP-102 purgative product
Colorectal Cancer - Sequential proteome alterations during genesis and progression of colon cancer
Complementary & Alternative Medicine - Herbs and spices have antimicrobial and chemopreventive properties
Complementary and Alternative Medicine - Bio-One says second quarter revenue to exceed $13 million
Congenital Heart Defects - Researchers develop milrinone pharmacokinetic model in children
Congestive Heart Failure - Beta-blocker drugs well tolerated for heart failure patients
Continuing Medical Education - Doctors support pharmaceutical industry involvement in CME, survey shows
Contraception - New delivery systems in contraception include vaginal rings
Coronary Artery Constriction - CuZn-superoxide dismutase may maintain perfusion in mouse coronary artery
Coronary Artery Disease - Carvedilol prevents cardiac remodeling in coronary artery disease
Coronary Heart Disease - Studies show Lovenox as an effective treatment of acute coronary syndromes
Cytomegalovirus - Cytomegalovirus control after stem cell transplant is inconsistent
Cytomegalovirus - Real-time qPCR more sensitive than COBAS Amplicor for CMV DNA detection
DNA Repair - 53BP1 required for class switch recombination
DNA Vaccine - Microparticles act as carriers to deliver plasmid DNA in vaccines
Data Mining - Discordant data from microarray platforms make drug research challenging
Depression - ACE polymorphism affects therapeutic outcome in depressed women
Depression - Zinc stimulates cortical brain-derived neurotrophic factor gene expression
Dermatology - Genetic studies of psoriasis susceptibility should focus on the PSORS1 locus
Dermatology - Protopic more effective for eczema in children than pimecrolimus
Dermatology - Reconstructed skin model useful for drug evaluation
Dermatology - Recruitment complete for Phase II trial of AVAC in childhood eczema
Diabetes Pathogenesis - Central tolerance plays key role in pathogenesis of type 1 diabetes
Diabetes Pathogenesis - Integrins and Src involved in insulin signaling in rat liver
Diabetes Pathogenesis - Natural killer cells distinguish forms of pancreatic islet autoimmunity
Diabetes Risk Factor - Relation between schizophrenia and diabetes described
Diabetes Therapy - Benefits of continuous glucose monitoring reviewed
Diabetes Therapy - Experiences with metformin-associated lactic acidosis reported
Diabetes Therapy - Glibenclamide-induced hemolytic anemia reveals G6PD-deficiency
Diabetes Therapy - New classification of diabetic foot infections proposed
Diabetes Therapy - Vitamin E improves metabolic parameters of diabetic rats
Diabetic Neuropathy - Laser evoked potentials for assessing sensory neuropathy described
Diabetic Neuropathy - Surgical revascularization to manage diabetic foot wounds described
Diagnostics - First predictive diagnostic to combat high sepsis mortality rates released
Diagnostics - Label-free gene sensors accelerate studies of nucleic acid binding events
Diagnostics - Methylated DNA collected by tampons detects endometrial cancer
Diagnostics - NeutroSpec approved by FDA
Diagnostics - Tests for hepatitis C virus infection show variable complementarity
Diet & Nutrition - Child nutritional status from African and Indian regions compared
Discount Drug Card - PA Secretary of Aging to serve on Medicare drug benefit commission
Distribution Agreement - Curacyte signs agreement for distribution of serine protease inhibitors
Divestiture - Elan sells its Myobloc rights
Drug Delivery - Cationic charges fortify transfection after liposome-based gene delivery
Drug Delivery - Company announces patent related to transdermal delivery of amine drugs
Drug Delivery - DURECT announces positive clinical results with its ORADUR technology
Drug Delivery - FDA approves new dosing options for PREVACID
Drug Delivery - GlaxoSmithKline selects Micropump formulation for clinical trials
Drug Delivery - MFX imaging useful in evaluation of controlled-release tablets
Drug Delivery - Matrix-in-cylinder system shows promise
Drug Delivery - Medrad MR Infusion System holds small-volume syringes, multiple fluids
Drug Delivery - Microparticles prolong the effect of glycyrrhetic acid in the liver
Drug Delivery - Mirror-image of tarantula venom peptide shows promise as a drug
Drug Delivery - Novel liposome enables MRI drug monitoring
Drug Delivery - Osmotically-controlled oral glipizide delivery system developed
Drug Delivery - Pharmaceuticals company gets approval to market testosterone drug in Europe
Drug Delivery - Sterile injectable, bulk drug facilities in India receive U.S. FDA approval
Drug Development - Cocos nucifera extract has potent leishmanicidal activity
Drug Development - 1,4-Naphthoquinone derivatives have antiviral/antifungal/anticancer activities
Drug Development - Antimalarial substances found in New Caledonian sponges
Drug Development - Astilbin seizes control of tumor necrosis factor to abate liver injury
Drug Development - BRET 7TM receptor/beta-arrestin assay useful in drug discovery
Drug Development - Biotech company and FDA meet at end of phase II on respiratory drug development
Drug Development - Biotech company, Merck collaborate to facilitate biomarker identification
Drug Development - Carbohydrate microarray improves fucosyltransferase inhibitor screening
Drug Development - CombiMatrix announces human drug metabolism array
Drug Development - Critical human skeletal muscle ischemia displays distinct gene patterning
Drug Development - Drug company publishes preclinical evaluation of compound for neurologic injury
Drug Development - Effects of naltrindole-based immunosuppressants characterized
Drug Development - Gene-based products company expands AAV patent portfolio
Drug Development - Grant to study snake venom awarded
Drug Development - Novel CCL3/CCR1 inhibitor identified
Drug Development - Pharmaceutical hearing loss treatment gets USPTO notice of allowance for patent
Drug Development - Pharmaceuticals company names protein structure service provider
Drug Development - Phase II clinical trial of interferon enhancing therapy for MS approved
Drug Development - Phase III trials of inhaled corticosteroid asthma treatment completed
Drug Development - Protein phosphatase 1 isoform acts as cellular stress marker
Drug Development - Salix Pharmaceuticals acquires rights to cortisone cream, suppository products
Drug Development - Single-time-point high-throughput microsomal stability assay feasible
Drug Development - Support vector machine approach helps identify torsade-causing drugs
Drug Development - Third phase 3 study initiated for Cardiome's atrial arrhythmia product
Drug Development - Toyama Chemical re-acquires rights to quinolone synthetic antibacterial agent
Drug Discovery - Chemical Diversity Labs announces drug discovery agreement
Drug Discovery - De Novo and partner announce successful completion of GPCR Library
Drug Discovery - Genedata collaboration creates framework for drug discovery
Drug Interaction - Drug-drug, drug-dietary supplement, and drug-food interactions reviewed
Drug Metabolism - First in series of catalog expression arrays launched
Drug Toxicity - New product removes high-abundance proteins from mouse blood serum
Drug-Related Diarrhea - Positive study results announced for Lexiva in drug-related diarrhea
Eating Disorder - Computer program measures body size distortion and body dissatisfaction
Edema - Sarcoidosis is a possibility when painful pitting edema arises
Embryogenesis - Transcription factor HAND1 regulates extra-embryonic vascular development
Encephalomyelitis - Myelin peptide induces severe chronic autoimmune encephalomyelitis
Endocrinology - Androstenedione had few effects on in utero development in rats
Endocrinology - Growth factor interactions with estrogen impact endothelial cell activity
Endocrinology - Hormone replacement therapy may protect against colon cancer
Endocrinology - Mineralocorticoid receptor antagonists do not block ERK activation
Endocrinology - RNA interference might treat growth hormone-related disorders
Endothelium - Ablation of MAPK-MEF2 signaling undermines the endothelium
Environmental Health - Method for measuring pesticide metabolites in urine developed
Environmental Health - Organochlorine residues in breast milk pose risk for infants in Vietnam
Environmental Health - Organohalogenated pollutants in breast milk from Turkey reported
Environmental Health - Serum levels of polybrominated diphenyl ethers increasing in U.S.
Enzymology - Protein phosphatase 1 and actin regulatory proteins identified
Enzymology - Restriction enzyme digestion gives real-time accounts of nucleic acids
Enzymology - The world of tumor angiogenesis harbors complex proteolytic systems
Epidemiology - Genetic markers identify populations in India
Epilepsy - Several genes associate with the risk for human idiopathic epilepsy
Epstein Barr Virus - EBV viral load increases and reaches setpoint after HIV seroconversion
Ethics - Company introduces whistleblower policy
Exercise - Interleukin-6 deficient mice exhibit reduced exercise endurance
Fertility Preservation - Fertility preservation in females receiving cancer therapy is reviewed
Finance - 1 billion pound boost for U.K. science and innovation announced
Finance - Biologics company completes $16.8M financing to construct Oklahoma facility
Finance - Biopharmaceutical company announces going concern qualification
Finance - Biopharmaceutical company announces launch of initial public offering
Finance - Biopharmaceutical company reports second quarter financial results
Finance - Biotech company's first quarter profits soar 112%
Finance - Biotech firm reports selected unaudited financial results
Finance - Biotech firm retains company to develop investor awareness program
Finance - Cash tender offer by ALARIS Medical Systems announced
Finance - Cell cycle-based biopharma announces IPO registration
Finance - Company announces increase in revenue guidance based on sterols sales
Finance - Dermatology company raises additional $40M in financing
Finance - Disease-management company applies for listing on American Stock Exchange
Finance - Distributor of OTC drugs, supplements, reports record revenues for 2004
Finance - Drug-delivery company files 5M share shelf registration statement
Finance - Gene-transfer therapy company announces $9.85 million private placement
Finance - Healthcare products manufacturer reports 11% increase in second quarter sales
Finance - Imaging company closes $3 million private placement transaction
Finance - Marketer for drug companies celebrates fifth anniversary of NASDAQ listing
Finance - OTC pharmaceuticals manufacturer updates second quarter outlook
Finance - Ophthalmic drug company debuts with $26.75M in series A financing
Finance - Pennsylvania group to invest again in early stage life science enterprises
Finance - Pharmaceutical firm closes $25M equity investment in Orthovita
Finance - Pharmaceutical firm secures $75M committed equity financing facility
Finance - Project aims to create new companies in biotech, life sciences in Italy
Finance - Psoriasis drug maker's registration statement declared effective by SEC
Finance - Rituxan maker announces positive Q2 results, tops $1B in quarterly revenue
Finance - Specialty pharmaceutical company reports a 23% increase in net sales
Finance - Stem cell banking firm reports on annual shareholders meeting
Fluorophores - Production has begun on biotin-activated quantum dots
Food-Borne Illness - Food risks in the Sydney press reviewed
Food-Borne Illness - Macrolide use in food animals poses little risk to humans
Food-Borne Illness - Polyphenol oxidase activity indicates adequate pasteurization of cider
Funding - Sweden provides WHO funding for HIV/AIDS prevention and care programs in China
Fungal Infection - Pneumocystis jirovecii identified in lung tissue sections from SIDS victims
Fungal Infection - Similar P. jirovecii genotypes found in different forms of infection
Gastric Cancer - Beta-catenin translocalization in nuclei indicate tumor invasion
Gastric Cancer - Cdx2 is present in early gastric cancers
Gastric Cancer - New classification of intramucosal neoplastic lesions proposed
Gastric Cancer - Runx3 major growth regulator of gastric epithelial cells
Gastroenterology - Major proteins play pivotal roles in colon cancer angiogenesis
Gene Array - CombiMatrix inks comarketing agreement
Gene Detection - An improved microarray-based assay identifies MEFV mutations
Gene Expression - Promoter element location directs testis-specific Hst70/Hsp70.2 expression
Gene Expression - Role of TEL-AML1 fusion gene in molecular pathogenesis of ALL elucidated
Gene Recognition - Novel gene labels track the travel of probiotic lactic acid bacteria
Gene Reporters - New research determines the kinetics and stability of luciferase
Gene Transfer - Biologic brachytherapy extends drug delivery with microvascular free flaps
Gene Transfer - Gene transfection can alter social behavior in mammals
Generic Drugs - Generic drug to treat urinary tract disorders gets FDA approval for U.S. sales
Generic Drugs - New combination drugs ward off generic competition
Genome Analysis - Structure and function of chromosome 13q14 characterized
Genomics - Chiron acquires San Diego company
Genomics - Lentiviral vectors mediate CRE recombinase-inducible RNA interference
Genomics - New mechanism of action for anti-integrase agents published
Genomics & Genetics - Genes with expression level linked to time of day identified
Geriatrics - Caloric restriction retards aging in neural retina
Glaucoma - Latanoprost safe and well tolerated for glaucoma treatment
Global Health - Does the will and capacity exist to ensure universal access to HIV treatment?
Graft Versus Host Disease - DC stimulation of donor CD8+ T cells may be useful for prevention of GVHD
Gynecology - Prostaglandin EP2 receptor mediates endometrial cancer angiogenesis
HIV Diagnosis - Clinical trials commence for HIV rapid test
HIV Therapy - Many patients missing opportunity to benefit from HIV breakthrough
HIV/AIDS - NIH cancels contract for HIV vaccine program
HIV/AIDS Care - Kidney transplant in HIV infection plausible in era of HAART/immunosuppressives
HIV/AIDS Epidemic - West African community joins HIV/AIDS community treatment support program
HIV/AIDS Research - Chromatin structure affects HIV-1/ASV integration site selection opposite ways
HIV/AIDS Research - Differentially expressed genes in HIV-1-resistant cells analyzed by microarray
HIV/AIDS Research - Diketo acid integrase inhibitor resistance impairs HIV-1 replication/integration
HIV/AIDS Research - HIV-induced macrophage alterations play role in HIV encephalopathy pathogenesis
HIV/AIDS Research - Resistance mutations sustain or enhance CTL recognition of HIV-1 Pol epitopes
HIV/AIDS Research - Species-specific tropism determinants found in the HIV-1 capsid
HIV/AIDS Research - Tsg-101 protein has role in HIV Gag particle release
HIV/AIDS Therapy - $14.2 million NIH contract awarded for pathogen drug and diagnostic development
HIV/AIDS Therapy - Favorable resistance data reported from Kaletra trial
HIV/AIDS Therapy - NNRTI stereochemistry and regiochemistry profoundly affect anti-HIV activity
HIV/AIDS Therapy - New edition of WHO prequalification list to include four new anti-AIDS medicines
HIV/AIDS Therapy - Subcutaneous IL-2 therapy maintains CD4 cell increases in HIV-1 infection
HIV/AIDS Treatment - Support program helps physicians, patients overcome injection-related barriers
HIV/AIDS Treatment - WHO says world has 'failed miserably' in getting AIDS drugs to millions
HIV/AIDS-Related Disease - BCL-6 mutations seen in HIV-related pulmonary lymphoproliferative disorders
HIV/AIDS-Related Disease - HAART increases survival of patients with HIV-associated Hodgkin disease
Hantavirus - Tula hantavirus L protein is perinuclear membrane-associated protein
Head and Neck Cancer - Protein collusion foretells poor prognoses for maxillary sinus cancer patients
Headache and Migraine - Novel A1A2 Na+/K+-ATPase variants associate with neuropathic disease
Healthcare Coverage - Drug company launches initiative to expand prescription medication access
Healthcare Coverage - Medicare drug cards save money now for beneficiaries with chronic conditions
Healthcare Coverage - Pennsylvania Governor celebrates anniversary of PACE prescription-drug program
Healthcare Coverage - Pharmacy offers generic pricing guaranty versus Medicare.gov
Healthcare Coverage - aiWorks launches prescription drug program in Dallas-Fort Worth
Hearing Disorder - Hearing loss mediated by T cells specific for inner ear peptides
Hearing Loss - Profoundly deaf children display GJB6 gene deletions
Heart Attack - First patient enrolled in FLAME clinical trial
Heart Attack Risk - Guidelines urge drastic lowering of bad cholesterol for heart attack patients
Heart Failure - Carvedilol better than metoprolol tartrate in reducing mortality
Heart Failure - Carvedilol has good tolerability
Heart Failure - Carvedilol is a powerful treatment for heart failure patients
Heart Failure - Carvedilol reduces morbidity and mortality of patients in heart failure
Heart Failure - Combining beta-blockers and ACE inhibitors may best reduce heart failure mortality
Heart Failure - Predischarge initiation of carvedilol helps postdischarge patient compliance
Heart Failure Model - ET-1-mediated coronary vasoconstriction did not limit heart's oxygen uptake
Helicobacter - Expression of toll-like receptors in H. pylori infection described
Hematologic Disease - Hepatitis C virus associates with thrombocytopenia formation
Hematologic Malignancy - Notch-1 signaling mediates BMS influence on hematologic malignant cell growth
Hematology - Hemophagocytic syndrome can erupt after liver transplantation
Hematology - Novel human platelet septin SEPT8 is interaction partner of SEPT4
Hematology - Single recombinant anti-RhD IgG prevents RhD immunization
Hematopoietic Disease - Malignant hematopoietic disease from internal exposure to Pu-239 uncertain
Hepatitis A Vaccine - Live and inactivated hepatitis A vaccines induced immunity in children
Hepatitis A Vaccine - Methods predict hepatitis A vaccination in men who have sex with men
Hepatitis B Vaccine - Deficit in dendritic cell-T cell interaction crucial in hepatitis B
Hepatitis C Virus - CHMP recommends approval of shorter course of PegIntron/Rebetol therapy
Hepatitis C Virus - HCV screening for drug users/transfusion patients only is most cost-effective
Hepatitis C Virus - History of intravenous drug use strongest predictor for HIV/HCV coinfection
Hepatitis C Virus Screening - Trak-C offers rapid screening for hepatitis C virus core antigen
Hepatocellular Carcinoma - PIN1 overexpression/beta-catenin gene mutations distinct oncogenic events in HCC
Hepatology - TWEAK expression may play a central role in liver cancer proliferation
Hereditary Angioedema - Esteve reaches development, marketing and sales agreement for rhC1INH
Herpesvirus Vaccine - Herpes simplex virus type 2 vaccines under development
Herpesvirus Vaccine - Tumor necrosis factor DNA enhances immune response against herpes
Hormone Replacement Therapy - HRT could have more benefits than risks when started early in menopause
Hormone Replacement Therapy - Transdermal and low-dose oral ERT does not affect homocysteine metabolism
Hormone Therapy - Self-emulsifying system enhances progesterone bioavailability
Human Papillomavirus Vaccine - DNA microarray format for subtyping human papillomavirus developed
Hypercholesterolemia - Cholesteryl ester transfer protein linked to LDL heterogeneity
Hypercholesterolemia - HMG-CoA reductase inhibitors reduced total cholesterol levels
Hypercholesterolemia - More intensive cholesterol treatment an option for high-risk heart patients
Hypertension - Vasopeptidase inhibition has a potentially serious side effect
Hypertension Risk Factor - Proteins associated with bone morphogenetic protein receptor identified
Hyperthyroidism - Vaccine with DNA encoding thyrotropin receptor induced hyperthyroidism
Illegal Drug Use - U.S. Air Force Academy begins random steroid tests amid investigation of drug use
Imaging - FDA approves NeutroSpec imaging agent to help detect appendicitis
Imaging - Neuroscientist develops tool to image brain function at the cellular level
Immunizations - Adult immunization in primary care and specialty practices reported
Immunogene Therapy - Lentiviral vectors transduce naive murine B cells
Immunology - Entamoeba histolytica protein recognized by IgA from carriers
Immunology - Differential effects of immune cells in epithelial cells described
Immunology - HSP70 mutants separate antigen delivery from DC stimulation
Immunology - Hepatitis C virus core binding to T cell gC1qR impairs Lck and Akt activation
Immunology - Human immunodeficiency virus fosters hepatitis C virus replication
Immunology - IL-5 plays role in cell survival and Ig production in mature B-1 cells
Immunology - Immune regulation plays crucial role in wound healing
Immunology - Immunoglobulin GM genotype heightens susceptibility to hepatitis C infection
Immunology - New findings in lymphangiogenesis research provide targets for novel therapies
Immunology - Role of lactoferrin in iron homeostasis and host defense defined
Immunology - Sunscreen immune protection factors determined using dendritic cell suspensions
Immunosuppression - Positive data from ISA247 single ascending dose trial
Immunotherapy - Company files supplemental application for expanded use of BEXXAR
In-Stent Restenosis - Eptifibatide treatment does not affect IRT efficacy
Infection Control - Reprocessing endoscopes in the United States reviewed
Inflammation - PPAR-gamma activation inhibits prostaglandin E2 synthase expression
Influenza Vaccine - Program helps care providers increase pediatric influenza vaccination rates
Information Technology - European distributor appointed for ADME molecular sofware product
Insulin - Protein deficiency reduces lipogenesis as well as glycolysis
Insulin Resistance - SomatoKine approved in Italy, France for insulin resistance, PLS
Insurance Coverage - Arizona names pharmacy benefit provider for state employees
Intrauterine Growth Retardation - IGF-I reduced in placenta from intrauterine growth retardation
Legal Issues - Agreement reached to settle Rezulin lawsuit in Illinois
Legal Issues - Augmentin antitrust litigation settled
Legal Issues - Class action suit alleges IntraBiotics issued false statements about iseganan
Legal Issues - Court ruling on Latanoprost patent infringement announced
Legal Issues - Judge says three doctors should remain free in OxyContin case
Legal Issues - Pharmaceutical company comments on Diastat litigation
Legal Issues - Pharmaceutical company prevails in Xalatan patent suit
Legal Issues - Settlement and license agreement ends paclitaxel litigation
Leptin Studies - Leptin and development of hypothalamic feeding circuits reviewed
Leukemia - Variant MYST4-CBP gene fusion found in t(10;16) acute myeloid leukemia
Leukemogenesis - Mechanism of leukemogenesis described
Leukemogenesis - Molecular mechanisms of leukemogenesis by AML1/EVI-1 described
Licensing Agreement - GlaxoSmithKline renews PER.C6 license agreement with Dutch biotech company
Lipdystrophy - Growth hormone control may be important HIV lipodystrophy treatment
Lung Cancer - Brochure helps lung cancer patients better understand treatment
Lung Cancer Risk Factor - Coal burning and genetics linked to lung cancer in Xuan Wei, China
Magnetic Resonance Imaging - Company launches MS-325 clinical trial in high resolution vascular MRI
Malaria - $1.4M grant to support development of malaria vaccine
Malaria - Pharmaceutical company expands malaria research project with NIH grant
Malaria Diagnosis - Rapid diagnostic test for assessing malaria during pregnancy evaluated
Malaria Vaccine - Plasmodium vivax merozoite surface proteins possess immunogenicity
Malaria Vaccine - RTS,S+TRAP malaria vaccine shows promise for infant immunization
Malignant Mesothelioma - Novel chemotherapeutic agents promising for malignant mesothelioma
Market Analysis - $3B early stage drug discovery market faces new demands
Market Analysis - Biotech market is sluggish in June
Market Analysis - Study reports tactics to achieve and sustain market leadership
Market Analysis - Study shows companies reorganizing medical education and communications
Marketing - Agency launches pharmaceutical marketing blog
Marketing - Under 25% of pharma companies do market research in preclinical development
Marketing Trends - Study: Pharmas explanding MSL teams
Medication Compliance - Africans take anti-HIV meds at a higher rate than many anticipated
Medication Compliance - Study finds 20% of new scripts go unfilled; 85% of scripts never refilled
Melanoma - Researchers use human antibody to cure malignant melanoma in mice
Meningococcal B - Company receives license for new meningococcal B vaccine for New Zealand
Menorrhagia - European rights to Cyklokapron and Cyklo-F acquired
Mental Health - Polymorphisms in GABAA receptor genes correlate with schizophrenia
Mergers & Acquisitions - Acquisition of Atto Bioscience made for $25M
Mergers & Acquisitions - American Capital invests $33M in acquisition
Mergers & Acquisitions - Canadian biotech company acquires NewBiotics Inc.
Mergers & Acquisitions - Cardinal Health completes acquisition
Mergers & Acquisitions - Definitive agreement signed to acquire Laxdale
Mergers & Acquisitions - Del Laboratories to be acquired in $465M transaction
Mergers & Acquisitions - DuPont completes purchase of Maxygen subsidiary
Mergers & Acquisitions - Holding company merges with developer of transdermal drug delivery systems
Mergers & Acquisitions - Medical products company completes acquisition of Hudson Respiratory Care
Mergers & Acquisitions - Peoples Genetics' technologies acquired for genetic analyses
Mergers and Acquisitions - Acquisition of Integrity Healthcare Services complete
Mergers and Acquisitions - Pharmaceutical manufacturing facility in Mexico acquired
Mergers and Acquisitions - Women's OTC healthcare products acquired from Columbia Laboratories
Metastasis - S100A4 triggers a pro-metastatic cascade in tumors
Metastasis - The effects of chemokines on tumor invasion are not fully understood
Mosquito-Borne Disease - Human attraction patterns of culicine mosquitoes in Peru reported
Multiple Myeloma - Intensive chemotherapy alone most cost effective option for stage II/III MM
Multiple Myeloma - Phase I trial to investigate 17-AAG in multiple myeloma patients
Mutagenesis - Aprataxin mutations cause early onset ataxia
Myelodysplastic Syndromes - Vidaza U.S. commercial launch announced
Myeloma - Thalidomide's promising future in fighting cancer explored
Myocardial Infarction - Carvedilol reduced all-cause mortality in postinfarct patients
Myocardial Infarction - Thrombolysis in ST-elevation myocardial infarction in Germany is underused
Myocardial Infarction Model - Acetaminophen is safe in experimental acute myocardial infarction
Nanoscience - Nanoprobe creates world of new possibilities
Neonatal Jaundice - New guidelines released for management of hyperbilirubinemia in newborns
Neurodegeneration - Drosophila carbonyl reductase sniffer prevents neurodegeneration
Neurodegeneration - BioChancePlus grant awarded to neurodegeneration drug-discovery program
Neurodegeneration - Rescue of TNF alpha-inhibited neuronal cells by IGF-1 involves kinases
Neurodegeneration - Sequencing tests suggest human enteroviruses cause motor neuron diseases
Neurodegenerative Disease - Positive results reported on neurodegenerative disease blood test
Neurodegenerative Diseases - Biopharmaceutical companies to develop neurodegenerative disease treatments
Neurodegenerative Disorders - Alpha syrtuclein linked to Parkinson, Alzheimer disease
Neurology - Study reveals positive response of relapsed or refractory PCNSL to topotecan
Neuronal Dysfunction - Clenbuterol retards loss of motor function in motor neuron degeneration
Neuroscience - BAI1-AP4 promoter drives transgene expression in murine brains
Neuroscience - Central serotonergic neurons require Ascl1/Mash1 for proper development
Neuroscience - Coadministration of Pgp inhibitors improves docetaxel penetration into brain
Neuroscience - Expression pattern of connexin36 lacZ reporter gene reported
Neuroscience - IL-1alpha and IL-6 protect neuronal SH-SY5Y cells from oxidative damage
Neuroscience - PC12 cells require dystrophin Dp71 for neurite outgrowth
Newborn Health - Surfaxin receives positive opinion from European orphan drug evaluation agency
Nucleotide Labeling - Metal-enhanced fluorescence improves the utility of fluorophores
Obesity Genomics & Genetics - Detailed genetic mapping reveals complexity of obesity trait locus
Obesity Pathogenesis - Angiotensinogen gene expression in obesity modulated by adipose depot
Obesity Pathogenesis - Hepatic insig overexpression reduces lipogenesis in obese rats
Obesity Therapy - Food intake inhibited by oral oleoylethanolamide
Obesity Therapy - Medication can help diabetics lose weight, but long-term effects uncertain
Obesity Therapy - Orexigenic action of peripheral ghrelin mediated by proteins
Obesity Therapy - Oxyntomodulin reduces food intake and body weight gain in rats
Obesity Therapy - Successful phase Ia trial results reported on anti-obesity compound
Obesity and Diabetes - Developmental origins of metabolic syndrome presented
Obstetrics - Case of normal pregnancy after exposure to antidiabetic drugs reported
Obstetrics - Maternal asthma affects, and is affected by, female fetus
Ocular Diseases - Study: Squalamine effective for extraretinal neovascularization
Oncogene - p21-dependent cell cycle arrest guards against unrestricted cell proliferation
Oncogenes - Findings suggest need for new view of p53 cancer protein's interaction with DNA
Oncogenes - P13K signaling essential for ABL oncogene-mediated B cell transformation
Oncogenesis - Raf and RhoA cooperate to transform intestinal epithelial cells
Oncogenesis - The kinase inhibitor p27Kip1 is deregulated in thyroid cancer
Oncogenesis - Werner syndrome protein protects the genome from carcinogenic events
Oncology - Thiadiazole urea inhibitors bind selectively to stromelysin-1
Open-Heart Surgery - S+-ketamine's neuroprotective effects not better than remifentanil's effects
Ophthalmology - 'Flying eye hospital' brings sight-saving help to Paraguay and other countries
Ophthalmology - Genome scans detect loci common to early-onset primary open-angle glaucoma
Oral Health - Prolonged aspirin chewing can damage teeth
Organ Rejection - FDA grants permission for TAFA-93 clinical trial
Orthopedics - Bone morphometric protein-2 finding use in orthopedic applications
Osteogenesis - Angiogenic factor supports chondrocyte survival during bone formation
Osteoporosis - IL-6-174G/C genotype associated with BMD response to postmenopausal ERT
Osteoporosis - Phase III study shows intravenous Boniva effectively manages osteoporosis
Osteosarcoma - HER-2 oncogene overexpression does not play role in osteosarcomas
Osteosarcoma - Mepact granted Orphan Medicinal Product Designation in E.U. for osteosarcoma
Ovarian Cancer - IND, SPA submitted to FDA for pivotal trial of XYOTAX
Pain Medicine - Based on new data, company files amendment to Prialt's NDA
Pain Medicine - Company, FDA agree on new trial design of oxymorphone ER
Pain Medicine - Mechanism for proteinase-induced inflammatory pain proposed
Pain Medicine - Role of neuropeptide FF in pain modulation elucidated
Pain Medicine - Utility of peripheral kappa-opioid agonists for visceral pain reviewed
Pain Medicine - Valdecoxib acts faster than rofecoxib on acute postsurgical pain
Papillomavirus - HPV-11 early protein E6 dominant inducer of cytokine expression in RRP
Patents - Drugs give HIV patients longer lives in victory for anti-patent activists
Patents - Patent issued for development of HIV/AIDS drug
Pediatric HIV/AIDS - Severe childhood malnutrition increases morbidity/mortality risk in HIV/AIDS
Pediatric Vaccine - Universal childhood vaccination benefits society
Peptide Synthesis - Nucleobase switching runs the recognition behavior of peptide ribonucleic acid
Perinatal HIV/AIDS - WHO publishes new guidelines on preventing mother to child transmission of HIV
Personnel - Alan D. Cherrington elected president of diabetes group
Personnel - Biopharmaceutical R&D company announces management changes
Personnel - Biopharmaceutical company announces new president and CEO
Personnel - Biopharmaceutical company appoints vice president, clinical development
Personnel - Biotech company names Franklin Berger to board of directors
Personnel - Biotech company names Martha Vincent VP, clinical R&D
Personnel - Bruce J. Brennan joins CRO's board of directors
Personnel - Clinical research organizations adds two to senior management team
Personnel - David Ferrick named VP of California biotech/device company
Personnel - David Lawrence named CFO at UK pharmaceutical firm
Personnel - Diagnostics company names Sarah Gunhouse VP of U.S. sales
Personnel - Dr. Mingyi Trimble joins research firm as toxicology technical director
Personnel - Dr. Rajinder Kumar appointed head of R&D of India-based pharma
Personnel - Former CEO of Quintiles appointed to board
Personnel - Health care technology company names David J. McLean CEO
Personnel - Healthcare investment firm hires two key executives
Personnel - Intelligent electronic lab notebooks provider announces new board member
Personnel - Joshua Ofman named VP at biotechnology company
Personnel - Life sciences venture capital firm names former J&J to advisory board
Personnel - Michael N. Avallone named CFO at pharmaceutical firm
Personnel - Michigan biotech company hires lab administrator, staff scientist
Personnel - PharmaLinkFHI names Richard Staub as president and COO
Personnel - Pharmaceutical company announces changes in senior leadership
Personnel - Pharmaceutical company announces changes to board of directors
Personnel - Pharmaceutical company announces retirement of board member
Personnel - Pharmaceutical company announces the departure of president of R&D
Personnel - Pharmaceutical company appoints new member to executive board
Personnel - Pharmaceutical company names executive VP of global clinical operations
Personnel - Pharmaceutical company names executive for licensing and development
Personnel - Pharmaceutical firm announces several new appointments
Personnel - Pharmaceutical supplier promotes Regan Miles to executive VP
Personnel - Pharmaceuticals company announces departure of board members Livolsi and Parenti
Personnel - Philip Livingston, MD joins advisory board
Personnel - Proteomics company names Dr. Wenpei Su as director of genomics applications
Personnel - SIGA announces the appointment of Bernard L. Kasten, MD as CEO
Personnel - Sam Barnett, Philippe Magistretti named directors of New Jersey biotech
Personnel - Specialty pharmaceutical company names executive VP, clinical research
Personnel - Ventavis maker seeks new CEO, announces NDA
Pertussis Vaccine - Efficacies of pertussis vaccines against B. parapertussis compared
Pharmacogenetics - Pharmacogenetics can improve identification of high-risk ALL patients
Pharmacogenomics - Wyeth inks contract for regulatory-compliant pharmacogenomic testing services
Pharmacokinetics - Liquid chromatography/tandem mass spectrometry quantifies SU5416 E-isomer
Pneumonia - FDA approves Levaquin for multi-drug resistant form of S. pneumoniae in CAP
Polycystic Kidney Disease - Premature cell cycle transitions follow polycystin-1 protein depletion
Post-Operative Pain - Clinical trial to study M40403 with morphine for post-operative pain
Postpolio Syndrome - IvIg treatment reduces proinflammatory cytokine production
Prescription Drugs - 'Rex' The Talking Bottle firm gets goverment contract, names general manager
Prescription Drugs - Alabama public health hospital sues drug makers over prices
Prescription Drugs - Campaign launched to warn people against illegal prescriptions
Prescription Drugs - Makers of erectile dysfunction drug offer "Cialis Promise"
Product Licensing - Teva receives approvable letter for Agilect for Parkinsons
Prostate Cancer - Hormone refractory prostate cancer trial extended to additional Canadian sites
Prostate Cancer - New evidence shows Her-2/neu receptor correlates with prostate cancer risk
Protein Crystallization - Collaboration to provide automated protein crystallization platform
Proteomics - Combined approach to analysis of protein mutant outlined
Proteomics - Hypoxia-inducible factor 1 facilitates a number of human pathologies
Proteomics - License agreement for LentiVector gene delivery technology announced
Proteomics - Several new proteins are implicated for causing fatty liver
Psychiatry - Neuregulin gene mutations increase one's risk for schizophrenia
Psychology - DUP25 expression doesn't associate with panic disorder
Psychosis - Newer antipsychotics associated with lower mortality than haloperidol in elderly
Pulmonary Hypertension - Guideline challenges use of common medication
Pulmonary Medicine - CD34-positive alveolar capillaries increase in idiopathic pulmonary fibrosis
Pulmonary Medicine - Multiplex PCR dissects the etiology of community-acquired pneumonia
Rabies Diagnosis - RT-PCR method specifically for European bat lyssavirus 1 developed
Radiotherapy - Radiolabeled peptide nucleic acids elicit site-specific DNA damage
Receptor Studies - Current status of drug receptor nomenclature reviewed
Receptor Studies - Mutant spacer sequence makes Plac promoter hyperactive
Receptor Studies - Retinal insulin receptor interacts with phosphoinositide kinase subunit
Recombinant Research - Antisense transcription of antigen receptor genes involves V region remodeling
Renal Cancer - Initiation of Xcytrin Phase 2 clinical trial in renal cell carcinoma announced
Renal Disease - Endogenous antisense transcripts regulate nephrin expression
Renal Disease - Fibrillex selected for new FDA Pilot 2 program
Reproductive Medicine - Analogs of arginine vasopressin synthesized
Reproductive Medicine - Effects of levonorgestrel and mifepristone on ovarian function characterized
Respiratory Syncytial Virus - Sendai virus expressing RSV glycoprotein elicits immune protection
Retinitis Pigmentosa - Vitamins, cell transplants, and other drugs target hereditary eye disease
Retrovirus - HTLV-I dimerization initiation site forms hairpin loop
Rhabdomyosarcoma - Novel t(2;20)(Q35;p12) seen in childhood RMS with embryonal histology
Rubella Vaccine - Prevalence of anti-rubella antibodies decline in Polish women
SARS - Novel protein from SARS coronavirus identified
Salmonella - Method to detect Salmonella in eggs by real-time PCR developed
Salmonella - Methods for recovery of Salmonella from cantaloupes compared
Salmonella Vaccine - T cells from Salmonella vaccine cause interclonal competition
Schistosomiasis - Antibody isotype patterns to Schistosoma antigens identified
Schistosomiasis - Schistosome digestive peptidases reviewed
Schizosaccharomyces - N-terminal domain of S. pombe Cdc11p needed for SIN signaling
Scleroderma - TGF-beta1 polymorphisms are not a factor in systemic sclerosis
Seasonal Allergic Rhinitis - Agreements signed for supply, distribution of loratadine products
Skin Cancer - FDA approval granted for Aldara for superficial basal cell carcinoma
Skin Cancer - Oxidative stress/antioxidant network provide rationale for skin cancer treatment
Skin Damage - Green tea polyphenols prevent ultraviolet light-induced oxidative damage
Spermatogenesis - Vam6P and SNAP involved in sperm-zona pellucida interactions
Stem Cell Research - Apoptosis has role in development of AGM HSC revealed by Bcl-2 overexpression
Stem Cell Research - ESC-derived CD34+CD38-precursors exhibit embryonic gene expression pattern
Stem Cell Research - Epigenic regulation of HSC level directly affects the mature progeny
Stem Cell Research - FGFs enriches embryonic liver cultures for hepatic progenitors
Stem Cell Research - Gutlike organ formed from mouse embryonic stem cells characterized
Stem Cell Research - Interleukin-6 is an in vivo growth factor for mesenchymal precursors
Stem Cell Research - MGDF potent growth factor for primitive hematopoietic progenitors in the fetus
Stem Cell Research - PF4 enhances normal/leukemic stem/progenitor cell adhesion to endothelial cells
Stem Cell Research - PU.1 determines self-renewal capacity of erythroid progenitor cells
Stem Cell Research - Reductions in linker histone levels are tolerated in developing spermatocytes
Stem Cell Research - TNF-alpha suppresses GVHR by inhibiting IFN-gamma-dependent donor type-1 immunity
Stem Cell Transplantation - ATG added to conditioning regimen improves outcome in unrelated donor SCT
Stem Cell Transplantation - CMV-specific CD4+ and CD8+ T-cell lines rapidly generated for SCT
Stem Cell Transplantation - Combined stratification of refractory anemia improves prognosis in SCT
Stem Cell Transplantation - Donor treatment with pegylated G-CSF promotes transplantation tolerance
Stem Cell Transplantation - Encephalopathy in pediatric patients after HSCT associated with poor prognosis
Stem Cell Transplantation - GVHD major predictive factor for response to donor lymphocyte infusions in MM
Stem Cell Transplantation - IL-10/TNF alpha region haplotypes predict mortality after unrelated donor SCT
Stem Cell Transplantation - Infused autograft lymphocyte dose affects clinical outcome post-SCT in MM
Stem Cell Transplantation - Infused cell dose predictive of outcomes after unrelated cord blood transplant
Stem Cell Transplantation - Primary systemic amyloidosis patients have increased survival following PBSCT
Stem Cell Transplantation - Steroid and cyclosporine A use are risk factors for bone loss following SCT
Stroke - Forest Laboratories announces desmoteplase agreement
Syphilis - Antibiotic-resistant syphilis spreading
Testicular Infection - Early diagnosis and treatment paramount in P. boydii infections
Thrombosis - Claudication affects the collateralization of vascular beds
Thrombosis - Multielement intravascular ultrasound reduces enoxaparin efficacy
Tick-Borne Disease - Anaplasma phagocytophilum infection affects molting of tick larvae
Tick-Borne Disease - Gene of Borrelia lonestari differentiates Borrelia species
Toxicology - Features linked to antibody protection against ricin determined
Transgene Expression - A novel viral hybrid system stably transforms mammalian cells
Transplant Medicine - Sequential therapy treats recurrent hepatitis C after liver transplantation
Transplant Medicine - Study sets best time for bone marrow transplant in patients with blood disorder
Transplant Medicine - Washington state authorizes liver transplants at medical center
Trends - Survey uncovers life sciences industry trends
Tropical Disease - Institute for tropical diseases opens in Singapore
Tuberculosis Vaccine - Immunomodulatory action of mycobacterial secretory proteins reviewed
Tuberculosis Vaccine - Protein microspheres elicit immune response against M. tuberculosis
Tumor Suppression - RUNX3 is a bona fide tumor suppressor of gastric cancers
Tumor Suppression - Reduced menin encourages intestinal cell tumorigenesis
Tumor Suppression - Vascular normalization improves drug penetration in tumors
Tumor Suppression - p300 and CBP are suppressors of hematological tumor formation
Tumor Suppressor Gene - Somatic inactivation of Nfl induces a progressive myeloproliferative disorder
Tumorigenesis - Brca1 and Chk2 have collaborative roles in tumorigenesis
Tumorigenesis - Estrogen is an angiogenic switch in human breast cancers
Type 2 Diabetes - Positive data presented on naveglitazar for type 2 diabetes
Tyrosine Kinase - LFM-A13 is a potent inhibitor of Jak2 kinase activity
Vaccine Adjuvant - Glycol chitosan improves efficacy of bovine herpesvirus vaccine
Vaccine Adjuvant - Molecular adjuvants for mucosal immunity reviewed
Vaccine Delivery - Bacterial ghosts are an efficient delivery system for DNA vaccines
Vaccine Delivery - Toxin from Bordetella pertussis offers promise for antigen delivery
Vaccine Development - Antigen distribution in mono-valent and combination vaccines reported
Vaccine Development - Bilayer composition affects dendritic cell-liposome interactions
Vaccine Development - CD70 stimulation promotes strong cytotoxic T cell responses in vivo
Vaccine Development - Cochrane Vaccines Field develop criteria for vaccine evaluation
Vaccine Efficacy - IgG1 suppression occurs with IL-6 overexpression in immunized mice
Vaccine Efficacy - Neonatal dendritic cells deficient in presentation of soluble antigen
Vaccine Efficacy - Success of immunization may also be its downfall
Vaccine Safety - Hospitalization and adverse events temporally linked to immunization
Vaccine Safety - Methodological issues arising from reviews of vaccine safety outlined
Vaccine Safety - Technologies to increase safety of vaccine administration described
Vaccine Safety - Vaccine safety research more important after 11 September 2001
Vaccine Safety - Vaccine surveillance helps evaluate safety of vaccines
Vector Development - Demineralized bone matrix putty maintains site-directed gene transfer
Viral Genomics - Human adenovirus genomes display resistance to chemical disinfectants
Viral Proteomics - Hepatitis C virus core protein amino acids hold the key to viral localization
Viremia - Core antigen tests predict patient response to hepatitis C virus therapy
Virology - Human tissues play host to several adeno-associated virus clades
Virology - Large peptide insertions extend the utility of adeno-associated virus vectors
Virology - Spontaneous clearance is common with hepatitis C virus genotype 3 infections
West Nile Virus - NIAID expands WNV treatment trial
West Nile Virus - WNV vaccine shows 100% protection in animal study, company reports
Wound Care - Protocols for testing of diabetic foot ulcers presented
Yersinia Vaccine - Inverted pathogenicity useful for prevention or therapy of disease
Zollinger-Ellison Syndrome - Company receives European authorization for PARIET for ZES
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