Drug Week
Susan Hasty, Publisher
Table of Contents . . . October 1st, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Drug Week | Other Publications
Adverse Drug Events - Erythromycin combined with common drugs may increase cardiac death risk
Alzheimer Disease - Neramexane did not demonstrate statistical significance in recent AD trial
Drug Interactions - Results from Thelin and Viagra drug interaction study announced
Heart Disease Therapy - Milestone II Registry reaffirms positive safety outcomes stent system
West Nile Virus - West Nile Virus clinical study initiated
AIDS Vaccines - Promising results announced for AdVac
AIDS/HIV Vaccine - SIVmac Gag p27 capsid protein gene expression in potato reported
ARDS - Osteopontin is expressed in the lungs of acute respiratory distress syndrome
Acne - NDA submitted to FDA for acne product
Acne Vulgaris - Acne treatments do not increase sunburn risk
Acromegaly - Serum levels of 20 kilodalton human growth hormone key in acromegaly patients
Addiction - Effects of cannabis on information-processing speed explored
Addiction - Federal study shows drug treatment among 12-17 year olds up 65% over decade
Addiction Medicine - Biopharmaceutical company receives clearance for Remoxy clinical trials
Addiction Medicine - Prerecorded presentation on HANDS protocol available online
Addiction Medicine - Study documents benefits of adolescent substance abuse treatment
Adverse Drug Effects - Substance P may play role in hypersensitivity reactions induced by paclitaxel
Age Related Macular Degeneration - FDA advisory committee reviews clinical submission for Macugen
Age-Related Macular Degeneration - FDA advisory committee reviews Macugen data
Allergy - Buzz in the air can cause stinging insect allergies, asthma group advises
Allergy - Wheat gluten causes dendritic cell maturation and chemokine secretion
Allergy Medicine - FDA approves Clarinex syrup for allergies and hives in children
Allergy Medicine - Pharmaceutical company changes symbol from "CBSC" to "CLSC"
Alzheimer Disease - 12-Lipoxygenase blockade protects neurons from peptide-induced degeneration
Alzheimer Disease - Acetylcholine minor role in prepulse inhibition regulation in Alzheimer disease
Alzheimer Disease - Alzheimer researchers eye brain buildup
Angina - GENASIS phase IIb clinical trial for severe cardiovascular disease begins
Angiology - Angiogenic response is heightened in collagen XVIII/endostatin-null mice
Angiology - Caveolin-1 is critical for vascular remodeling following limb ischemia
Angiology - Most widely used stress modality for CMR perfusion studies is adenosine
Angiology - Superoxide dismutase gene transfer improves impaired aortic relaxation
Angioplasty - Inhibition may aid protective effect of IL-10 on postangioplasty restenosis
Angiotensin - Captopril works without affecting cardiac sympathetic neurotransmission
Angiotensin - Enalapril and ramipril provide similar clinical benefits in animals
Anorexia Nervosa - Predictors of leptin in adolescent girls with anorexia identified
Anthrax - U.S. FDA approves ciprofloxacin to manage postexposure inhalational anthrax
Anti-Infectives - Dinitroanilines disrupt protozoan microtubules by binding alpha-tubulin
Antibiotic Resistance - Nisin forms cage-like structure around bacterial cell wall
Antibiotics - Pharma company completes hiring of sales team for FACTIVE
Anticoagulation - Optimal level of anticoagulation remains matter of debate
Antidepressants - Use of antidepressants by children debated after shooting in Houston
Antimicrobials - Bioscience company files patent for silver dihydrogen citrate formulations
Antisense Technology - Double-stranded complexes increase antisense oligonucleotide uptake
Antiviral Therapy - Chronic hepatitis C nonresponders are a challenge to clinical management
Arthritis - Impact of genetic variations on treatment of early rheumatoid arthritis studied
Asthma - Allergens, endotoxins don't have same effects in tropical environments
Atherosclerosis - Antimicrobial-coated vascular grafts provide antimicrobial protection
Autism - Immune system's neuroprotective response to brain injury analyzed
Autoimmune Disease - Genetically modified bone marrow cells produce tolerance to self antigens
Autoimmunity - Some SCPs are relevant to our understanding of autoimmunity
Awards - IADR, GlaxoSmithKline Consumer Healthcare sponsor Innovation in Oral Care Awards
Awards - Myeloma research group announces 2004 senior Research and Fellows Awards winners
BAP Culture - Rapid diagnosis of pharyngitis caused by group A streptococci is vital
Bacteriology - Model system assesses Escherichia coli evolution during stationary phase
Biotech Trends - Association: German biotech industry sees light at the end of the tunnel
Bipolar Disorder - Newer anticonvulsants for treating bipolar disorder reviewed
Body Mass Index - BMI determines evoked growth hormone responsiveness in healthy male subjects
Bone Healing - Diabetic metabolic state affects healing of large bone defects
Botulism - Symptoms predictive of death in patients with food-borne botulism reported
Brain Cancer - Urokinase receptor ligands spoil glioma growth via antiangiogenesis
Brain Cancer - iBAC system-mediated gene delivery stifles glioma cell growth
Breast Cancer - Breast tumor cells may swell in response to tamoxifen methiodide treatment
Breast Cancer - Breast-conserving surgery plus radiation good for older women, too
Breast Cancer - Prevention study seeks postmenopausal women at high risk for breast cancer
Breast Cancer Therapy - Anti-HER-2 mAbs synergistically kill breast tumor cells
Business & Finance - CRO announces cost reduction initiatives
Business & Finance - Cancer drug maker provides corporate update
Business & Finance - Novo Nordisk A/S completes investment in biopharma company
Business & Finance - Pharmaceutical firm closes EUR12M financing, provides pipeline update
Business Update - Biopharmaceutical firm completes re-incorporation to Delaware
Business Update - Biotech company adds general counsel, exercises of over-allotment option
Business Update - Biotech company business update includes vaccine development, financing, growth
Business Update - China-based pharmaceutical changes trading symbol to "CPICF"
Business Update - Companies agree to discontinue business arrangements on antifungal drug
Business Update - Diosynth, Organon integrated to reinforce human pharmaceutical business
Business Update - GSK acquires Fraxiparine, Fraxodi, Arixtra, and associated manufacturing plant
Business Update - Glenmark has acquired two FDA-approved products
Business Update - India-based pharmaceutical company signs supply agreement with U.S. company
Business Update - Japan-based contract research organization launches operations in U.S.
Business Update - Maker of OTC migraine therapy adds retailers, distributes stock dividend
Business Update - Oralin dossier submitted to the Ecuador Ministry of Public Health
Business Update - Pharma company announces share purchase plan, awards and legal update
Business Update - Pharma company reaffirms value of U Share Card and receives approval for Lyrica
Business Update - Pharmaceutical firm named as one of fastest-growing companies
Business Update - Pharmaceuticals firm to expand Scandinavian chemistry operations
Business Update - Pharmacy benefit company expands PrimeRxSpecialty program, enhances Web site
Business Update - Study shows pharma companies average 46 medical science liaisons
Business Update - Technology upgrade cuts costs, improves earnings for China-based company
Business Update - Transaction processing and e-commerce company adds pharmacy chains to network
Business Update - Wellness solution provider announces contract with biotechnology company
COPD - Positive data reported from study of Alpha 1-Antitrypsin
COX-2 Inhibitors - Effect of flavonoids and vitamin E on cyclooxygenase-2 transcription reported
Cancer - Calcitriol shows potential as anti-cancer agent
Cancer Mortality - Fruit, vegetable intake reduces cancer death risk after radiation exposure
Cancer Research - Pet models are a valuable part of cancer research
Cancer Risk Factor - Leucomalachite green is mutagenic in female Big Blue B6C3F1 mice
Cancer Risk Factor - Micronucleus test used on epithelial cells from oral cavity of beedi smokers
Cancer Therapeutics - Phase I clinical study initiated for novel anti-tumor protein
Cancer Therapy - Advexin cancer therapy featured in Conquest magazine
Cancer Therapy - Cyclacel initiates patient enrollment in third phase I clinical trial of CYC682
Cancer Therapy - Genes causing inherited cancer can help elucidate chemoresistance
Cancer Therapy - Liposomal and standard paclitaxel formulations have comparable efficacy
Cancer Therapy - National Cancer Institute funds cancer therapy development
Cancer Therapy - New patent for compounds delivering drugs directly to tumor granted
Cancer Therapy - Preclinical data demonstrate antitumor effects of T-oligo technology
Cancer Therapy - Sea sponges may yield cancer drug
Cancer Vaccine - NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad immune response
Cardiac Ischemia - Negative inotropic drugs are less capable of reducing [Ca2+] after ischemia
Cardiology - Bone marrow angioblasts improve cardiac function after ischemic insult
Cardiology - Hydralazine boosts the angiogenic phenotype through enzyme suppression
Cardiology - Treatment with NE or CT-1 enhanced 3H-myristic acid in a PC compartment
Cardiology - Vasorin mediates the arterial response to injury
Cardioprotection - Manganese superoxide dismutase is not vital for preventing myocardial stunning
Cardiovascular Disease - Dominant negative 14-3-3 promotes cardiomyocyte apoptosis in type 1 diabetes
Cardiovascular Disease - European agency issues new warnings about the use of COX-2 inhibitors
Cardiovascular Disease - Patent for BiDil treatment of African Americans with heart failure announced
Cardiovascular Disease - Perindopril reduces cardiovascular death and myocardial infarction risk
Cardiovascular Disease - Study examines role of insulin resistance in predicting cardiovascular disease
Catheters - FDA clears new hydrophilic antimicrobial catheter for U.S. sales
Cell Biology - A new protein is discovered to play a key role in cancer progression
Cell Biology - Endoglin blocks transforming growth factor-beta-Smad3 signals
Cell Research - ANG II and PKC activation increases DVR pericyte divalent ion conductance
Cellular Migration - US28 mediates smooth muscle cell migration through G alpha 12
Cervical Cancer - Chemoradiation therapy may benefit patients with periaortic LN metastasis
Cervical Cancer - Tumor-stromal interactions rule the power of aminopeptidase in cancer invasion
Childhood Immunization - Dominican Republic immunization project announced
Childhood Immunization - Further evidence refutes link between MMR vaccine and autism
Cholesterol - Libracol with HEP-30 to be sold in 3,800 Canadian drugstores, health food stores
Chronic Hepatitis C - Over-reaction to CD1d-presented liver antigens promotes liver injury
Chronic Illness - HIV/AIDS needs to be conceptualized as a chronic, long-term illness
Chronic Liver Disease - Silent hepatitis B does not alter hepatitis C-related liver disease
Chronic Obstructive Pulmonary Disease - Patients with COPD may be missing out on appropriate treatment
Clinical Trials - Clinical study of rheumatoid arthritis drug started, second phase 1b initiated
Clinical Trials - High awareness reported for cancer clinical trials advertising section
Clinical Trials - Major pharma posts data on clinical trial register
Clinical Trials - Noncompliance is not necessarily uninformative
Clinical Trials - Pharmaceuticals announces phase 1/2 trial of combination lung cancer drug
Clostridium Difficile - C. difficile presence from hospitalized children with diarrhea not significant
Collaborations - Cedax agreements terminated; Shionogi to market Cedax in U.S.
Collaborations - Diabetes group, pharma firm partner for research
Collaborations - Pharmaceutical firm collaborates for depression gene program
Collaborations - Pharmaceutical firm signs research agreement with AstraZeneca
Collaborations - Services agreement signed for CarGel clinical trials
Collaborations - Technology will enable chemical depiction in electronic lab notebook
Colon Cancer - Phase II trials of TroVax and chemotherapy endpoints reached
Colonoscopy - Phase III study initiated for advanced generation purgative product
Colorectal Cancer - Phase I/II trial of NV1020 initiated for liver metastases from colorectal cancer
Complementary & Alternative Medicine - Natural Standard available on handheld devices
Complementary & Alternative Medicine - Network marketer of nutritional supplements announces management reorganization
Complementary and Alternative Medicine - Expert warns of dangers of self-medicating with herbal medicines
Complementary and Alternative Medicine - The traditional Korean medicine Soamsan has antitumor properties
Congenital Muscular Dystrophy - Laminin alpha1 chain transgenes correct genetically deficient mice
Constipation - FDA approves Zelnorm as therapy for chronic constipation
Contraception - Marketing distribution company and Organon ink generic supply agreement
Coronary Artery Disease - Myocardial gene therapy initiates collateral development in occluded hearts
Cryptosporidium - Host-adapted Cryptosporidium species in Canadian geese reported
Cystic Fibrosis - Cyproheptadine is an effective appetite stimulant in cystic fibrosis
Cystic Fibrosis - Novel inhalation device enables efficient glutathione treatment
Cytomegalovirus Infection - Cytomegalovirus encephalitis found in an immunocompetent pregnant woman
DNA Vaccine - Cholera toxin gene enhances mucosal immune responses of DNA vaccine
Data Access - Medical journals' policy requires public data registry
Deep Vein Thrombosis - Recruitment and testing of patients completed for ThromboView phase Ib trial
Deep-Vein Thrombosis - Study confirms the use of mechanical prophylaxis of DVT after hip replacement
Depression - Treatments for depression have dental side effects
Dermatology - Clinical trial of the safety and tolerability of SPB002 for psoriasis commences
Dermatology - Dermatology drug market expected to grow 8% per year through 2008
Diabetes Pathogenesis - Cytokine-induced PGE2 formation reduced from iNOS-deficient murine islets
Diabetes Pathogenesis - MODY5 gene deletion in beta cells leads to defective insulin release
Diabetes Pathogenesis - Molecular mechanisms regulating glucose uptake reviewed
Diabetes Pathogenesis - Nitric oxide plays immunoregulatory role in virus-induced autoimmune diabetes
Diabetes Therapy - Rehmannia glutinosa extract lowers plasma glucose in diabetic rats
Diabetes Therapy - Cardiovascular effects of rosiglitazone reviewed
Diabetes Therapy - Glycemic and lipidemic effect of monopril and losartan investigated
Diabetes Therapy - Insulin therapy regulates somatotropic axis during protracted illness
Diabetes Therapy - Method to assess pancreatic islets after transportation reported
Diabetes Therapy - Repaglinide plus metformin enhance insulin secretion and sensitivity
Diabetes Therapy - Sanguis draxonis dramatically reduces glucose levels in diabetic rats
Diabetic Nephropathy - Oral adsorbent protects renal function in diabetic nephropathy
Diagnostic Imaging - Immunoliposomes depict molecular markers in stimulated endothelial cells
Diagnostics - CMV-DNA and pp65-antigen tests predict human cytomegalovirus symptom onset
Diagnostics - Digital image analysis tracks antiangiogenic activity in a modified assay
Diagnostics - First chip-based test for broad diagnostic use in E.U. has CE mark
Diet and Nutrition - Dietary fat quantity and composition affect insulin sensitivity
Diet and Nutrition - Micronized dispersible ferric pyrophosphate has high bioavailability in rats
Diet and Nutrition - Relation found between dietary habits and plasma fatty acids levels
Disease Associations - Human papillomavirus in HIV infection increases risk of pathologic conditions
Disease Associations - K8 gene is expressed in both immediate-early and delayed-early phases of KSHV
Disease Associations - Less morbidity/mortality from opportunistic infections in Mexico since HAART
Disease Associations - Lymphoproliferative disorders flourish with hepatitis C virus infections
Disease Associations - Mixed strains of L. infantum lead to treatment failure in HIV-1-infected patient
Disease Management - Cancer survivors' other medical problems poorly managed
Drug Abuse Treatment - Court to hear arguments on who should determine drug, alcohol treatment
Drug Delivery - Collagen and methylated collagen gene carriers offer sustained transgenics
Drug Delivery - Effect of carrier size on SX dispersion from interactive mixtures determined
Drug Delivery - Flexible coils may be a new method of controlled delivery of drugs to the eye
Drug Delivery - Micro- and nanosystems are two new approaches to drug delivery
Drug Development - Biotech president looks forward to cash flow from diabetes drug
Drug Development - Biotechnology company secures seed financing to develop metabolic disease drugs
Drug Development - Collaboration agreement announced on novel therapeutic protein
Drug Development - Collaboration agreement focuses on aptamers in the validation of targets
Drug Development - Drug development, testing company launches technology to accelerate process
Drug Development - Five-year study launched to investigate cardiovascular risk reduction with Omacor
Drug Development - Japenese drug developer acquires U.S. rights to market bronchial-otic antibiotic
Drug Development - Microgravity in space may change drug properties
Drug Development - Polymer microspheres differ in their penetration of tissue in the GI tract
Drug Development - Research group, biomedical company sign research agreement for drug development
Drug Development - Screener version 3.0 released
Drug Development - Study results of infusions of congestive heart failure drug published
Drug Development - Study shows established anithypertensive drug also reduces future stroke risk
Drug Development - T-cell lymphoma patients achieve long-lasting responses with human antibody drug
Drug Development - Testing with West Nile Virus assay initiated under investigational protocol
Drug Development - The antimalarial drug artesunate obstructs new vessel growth
Drug Development - The lipid lowering agent pravastatin may fight cancer
Drug Development - Ximelagatran pharmacokinetics unaffected by alcohol
Drug Discovery - Collaboration aims to expand application of high content screening in China
Drug Discovery - U.K.-based CRO to help with U.S. in-house accelerator mass spectrometer facility
Drug Importation - Wisconsin suburb to allow city workers, retirees to buy Canadian drugs
Drug Resistance - Antibiotic resistance comes with a fitness cost to the pathogen
Drug Resistance - Cells with pleiotropic drug resistance can be targeted with anticancer therapy
Drug Resistance - Malarone treatment failures in Africa point to alternate causalities
Duodenal/Gastric Ulcers - Pharmaceutical company launches Omeprazole Delayed Release Capsules 20 mg
Dyslipidemia - Report: Dyslipidemia drug-treated population to grow 4% annually
E. Coli - Effect of nonselective NOS inhibition in critically ill patients reported
Endocrinology - Fat cell heterogeneity correlates with gene expression differences
Endocrinology - Gender-based differences in DHEA metabolism noted in hamsters
Endocrinology - Lipase deficiency in islets abolishes cholesterol ester hydrolase activity
Endocrinology - Melatonin should be considered for use against free radical-based diseases
Endocrinology - Most newly synthesized proinsulin aggregates in non-beta-cell lines
Enterovirus Uveitis - Enterovirus uveitis is a new infant eye disease causing sporadic outbreaks
Environmental Health - Combined technologies detect hepatitis A virus in environmental samples
Enzymology - Grain components staunch matrix metalloproteinases in laboratory assays
Epilepsy - Pharma company receives tentative approval for Gabapentin capsules
Escherichia Coli - New family of potent AB5 cytotoxins produced by Shiga toxigenic E. coli
Exercise - AMPK activity diminished in tissues of IL-6 knockout mice
Exercise - Interleukin-1 gene variations modify the body's response to exercise
Eye Health - Possible link found between hypothyroidism and glaucoma in men
FDA Compliance - Cordis Corporation contracts for expanded FDA regulatory compliance services
Fabry Disease - Enzyme replacement therapy for Fabry disease reviewed
Female Sexual Dysfunction - Phase II clinical trial results reported for testosterone gel product
Fibromyalgia - Antidepressant shown to improve symptoms, relieve pain of fibromyalgia
Finance - Australian biotech's share purchase plan increased
Finance - Australian oncology company raises AUD$3.8M
Finance - Australian pharmaceutical firm initiates IPO
Finance - Biopharmaceutical company reports limited strong revenue growth for FY 2004
Finance - Biopharmaceutical research company eliminates $540K of secured debt
Finance - Biotech company engages investment advisory services firm
Finance - Biotech firm issues notice to stockholders about offering
Finance - Biotech firm issues revised quarterly results statement
Finance - Biotech firm reaches significant operational milestones, cleans up balance sheet
Finance - Cancer drug development company reports solid financial performance
Finance - Company receives $5.4 million grant from Spinal Muscular Atrophy Foundation
Finance - Diabetes drug maker begins investor awareness program for fall period
Finance - Drug-development company files registration statement for IPO
Finance - EDA, partner, to invest $40M in New Jersey-based emerging biotech companies
Finance - Genomics-focused company reports Q2 2004 financial results; revenues up
Finance - Holdings company announces proposed offering of common stock
Finance - Med-Emerg International announces 82% decrease in net loss
Finance - Nutritional supplement manufacturer reports highest net sales in company history
Finance - Pharmaceutical company raises $19 million in Series C financing
Finance - Pharmaceutical company raises $44M in Series C financing
Finance - Pharmaceutical company raises $7.4M in gross proceeds through sale of securities
Finance - Pharmaceutical firm obtains $175M credit facility
Finance - Pharmaceutical firm reports 15% increase in income
Finance - Pharmaceuticals board OKs repurchase of up to $300 million of its securities
Finance - Protien therapeutics company announces strong first half 2004 results
Finance - Rite Aid lowers financial projections for fiscal 2005
Finance - Stent maker provides update on Taxus sales
Finance - Therapeutics company reports second quarter financial results
Financing - Company raises $20M, begins phase I trial on antibiotic EP-013420
Fitness & Wellness - Companies form joint venture to create Wellness Watchers Systems, LLC
Fitness & Wellness - Company launches psychological services for morbid obesity disease management
Formulary Design - Testimony underscores flexibility in formulary design
Funding - Infectech researcher received grant for Johne disease pathogen treatment
Fungal Infection - A. fumigatus spore exposure induces chemokine expression in macrophages
Gene Delivery - Outgrowth endothelial cells host gene vectors that target tumor vessels
Gene Expression - Molecular images track the activity of cancer gene therapy
Gene Expression - Multiple sclerosis pathogenesis encompasses the full central nervous system
Gene Expression - ZIP1 is a potential biomarker of zinc status in humans
Gene Suppression - Several strategies eliminate multidrug resistance gene expression
Gene Therapy - Modular protein engineering safer than viral vectors for gene therapy
Gene Therapy - RNA interference is a potent tool for gene-specific therapeutics
Gene Transfer - Centrifugation concentrates retroviruses used for transfection
Gene Transfer - Hypoxia enhances the use of survivin promoter in cancer gene therapy
Gene Transfer - Inflammation constrains a key gene therapy receptor on endothelial cells
Gene Transfer - Nuclear images monitor the efforts of PEGylated polyethylenimine vectors
Generic Drugs - Generic pharmaceuticals maker named to Fortunes 100 fastest growing company list
Genomics - siGENOME siRNA launched for mouse and rat genomes
Geriatrics - Genetic changes in the olfactory mucosae are intrinsic during aging
Gynecology - Serum VEGF predicts survival and progression in ovarian cancer patients
H. pylori Infection - Natural antibiotics in human gastric mucin protect against H. pylori
HIV/AIDS - HIV vaccine progresses towards next phase
HIV/AIDS - ReceptoPharm discovered cobra venoms as raw material for HIV therapy
HIV/AIDS Coinfection - Dissociation found between serum and liver HCV RNA in HIV/HCV coinfection
HIV/AIDS Coinfection - HAART increases rate of hapatotoxicity in hepatitis C virus coinfection
HIV/AIDS Coinfection - Hepatitis C virus type 5 highly prevalent in central France from 1996 to 2002
HIV/AIDS Diagnostics - Bayer Versant bDNA HIV and HCV assays run together for improved workflow
HIV/AIDS Drug Resistance - Antiretroviral resistance mutations detected by high-density DNA probe arrays
HIV/AIDS Healthcare - HIV care providers need to address social issues
HIV/AIDS Healthcare - Model estimates resource needs for global HIV/AIDS healthcare services to 2007
HIV/AIDS Healthcare - Rapid-feedback model improves retention rate of HIV/AIDS healthcare intervention
HIV/AIDS Infection - HIV infection still increasing in many parts of the world
HIV/AIDS Infection - Rate of CD4 decline not different in patients with transmitted drug resistance
HIV/AIDS Research - HIV-1 down-regulates cell surface expression of HLA-G1
HIV/AIDS Research - HIV-1-specific cytotoxicity mediated by CD8+ subset producing IFN-g and TNF-a
HIV/AIDS Research - Nup98 on the nuclear pore complex participates in nuclear entry of HIV-1 cDNA
HIV/AIDS Research - SIV vaccine study data presented at AIDS Vaccine 2004
HIV/AIDS Research - SNPs associated with increased susceptibility to HIV infection
HIV/AIDS Research - Thymus function in younger persons preserved at early/intermediate HIV stages
HIV/AIDS Therapy - Amprenavir/saquinavir/ritonavir may be a viable salvage regimen
HIV/AIDS Therapy - Baseline CD4 cell counts can guide initiation of HAART regardless of viral load
HIV/AIDS Therapy - Clinical benefits of tenofovir larger than predicted by plasma viral RNA levels
HIV/AIDS Therapy - Current guidelines to prevent opportunistic infections in HIV infection detailed
HIV/AIDS Therapy - Delavirdine boosts amprenavir trough levels more than 10-fold in children
HIV/AIDS Therapy - HAART increases risk of metabolic complications in HIV-1 infection
HIV/AIDS Therapy - Hyperlactatemia does not recur when switching from stavudine to other therapy
HIV/AIDS Therapy - Optimization of antiretroviral resources is necessary to provide better access
HIV/AIDS Therapy - Resistance testing can help guide therapy in antiretroviral-experienced patent
HIV/AIDS Therapy - Ritonavir blocks osteoclastogenesis by impairing RANKL-induced signaling
HIV/AIDS Therapy - TB clinics in resource-limited settings effectively monitors once-daily HAART
HIV/AIDS Therapy - UNAIDS Drug Access Initiative evaluated in Chile
HIV/AIDS Transmission - Heterosexual transmission of HIV-1 is primary mode of infection in Saudi Arabia
HIV/AIDS-Related Infection - Clinical relevance of pulmonary M. konsasii isolates in HIV infection reviewed
HIV/AIDS-Related Infection - Incidence and mortality of CMV retinitis decreased during HAART era
HIV/AIDS-Related Infection - Large diversity of Candida species in HIV-infected patients in Brazil
HIV/AIDS-Related Infection - Oral/intraocular CMV retinitis treatment more cost effective than i.v. treatment
Head and Neck Cancer - Mutant p27 gene elicits anticancer effects in oral cancer cell lines
Health Education - HPV test maker supports cervical cancer and HPV information campaign
Healthcare Coverage - Guidant applauds proposed coverage of carotid artery stenting
Healthcare Coverage - Ohio insurance company offers coverage for alternative medical care
Healthcare Marketing - Dialog Group signs exclusive marketing agreement
Heart Attack - Can sudden cardiac death be treated?
Heart Attack - Investigational agent comparable to Plavix in treatment of heart disease
Heart Disease - Rosiglitazone did not affect flow-mediated dilation of brachial artery
Heart Failure - Nebivolol effective in elderly study patients with chronic heart failure
Helicobacter Pylori - Stool antigen test for H. pylori infection reliable 4-6 weeks post-treatment
Hematology - Autocrine mechanisms sustain vascular endothelial growth factor 189 secretion
Hematology - Biopharma company confirms evidence of PBI-1402's positive effect
Hematology - Differential domains of heparin affin regulatory peptide regulate angiogenesis
Hematology - Microvessel status is divergent in blood cancers and bone marrow metastases
Hematology - Rituximab may have use in hemophilia with inhibitors
Hepatitis - Application filed to market Pegasys for hepatitis and AIDS coinfection
Hepatitis - Conserved hepatitis C E2 protein binding regions steer T-cell binding affinity
Hepatitis B Vaccine - Dendritic cell vaccine for hepatitis B infection therapy is promising
Hepatitis B Vaccine - Hepatitis vaccine nonresponse linked to impaired lymphocyte activation
Hepatitis B Virus - Structure of glycans in hepatitis B virus surface proteins determined
Hepatitis Delta Virus - Large hepatitis D virus antigen regulates amber/W editing and viral assembly
Hepatitis Vaccine - Enrollment complete for phase II/III hepatitis B prophylactic vaccine trial
Hereditary Angioedema - Pivotal registration study initiated for Icatibant in hereditary angioedema
Herpesvirus - ER processing and mitochondrial importation of UL37 proteins related in CMV
Herpesvirus - HHV-8-GPCR involvement in KS pathogenesis elucidated
Herpesvirus - HSV-2 EIAs vary in sensitivity/specificity of sub-Saharan African samples
Herpesvirus - NF-kappa B induction required in production of replication-competent HHV-8
Herpesvirus Vaccine - HSV-1 vaccine prevents clinical changes of HSV-1 encephalitis
Human Growth Hormone - FDA defers decision on Omnitrope application
Hypertension - 24-hour BP control should be part of antihypertensive drug treatment strategies
Hypertension - Data presented from STRIDE-1 trial in pulmonary arterial hypertension
Hypertension - Mice with P465L PPAR-gamma exhibit hypertension and abnormal fat distribution
Hypertension - Molecular basis of obesity-related hypertension poorly understood
Hypertension - Vitamin D may be an important endocrine regulator of blood pressure
Hypertension & Stroke - Teveten reduces risk of second stroke in hypertensive stroke patients
Hypovitaminosis D - Hypovitaminosis D poses serious health issue in sunny and cold climates in U.S.
Illegal Drug Use - Use of illegal drugs among youths declining, prescription drugs increasing in U.S.
Immune Reactions - Antisecretory factor found to play unsuspected role in regulating immune system
Immunizations - Childhood vaccinations are seen as important, but parental worries persist
Immunology - Effect of local anesthetics on monocyte receptor expression determined
Immunology - Fine-needle aspiration biopsies predict how hepatitis C will respond to therapy
Immunology - Human CC chemokine CCL15 exhibits proangiogenic activity
Immunology - MKP5 may be a novel target for therapeutic intervention of immune diseases
Immunology - Neonatal IFN-gamma responses may influence antiviral activity
Immunology - Nucleosome-specific genetically engineered T cells staunch autoimmune disease
Immunology - Sphingosine kinase 1 knockdown vanquishes proinflammatory mediators
Implantable Cardioverter Defibrillators - Inappropriate therapies occur in high rates in children and adolescents with ICDs
Infection - A select series of steps guides hepatitis B virus entry into cells
Inflammation - Genipin displays anti-inflammatory and antiangiogenic properties
Inflammatory Diseases - Vitaxin trials discontinued in rheumatoid arthritis and psoriasis
Influenza - "Defensive" action demonstrated by viruses
Influenza - Antiviral medication Tamiflu to play role in pandemic flu preparedness
Influenza - Distributor of medical products comments on availability of influenza vaccine
Influenza - Pharmaceutical firm provides update on flu vaccines for 2004-2005
Information Technology - Configurable chemical inventory system launched for multisite applications
Information Technology - New drug target databases released
Information Technology - New pharmaceutical method validation software launched
Information Technology - Security vendor installs products at Chicago hospitals
Information Technology - Software company releases new adverse event reporting software
Information Technology - Technology company releases acuity, productivity and benchmarking system
Information Technology - Technology could bring personalized medicine one step closer to reality
Insomnia - Positive results reported from indiplon modified release 15 mg trial in insomnia
Insulin - Exenatide new drug application accepted for review by the FDA
Insulin - Sequences of B-chain of insulin determine folding behavior
Insulin Delivery - Oral delivery of insulin accomplished using intestinal patches
Insulin Resistance - Adenovirus-mediated chronic 'hyper-resistinemia' causes insulin resistance
Insulin Resistance - Aerobic exercise training improvement in insulin resistance reviewed
Insulin Resistance - Insulin resistance and the endothelium reviewed
Insulin Resistance - Insulin resistance enhanced in adrenomedullin-deficient mice
Irritable Bowel Syndrome - Cilansetron NDA granted priority review for IBS with diarrhea predominance
Ischemic Heart Disease - Raloxifene lowers cardiac ischemia susceptibility in ovariectomized rats
Kaposi Sarcoma - HAART has reduced the risk of Kaposi sarcoma
Latino Health Issues - Cancer-prevention expert joins cancer research facility
Legal Issues - Agency gets guilty pleas
Legal Issues - Attorney for family of drug trial suicide victim questions U.S. FDA
Legal Issues - Biopharmaceutical company updates enzyme-related U.S. patent litigation
Legal Issues - Pharma company files suit against Internet sites selling illegal Lipitor
Leishmaniasis - Health conditions should be considered in Leishmaniasis
Leptin Studies - mRNA expression of adipocyte-derived factors affected by fasting and leptin
Leukemia - Identification of biochemical pathway could lead to new treatments
Lipid Peroxidation - Antioxidant effects of ferulic acid elucidated
Lipid Studies - Adiponectin protects LPS-induced liver injury through modulation of TNF-alpha
Lipid Studies - Cessation of physical activity induces lipid profile disorders in athletes
Lipid Studies - Fatty acid-binding proteins reviewed
Lipid Studies - Serum leptin levels decrease during prolonged high altitude exposure
Listeria - Listeria innocua strains with L. monocytogenes genes reported
Liver Cancer - 1,25-Dihydroxyvitamin D-3 is a potent hepatocellular carcinoma destroyer
Liver Cancer - FDA will allow trials for the use of ThermoDox with RFA for liver cancer
Liver Fibrosis - Hepatitis B virus X antigen activates fibrinogen gene expression
Lung Cancer - BLP25 liposome vaccine phase IIb data to be subject of presentation
Lung Cancer - Lung carcinogenesis in hamsters is inhibited by green tea
Lung Cancer - Phase I/II trial of satraplatin in combination with radiation therapy opens
Lupus - Recognition of vasculitis in lupus erythematosus key to reducing mortality
Lymphoma Therapy - Rituximab with chemotherapy shows promise for splenic MZL treatment
Macular Degeneration - Confidence in Visudyne's potential reiterated for macular degeneration
Malaria - Biotech corporation creates private foundation to help fight infectious diseases
Malaria - Math model studies effect of environmental fluctuations on malignant malaria
Malaria Transmission - Anopheles quadrimaculatus distribution and role in malaria reported
Market Analysis - Biotech market simmers in August
Market Analysis - Half of pharma deals are driven by the need to fill gaps in pipeline
Marketing Agreement - Galderma extends relationship marketing program
Medical Devices - Diagnostic microarray system launched by partnership in European Union
Medical Devices - Research results on nocturnal polyuria presented at meeting, test kit introduced
Medical Equipment - Diagnostic systems maker receives U.S. FDA clearance on antibacterial test label
Medication Compliance - Many patients never tell doctors they underuse medications because of costs
Melanoma - Curcumin studied as a potential therapy for patients with melanoma
Melanoma - Researchers find that DNA fragments can destroy skin cancer cells
Melanoma - Synthetic peptide may play key role in cancer immune therapies
Melanoma Vaccine - Response to melanoma dendritic cell vaccine provides therapy insights
Menopause - Drospirenone/estradiol safe, effective for treating climacteric symptoms
Mergers & Acquisitions - Healthcare sales and marketing company acquires assets of Pharmakon
Mergers & Acquisitions - Research services organization has acquired clinical development company BBCI
Mergers & Acquisitions - Shiprock acquires private biopharm, changes name and trade symbol, issues stock
Mergers & Acquisitions - Zonulin technologies acquired from UMB
Mergers and Acquisitions - Aesgen, Inc., acquired for $32 million
Mergers and Acquisitions - Subsidiary of U.S. pharmaceutical company to acquire France-based Biapharm
Metabolic Disease - Virus vector-mediated gene transfer corrects phenylketonuria in murine models
Metabolic Syndrome - Proteomics company announces research agreement with Baylor College of Medicine
Metabolism - High glucose levels alter vascular cytokines and capillary structure
Metabolism - Metabolic abnormalities found in HIV-infected patients 1 year following HAART
Metabolism - Metabolic abnormalities from HAART may be future cause of mortality
Metabolism - The major zinc transporter families harbor contrasting characteristics
Microbial Biofilms - Molecular analysis finds microbes on vinyl shower curtains
Microbial Genomics - Fission yeast bear mammalian-like properties
Motor Nerves - Beta-bungarotoxin-induced depletion of synaptic vesicles studied
Mucosal Immunization - Overcoming barriers to mucosal immunity reviewed
Multiple Sclerosis - Fatigue test scores in multiple sclerosis patients correlate with depression
Muscular Dystrophy - Biopharmaceutical company awarded grant from muscular dystrophy association
Mutagenesis - Renal phosphate wasting plagues patients with X-linked lissencephaly
Mutagenesis - Screenings for redundancies could cure many genetically-related disorders
Myelodysplastic Syndromes - Worldwide license agreement announced for Dacogen
Myocardial Infarction - Adherence to guidelines results in better heart outcomes for diabetics
Myocardial Infarction - Bone marrow stromal cells renew cardiac function in healed infarcted hearts
Myocardial Infarction - Canadian regulatory clearance received for RAMP Cardiac Marker Tests
Neovascularization - Canine hemangiosarcoma derivatives model the biology of human endothelial cells
Nephrology - Renal vascular endothelial growth factor levels change after ischemia induction
Nerve Healing - FDA issues 510(k) clearance for NeuraWrap Nerve Protector
Neurodegeneration - Mutants of familial amyotrophic lateral sclerosis patients have the same origin
Neurodegeneration - Neural stem cells have the potential for reconstructing damaged nervous systems
Neurology - Effects of zolpidem on motor behavior determined in rats
Neuropharmacology - Decrease in binding affinity to CRF1 correlated with alpha-helicity decrease
Neuroscience - ATP1A3 gene mutations mark rapid-onset dystonia parkinsonism
Neuroscience - Glial cell line-derived neurotrophic factor lowers tyrosine hydroxylase levels
Non-Hodgkin Lymphoma - Chemokines drive migration of malignant B cells in non-Hodgkin lymphomas
Nutrition - Cancer experts respond to U.S.D.A. dietary guidelines report
Nutrition - Some changes in markers of oxidative damage correlate with seasonal diet changes
Obesity - Health department announces revised growth-screening program for schools
Obesity - Study confirms benefits of Rimonabant in weight loss, waist circumference
Obesity Pathogenesis - IGF-I stimulates cell growth and lipogenesis during adipocyte differentiation
Obesity Risk Factor - Ghrelin and measures of satiety are altered in polycystic ovary syndrome
Obesity Surgery - Plasma ghrelin levels rise after weight loss from gastric banding
Obesity Therapy - Croatian experience with sibutramine for obesity treatment described
Obesity and Diabetes - Calpain-10 gene variation linked to elevated triglyceride levels
Obesity and Diabetes - Cellular approach to prevent insulin resistance through exercise presented
Obesity and Diabetes - Family of Acrp30/adiponectin structural and functional paralogs reviewed
Obesity and Diabetes - Glucose uptake reduction by peroxynitrite concurrent with receptor nitration
Obesity and Diabetes - Insulin resistance correlated with visceral fat to skeletal muscle ratio
Obesity and Diabetes - Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors
Obesity and Diabetes - Lipoplasty improves metabolic parameters in diabetic patients
Obesity and Diabetes - Metabolic activations may lead to obesity and diabetes therapies
Obesity and Diabetes - T-cadherin is receptor for hexameric and high-molecular-weight adiponectin
Obesity and Diabetes - Weight loss and exercise reviewed
Obstetrics - Angiogenesis prevails in the upper zone of the endometrium in early pregnancy
Obstetrics - Antenatal corticosteroid regimen for respiratory distress reaches both twins
Obstetrics - German-Austrian recommendations for HIV therapy in pregnancy updated
Obstetrics - Some pregnant women are prescribed unsafe drugs
Ocular Disease - Scientists discuss antioxidants for ideal ocular nutritional supplement
Oncogene - The interference of urokinase promoter hypomethylation fights metastasis
Oncology - Bone marrow angiogenesis predicts the response of myeloma to high-dose therapy
Oncology - RNA molecules have shown promise as cancer therapy
Oncology - VEGF D and flt-4t are targets for the prevention of lymph node metastasis
Oncovirus - Occult hepatitis B virus in liver cancer is uncommon where chronicity is low
Oral Tumors - Citrus liminoids show some anticancer activity against oral tumors
Orthopedics - Use of beta-blockers associated with decreased risk for fractures
Osteogenesis - Vascular endothelial growth factor helps bone replace cartilage after birth
Osteoporosis - Strontium ranelate promising therapy for postmenopausal bone loss
Osteoporosis - Teriparatide called "breakthrough" in treatment of severe osteoporosis
Osteoporosis - Two steroid synthesis inhibitors boost bone health, lower cholesterol in rats
Ovarian Cancer - Cell models developed as tools to assess ovarian carcinoma chemoresistance
Ovarian Cancer - Heat therapy increases efficacy of melphalan treatment in rat study
Ovarian Cancer - Insurance firm joins Ovarian Cancer National Alliance
Ovarian Cancer - Polymorphism may serve as marker for chemotherapy options
Ovarian Cancer - siRNA modulation of gene expression sensitizes drug-resistant cancer cells
Ovarian Cancer Vaccine - Immunotherapy of ovarian cancer with antibodies reviewed
Pain Medicine - Pharmacokinetics of subcutaneously administered apomorphine reviewed
Pancreatic Cancer - FDA orphan drug designation granted for AGRO100 in pancreatic cancer
Pancreatic Islets - Pancreatic islets abnormal in pancreatic polypeptide-overexpressing mice
Parkinson Disease - FDA approves Parcopa orally dissolving tablets for Parkinson disease
Parkinson Disease - FDA grants final approval for Parcopa
Parkinson Disease - Proteins delivered via engineered virus prevented loss of nerve cells
Patents - Agreement signed to license patent from M.D. Anderson Cancer Center
Patents - Antibody screening technology patent granted by the European Patent Office
Patents - Company announces termination of litigation with Novartis
Patents - Patent issued for compounds that target cancer drug delivery
Patents - Patent protection strengthened for novel approach to cancer therapy
Pathology - Liver biopsies are essential for evaluating patients with chronic hepatitis C
Pathology - Lymphangiogenesis has prognostic significance in lymphangioleiomyomatosis
Peripheral Artery Disease - Clinical trial begins for therapy designed to grow new blood vessels
Personnel - Biopharma company appoints new president and CEO
Personnel - Biopharmaceutical firm appoints three new members to board of directors
Personnel - Biopharmaceutical production company appoints executives to senior management
Personnel - Cancer-vaccine maker appoints Konstantine Sarafis as COO
Personnel - Craig R. Smith, MD, will retire as chairman, president, and CEO
Personnel - Diagnostic imaging services elects new board member
Personnel - Diagnostics-focused EviMed company names two to key executive positions
Personnel - Dr. Carolyn F. Sidor named chief medical officer of cancer-focused company
Personnel - Drug discovery company strengthens its supervisory board
Personnel - E-drug company names Kirk Kirkman, Brent Sanders to vice presidential posts
Personnel - ECO-04601 maker expands its drug development team
Personnel - Harry Mansbach, MD, named chief medical officer and VP, clinical development
Personnel - Infection control company hires new executive VP, COO
Personnel - Jacquesson becomes head of business development for pharma company
Personnel - James Frates joins supervisory board of satraplatin maker
Personnel - Lenny Liscio leaves functional genomics company
Personnel - Life science company's biological defense systems names advisory board
Personnel - Medical products company appoints new chairman, CEO
Personnel - New CEO named at pharmaceutical firm
Personnel - New chief staff officer named for diabetes group
Personnel - Noam Shani, PhD, named VP of genomics-based company
Personnel - Nola Masterson, David Poorvin nominated for pharmaceutical company board seats
Personnel - Non-independent board member seeks removal of independent board members
Personnel - Pharmaceutical company appoints regulatory affairs executive
Personnel - Pharmaceutical firm names Albert Stroucken to board of directors
Personnel - Protein therapeutics firm expands board of directors
Personnel - Richard Hall named director of oncology-focused drug company
Personnel - Steve Cottrell named interim president of development by pharmaceutical company
Personnel - U.S. merchant banker appointed to board of Australian biotechnology company
Pharmacologic Stress - Regadenoson holds significant potential as a pharmacologic stress agent
Pill Swallowing - Analgesic throat spray for pill swallowing to make early release
Pneumocystis Infection - DHPS gene mutation found in P. jiroveci isolates from sulfonamide-naïve patients
Pompholyx - Pharmacotherapy of pompholyx include topical and systemic treatments
Prediabetes - Most people with CVD or risk factors have diabetes or glycemic abnormalities
Prescription Drugs - Common antibiotic can trigger cardiac deaths when used with other drugs
Prescription Drugs - Minnesota gets approval for Medicaid drug pooling program
Professional Education - Educational tools provider launches new prescription drug quick reference guide
Prostate Cancer - CX3CR1-fractalkine expression regulates prostate cancer cellular mechanisms
Prostrate Cancer - Alpharadin phase II trial extended for prostate cancer to U.K.
Proteomics - Angiopoietin-related/angiopoietin-like proteins police new vessel growth
Proteomics - Increase in embryo morphogenesis by insulin linked to altered gene expression
Proteomics - Novel proteomics approach identifies biomarkers for variety of diseases
Proteomics - Nucleotide exchange factor ECT2 regulates PKC xi activity
Proteomics - Rat multidrug resistance protein 4 cloned and characterized
Proteomics - Researchers publish study on methodology for analyzing reverse phase arrays
Psoriasis - Promising results reported on new oral psoriasis treatment
Psychiatry - A new inducible knock-out system expands genetic exploration of the brain
Psychotropic Drugs - FDA grants SPA for 2 pivotal phase III trials of CORLUX
Pulmonary Sarcoidosis - Possible remedy for pulmonary sarcoidosis discovered
Radiology - Radiation therapy provider announces cessation of Theseus operations
Recombinant Research - Lymphoblastoid interferon may clear hepatitis B better than recombinant therapy
Regulatory Issues - FDA makes correction: Extina user fee goal date is November 26, 2004
Renal Cell Carcinoma - Metronomic chemotherapy shows antiangiogenic activity in renal cancer models
Reproductive Medicine - Idiopathic premature ovarian failure is not linked to FOXL2 gene mutations
Respiratory Disease - Pirfenidone attenuates heat shock protein 47 in pulmonary fibrosis models
Respiratory Disease - Reverse genetics creates a recombinant human metapneumovirus
Respiratory Medicine - Multitarget vaccine against respiratory infections may be possible
Respiratory Medicine - Utility of asthma drug delivery devices compared in young children
Restenosis - Treatment strategy may target the interaction between platelets and neutrophils
Resynchronization Therapy - Cardiac resynchronization can improve synchrony of ventricular contractility
Retinitis Pigmentosa - Omega-3 fatty acids do not slow eye disease in patients receiving vitamin A
Retrovirology - Tal regulates receptor endocytosis and retrovirus budding
SARS - Laboratory and clinical features of SARS is described
SARS - Simultaneous multigene DNA sequencing identifies SARS coronavirus
SARS - Traditional antimalarial drug works against coronavirus infection
SARS Virus - Method to detect coronavirus nucleocapsid protein in SARS patients developed
Salmonella - Multidrug-resistant typhoid result of 1-2 clones with single resistant plasmid
Salmonella - Probiotics prevent Salmonella fecal shedding in hospitalized horses
Sickle Cell Disease - Milestone payment issued for ongoing development of sickle cell disease therapy
Skin Cancer - Data presented on skin cancer product Carcinoderm
Skin Cancer - PEPOO5 Topical trials initiated in non-melanoma skin cancer, actinic keratosis
Small Cell Lung Cancer - ProGRP does not show independent prognostic significance as SCLS biomarker
Smallpox Vaccine - Virus B5R protein antibodies neutralize vaccinia immune globulin
Spinal Cord Injury - Leukemia inhibitory factor is therapeutic target in spinal cord injury
Staphylococcus Aureus - Berlin MSRA clone with low-level oxacillin resistance predominant in Netherlands
Staphylococcus Aureus - Math model explains MRSA outbreaks and success/failure of control measures
Statins - All statins are not interchangeable as lipid-lowering therapy
Stem Cell Research - Bone marrow stromal cells alternative source for SCT in liver repair
Stem Cell Research - Delayed rectifier K+ current activation in stem cells related to apoptosis
Stem Cell Research - Failure to express GAP-43 inhibits astrocyte differentiation
Stem Cell Research - Growth factor combination important key for chondrogenesis induction
Stem Cell Research - Hypothesis of plasticity of adult stem cells is explored
Stem Cell Research - Novel system characterizes the expression of totipotency-specific genes
Stem Cell Research - m-Calpain has role in control of muscle precursor cell activation
Steroids - Oxandrolone blocks glucocorticoid signaling in androgen receptor-dependent way
Streptococcus Vaccine - Group A streptococcal vaccine with broad coverage being developed
Stroke - Independent review reaffirms benefit of clot-buster tPA for stroke
Supply Agreement - Company expands RNAi supply agreement with Wyeth
Systemic Lupus Erythematosus - Cancer drug may reduce kidney disease in lupus
Systemic Lupus Erythematosus - Prasterone reduces disease flares, improves blood lipid levels in clinical trial
Technology - Super computing resources assembled for medical research by software developer
Testicular Carcinoma - Genome-wide gene expression profiling identifies testicular CIS genes
Tissue Engineering - Gelatin-based adhesive has fibrin sealant benefit without use of blood products
Tissue Engineering - Novel nerve guidance scaffolds for spinal cord injury developed
Tobacco Smoke Exposure - Urinary cotinine/creatinine ratio measures children's exposure to tobacco smoke
Tobacco Use - Chromosomal factors contribute to smoking practices in the Netherlands
Tobacco Use - No ethnic differences observed in smoking topography or cardiovascular response
Transfusion Medicine - Fatalities caused by transfusion-related acute lung injury reviewed
Transplant Medicine - FDA issues approvable letter for Certican
Transplantation Medicine - Korean government regulations on cellular therapy outlined
Tuberculosis - Hierarchy of control technologies improve health care facility infection control
Tuberculosis - Simple assay monitors treatment for pulmonary tuberculosis
Tuberculosis - Unusual case of tuberculous epididymitis reported
Tuberculosis Risk Factor - Tuberculosis associated with etanercept, a tumor necrosis factor inhibitor
Tuberculosis Vaccine - IL-4 expression increased in cells from contacts of M. tuberculosis
Tumor Suppression - Thrombospondin-1 type 1 repeats up-regulate TGF-beta to defeat cancer growth
Type 1 Diabetes - B7.1 molecule expression abrogates need for CD4 T cells in type 1 diabetes
Type 1 Diabetes - Diabetic children learn to estimate blood glucose by careful self-monitoring
Type 1 Diabetes - IA-2, GAD, and topoisomerase autoantibodies found in type 1 diabetic patients
Type 1 Diabetes - Inhibiting advanced glycation end product receptor blocks type 1 diabetes
Type 1 Diabetes - Recurrent hepatomegaly due to glycogen storage reported in diabetic patient
Type 2 Diabetes - IHPK1 gene disrupted in family with type 2 diabetes
Vaccine Adjuvant - Toll-like receptor agonists as vaccine adjuvants reviewed
Vaccine Delivery - Improved delivery enhances vaccine potency
Vaccine Delivery - Ultrasound and transdermal drug delivery reviewed
Vaccine Development - Enrichment of monospecific polyclonal antibodies reported
Vaccine Safety - Fever after immunization reviewed
Vaccinia Vaccine - Vaccinia virus-specific CD8+ CTL responses may indicate immunogenicity
Varicella-Zoster Virus - Three major genotypes of varicella-zoster virus identified
Vascular Gene Therapy - NIH awards grant to conduct research for vascular gene delivery
Vector Development - Cyclodextrin-modified polyethylenimine polymers deliver genes without toxicity
Vector Development - Lipoplexes bearing triantennary galactosyl ligand strengthen gene transfer
Vectors - FIV-based lentiviral vector used for gene delivery to treat metabolic diseases
Vibrio - Diversity and dynamics of north Atlantic coastal Vibrio community reported
Viral Genomics and Genetics - Adaptive mutations favor the replication of hepatitis C virus genotype 1a
Virology - Alpha-dystroglycan fragment with virus receptor sites characterized
Virology - Common viruses use La autoantigen for IRES-dependent translation
Virology - L surface antigen regulates superinfection exclusion in hepadnavirus infections
Women's Health - Foundation distributes information for women on cancer treatment
Wound Care - Recombinant human erythropoietin heals ischemic skin wounds
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