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Obesity and Diabetes

Calpain-10 gene variation linked to elevated triglyceride levels

Published in Drug Week, October 1st, 2004

Variation in the calpain-10 gene is associated with elevated triglyceride levels and reduced adipose tissue messenger ribonucleic acid expression in obese Swedish subjects.

"Our aim was to investigate the possible role of the type 2 diabetes susceptibility gene CAPN10 in obesity. A case control study consisting of 235 obese Swedish subjects [body mass index, 40 (35-45) kg/m2] and 235 controls matched for age and gender [body mass index, 22 (21-24) kg/m2], and a transmission disequilibrium test consisting of 116 parents-offspring trios, where the offspring was abdominally obese [waist, 100 (95-110) cm], were performed. CAPN10 mRNA expression was...

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